CU23973B1 - Anticuerpos neutralizadores contra el receptor de prolactina - Google Patents

Anticuerpos neutralizadores contra el receptor de prolactina

Info

Publication number
CU23973B1
CU23973B1 CU2012000093A CU20120093A CU23973B1 CU 23973 B1 CU23973 B1 CU 23973B1 CU 2012000093 A CU2012000093 A CU 2012000093A CU 20120093 A CU20120093 A CU 20120093A CU 23973 B1 CU23973 B1 CU 23973B1
Authority
CU
Cuba
Prior art keywords
prolactin receptor
benign
antibodies against
neutralizing antibodies
treatment
Prior art date
Application number
CU2012000093A
Other languages
English (en)
Other versions
CU20120093A7 (es
Inventor
Christiane Otto
Siegmund Wolf
Christoph Freiberg
Axel Harrenga
Simone Greven
Mark Trautwein
Sandra Bruder
Andrea Eicker
Andreas Wilmen
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42091520&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU23973(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of CU20120093A7 publication Critical patent/CU20120093A7/es
Publication of CU23973B1 publication Critical patent/CU23973B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

El anticuerpo neutralizador contra el receptor de prolactina 005-C04, formas maduras de éste y fragmentos de unión al antígeno de éste. Composiciones farmacéuticas que los contienen. Su uso en el tratamiento o la prevención de trastornos e indicaciones benignos mediados por el receptor de prolactina, tales como la endometriosis, la adenomiosis, la anticoncepción femenina no hormonal, la enfermedad mamaria benigna y la mastalgia, la inhibición de la lactancia, la hiperplasia prostática benigna, los fibroides, la pérdida de cabello hiper y normoprolactinémica, y como tratamiento concurrente en una terapia hormonal combinada, con el fin de inhibir la proliferación de las células del epitelio mamario. Los anticuerpos de la invención bloquean la señalización mediada por el receptor de prolactina.
CU2012000093A 2009-12-10 2012-06-07 Anticuerpos neutralizadores contra el receptor de prolactina CU23973B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09075546A EP2332995A1 (en) 2009-12-10 2009-12-10 Neutralizing prolactin receptor antibodies and their therapeutic use
PCT/EP2010/067747 WO2011069799A1 (en) 2009-12-10 2010-11-18 Neutralizing prolactin receptor antibodies and their therapeutic use

Publications (2)

Publication Number Publication Date
CU20120093A7 CU20120093A7 (es) 2012-10-15
CU23973B1 true CU23973B1 (es) 2013-12-27

Family

ID=42091520

Family Applications (2)

Application Number Title Priority Date Filing Date
CU2012000093A CU23973B1 (es) 2009-12-10 2012-06-07 Anticuerpos neutralizadores contra el receptor de prolactina
CU2012000092A CU20120092A7 (es) 2009-12-10 2012-06-07 Anticuerpos neutralizadores contra el receptor de prolactina

Family Applications After (1)

Application Number Title Priority Date Filing Date
CU2012000092A CU20120092A7 (es) 2009-12-10 2012-06-07 Anticuerpos neutralizadores contra el receptor de prolactina

Country Status (40)

