CU23388B6 - Composición farmacéutica de microesferas para prevenir la amputación del pie diabético - Google Patents
Composición farmacéutica de microesferas para prevenir la amputación del pie diabéticoInfo
- Publication number
- CU23388B6 CU23388B6 CU20060021A CU20060021A CU23388B6 CU 23388 B6 CU23388 B6 CU 23388B6 CU 20060021 A CU20060021 A CU 20060021A CU 20060021 A CU20060021 A CU 20060021A CU 23388 B6 CU23388 B6 CU 23388B6
- Authority
- CU
- Cuba
- Prior art keywords
- pharmaceutical composition
- microspheres
- diabetic foot
- administration
- prevent amputation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Una composición farmacéutica que contiene microesferas cargadas con Factor de Crecimiento Epidérmico para ser administrada por vía parental en los miembros inferiores de pacientes diabéticos aquejados de lesiones isquémicas cutáneas crónicas. La composición de la presente invención, en contraste al estado de la técnica anterior, es útil porque reduce la frecuencia de administración durante el tratamiento y permite que la cicatrización de las lecciones sea más rápida comparada con la administración de cantidades equivalentes del Factor libre en solución.
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20060021A CU23388B6 (es) | 2006-01-31 | 2006-01-31 | Composición farmacéutica de microesferas para prevenir la amputación del pie diabético |
MYPI20082850A MY143742A (en) | 2006-01-31 | 2007-01-29 | Pharmaceutical composition of microspheres for preventing diabetic limb amputation |
DK07702319T DK1987817T3 (da) | 2006-01-31 | 2007-01-29 | Farmaceutisk sammensætning til mikrosfærer til forebyggelse af diabetisk fodamputation |
KR1020087021210A KR101401273B1 (ko) | 2006-01-31 | 2007-01-29 | 당뇨병성 발 절단을 예방하기 위한 마이크로스피어의 약학적 조성물 |
ES07702319T ES2330688T3 (es) | 2006-01-31 | 2007-01-29 | Composicion farmaceutica de microesferas para prevenir la amputacion de pie diabetico. |
EP07702319A EP1987817B1 (en) | 2006-01-31 | 2007-01-29 | Pharmaceutical composition of microspheres for preventing diabetic foot amputation |
SG201100715-0A SG169366A1 (en) | 2006-01-31 | 2007-01-29 | Pharmaceutical composition of microspheres for preventing diabetic foot amputation |
CN201410189221.8A CN103933552A (zh) | 2006-01-31 | 2007-01-29 | 用于预防糖尿病足截除的微球体药物组合物 |
JP2008552668A JP5219841B2 (ja) | 2006-01-31 | 2007-01-29 | 糖尿病の足切断を防止するためのマイクロスフェア医薬組成物 |
US12/162,505 US8741848B2 (en) | 2006-01-31 | 2007-01-29 | Pharmaceutical composition of microspheres for preventing diabetic foot amputation |
CA2640743A CA2640743C (en) | 2006-01-31 | 2007-01-29 | Pharmaceutical composition of microspheres for preventing diabetic limb amputation |
PL07702319T PL1987817T3 (pl) | 2006-01-31 | 2007-01-29 | Kompozycja farmaceutyczna mikrosfer do zapobiegania amputacji stopy cukrzycowej |
AT07702319T ATE437631T1 (de) | 2006-01-31 | 2007-01-29 | Pharmazeutische zusammensetzung von mikrokügelchen zur verhinderung einer amputation eines diabetischen fusses |
CNA2007800090345A CN101400338A (zh) | 2006-01-31 | 2007-01-29 | 用于预防糖尿病足截除的微球体药物组合物 |
