CS248731B2 - Production method of the phenyl dihydropyridazinon derivatives - Google Patents
Production method of the phenyl dihydropyridazinon derivatives Download PDFInfo
- Publication number
- CS248731B2 CS248731B2 CS85202A CS20285A CS248731B2 CS 248731 B2 CS248731 B2 CS 248731B2 CS 85202 A CS85202 A CS 85202A CS 20285 A CS20285 A CS 20285A CS 248731 B2 CS248731 B2 CS 248731B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- methyl
- compounds
- formula
- phenyl
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848400863A GB8400863D0 (en) | 1984-01-13 | 1984-01-13 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CS248731B2 true CS248731B2 (en) | 1987-02-12 |
Family
ID=10554924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS85202A CS248731B2 (en) | 1984-01-13 | 1985-01-10 | Production method of the phenyl dihydropyridazinon derivatives |
Country Status (31)
Country | Link |
---|---|
US (1) | US4654342A (fr) |
EP (1) | EP0150937B1 (fr) |
JP (3) | JPS60158181A (fr) |
KR (1) | KR920006781B1 (fr) |
CN (1) | CN85101722A (fr) |
AT (1) | ATE37179T1 (fr) |
AU (1) | AU572252B2 (fr) |
CA (2) | CA1251209A (fr) |
CS (1) | CS248731B2 (fr) |
DD (1) | DD231350A5 (fr) |
DE (1) | DE3564941D1 (fr) |
DK (1) | DK162519C (fr) |
ES (3) | ES8607949A1 (fr) |
FI (1) | FI850140L (fr) |
GB (1) | GB8400863D0 (fr) |
GR (1) | GR850068B (fr) |
HU (1) | HU193591B (fr) |
IE (1) | IE57969B1 (fr) |
IL (1) | IL74031A (fr) |
JO (1) | JO1351B1 (fr) |
MY (1) | MY100124A (fr) |
NO (1) | NO850129L (fr) |
NZ (1) | NZ210816A (fr) |
PH (1) | PH22136A (fr) |
PL (1) | PL147123B1 (fr) |
PT (1) | PT79819B (fr) |
RO (1) | RO92607A (fr) |
SU (1) | SU1396963A3 (fr) |
WO (1) | WO1985003076A1 (fr) |
ZA (1) | ZA85251B (fr) |
ZW (1) | ZW385A1 (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1251448A (fr) * | 1985-03-27 | 1989-03-21 | William J. Coates | Derives de pyridazinone |
US4946842A (en) * | 1985-07-05 | 1990-08-07 | Smith Kline & French Laboratories Limited | Novel guanidino pyridazinones as cardiac stimulants |
GB8603780D0 (en) * | 1986-02-15 | 1986-03-19 | Smith Kline French Lab | Chemical compounds |
GB8722776D0 (en) * | 1987-09-28 | 1987-11-04 | Smith Kline French Lab | Chemical compounds |
US5011837A (en) * | 1988-08-09 | 1991-04-30 | E. R. Squibb & Sons, Inc. | Aryl cyanoguanidines: potassium channel activators and method of making same |
NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
AU2002254124A1 (en) | 2001-02-27 | 2002-09-12 | Mitokor | Aryl-n-cyanoguanidines and methods related thereto |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
DE102004011512B4 (de) | 2004-03-08 | 2022-01-13 | Boehringer Ingelheim Vetmedica Gmbh | Pharmazeutische Zubereitung enthaltend Pimobendan |
US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
EP1579862A1 (fr) * | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Utilisation des inhibiteurs de PDE III pour la réduction de la taille du coeur chez des mammifères souffrant d'insufficances cardiaques |
ZA200804550B (en) | 2005-11-09 | 2009-08-26 | Combinatorx Inc | Methods, compositions, and kits for the treatment of medical conditions |
ES2631879T3 (es) * | 2005-11-14 | 2017-09-05 | Boehringer Ingelheim Vetmedica Gmbh | Uso de pimobendano para el tratamiento de la insuficiencia cardíaca asintomática (oculta) |
EP1920785A1 (fr) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Préparation liquide contenant un complexe du pimobendane et de la cyclodextrine |
US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2527360B1 (fr) | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles |
US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
