CU23431B6 - Método para la inhibición de la proliferación de células tumorales y el tratamiento del cáncer - Google Patents
Método para la inhibición de la proliferación de células tumorales y el tratamiento del cáncerInfo
- Publication number
- CU23431B6 CU23431B6 CU20050091A CU20050091A CU23431B6 CU 23431 B6 CU23431 B6 CU 23431B6 CU 20050091 A CU20050091 A CU 20050091A CU 20050091 A CU20050091 A CU 20050091A CU 23431 B6 CU23431 B6 CU 23431B6
- Authority
- CU
- Cuba
- Prior art keywords
- proliferation
- cancer
- treatment
- tumor cells
- inhibition
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 230000035755 proliferation Effects 0.000 title abstract 2
- 210000004881 tumor cell Anatomy 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 102000052052 Casein Kinase II Human genes 0.000 abstract 4
- 108010010919 Casein Kinase II Proteins 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000026731 phosphorylation Effects 0.000 abstract 3
- 238000006366 phosphorylation reaction Methods 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000126 in silico method Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000000302 molecular modelling Methods 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
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- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/224—Phosphorus triamides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Métod para inhibir la proliferación de células tumorales que se caracteriza por la administración de compuestos químicos que bloquean la fosforilación por Caseína Kinasa 2 (CK2). Los compuestos químicos se identifican por modelación molecular in silico, y su estructura permite el bloqueo de la fosforilación mediante la interacción de dichos compuestos con el dominio de la fosforilación o su entorno en los sustratos de CK2. La invención comprende un método para el tratamiento del cáncer, y de otras enfermedades donde la CK2 posea un papel patológico, mediante la administración de los compuestos químicos identificados.
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20050091A CU23431B6 (es) | 2005-05-12 | 2005-05-12 | Método para la inhibición de la proliferación de células tumorales y el tratamiento del cáncer |
MX2007014216A MX2007014216A (es) | 2005-05-12 | 2006-05-05 | Compuestos con accion antineoplasica y composiciones farmaceuticas que los contienen. |
EP12160680.0A EP2474528B1 (en) | 2005-05-12 | 2006-05-05 | Antineoplasic compounds and pharmaceutical compositions thereof |
CA2607298A CA2607298C (en) | 2005-05-12 | 2006-05-05 | Antineoplastic compounds and pharmaceutical compositions thereof |
JP2008510389A JP5117377B2 (ja) | 2005-05-12 | 2006-05-05 | 抗腫瘍化合物及びその医薬組成物 |
CN2006800219987A CN101203522B (zh) | 2005-05-12 | 2006-05-05 | 抗肿瘤化合物及其药物组合物 |
PT121606800T PT2474528E (pt) | 2005-05-12 | 2006-05-05 | Compostos antineoplásicos e composições farmacêuticas dos mesmos |
AU2006246204A AU2006246204B2 (en) | 2005-05-12 | 2006-05-05 | Antineoplastic compounds and pharmaceutical compositions thereof |
PCT/CU2006/000002 WO2006119713A2 (es) | 2005-05-12 | 2006-05-05 | Compuestos con acción antineoplásica y composiciones farmaceuticas que los contienen |
RU2007146169/04A RU2404987C2 (ru) | 2005-05-12 | 2006-05-05 | Антинеоплазические соединения и фармацевтические композиции на их основе |
