CR20220668A - Derivados de tetrazol como inhibidores de trpa1 - Google Patents

Derivados de tetrazol como inhibidores de trpa1

Info

Publication number
CR20220668A
CR20220668A CR20220668A CR20220668A CR20220668A CR 20220668 A CR20220668 A CR 20220668A CR 20220668 A CR20220668 A CR 20220668A CR 20220668 A CR20220668 A CR 20220668A CR 20220668 A CR20220668 A CR 20220668A
Authority
CR
Costa Rica
Prior art keywords
tetrazole derivatives
trpa1
trpa1 inhibitors
inhibitors
derivatives
Prior art date
Application number
CR20220668A
Other languages
English (en)
Inventor
Martin Thomas Fleck
Jens Willwacher
Florian Paul Christian Binder
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CR20220668A publication Critical patent/CR20220668A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

La presente divulgación proporciona algunos derivados de tetrazol que son inhibidores de potencial de receptor transitorio anquirina 1 (TRPA1) y que, por ende, son útiles para el tratamiento de las enfermedades que se pueden tratar mediante inhibición de TRPA1. Asimismo, se proporcionan composiciones farmacéuticas que lo contienen, y procesos para la preparación de dichos compuestos..<br /> <br />
CR20220668A 2020-06-29 2021-06-25 Derivados de tetrazol como inhibidores de trpa1 CR20220668A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20182987 2020-06-29
PCT/EP2021/067467 WO2022002780A1 (en) 2020-06-29 2021-06-25 Tetrazole derivatives as trpa1 inhibitors

Publications (1)

Publication Number Publication Date
CR20220668A true CR20220668A (es) 2023-03-10

Family

ID=71401655

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220668A CR20220668A (es) 2020-06-29 2021-06-25 Derivados de tetrazol como inhibidores de trpa1

Country Status (19)

Country Link
US (1) US11891403B2 (es)
EP (1) EP4171571A1 (es)
JP (1) JP2023533189A (es)
KR (1) KR20230028546A (es)
CN (1) CN116157130A (es)
AR (1) AR122778A1 (es)
AU (1) AU2021301140A1 (es)
BR (1) BR112022021386A2 (es)
CA (1) CA3182143A1 (es)
CL (1) CL2022003325A1 (es)
CO (1) CO2022016762A2 (es)
CR (1) CR20220668A (es)
DO (1) DOP2022000270A (es)
EC (1) ECSP22088958A (es)
IL (1) IL299172A (es)
MX (1) MX2022016272A (es)
PE (1) PE20240594A1 (es)
TW (1) TW202216729A (es)
WO (1) WO2022002780A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL306086A (en) 2021-04-14 2023-11-01 Boehringer Ingelheim Int History of 3H, 4H, 5H, 6H, 7H-pyrimido[5,4-B][4,1]oxazin-6,4-dione as TRPA1 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017060488A1 (en) 2015-10-09 2017-04-13 Almirall, S.A. New trpa1 antagonists
IL306086A (en) 2021-04-14 2023-11-01 Boehringer Ingelheim Int History of 3H, 4H, 5H, 6H, 7H-pyrimido[5,4-B][4,1]oxazin-6,4-dione as TRPA1 inhibitors

Also Published As

Publication number Publication date
CA3182143A1 (en) 2022-01-06
KR20230028546A (ko) 2023-02-28
ECSP22088958A (es) 2022-12-30
JP2023533189A (ja) 2023-08-02
DOP2022000270A (es) 2023-01-15
CL2022003325A1 (es) 2023-03-31
EP4171571A1 (en) 2023-05-03
PE20240594A1 (es) 2024-03-21
AU2021301140A1 (en) 2022-11-10
US20210403482A1 (en) 2021-12-30
MX2022016272A (es) 2023-02-09
WO2022002780A1 (en) 2022-01-06
US11891403B2 (en) 2024-02-06
IL299172A (en) 2023-02-01
TW202216729A (zh) 2022-05-01
CO2022016762A2 (es) 2022-12-09
CN116157130A (zh) 2023-05-23
AR122778A1 (es) 2022-10-05
BR112022021386A2 (pt) 2023-01-10

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