SI200730087T SI1987817T1 (sl) | 2006-01-31 | 2007-01-29 | Farmacevtski sestavek mikrokroglic za preprečevanje amputacije diabetičnih nog |
AU2007211753A AU2007211753B2 (en) | 2006-01-31 | 2007-01-29 | Pharmaceutical composition of microspheres for preventing diabetic foot amputation |
PT07702319T PT1987817E (pt) | 2006-01-31 | 2007-01-29 | Composição farmacêutica de microesferas para prevenir a amputação do pé diabético |
DE602007001786T DE602007001786D1 (de) | 2006-01-31 | 2007-01-29 | Pharmazeutische zusammensetzung von mikrokügelchen zur verhinderung einer amputation eines diabetischen fusses |
PCT/CU2007/000002 WO2007087759A2 (es) | 2006-01-31 | 2007-01-29 | Composición farmacéutica de microesferas para prevenir la amputación del pie diabético |
BRPI0707395-0A BRPI0707395A2 (pt) | 2006-01-31 | 2007-01-29 | uso de uma composição farmacêutica que contém microesferas de fator de crescimento epidérmico |
RU2008135354/15A RU2426528C2 (ru) | 2006-01-31 | 2007-01-29 | Фармацевтическая композиция в виде микросфер для профилактики ампутации конечностей при диабете |
ARP070100377A AR059234A1 (es) | 2006-01-31 | 2007-01-30 | Composicion farmaceutica de microesferas para prevenir la amputacion del pie diabetico |
ZA200806648A ZA200806648B (en) | 2006-01-31 | 2008-07-30 | Pharmaceutical composition of microspheres for preventing diabetic foot amputation |
CY20091101105T CY1109513T1 (el) | 2006-01-31 | 2009-10-23 | Φαρμακευτικη συνθεση μικροσφαιριδιων για την προληψη του ακρωτηριασμου διαβητικου ποδιου |
HK14112245.2A HK1198743A1 (en) | 2006-01-31 | 2014-12-04 | Pharmaceutical composition of microspheres for preventing diabetic foot amputation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20060021A CU23388B6 (es) | 2006-01-31 | 2006-01-31 | Composición farmacéutica de microesferas para prevenir la amputación del pie diabético |
Publications (1)
Publication Number | Publication Date |
---|---|
CU23388B6 true CU23388B6 (es) | 2009-07-16 |
Family
ID=38185604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20060021A CU23388B6 (es) | 2006-01-31 | 2006-01-31 | Composición farmacéutica de microesferas para prevenir la amputación del pie diabético |
Country Status (24)
Country | Link |
---|---|
US (1) | US8741848B2 (es) |
EP (1) | EP1987817B1 (es) |
JP (1) | JP5219841B2 (es) |
KR (1) | KR101401273B1 (es) |
CN (2) | CN103933552A (es) |
AR (1) | AR059234A1 (es) |
AT (1) | ATE437631T1 (es) |
AU (1) | AU2007211753B2 (es) |
BR (1) | BRPI0707395A2 (es) |
CA (1) | CA2640743C (es) |
CU (1) | CU23388B6 (es) |
CY (1) | CY1109513T1 (es) |
DE (1) | DE602007001786D1 (es) |
DK (1) | DK1987817T3 (es) |
ES (1) | ES2330688T3 (es) |
HK (1) | HK1198743A1 (es) |
MY (1) | MY143742A (es) |
PL (1) | PL1987817T3 (es) |
PT (1) | PT1987817E (es) |
RU (1) | RU2426528C2 (es) |
SG (1) | SG169366A1 (es) |
SI (1) | SI1987817T1 (es) |
WO (1) | WO2007087759A2 (es) |
ZA (1) | ZA200806648B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU23411B6 (es) * | 2005-12-29 | 2009-09-08 | Ct Ingenieria Genetica Biotech | Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético |
ES2340902B1 (es) | 2008-07-01 | 2011-05-03 | Laboratorios Farmaceuticos Rovi, S.A. | Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas. |