Country Link
US (6) US20120321632A1 (es)
EP (13) EP2332995A1 (es)
JP (7) JP6066474B2 (es)
KR (2) KR101790366B1 (es)
CN (6) CN102884082B (es)
AP (1) AP2012006343A0 (es)
AR (6) AR079351A1 (es)
AU (2) AU2010330161B2 (es)
BR (2) BR112012015852B8 (es)
CA (6) CA2783610C (es)
CL (2) CL2012001540A1 (es)
CR (2) CR20120310A (es)
CU (2) CU23973B1 (es)
CY (2) CY1118209T1 (es)
DK (2) DK2510006T3 (es)
DO (2) DOP2012000159A (es)
EA (2) EA029327B1 (es)
EC (2) ECSP12011966A (es)
ES (2) ES2610654T3 (es)
GT (1) GT201200186A (es)
HK (2) HK1180354A1 (es)
HR (2) HRP20161401T1 (es)
HU (2) HUE031631T2 (es)
IL (2) IL220149A (es)
IN (2) IN2012DN05082A (es)
LT (2) LT2510006T (es)
MA (1) MA33888B1 (es)
ME (1) ME02577B (es)
MX (2) MX339343B (es)
NZ (2) NZ600512A (es)
PE (3) PE20171134A1 (es)
PL (2) PL2510002T3 (es)
PT (2) PT2510002T (es)
RS (2) RS55277B1 (es)
SG (2) SG181511A1 (es)
SI (2) SI2510006T1 (es)
TN (1) TN2012000294A1 (es)
TW (5) TW201138817A (es)
WO (6) WO2011069799A1 (es)
ZA (2) ZA201204214B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2332995A1 (en) * 2009-12-10 2011-06-15 Bayer Schering Pharma Aktiengesellschaft Neutralizing prolactin receptor antibodies and their therapeutic use
LT2542257T (lt) 2010-03-01 2017-11-27 Bayer Healthcare Llc Optimizuoti monokloniniai antikūnai prieš audinių faktoriaus kelio slopiklį (tfpi)
EP2530089A1 (en) * 2011-06-03 2012-12-05 Bayer Pharma Aktiengesellschaft Neutralising prolactin receptor antibody Mat3 and its therapeutical use
EP3421488A3 (en) 2012-03-14 2019-04-17 Regeneron Pharmaceuticals, Inc. Multispecific antigen-binding molecules and uses thereof
US8883979B2 (en) * 2012-08-31 2014-11-11 Bayer Healthcare Llc Anti-prolactin receptor antibody formulations
US9592297B2 (en) * 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
MX359532B (es) 2012-12-24 2018-10-01 Abbvie Inc Proteinas de union al receptor de prolactina y usos de las mismas.
AR095496A1 (es) 2013-03-15 2015-10-21 Bayer Healthcare Llc Formulaciones de anticuerpos anti-receptor de prolactina
US9545451B2 (en) 2013-08-21 2017-01-17 Regeneron Pharmaceuticals, Inc. Anti-PRLR antibodies and methods for killing PRLR-expressing cells
TWI641620B (zh) 2013-08-21 2018-11-21 再生元醫藥公司 抗－ｐｒｌｒ抗體及其用途
US10308697B2 (en) 2014-04-30 2019-06-04 President And Fellows Of Harvard College Fusion proteins for treating cancer and related methods
EP3200823B1 (en) 2014-10-02 2022-11-23 City of Hope Multivalent meditopes, meditope-binding antibodies and uses thereof
KR20170105558A (ko) 2015-01-30 2017-09-19 각코우호우징 사이타마이카다이가쿠 항 alk2 항체
EP3319994B1 (en) 2015-07-06 2024-02-07 Regeneron Pharmaceuticals, Inc. Multispecific antigen-binding molecules and uses thereof
WO2017190079A1 (en) 2016-04-28 2017-11-02 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
MX2019006131A (es) 2016-11-29 2019-08-21 Regeneron Pharma Metodos para tratar cancer de mama positivo para prlr.
FR3062213B1 (fr) * 2017-01-20 2021-02-26 Endodiag Utilisation du recepteur cd71 dans la detection et le traitement de l’endometriose
TW201836647A (zh) 2017-04-06 2018-10-16 美商艾伯維有限公司 抗－ｐｒｌｒ抗體藥物軛合物（ａｄｃ）及其用途
JP2020519639A (ja) * 2017-05-12 2020-07-02 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． トリアザスピロ［４．５］デカノンによる胃不全麻痺の処置
EP3652205A1 (en) 2017-07-10 2020-05-20 Bayer Pharma Aktiengesellschaft Prolactin receptor antibody for male and female pattern hair loss