MX2011005444A (es) | 2008-11-25 | 2011-06-09 | Boehringer Ingelheim Vetmed | Inhibidores de la fosfodiesterasa tipo iii (pde iii) o agentes sensibilizantes a iones de ca(2+) para el tratamiento de la cardiomiopatia hipertrofica. |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CA2828346C (fr) | 2011-03-01 | 2021-01-26 | Synergy Pharmaceuticals Inc. | Procede de preparation d'agonistes du guanylate cyclase c |
WO2013106547A1 (fr) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation |
US10398705B2 (en) | 2012-03-15 | 2019-09-03 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
EP3718557A3 (fr) | 2013-02-25 | 2020-10-21 | Bausch Health Ireland Limited | Agoniste du récepteur de la guanylate cyclase sp-333 à utiliser lors du nettoyage du côlon |
EP2970384A1 (fr) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonistes de la guanylate cyclase et leurs utilisations |
CA2905435A1 (fr) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions utiles pour le traitement de troubles gastro-intestinaux |
EA201592263A1 (ru) | 2013-06-05 | 2016-05-31 | Синерджи Фармасьютикалз, Инк. | Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования |
CN105377235A (zh) | 2013-07-19 | 2016-03-02 | 勃林格殷格翰动物保健有限公司 | 含有防腐的醚化的环糊精衍生物的液体水性药物组合物 |
CA2920856A1 (fr) | 2013-08-09 | 2015-02-12 | Ardelyx, Inc. | Composes modulant le ph pour diminuer l'absorption gastro-intestinale dephosphate |
CA3176466A1 (fr) | 2013-12-04 | 2015-06-11 | Boehringer Ingelheim Vetmedica Gmbh | Compositions pharmaceutiques ameliorees de pimobendan |
CN104987310A (zh) * | 2015-06-03 | 2015-10-21 | 青岛农业大学 | 左西孟旦的合成工艺 |
US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
CN110117257B (zh) * | 2018-02-05 | 2022-12-06 | 安徽省新星药物开发有限责任公司 | 一种含胍基的p2y12受体拮抗剂、制备方法及其用途 |
JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス, インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3822260A (en) * | 1970-10-09 | 1974-07-02 | American Cyanamid Co | 6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones |
BE791539A (fr) * | 1971-11-19 | 1973-05-17 | Basf Ag | Dihydropyridazones, leur preparation et leurs utilisations therapeutiques |
EP0030835B1 (fr) * | 1979-12-05 | 1983-05-11 | Morishita Pharmaceutical Co. Ltd. | Dérivés de 6-phényl-3(2H)-pyridazinones substituées en position 2, leur production et compositions pharmaceutiques les contenant |
FI72718C (fi) * | 1981-03-04 | 1987-07-10 | Ciba Geigy Ag | Foerfarande foer framstaellning av terapeutiskt verkande, substituerade 6-(4-morfolino-fenyl)-4,5-dihydro- 3(2h)-pyridazinoner och deras syraadditionssalter. |
JPS58113180A (ja) * | 1981-12-28 | 1983-07-05 | Mitsui Toatsu Chem Inc | ピリダジノン誘導体 |
JPS58140076A (ja) * | 1982-02-09 | 1983-08-19 | Mitsubishi Chem Ind Ltd | ピリダジノン誘導体又はその塩類 |
DE3204375C2 (de) * | 1982-02-09 | 1983-12-01 | J. Rettenmaier & Söhne GmbH + Co, 7091 Holzmühle | Verfahren zur Herabsetzung der Saugfähigkeit von Holz |
DE3302021A1 (de) * | 1983-01-22 | 1984-07-26 | Basf Ag, 6700 Ludwigshafen | 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung |
US4946842A (en) * | 1985-07-05 | 1990-08-07 | Smith Kline & French Laboratories Limited | Novel guanidino pyridazinones as cardiac stimulants |
-
1984
- 1984-01-13 GB GB848400863A patent/GB8400863D0/en active Pending
-
1985
- 1985-01-02 JO JO19851351A patent/JO1351B1/en active
- 1985-01-07 ZW ZW3/85A patent/ZW385A1/xx unknown
- 1985-01-07 CA CA000471594A patent/CA1251209A/fr not_active Expired
- 1985-01-08 DK DK009185A patent/DK162519C/da not_active IP Right Cessation
- 1985-01-09 PH PH31697A patent/PH22136A/en unknown
- 1985-01-10 GR GR850068A patent/GR850068B/el unknown
- 1985-01-10 DD DD85272500A patent/DD231350A5/de not_active IP Right Cessation
