CR20210077A - Nuevos compuestos heterocíclicos como inhibidores de la monoacilglicerol lipasa - Google Patents
Nuevos compuestos heterocíclicos como inhibidores de la monoacilglicerol lipasaInfo
- Publication number
- CR20210077A CR20210077A CR20210077A CR20210077A CR20210077A CR 20210077 A CR20210077 A CR 20210077A CR 20210077 A CR20210077 A CR 20210077A CR 20210077 A CR20210077 A CR 20210077A CR 20210077 A CR20210077 A CR 20210077A
- Authority
- CR
- Costa Rica
- Prior art keywords
- heterocyclic compounds
- new heterocyclic
- lipase inhibitors
- monoacylglycerol lipase
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
<p>La invención proporciona nuevos compuestos heterocíclicos que presentan la fórmula general (I) en donde A, L, X, m, n, R1 y R2 son como se describe en la presente, composiciones que incluyen los compuestos, procesos de fabricación de los compuestos y métodos de utilización de los compuestos.</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18188681 | 2018-08-13 | ||
PCT/EP2019/071520 WO2020035424A1 (en) | 2018-08-13 | 2019-08-12 | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20210077A true CR20210077A (es) | 2021-03-11 |
Family
ID=63244467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20210077A CR20210077A (es) | 2018-08-13 | 2019-08-12 | Nuevos compuestos heterocíclicos como inhibidores de la monoacilglicerol lipasa |
Country Status (22)
Country | Link |
---|---|
US (3) | US20200308190A1 (es) |
EP (1) | EP3837263A1 (es) |
JP (1) | JP2021534139A (es) |
KR (1) | KR20210045992A (es) |
CN (1) | CN112867720A (es) |
AR (1) | AR116666A1 (es) |
AU (1) | AU2019322538B2 (es) |
BR (1) | BR112021002298A2 (es) |
CA (1) | CA3104928A1 (es) |
CL (1) | CL2021000362A1 (es) |
CO (1) | CO2021002382A2 (es) |
CR (1) | CR20210077A (es) |
IL (1) | IL279173A (es) |
MA (1) | MA53219A (es) |
MX (1) | MX2021001433A (es) |
PE (1) | PE20211089A1 (es) |
PH (1) | PH12021500013A1 (es) |
RU (1) | RU2769507C1 (es) |
SG (1) | SG11202013064WA (es) |
TW (1) | TWI812770B (es) |
UA (1) | UA127629C2 (es) |
WO (1) | WO2020035424A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR114136A1 (es) | 2017-10-10 | 2020-07-29 | Hoffmann La Roche | Compuestos heterocíclicos |
EP3717477B1 (en) | 2017-11-28 | 2022-07-20 | F. Hoffmann-La Roche AG | New heterocyclic compounds |
JP7269943B2 (ja) | 2018-01-08 | 2023-05-09 | エフ. ホフマン-ラ ロシュ アーゲー | Magl阻害剤としてのオクタヒドロピリド[1,2-アルファ]ピラジン |
US20190292188A1 (en) | 2018-02-27 | 2019-09-26 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors |
US11168089B2 (en) | 2018-05-18 | 2021-11-09 | Incyte Corporation | Fused pyrimidine derivatives as A2A / A2B inhibitors |
MX2021001433A (es) | 2018-08-13 | 2021-04-12 | Hoffmann La Roche | Nuevos compuestos heterociclicos como inhibidores de la monoacilglicerol lipasa. |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及***并吡啶 |
KR20220058553A (ko) * | 2019-09-05 | 2022-05-09 | 루난 파마슈티컬 그룹 코퍼레이션 | Magl 억제제 및 이의 제조 방법, 용도 |
US20210094971A1 (en) * | 2019-09-09 | 2021-04-01 | Hoffmann-La Roche Inc. | Heterocyclic compounds |
CN114269755A (zh) | 2019-09-12 | 2022-04-01 | 豪夫迈·罗氏有限公司 | 作为magl抑制剂的4,4a,5,7,8,8a-六吡啶并[4,3-b][1,4]噁嗪-3-酮化合物 |
KR20220066894A (ko) * | 2019-09-23 | 2022-05-24 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 화합물 |
AR120030A1 (es) * | 2019-09-24 | 2022-01-26 | Hoffmann La Roche | Compuestos heterocíclicos |
AR120029A1 (es) * | 2019-09-24 | 2022-01-26 | Hoffmann La Roche | Compuestos heterocíclicos |
MX2022004128A (es) * | 2019-10-07 | 2022-06-16 | De Shaw Res Llc | Compuestos heterociclicos de arilmetileno como bloqueadores del canal shaker de potasio kv1.3. |