WO2019157224A1 (en) 2018-02-07 2019-08-15 Regeneron Pharmaceuticals, Inc. Methods and compositions for therapeutic protein delivery
WO2019169330A1 (en) * 2018-03-02 2019-09-06 Oncolix, Inc. Method for treating cancers expressing prolactin receptor
CN109627340B (zh) * 2018-12-05 2021-02-12 上海交通大学 Cd3和prlr双特异性抗体及其构建与应用
US10467487B1 (en) * 2018-12-11 2019-11-05 Chongqing Jinkang New Energy Automobile Co., Ltd. Fusion-based traffic light recognition for autonomous driving
CN112425568A (zh) * 2020-12-11 2021-03-02 上海市计划生育科学研究所 一种建立具有emt特征的良性***增生bph犬模型的方法
UY39610A (es) 2021-01-20 2022-08-31 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
CN114853890B (zh) * 2022-03-16 2023-04-28 沈阳三生制药有限责任公司 一种prlr抗原结合蛋白及其制备方法和应用
CN114634574B (zh) * 2022-04-18 2022-12-20 先进生物(苏州)有限公司 抗B7H6的scFv抗体、其编码基因及其应用
CN117285625B (zh) * 2023-11-24 2024-01-23 南京佰抗生物科技有限公司 抗泌乳素蛋白的单克隆抗体及应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US4986615A (en) 1988-10-17 1991-01-22 The Vendo Company Vending apparatus
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
GB9105245D0 (en) * 1991-03-12 1991-04-24 Lynxvale Ltd Binding molecules
US5766886A (en) 1991-12-13 1998-06-16 Xoma Corporation Modified antibody variable domains
AU725609C (en) 1995-08-18 2002-01-03 Morphosys Ag Protein/(poly)peptide libraries
US6110471A (en) * 1996-09-13 2000-08-29 The Board Of Trustees Of The Leland Stanford Junior University Non-hormonal method of contraception
GB9701425D0 (en) 1997-01-24 1997-03-12 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
US6867187B2 (en) * 2000-12-22 2005-03-15 Trustees Of The University Of Pennsylvania Composition and method for modulating somatolactogenic function
EP1325930A1 (en) * 2002-01-08 2003-07-09 Institut National De La Sante Et De La Recherche Medicale (Inserm) Mammal prolactin variants
CA2509825A1 (en) * 2002-12-13 2004-07-01 The Ohio State University Antagonists for human prolactin
GB0305790D0 (en) * 2003-03-13 2003-04-16 Glaxosmithkline Biolog Sa Novel Composition
ATE541585T1 (de) * 2004-10-28 2012-02-15 Kyowa Hakko Kirin Co Ltd Antikörper gegen il-5-rezeptor zur verwendung in der behandlung von endometriose.
WO2006089678A2 (en) * 2005-02-22 2006-08-31 Bioinvent International Ab Antibodies and peptides binding to hiv tat, and uses thereof
GB0517878D0 (en) * 2005-09-02 2005-10-12 Bioinvent Int Ab Immunotherapeutic treatment
US7422899B2 (en) 2005-10-05 2008-09-09 Biogen Idec Ma Inc. Antibodies to the human prolactin receptor
EA201201533A1 (ru) * 2006-08-18 2014-11-28 Новартис Аг Prlr-специфическое антитело и его применения
WO2009013621A2 (en) 2007-05-30 2009-01-29 Auckland Uniservices Limited Inhibitors for growth hormone and related hormones, and methods of use thereof
EP2025683A1 (en) * 2007-08-13 2009-02-18 INSERM (Institut National de la Santé et de la Recherche Medicale) Variants of prolactin as antagonists of its receptor
EP2332995A1 (en) * 2009-12-10 2011-06-15 Bayer Schering Pharma Aktiengesellschaft Neutralizing prolactin receptor antibodies and their therapeutic use
WO2011139375A1 (en) * 2010-05-06 2011-11-10 Ludwig Institute For Cancer Research Ltd Antibodies directed against carbonic anhydrase ix and methods and uses thereof
GB201020995D0 (en) * 2010-12-10 2011-01-26 Bioinvent Int Ab Biological materials and uses thereof

