CS273198B2 - Method of 4-demethoxydaunomycinone production - Google Patents
Method of 4-demethoxydaunomycinone production Download PDFInfo
- Publication number
- CS273198B2 CS273198B2 CS80789A CS80789A CS273198B2 CS 273198 B2 CS273198 B2 CS 273198B2 CS 80789 A CS80789 A CS 80789A CS 80789 A CS80789 A CS 80789A CS 273198 B2 CS273198 B2 CS 273198B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- formula
- resulting
- group
- process according
- demethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/38—Quinones containing —CHO or non—quinoid keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888803301A GB8803301D0 (en) | 1988-02-12 | 1988-02-12 | Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin |
Publications (2)
Publication Number | Publication Date |
---|---|
CS80789A2 CS80789A2 (en) | 1990-06-13 |
CS273198B2 true CS273198B2 (en) | 1991-03-12 |
Family
ID=10631620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS80789A CS273198B2 (en) | 1988-02-12 | 1989-02-07 | Method of 4-demethoxydaunomycinone production |
Country Status (26)
Country | Link |
---|---|
US (1) | US5015745A (no) |
EP (1) | EP0328399B1 (no) |
JP (1) | JP2784202B2 (no) |
KR (1) | KR970000484B1 (no) |
CN (1) | CN1020592C (no) |
AT (1) | ATE92457T1 (no) |
AU (1) | AU605960B2 (no) |
CA (1) | CA1339634C (no) |
CS (1) | CS273198B2 (no) |
DE (1) | DE68907934T2 (no) |
DK (1) | DK170248B1 (no) |
ES (1) | ES2059718T3 (no) |
FI (1) | FI92186C (no) |
GB (1) | GB8803301D0 (no) |
HU (1) | HU200979B (no) |
IE (1) | IE62954B1 (no) |
IL (1) | IL89198A (no) |
MY (1) | MY104941A (no) |
NO (1) | NO169483C (no) |
NZ (1) | NZ227873A (no) |
PH (1) | PH27328A (no) |
PT (1) | PT89663B (no) |
RU (1) | RU1819256C (no) |
UA (1) | UA19151A (no) |
YU (1) | YU47206B (no) |
ZA (1) | ZA891018B (no) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ224252A (en) * | 1987-04-21 | 1991-09-25 | Erba Carlo Spa | An anthracycline glycoside and its preparation |
GB8808475D0 (en) * | 1988-04-11 | 1988-05-11 | Erba Carlo Spa | Process for preparing 4-demethoxydauno-mycinone |
IT1275953B1 (it) * | 1995-03-22 | 1997-10-24 | Sicor Spa | Procedimento per la preparazione di antibiotici della classe delle antracicline |
AUPQ319799A0 (en) * | 1999-10-01 | 1999-10-28 | Institute Of Drug Technology Australia Limited | Chemical methods |
US7053191B2 (en) | 2003-05-21 | 2006-05-30 | Solux Corporation | Method of preparing 4-R-substituted 4-demethoxydaunorubicin |
TW200621698A (en) * | 2004-08-23 | 2006-07-01 | Sicor Inc | Synthesis of idarubicin aglycone |
RU2450013C2 (ru) | 2005-12-13 | 2012-05-10 | Солюкс Корпорейшен | Способ получения 4-деметилдаунорубицина |
US8802830B2 (en) | 2005-12-20 | 2014-08-12 | Solux Corporation | Synthesis of epirubicin from 13-dihydrodaunorubicine |
US8357785B2 (en) | 2008-01-08 | 2013-01-22 | Solux Corporation | Method of aralkylation of 4′-hydroxyl group of anthracylins |
US8846882B2 (en) * | 2011-04-29 | 2014-09-30 | Synbias Pharma Ag | Method of producing 4-demethoxydaunorubicin |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3862225A (en) * | 1961-08-18 | 1975-01-21 | Pfizer | D-ring substituted tetracyclines |