- 1985-01-10 PT PT79819A patent/PT79819B/pt not_active IP Right Cessation
- 1985-01-10 IL IL74031A patent/IL74031A/xx unknown
- 1985-01-10 CS CS85202A patent/CS248731B2/cs unknown
- 1985-01-10 ES ES539446A patent/ES8607949A1/es not_active Expired
- 1985-01-11 JP JP60003912A patent/JPS60158181A/ja active Pending
- 1985-01-11 EP EP85300196A patent/EP0150937B1/fr not_active Expired
- 1985-01-11 ZA ZA85251A patent/ZA85251B/xx unknown
- 1985-01-11 FI FI850140A patent/FI850140L/fi not_active Application Discontinuation
- 1985-01-11 NZ NZ210816A patent/NZ210816A/en unknown
- 1985-01-11 NO NO850129A patent/NO850129L/no unknown
- 1985-01-11 AT AT85300196T patent/ATE37179T1/de active
- 1985-01-11 PL PL1985251516A patent/PL147123B1/pl unknown
- 1985-01-11 AU AU37611/85A patent/AU572252B2/en not_active Ceased
- 1985-01-11 HU HU85109A patent/HU193591B/hu not_active IP Right Cessation
- 1985-01-11 WO PCT/GB1985/000014 patent/WO1985003076A1/fr unknown
- 1985-01-11 DE DE8585300196T patent/DE3564941D1/de not_active Expired
- 1985-01-11 IE IE69/85A patent/IE57969B1/en not_active IP Right Cessation
- 1985-01-12 KR KR1019850000179A patent/KR920006781B1/ko not_active IP Right Cessation
- 1985-01-14 US US06/690,911 patent/US4654342A/en not_active Expired - Fee Related
- 1985-04-01 CN CN198585101722A patent/CN85101722A/zh active Pending
- 1985-09-12 RO RO85120090A patent/RO92607A/fr unknown
- 1985-09-12 SU SU853958649A patent/SU1396963A3/ru active
- 1985-12-05 ES ES549629A patent/ES8703846A1/es not_active Expired
-
1986
- 1986-05-14 ES ES554965A patent/ES8706645A1/es not_active Expired
-
1987
- 1987-06-02 MY MYPI87000758A patent/MY100124A/en unknown
-
1988
- 1988-05-09 JP JP63113410A patent/JPS63313775A/ja active Pending
- 1988-05-09 JP JP63113411A patent/JPS63313776A/ja active Pending
- 1988-10-21 CA CA000581012A patent/CA1260471A/fr not_active Expired
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CS248731B2 (en) | Production method of the phenyl dihydropyridazinon derivatives | |
RU2068844C1 (ru) | Производные азотсодержащих гетероциклических соединений или их фармацевтически приемлемые соли с щелочными или щелочно-земельными металлами | |
DE69030206T2 (de) | Pyrazolopyridinverbindungen und Verfahren zu ihrer Herstellung | |
CZ277698B6 (en) | Racemic or optically active bis-aza-bicyclic compounds, process for preparing thereof, intermediates and use thereof | |
EP0208518B1 (fr) | Composés 6-phényl-pyridazinyliques | |
FR2479225A1 (fr) | Imidazopyridines, leur preparation et leur utilisation comme agents cardiotoniques | |
EP0201988B1 (fr) | Dérivés de dihydropyridazinone | |
LU82728A1 (fr) | 6-(pyridinyl)-3(2h)pyridazinones,leur preparation et leur utilisation therapeutique | |
EP0164247B1 (fr) | Dihydropyridines | |
US4766122A (en) | Cyanoamidine compounds and derivatives thereof | |
US4766123A (en) | Methylamidine compounds | |
JPH0196180A (ja) | ベンゾイミダゾール化合物、その製造法およびこれらの化合物を含有する心機能不全治療用組成物 | |
US4962110A (en) | Pyridazinone derivatives | |
LU83251A1 (fr) | Derives d'imidazo(4,5-b)pyridine,leur preparation et leur utilisation comme agents cardiotoniques | |
JPS61212583A (ja) | 2‐アミノピリミジノン誘導体 | |
JPS61212582A (ja) | ジヒドロピリダジノン誘導体 | |
EP0197664A2 (fr) | Dérivés de 2-aminopyrimidinones | |
JPS61221177A (ja) | シアノアルカンイミドアミド化合物 | |
EP0146282A2 (fr) | Composés de pyrazinone | |
JPS6212764A (ja) | ジヒドロピリダジノン誘導体 | |
LU83320A1 (fr) | 4,5-dihydro-6-(pyridinyl)-3(2h)-pyridazinones,leur preparation et leur utilisation comme agents cardiotoniques | |
JPH07316162A (ja) | 三環式化合物 | |
CZ215992A3 (cs) | Nové acylaminohetrazepinové deriváty, způsob výroby a farmaceutické prostředky sjejích obsahem |