Also Published As

Publication number Publication date
EA201200860A1 (ru) 2013-01-30
AU2010330161A1 (en) 2012-07-05
AU2010330165A1 (en) 2012-07-19
AR079348A1 (es) 2012-01-18
CU20120092A7 (es) 2012-10-15
JP6066474B2 (ja) 2017-01-25
PE20121561A1 (es) 2012-11-25
CR20120312A (es) 2012-08-27
PT2510006T (pt) 2017-01-20
LT2510002T (lt) 2016-11-25
ME02577B (me) 2017-06-20
JP2013513559A (ja) 2013-04-22
CN102858803A (zh) 2013-01-02
CN102884082B (zh) 2015-05-20
KR20120112527A (ko) 2012-10-11
AR079641A1 (es) 2012-02-08
HRP20161401T1 (hr) 2016-12-16
ZA201204214B (en) 2014-08-27
RS55589B1 (sr) 2017-06-30
GT201200186A (es) 2014-01-06
SG181511A1 (en) 2012-07-30
WO2011069797A1 (en) 2011-06-16
US20130171147A1 (en) 2013-07-04
TW201130504A (en) 2011-09-16
BR112012014048B1 (pt) 2021-10-26
US9241989B2 (en) 2016-01-26
CA2783654A1 (en) 2011-06-16
EP2510006A1 (en) 2012-10-17
EP2567977A1 (en) 2013-03-13
CA2783513C (en) 2018-08-14
JP2013513363A (ja) 2013-04-22
HUE031631T2 (en) 2017-07-28
EP2510007A1 (en) 2012-10-17
CA2783678A1 (en) 2011-06-16
HK1180700A1 (en) 2013-10-25
EP2510002B1 (en) 2016-08-24
NZ600512A (en) 2014-11-28
US9649374B2 (en) 2017-05-16
JP2013513364A (ja) 2013-04-22
WO2011069795A1 (en) 2011-06-16
US20130022606A1 (en) 2013-01-24
PE20121360A1 (es) 2012-10-11
EP2567979A1 (en) 2013-03-13
WO2011069799A1 (en) 2011-06-16
TW201138817A (en) 2011-11-16
BR112012015852A8 (pt) 2017-06-27
AR079352A1 (es) 2012-01-18
CU20120093A7 (es) 2012-10-15
ECSP12011965A (es) 2012-07-31
MX2012006621A (es) 2012-10-05
EP2510005A1 (en) 2012-10-17
ES2603352T3 (es) 2017-02-27
IL220151A0 (en) 2012-07-31
PL2510006T3 (pl) 2017-06-30
PL2510002T3 (pl) 2017-02-28
CL2012001540A1 (es) 2013-01-18
AU2010330165B2 (en) 2015-07-16
ZA201204213B (en) 2014-08-27
ES2610654T3 (es) 2017-04-28
EP2567978A1 (en) 2013-03-13
EP2510004A1 (en) 2012-10-17
EA028678B1 (ru) 2017-12-29
SG181513A1 (en) 2012-07-30
MA33888B1 (fr) 2013-01-02
US20130129739A1 (en) 2013-05-23
TW201130505A (en) 2011-09-16
TWI487536B (zh) 2015-06-11
CY1118407T1 (el) 2017-06-28
PE20171134A1 (es) 2017-08-09
US20130272968A1 (en) 2013-10-17
JP2013513365A (ja) 2013-04-22
CN102947338B (zh) 2015-11-25
CA2783513A1 (en) 2011-06-16
KR101790366B1 (ko) 2017-10-26
RS55277B1 (sr) 2017-02-28
AP2012006343A0 (en) 2012-06-30
CN102741291A (zh) 2012-10-17
AR079349A1 (es) 2012-01-18
BR112012015852B8 (pt) 2021-05-25
DOP2012000159A (es) 2012-09-30
AR079351A1 (es) 2012-01-18
EP2510002A1 (en) 2012-10-17
US20120321632A1 (en) 2012-12-20
LT2510006T (lt) 2016-12-12
EP2570435A1 (en) 2013-03-20
EP2510003A1 (en) 2012-10-17
TN2012000294A1 (en) 2013-12-12
CY1118209T1 (el) 2017-06-28
IN2012DN05078A (es) 2015-10-23
HUE030143T2 (en) 2017-04-28
EP2570436A1 (en) 2013-03-20
JP6199930B2 (ja) 2017-09-20
TW201130507A (en) 2011-09-16
SI2510002T1 (sl) 2016-12-30
AR079350A1 (es) 2012-01-18
DOP2012000160A (es) 2012-09-30
TW201130506A (en) 2011-09-16
CA2783610A1 (en) 2011-06-16
MX339343B (es) 2016-05-20
TWI508744B (zh) 2015-11-21
DK2510002T3 (en) 2016-11-28
CA2783514A1 (en) 2011-06-16
JP2013513361A (ja) 2013-04-22
WO2011069796A1 (en) 2011-06-16
US20120315276A1 (en) 2012-12-13
PT2510002T (pt) 2016-11-23
EA029327B1 (ru) 2018-03-30
NZ600511A (en) 2014-01-31
WO2011069798A1 (en) 2011-06-16
IL220149A0 (en) 2012-07-31
JP2015180690A (ja) 2015-10-15
JP2013513362A (ja) 2013-04-22
SI2510006T1 (sl) 2017-02-28
DK2510006T3 (en) 2017-01-23
BR112012014048A2 (pt) 2017-10-31
HK1180354A1 (en) 2013-10-18
EP2567980A1 (en) 2013-03-13
CN102858801A (zh) 2013-01-02
BR112012015852A2 (pt) 2017-05-23
BR112012015852B1 (pt) 2020-12-29
EP2510006B1 (en) 2016-11-09
WO2011069794A1 (en) 2011-06-16
IN2012DN05082A (es) 2015-10-09
KR101765968B1 (ko) 2017-08-08
MX2012006620A (es) 2012-06-21
ECSP12011966A (es) 2012-07-31
HRP20170016T1 (hr) 2017-02-24
CA2783610C (en) 2018-10-30
KR20120112528A (ko) 2012-10-11
AU2010330161B2 (en) 2015-07-09
EP2332995A1 (en) 2011-06-15
CA2783651A1 (en) 2011-06-16
CR20120310A (es) 2012-08-01
CN102858804A (zh) 2013-01-02
WO2011069795A4 (en) 2011-08-18
CN102884082A (zh) 2013-01-16
CL2012001539A1 (es) 2012-10-12
EA201200851A1 (ru) 2013-01-30
IL220149A (en) 2017-09-28
CN102947338A (zh) 2013-02-27