DK06753157.4T DK1892245T3 (en) | 2005-05-12 | 2006-05-05 | ANTINEOPLASTIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF |
KR1020077028594A KR20080008407A (ko) | 2005-05-12 | 2006-05-05 | 항신생물의 화합물 및 이를 포함하는 약학적 조성물 |
DK12160680.0T DK2474528T3 (da) | 2005-05-12 | 2006-05-05 | Antineoplastiske forbindelser og farmaceutiske kompositioner deraf |
BRPI0608806-6A BRPI0608806A2 (pt) | 2005-05-12 | 2006-05-05 | compostos quìmicos, composição farmacêutica e uso de compostos quìmicos |
EP06753157.4A EP1892245B1 (en) | 2005-05-12 | 2006-05-05 | Antineoplastic compounds and pharmaceutical compositions thereof |
PT67531574T PT1892245E (pt) | 2005-05-12 | 2006-05-05 | Compostos antineoplásticos e composições farmacêuticas dos mesmos |
ES06753157.4T ES2550959T3 (es) | 2005-05-12 | 2006-05-05 | Compuestos antineoplásicos y composiciones farmacéuticas de los mismos |
US11/920,031 US8748411B2 (en) | 2005-05-12 | 2006-05-05 | Antineoplastic compounds and pharmaceutical compositions thereof |
ES12160680.0T ES2516240T3 (es) | 2005-05-12 | 2006-05-05 | Compuestos antineoplásicos y composiciones farmacéuticas de los mismos |
MYPI20062124A MY140530A (en) | 2005-05-12 | 2006-05-09 | Antineoplasic compounds and pharmaceuticals compositions thereof |
ARP060101868A AR057012A1 (es) | 2005-05-12 | 2006-05-10 | Compuestos nitrogenados con accion antineoplasica y composiciones farmaceuticas que los contienen |
ZA200709692A ZA200709692B (en) | 2005-05-12 | 2007-11-09 | Antineoplastic compounds and pharmaceutical compositions thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20050091A CU23431B6 (es) | 2005-05-12 | 2005-05-12 | Método para la inhibición de la proliferación de células tumorales y el tratamiento del cáncer |
Publications (1)
Publication Number | Publication Date |
---|---|
CU23431B6 true CU23431B6 (es) | 2009-10-16 |
Family
ID=40278789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20050091A CU23431B6 (es) | 2005-05-12 | 2005-05-12 | Método para la inhibición de la proliferación de células tumorales y el tratamiento del cáncer |
Country Status (18)
Country | Link |
---|---|
US (1) | US8748411B2 (es) |
EP (2) | EP1892245B1 (es) |
JP (1) | JP5117377B2 (es) |
KR (1) | KR20080008407A (es) |
CN (1) | CN101203522B (es) |
AR (1) | AR057012A1 (es) |
AU (1) | AU2006246204B2 (es) |
BR (1) | BRPI0608806A2 (es) |
CA (1) | CA2607298C (es) |
CU (1) | CU23431B6 (es) |
DK (2) | DK2474528T3 (es) |
ES (2) | ES2550959T3 (es) |
MX (1) | MX2007014216A (es) |
MY (1) | MY140530A (es) |
PT (2) | PT2474528E (es) |
RU (1) | RU2404987C2 (es) |
WO (1) | WO2006119713A2 (es) |
ZA (1) | ZA200709692B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2139461A2 (en) * | 2007-03-20 | 2010-01-06 | Recepticon Aps | Amino derivatives to prevent nephrotoxicity and cancer |
KR101671659B1 (ko) * | 2008-11-06 | 2016-11-01 | 닛산 가가쿠 고교 가부시키 가이샤 | 액정 배향 처리제 |
AT509045B1 (de) * | 2010-01-29 | 2011-06-15 | Planta Naturstoffe Vertriebsges M B H | Verbindungen zur behandlung von asthma bronchiale |
NL1038473C2 (en) * | 2010-12-24 | 2012-06-27 | Centre Nat Rech Scient | Cancer targeting using carbonic anhydrase isoform ix inhibitors. |
AU2018282841B2 (en) * | 2017-06-13 | 2024-03-28 | National Cancer Center | Carcinogenesis inhibitor |
CN107903196A (zh) * | 2017-11-08 | 2018-04-13 | 南京大学 | 刺激和增强保护性免疫反应化合物、制备方法及其用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2673859A (en) * | 1950-09-15 | 1954-03-30 | Allied Chem & Dye Corp | Production of urea derivatives |