EP4126825A1 (en) * | 2020-03-26 | 2023-02-08 | Janssen Pharmaceutica NV | Aminocyclobutanes as monoacylglycerol lipase modulators |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5214038A (en) | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
US7160888B2 (en) | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
US7579495B2 (en) | 2003-12-19 | 2009-08-25 | Momentive Performance Materials Inc. | Active-releasing cyclic siloxanes |
EP1863483A4 (en) | 2005-03-31 | 2010-03-31 | Janssen Pharmaceutica Nv | Bicyclic pyrazole compounds as anti-bacteriostatic agents |
ES2337728T3 (es) | 2005-06-20 | 2010-04-28 | Schering Corporation | Piperidinas sustituidas unidas a carbono y sus derivados utiles como antagonistas de histamina h3. |
EP1945222B1 (en) | 2005-11-02 | 2012-12-26 | Bayer Pharma Aktiengesellschaft | Pyrrolo[2,1-f] [1,2,4]-triazin-4-ylamines as igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases |
US7696229B2 (en) | 2006-02-17 | 2010-04-13 | Memory Pharmaceuticals Corporation | Compounds having 5-HT6 receptor affinity |
WO2007117557A2 (en) | 2006-04-05 | 2007-10-18 | Vitae Pharmaceuticals, Inc. | Diaminopropanol renin inhibitors |
CA2679754C (en) | 2007-03-12 | 2018-08-07 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
TW200942537A (en) | 2008-02-01 | 2009-10-16 | Irm Llc | Compounds and compositions as kinase inhibitors |
AU2009309869A1 (en) | 2008-10-29 | 2010-05-06 | F. Hoffmann-La Roche Ag | Novel phenyl amide or pyridil amide derivatives and their use as GPBAR1 agonists |
WO2011029804A1 (en) | 2009-09-10 | 2011-03-17 | F. Hoffmann-La Roche Ag | Inhibitors of jak |
WO2011059118A1 (ko) | 2009-11-10 | 2011-05-19 | Kim Hyun Jeen | 후각인지능력 검사 시스템 |
US9051296B2 (en) * | 2009-11-16 | 2015-06-09 | Raqualia Pharma Inc. | Aryl carboxamide derivatives as TTX-S blockers |
US8420661B2 (en) | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
WO2012155199A1 (en) | 2011-05-16 | 2012-11-22 | Bionomics Limited | Amine derivatives as potassium channel blockers |
WO2013059118A1 (en) | 2011-10-19 | 2013-04-25 | The Trustees Of Columbia University In The City Of New York | Cyclopropenimine catalyst compositions and processes |
WO2013080156A1 (en) | 2011-11-30 | 2013-06-06 | Actelion Pharmaceuticals Ltd | 3,7-disubstituted octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one antibiotics |
AP4055A (en) | 2011-12-22 | 2017-03-07 | Novartis Ag | Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives |
MX350788B (es) | 2012-01-06 | 2017-09-13 | Abide Therapeutics Inc | Compuestos de carbamato y preparación y uso de los mismos. |
GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
TW201422625A (zh) | 2012-11-26 | 2014-06-16 | Novartis Ag | 二氫-吡啶并-□衍生物之固體形式 |
ES2640482T3 (es) | 2013-04-16 | 2017-11-03 | Idorsia Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos |
WO2016109501A1 (en) | 2014-12-30 | 2016-07-07 | Karos Pharmaceuticals, Inc. | Amide compounds as tryptophan hydroxylase inhibitors |
US10106556B2 (en) | 2015-03-30 | 2018-10-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
EP3294729A1 (en) | 2015-05-13 | 2018-03-21 | Selvita S.A. | Substituted quinoxaline derivatives |
JP6703553B2 (ja) | 2015-05-21 | 2020-06-03 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Pad4阻害剤としてのベンゾイミダゾール誘導体 |
ES2849951T3 (es) | 2015-06-18 | 2021-08-24 | 89Bio Ltd | Derivados de piperidina 4-bencil y 4-benzoil sustituidos |
US10385057B2 (en) | 2015-11-20 | 2019-08-20 | Lundbeck La Jolla Research Center, Inc. | Pyrazole compounds and methods of making and using same |
WO2017087863A1 (en) | 2015-11-20 | 2017-05-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