US4020270A (en) * | 1974-05-02 | 1977-04-26 | Societa' Farmaceutici Italia S.P.A. | L-lyxohex-1-enopyranose derivative |
GB1467383A (en) * | 1974-06-12 | 1977-03-16 | Farmaceutici Italia | Daunomycin analogues |
GB1500421A (en) * | 1975-01-22 | 1978-02-08 | Farmaceutici Italia | Optically active anthracyclinones |
GB1509875A (en) * | 1976-06-14 | 1978-05-04 | Farmaceutici Italia | Optically active anthracyclinones and anthracycline glycosides |
GB1527050A (en) * | 1976-06-19 | 1978-10-04 | Farmaceutici Italia | Optically active anthracyclinones |
GB8317037D0 (en) * | 1983-06-23 | 1983-07-27 | Erba Farmitalia | 6-deoxyanthracyclines |
US4495103A (en) * | 1982-07-30 | 1985-01-22 | Sumitomo Chemical Company, Ltd. | Preparation of optically active 4-demethoxydaunomycinone |
EP0159357B1 (en) * | 1983-10-19 | 1992-09-09 | The University Of Melbourne | Carminomycinone precursors and analogues and derivatives thereof |
NZ224252A (en) * | 1987-04-21 | 1991-09-25 | Erba Carlo Spa | An anthracycline glycoside and its preparation |
GB8808475D0 (en) * | 1988-04-11 | 1988-05-11 | Erba Carlo Spa | Process for preparing 4-demethoxydauno-mycinone |
GB8824947D0 (en) * | 1988-10-25 | 1988-11-30 | Erba Carlo Spa | New 4-substituted anthracyclinones & process for preparing them |
-
1988
- 1988-02-12 GB GB888803301A patent/GB8803301D0/en active Pending
-
1989
- 1989-02-06 PH PH38165A patent/PH27328A/en unknown
- 1989-02-06 US US07/306,559 patent/US5015745A/en not_active Expired - Lifetime
- 1989-02-07 IL IL8919889A patent/IL89198A/en not_active IP Right Cessation
- 1989-02-07 IE IE38389A patent/IE62954B1/en not_active IP Right Cessation
- 1989-02-07 NZ NZ227873A patent/NZ227873A/xx unknown
- 1989-02-07 CS CS80789A patent/CS273198B2/cs unknown
- 1989-02-08 YU YU31089A patent/YU47206B/sh unknown
- 1989-02-08 KR KR1019890001402A patent/KR970000484B1/ko not_active IP Right Cessation
- 1989-02-08 AU AU29745/89A patent/AU605960B2/en not_active Ceased
- 1989-02-09 PT PT89663A patent/PT89663B/pt not_active IP Right Cessation
- 1989-02-09 ZA ZA891018A patent/ZA891018B/xx unknown
- 1989-02-09 UA UA4613419A patent/UA19151A/uk unknown
- 1989-02-09 RU SU894613419A patent/RU1819256C/ru not_active IP Right Cessation
- 1989-02-09 JP JP1030929A patent/JP2784202B2/ja not_active Expired - Fee Related
- 1989-02-09 NO NO890566A patent/NO169483C/no unknown
- 1989-02-09 FI FI890612A patent/FI92186C/fi active IP Right Grant
- 1989-02-10 AT AT89301282T patent/ATE92457T1/de not_active IP Right Cessation
- 1989-02-10 CA CA000590705A patent/CA1339634C/en not_active Expired - Fee Related
- 1989-02-10 ES ES89301282T patent/ES2059718T3/es not_active Expired - Lifetime
- 1989-02-10 HU HU89630A patent/HU200979B/hu unknown
- 1989-02-10 DE DE89301282T patent/DE68907934T2/de not_active Expired - Fee Related
- 1989-02-10 CN CN89100740A patent/CN1020592C/zh not_active Expired - Fee Related
- 1989-02-10 MY MYPI89000165A patent/MY104941A/en unknown
- 1989-02-10 EP EP89301282A patent/EP0328399B1/en not_active Expired - Lifetime
- 1989-02-10 DK DK063889A patent/DK170248B1/da not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
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IF00 | In force as of 2000-06-30 in czech republic |