US3957791A (en) * | 1972-09-25 | 1976-05-18 | Sandoz, Inc. | Hydroxyalkyl-piperazino-quinoline nitrates |
US6962698B1 (en) * | 1998-02-17 | 2005-11-08 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
JP2003523166A (ja) * | 1998-09-29 | 2003-08-05 | ガミダ セル リミテッド | 幹細胞および前駆細胞の増殖と分化を制御する方法 |
CU23225A1 (es) | 2001-12-20 | 2007-08-30 | Ct Ingenieria Genetica Biotech | PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES |
WO2005070042A2 (en) * | 2004-01-09 | 2005-08-04 | Smithkline Beecham Corporation | Novel chemical compounds |
WO2006065724A2 (en) * | 2004-12-14 | 2006-06-22 | Regents Of The University Of Minnesota | Casein kinase 2 antisense therapy |
-
2005
- 2005-05-12 CU CU20050091A patent/CU23431B6/es unknown
-
2006
- 2006-05-05 CA CA2607298A patent/CA2607298C/en not_active Expired - Fee Related
- 2006-05-05 EP EP06753157.4A patent/EP1892245B1/en active Active
- 2006-05-05 CN CN2006800219987A patent/CN101203522B/zh not_active Expired - Fee Related
- 2006-05-05 US US11/920,031 patent/US8748411B2/en not_active Expired - Fee Related
- 2006-05-05 MX MX2007014216A patent/MX2007014216A/es active IP Right Grant
- 2006-05-05 PT PT121606800T patent/PT2474528E/pt unknown
- 2006-05-05 RU RU2007146169/04A patent/RU2404987C2/ru not_active IP Right Cessation
- 2006-05-05 WO PCT/CU2006/000002 patent/WO2006119713A2/es active Application Filing
- 2006-05-05 EP EP12160680.0A patent/EP2474528B1/en active Active
- 2006-05-05 PT PT67531574T patent/PT1892245E/pt unknown
- 2006-05-05 BR BRPI0608806-6A patent/BRPI0608806A2/pt not_active IP Right Cessation
- 2006-05-05 ES ES06753157.4T patent/ES2550959T3/es active Active
- 2006-05-05 KR KR1020077028594A patent/KR20080008407A/ko not_active Application Discontinuation
- 2006-05-05 AU AU2006246204A patent/AU2006246204B2/en not_active Ceased
- 2006-05-05 JP JP2008510389A patent/JP5117377B2/ja not_active Expired - Fee Related
- 2006-05-05 ES ES12160680.0T patent/ES2516240T3/es active Active
- 2006-05-05 DK DK12160680.0T patent/DK2474528T3/da active
- 2006-05-05 DK DK06753157.4T patent/DK1892245T3/en active
- 2006-05-09 MY MYPI20062124A patent/MY140530A/en unknown
- 2006-05-10 AR ARP060101868A patent/AR057012A1/es unknown
-
2007
- 2007-11-09 ZA ZA200709692A patent/ZA200709692B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1892245A2 (en) | 2008-02-27 |
RU2404987C2 (ru) | 2010-11-27 |
CN101203522A (zh) | 2008-06-18 |
CA2607298A1 (en) | 2006-11-16 |
US8748411B2 (en) | 2014-06-10 |
DK1892245T3 (en) | 2015-11-02 |
ES2516240T3 (es) | 2014-10-30 |
MX2007014216A (es) | 2008-02-07 |
EP1892245B1 (en) | 2015-07-29 |
PT1892245E (pt) | 2015-11-12 |
ZA200709692B (en) | 2008-11-26 |
EP2474528A1 (en) | 2012-07-11 |
ES2550959T3 (es) | 2015-11-13 |
JP5117377B2 (ja) | 2013-01-16 |
CA2607298C (en) | 2014-12-09 |
WO2006119713A3 (es) | 2007-03-01 |
JP2008543735A (ja) | 2008-12-04 |
WO2006119713A2 (es) | 2006-11-16 |
US20090215730A1 (en) | 2009-08-27 |
CN101203522B (zh) | 2011-06-08 |
MY140530A (en) | 2009-12-31 |
AU2006246204B2 (en) | 2012-04-19 |
BRPI0608806A2 (pt) | 2011-03-15 |
AR057012A1 (es) | 2007-11-07 |
PT2474528E (pt) | 2014-10-28 |
RU2007146169A (ru) | 2009-06-20 |
KR20080008407A (ko) | 2008-01-23 |
EP2474528B1 (en) | 2014-09-24 |
AU2006246204A1 (en) | 2006-11-16 |
DK2474528T3 (da) | 2014-10-27 |
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