CY1107311T1 - Καμπτοθεκινες με εναν τροποποιημενο λακτονικο δακτυλιο - Google Patents

Καμπτοθεκινες με εναν τροποποιημενο λακτονικο δακτυλιο

Info

Publication number
CY1107311T1
CY1107311T1 CY20061101648T CY061101648T CY1107311T1 CY 1107311 T1 CY1107311 T1 CY 1107311T1 CY 20061101648 T CY20061101648 T CY 20061101648T CY 061101648 T CY061101648 T CY 061101648T CY 1107311 T1 CY1107311 T1 CY 1107311T1
Authority
CY
Cyprus
Prior art keywords
campaigns
modified
lacton
ring
lacton ring
Prior art date
Application number
CY20061101648T
Other languages
English (en)
Inventor
Mauro Marzi
Elena Marastoni
Sergio Penco
Claudio Pisano
Maria O Tinti
Loredana Vesci
Franco Zunino
Domenico Vergani
Tamara Danelli
Walter Cabri
Marco Allpegiani
Martin Patricio
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of CY1107311T1 publication Critical patent/CY1107311T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Ενώσεις του τύπου (Ι) ή (II) περιγράφονται: όπου οι ομάδες είναι όπως ορίζονται στην περιγραφή εδώ παρακάτω, τα ρακεμικά μείγματα, τα ξεχωριστά τους εναντιομερή, τα ξεχωριστά τους διαστερεοϊσομερή, τα μείγματα τους, και τα φαρμακευτικώς αποδεκτά άλατά τους. Οι εν λόγω ενώσεις είναι αναστολείς της τοποϊσομεράσης Ι.
CY20061101648T 2002-05-31 2006-11-14 Καμπτοθεκινες με εναν τροποποιημενο λακτονικο δακτυλιο CY1107311T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002RM000305A ITRM20020305A1 (it) 2002-05-31 2002-05-31 Camptotecine con anello lattonico modificato.
EP03730480A EP1511752B3 (en) 2002-05-31 2003-05-28 Camptothecins with a modified lactone ring

Publications (1)

Publication Number Publication Date
CY1107311T1 true CY1107311T1 (el) 2012-11-21

Family

ID=11456338

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20061101648T CY1107311T1 (el) 2002-05-31 2006-11-14 Καμπτοθεκινες με εναν τροποποιημενο λακτονικο δακτυλιο
CY20081101240T CY1108793T1 (el) 2002-05-31 2008-10-31 Καμπτοθεκινες με τροποποιημενο λακτονικο δακτυλιο

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20081101240T CY1108793T1 (el) 2002-05-31 2008-10-31 Καμπτοθεκινες με τροποποιημενο λακτονικο δακτυλιο

Country Status (22)

Country Link
US (1) US7273873B2 (el)
EP (2) EP1719775B1 (el)
JP (1) JP4693410B2 (el)
KR (1) KR101042042B1 (el)
CN (1) CN1656100A (el)
AR (1) AR040139A1 (el)
AT (2) ATE339422T1 (el)
AU (2) AU2003241160B2 (el)
BR (2) BR0311333A (el)
CA (2) CA2485201C (el)
CY (2) CY1107311T1 (el)
DE (2) DE60322754D1 (el)
DK (2) DK1511752T5 (el)
ES (2) ES2312090T3 (el)
IT (1) ITRM20020305A1 (el)
MX (1) MXPA04011682A (el)
PE (1) PE20050120A1 (el)
PL (1) PL374346A1 (el)
PT (2) PT1719775E (el)
SI (2) SI1719775T1 (el)
TW (1) TWI325866B (el)
WO (1) WO2003101995A2 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
ITRM20030344A1 (it) 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
DK2170900T3 (da) 2007-08-01 2013-03-11 Sigma Tau Ind Farmaceuti Krystallinsk form II af 7-(dimethoxy-methyl)camptothecin, dets anvendelse som mellemprodukt og produkter opnået derfra
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN104530066A (zh) * 2015-01-06 2015-04-22 华东师范大学 一类新型高喜树碱衍生物、制备方法和用途
SG11202111402PA (en) 2019-05-14 2021-11-29 Nuvation Bio Inc Anti-cancer nuclear hormone receptor-targeting compounds
US11952349B2 (en) 2019-11-13 2024-04-09 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
BR112023019420A2 (pt) * 2021-03-23 2023-10-24 Nuvation Bio Inc Compostos de direcionamento ao receptor de hormônio nuclear anticâncer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57116076A (en) * 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
FR2532591A1 (fr) 1982-09-02 1984-03-09 Hutchinson Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins
DK0835258T3 (da) * 1995-06-21 2003-02-03 Sod Conseils Rech Applic Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse
PT1044977E (pt) 1999-03-09 2002-09-30 Sigma Tau Ind Farmaceuti Derivados de camptotecina com actividade antitumoral

Also Published As

Publication number Publication date
DE60308368D1 (de) 2006-10-26
AU2003241160B2 (en) 2009-08-20
US7273873B2 (en) 2007-09-25
JP4693410B2 (ja) 2011-06-01
EP1719775B1 (en) 2008-08-06
WO2003101995A3 (en) 2004-02-19
AU2003241160A1 (en) 2003-12-19
DE60322754D1 (de) 2008-09-18
ATE339422T1 (de) 2006-10-15
CA2485201A1 (en) 2003-12-11
US20050154003A1 (en) 2005-07-14
DK1511752T5 (da) 2010-06-14
DK1511752T3 (da) 2007-01-29
JP2005531602A (ja) 2005-10-20
EP1511752B3 (en) 2010-03-10
AU2009236044A8 (en) 2011-07-21
EP1511752A2 (en) 2005-03-09
ATE403659T1 (de) 2008-08-15
EP1511752B8 (en) 2007-04-18
CA2485201C (en) 2010-11-02
AU2009236044B2 (en) 2011-03-24
DE60308368T3 (de) 2010-09-16
PE20050120A1 (es) 2005-03-04
SI1719775T1 (sl) 2009-04-30
AU2009236044B8 (en) 2011-07-21
ITRM20020305A0 (it) 2002-05-31
ES2312090T3 (es) 2009-02-16
AU2009236044A1 (en) 2009-12-03
DE60308368T2 (de) 2007-09-06
DK1719775T3 (da) 2008-11-17
TWI325866B (en) 2010-06-11
ES2273002T3 (es) 2007-05-01
AR040139A1 (es) 2005-03-16
BR0311329A (pt) 2005-02-22
KR101042042B1 (ko) 2011-06-16
CN1656100A (zh) 2005-08-17
SI1511752T1 (sl) 2007-02-28
BR0311333A (pt) 2005-03-15
EP1719775A1 (en) 2006-11-08
MXPA04011682A (es) 2005-03-31
TW200404806A (en) 2004-04-01
CA2706635A1 (en) 2003-12-11
PT1719775E (pt) 2008-09-30
ES2273002T7 (es) 2011-08-01
EP1511752B1 (en) 2006-09-13
ITRM20020305A1 (it) 2003-12-01
PT1511752E (pt) 2007-01-31
CY1108793T1 (el) 2014-04-09
WO2003101995A2 (en) 2003-12-11
KR20050036909A (ko) 2005-04-20
PL374346A1 (en) 2005-10-17
WO2003101995A8 (en) 2004-12-23

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