Similar Documents

Publication Publication Date Title
CU20120092A7 (es) Anticuerpos neutralizadores contra el receptor de prolactina
CU20130163A7 (es) El anticuerpo neutralizador del receptor de prolactina mat3 y su uso terapéutico
CL2015000431A1 (es) Anticuerpos y vacunas para utilizarse en el tratamiento de cánceres por ror1 y para inhibir la metástasis.
EA201691079A1 (ru) Комбинированная терапия для лечения онкологического заболевания
MX2019000586A (es) Virus adenoasociados (aav) sflt-1 para usarse en el tratamiento de degeneración macular relacionada con la edad (amd).
EA201691251A1 (ru) Цитотоксические пептиды и их конъюгаты
EA201792304A1 (ru) Комбинированная терапия для лечения рака
EA201391154A2 (ru) Способы и композиции для нацеливания на адипоциты у млекопитающих
CO6390114A2 (es) Anticuerpos anti cxcr4 para el tratamiento
CY1118022T1 (el) Αναστολεις αποπτωσεως και χρησεις αυτων
MY172530A (en) Method for treating gynecological diseases
CL2011001034A1 (es) Compuestos derivados de pirrolidina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como endometriosis, fibroides uterinos, menorragia, entre otras.
WO2010104691A3 (en) Estrogenic compounds and their methods of use
EA201492238A1 (ru) Композиция мизопростола
CL2010000569A1 (es) Extracto vegetal de partes aereas de especies de calceolaria, adesmia y fuchsia magellanica; y su uso para tratar miomas uterinos, cancer de mama y terapia hormonal de reemplazo entre otras enfermedades.
EA201590903A1 (ru) Применение и режим приема фармацевтической композиции, содержащей левоноргестрел и ингибитор цог, для контрацепции по мере необходимости ("on-demand")

Legal Events

Date Code Title Description
FG Grant of patent
FD Lapse (for not paying fees)