BR112023015425A2 - Derivados de uracila como inibidores de trpa1 - Google Patents

Derivados de uracila como inibidores de trpa1

Info

Publication number
BR112023015425A2
BR112023015425A2 BR112023015425A BR112023015425A BR112023015425A2 BR 112023015425 A2 BR112023015425 A2 BR 112023015425A2 BR 112023015425 A BR112023015425 A BR 112023015425A BR 112023015425 A BR112023015425 A BR 112023015425A BR 112023015425 A2 BR112023015425 A2 BR 112023015425A2
Authority
BR
Brazil
Prior art keywords
trpa1
derivatives
uracila
inhibitors
trpa1 inhibitors
Prior art date
Application number
BR112023015425A
Other languages
English (en)
Inventor
Paul Christian Binder Florian
Jens Willwacher
Thomas Fleck Martin
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR112023015425A2 publication Critical patent/BR112023015425A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

derivados de uracila como inibidores de trpa1. a presente invenção refere-se a certos derivados de uracila que são inibidores do potencial receptor transitório de anquirina 1 (trpa1), e são, portanto, úteis para o tratamento de doenças tratáveis pela inibição de trpa1. também são fornecidas composições farmacêuticas contendo os mesmos, e processos para preparar os referidos compostos.
BR112023015425A 2021-04-14 2022-04-13 Derivados de uracila como inibidores de trpa1 BR112023015425A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21168433 2021-04-14
PCT/EP2022/059816 WO2022219013A1 (en) 2021-04-14 2022-04-13 Uracil derivatives as trpa1 inhibitors

Publications (1)

Publication Number Publication Date
BR112023015425A2 true BR112023015425A2 (pt) 2023-11-07

Family

ID=75539076

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023015425A BR112023015425A2 (pt) 2021-04-14 2022-04-13 Derivados de uracila como inibidores de trpa1

Country Status (12)

Country Link
US (1) US11858921B2 (pt)
EP (1) EP4323355A1 (pt)
JP (1) JP2024512972A (pt)
KR (1) KR20230170934A (pt)
CN (1) CN117083269A (pt)
AU (1) AU2022259537A1 (pt)
BR (1) BR112023015425A2 (pt)
CA (1) CA3209982A1 (pt)
CL (1) CL2023002633A1 (pt)
IL (1) IL306065A (pt)
TW (1) TW202309015A (pt)
WO (1) WO2022219013A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11884652B2 (en) 2020-06-29 2024-01-30 Boehringer Ingelheim International Gmbh Tetrazole derivatives as TRPA1 inhibitors
WO2023150592A2 (en) * 2022-02-03 2023-08-10 D.E. Shaw Research, Llc N3-substituted uracil compounds as trpa1 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7361654B2 (en) 2005-01-13 2008-04-22 Bristol-Myers Squibb Co. Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2017060488A1 (en) 2015-10-09 2017-04-13 Almirall, S.A. New trpa1 antagonists
US11884652B2 (en) 2020-06-29 2024-01-30 Boehringer Ingelheim International Gmbh Tetrazole derivatives as TRPA1 inhibitors

Also Published As

Publication number Publication date
CN117083269A (zh) 2023-11-17
US20220340552A1 (en) 2022-10-27
JP2024512972A (ja) 2024-03-21
AU2022259537A1 (en) 2023-08-17
IL306065A (en) 2023-11-01
WO2022219013A1 (en) 2022-10-20
US11858921B2 (en) 2024-01-02
KR20230170934A (ko) 2023-12-19
CA3209982A1 (en) 2022-10-20
CL2023002633A1 (es) 2024-03-15
EP4323355A1 (en) 2024-02-21
TW202309015A (zh) 2023-03-01

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