GB0814302D0 (en) | 2008-08-05 | 2008-10-01 | Coretherapix Slu | Compounds and methods |
KR101156094B1 (ko) * | 2010-02-22 | 2012-06-20 | 경상대학교산학협력단 | 약물송달을 위한 양친성 PHA-mPEG 공중합 나노 컨테이너 |
ES2357601B1 (es) | 2011-01-26 | 2012-03-21 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento de preparación de derivados de glicosaminoglicanos donadores de óxido n�?trico y su uso en tratamiento de úlceras crónicas. |
EP2737895A1 (en) * | 2012-11-30 | 2014-06-04 | Praxis Pharmaceutical, S.A. | Microparticles with EGF, method of preparation and use |
EP2821077A1 (en) | 2013-07-04 | 2015-01-07 | Praxis Biopharma Research Institute | Lipid nanoparticles for wound healing |
EP3097922A1 (fr) | 2015-05-28 | 2016-11-30 | Denis Barritault | Composition pour le traitement des lesions tissulaires |
CN106267163A (zh) * | 2015-06-09 | 2017-01-04 | 济南博创医药科技有限公司 | 一种治疗皮肤创伤的药物组合物及其药物制剂 |
MX2016016339A (es) * | 2016-12-09 | 2018-06-08 | Desarrolladora Y Com De Tecnologias Biomedicas Decotecbio S A S De C V | Composicion coadyuvante de un factor de crecimiento y un neuropeptido para acelerar la cicatrizacion de heridas y la repitelizacion de organos. |
KR102218427B1 (ko) * | 2017-09-20 | 2021-02-22 | 차의과학대학교 산학협력단 | 단백질 약물을 포함하는 코아세르베이트 조성물 및 이를 포함하는 창상 치료제 |
CU20190022A7 (es) * | 2019-03-18 | 2020-10-20 | Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma | Composición farmacéutica para el tratamiento de la úlcera del pie diabético |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
NZ226171A (en) | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
JP2670680B2 (ja) * | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
US5034375A (en) | 1988-08-10 | 1991-07-23 | Institute Of Molecular Biology, Inc. | Process of wound healing using PDGF and EGF |
US4944948A (en) * | 1989-02-24 | 1990-07-31 | Liposome Technology, Inc. | EGF/Liposome gel composition and method |
EP0465588A4 (en) | 1989-04-04 | 1992-06-03 | Alcon Laboratories Inc | The use of liposomes for the delivery of therapeutic agents to wounds, cuts and abrasions |
US5130298A (en) * | 1989-05-16 | 1992-07-14 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
WO1991001719A1 (en) | 1989-08-01 | 1991-02-21 | The University Of Michigan | Topical delivery of peptides/proteins entrapped in dehydration/rehydration liposomes |
AU629316B2 (en) * | 1990-04-11 | 1992-10-01 | Flora Inc. | Periodontal disease treatment system |
US6902743B1 (en) * | 1995-05-22 | 2005-06-07 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix |
CA2251129A1 (en) * | 1996-05-03 | 1997-11-13 | Innogenetics N.V. | New medicaments containing gelatin cross-linked with oxidized polysaccharides |
US5861149A (en) * | 1997-06-04 | 1999-01-19 | Polyheal Ltd. | Methods for wound treatment |
JP2004534721A (ja) * | 2000-10-31 | 2004-11-18 | ピーアール ファーマシューティカルズ,インク. | 生理活性分子の向上した送達のための方法及び組成物 |
HK1077740A1 (en) * | 2001-12-20 | 2006-02-24 | Ct Ingenieria Genetica Biotech | Use of epidermal growth factor in the manufacture of a pharmaceutical injection composition for preventing diabetic limb amputation |
CN100571773C (zh) | 2002-03-12 | 2009-12-23 | 生物键有限公司 | 采用表皮生长因子治疗皮肤伤口的方法和组合物 |
CN1720989A (zh) * | 2004-07-15 | 2006-01-18 | 深圳市清华源兴生物医药科技有限公司 | 一种表皮生长因子缓释微球及其制备方法与应用 |
CU23411B6 (es) * | 2005-12-29 | 2009-09-08 | Ct Ingenieria Genetica Biotech | Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético |
-
2006
- 2006-01-31 CU CU20060021A patent/CU23388B6/es unknown
-
2007
- 2007-01-29 MY MYPI20082850A patent/MY143742A/en unknown
- 2007-01-29 PT PT07702319T patent/PT1987817E/pt unknown
- 2007-01-29 SI SI200730087T patent/SI1987817T1/sl unknown
- 2007-01-29 WO PCT/CU2007/000002 patent/WO2007087759A2/es active Search and Examination
- 2007-01-29 KR KR1020087021210A patent/KR101401273B1/ko active IP Right Grant
- 2007-01-29 AU AU2007211753A patent/AU2007211753B2/en active Active
- 2007-01-29 RU RU2008135354/15A patent/RU2426528C2/ru active
- 2007-01-29 PL PL07702319T patent/PL1987817T3/pl unknown
- 2007-01-29 SG SG201100715-0A patent/SG169366A1/en unknown
- 2007-01-29 CA CA2640743A patent/CA2640743C/en active Active
- 2007-01-29 CN CN201410189221.8A patent/CN103933552A/zh active Pending
- 2007-01-29 CN CNA2007800090345A patent/CN101400338A/zh active Pending
- 2007-01-29 AT AT07702319T patent/ATE437631T1/de active
- 2007-01-29 DE DE602007001786T patent/DE602007001786D1/de active Active
- 2007-01-29 BR BRPI0707395-0A patent/BRPI0707395A2/pt not_active Application Discontinuation
- 2007-01-29 JP JP2008552668A patent/JP5219841B2/ja active Active
- 2007-01-29 ES ES07702319T patent/ES2330688T3/es active Active
- 2007-01-29 US US12/162,505 patent/US8741848B2/en active Active
- 2007-01-29 DK DK07702319T patent/DK1987817T3/da active
- 2007-01-29 EP EP07702319A patent/EP1987817B1/en active Active
- 2007-01-30 AR ARP070100377A patent/AR059234A1/es unknown
-
2008
- 2008-07-30 ZA ZA200806648A patent/ZA200806648B/xx unknown
-
2009
- 2009-10-23 CY CY20091101105T patent/CY1109513T1/el unknown
-
2014
- 2014-12-04 HK HK14112245.2A patent/HK1198743A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1987817A2 (en) | 2008-11-05 |
ATE437631T1 (de) | 2009-08-15 |
CN101400338A (zh) | 2009-04-01 |
DK1987817T3 (da) | 2009-11-30 |
CN103933552A (zh) | 2014-07-23 |
JP2009525288A (ja) | 2009-07-09 |
US20090220608A1 (en) | 2009-09-03 |
ZA200806648B (en) | 2009-05-27 |
WO2007087759A3 (es) | 2007-09-20 |
WO2007087759A2 (es) | 2007-08-09 |
AU2007211753B2 (en) | 2012-03-01 |
DE602007001786D1 (de) | 2009-09-10 |
CA2640743C (en) | 2012-05-15 |
EP1987817B1 (en) | 2009-07-29 |
AU2007211753A1 (en) | 2007-08-09 |
MY143742A (en) | 2011-07-15 |
KR20080096804A (ko) | 2008-11-03 |
CA2640743A1 (en) | 2007-08-09 |
AR059234A1 (es) | 2008-03-19 |
JP5219841B2 (ja) | 2013-06-26 |
BRPI0707395A2 (pt) | 2011-05-03 |
CY1109513T1 (el) | 2014-08-13 |
SG169366A1 (en) | 2011-03-30 |
PT1987817E (pt) | 2009-10-26 |
RU2426528C2 (ru) | 2011-08-20 |
ES2330688T3 (es) | 2009-12-14 |
SI1987817T1 (sl) | 2009-12-31 |
RU2008135354A (ru) | 2010-03-10 |
US8741848B2 (en) | 2014-06-03 |
KR101401273B1 (ko) | 2014-05-29 |
HK1198743A1 (en) | 2015-06-05 |
PL1987817T3 (pl) | 2010-01-29 |
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