PE20190409A1 (es) | 2016-03-31 | 2019-03-14 | Takeda Pharmaceuticals Co | Compuesto heterociclico |
WO2017170830A1 (ja) | 2016-03-31 | 2017-10-05 | 武田薬品工業株式会社 | 複素環化合物 |
AU2017289318A1 (en) | 2016-06-30 | 2018-11-29 | Basilea Pharmaceutica International AG | Mitochondrial inhibitors for the treatment of proliferation disorders |
AU2018285131B2 (en) | 2017-06-12 | 2021-11-11 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as Vanin inhibitors |
AU2018338855B2 (en) | 2017-09-29 | 2022-04-28 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
AR114136A1 (es) | 2017-10-10 | 2020-07-29 | Hoffmann La Roche | Compuestos heterocíclicos |
EP3717477B1 (en) | 2017-11-28 | 2022-07-20 | F. Hoffmann-La Roche AG | New heterocyclic compounds |
TW201930300A (zh) | 2017-12-15 | 2019-08-01 | 瑞士商赫孚孟拉羅股份公司 | 新雜環化合物 |
JP7269943B2 (ja) | 2018-01-08 | 2023-05-09 | エフ. ホフマン-ラ ロシュ アーゲー | Magl阻害剤としてのオクタヒドロピリド[1,2-アルファ]ピラジン |
TWI818967B (zh) | 2018-03-22 | 2023-10-21 | 瑞士商赫孚孟拉羅股份公司 | 新穎雜環化合物 |
MX2021001433A (es) | 2018-08-13 | 2021-04-12 | Hoffmann La Roche | Nuevos compuestos heterociclicos como inhibidores de la monoacilglicerol lipasa. |
AU2019322161A1 (en) | 2018-08-13 | 2020-11-12 | F. Hoffmann-La Roche Ag | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
SI3883936T1 (sl) | 2018-11-22 | 2023-10-30 | F. Hoffmann - La Roche Ag | Nove heterociklične spojine |
AU2019382642A1 (en) | 2018-11-22 | 2021-06-10 | Qilu Regor Therapeutics Inc. | GLP-1R agonists and uses thereof |
CN113767105A (zh) | 2019-04-09 | 2021-12-07 | 豪夫迈·罗氏有限公司 | 作为单酰基甘油脂肪酶(magl)的抑制剂的杂环化合物 |
EP3994137A1 (en) | 2019-07-03 | 2022-05-11 | F. Hoffmann-La Roche AG | Heterocyclic monoacylglycerol lipase (magl) inhibitors |
JP2022539604A (ja) | 2019-07-09 | 2022-09-12 | エフ.ホフマン-ラ ロシュ アーゲー | 新規複素環化合物 |
US20210094971A1 (en) | 2019-09-09 | 2021-04-01 | Hoffmann-La Roche Inc. | Heterocyclic compounds |
CN114269755A (zh) | 2019-09-12 | 2022-04-01 | 豪夫迈·罗氏有限公司 | 作为magl抑制剂的4,4a,5,7,8,8a-六吡啶并[4,3-b][1,4]噁嗪-3-酮化合物 |
CN114650994A (zh) | 2019-09-12 | 2022-06-21 | 豪夫迈·罗氏有限公司 | 放射性标记的化合物 |
KR20220066894A (ko) | 2019-09-23 | 2022-05-24 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 화합물 |
JP2022549306A (ja) | 2019-09-24 | 2022-11-24 | エフ.ホフマン-ラ ロシュ アーゲー | モノアシルグリセロールリパーゼ(magl)の蛍光プローブ |
AR120030A1 (es) | 2019-09-24 | 2022-01-26 | Hoffmann La Roche | Compuestos heterocíclicos |
AR120029A1 (es) | 2019-09-24 | 2022-01-26 | Hoffmann La Roche | Compuestos heterocíclicos |
-
2019
- 2019-08-12 MX MX2021001433A patent/MX2021001433A/es unknown
- 2019-08-12 CA CA3104928A patent/CA3104928A1/en active Pending
- 2019-08-12 AU AU2019322538A patent/AU2019322538B2/en active Active
- 2019-08-12 KR KR1020217004221A patent/KR20210045992A/ko active Search and Examination
- 2019-08-12 CN CN201980053749.3A patent/CN112867720A/zh active Pending
- 2019-08-12 PE PE2021000135A patent/PE20211089A1/es unknown
- 2019-08-12 WO PCT/EP2019/071520 patent/WO2020035424A1/en unknown
- 2019-08-12 MA MA053219A patent/MA53219A/fr unknown
- 2019-08-12 BR BR112021002298-8A patent/BR112021002298A2/pt unknown
- 2019-08-12 UA UAA202101016A patent/UA127629C2/uk unknown
- 2019-08-12 RU RU2021106145A patent/RU2769507C1/ru active
- 2019-08-12 JP JP2021507457A patent/JP2021534139A/ja active Pending
- 2019-08-12 EP EP19755855.4A patent/EP3837263A1/en active Pending
- 2019-08-12 CR CR20210077A patent/CR20210077A/es unknown
- 2019-08-12 SG SG11202013064WA patent/SG11202013064WA/en unknown
- 2019-08-13 TW TW108128734A patent/TWI812770B/zh active
- 2019-08-13 AR ARP190102303A patent/AR116666A1/es unknown
-
2020
- 2020-04-09 US US16/844,262 patent/US20200308190A1/en not_active Abandoned
- 2020-12-03 IL IL279173A patent/IL279173A/en unknown
-
2021
- 2021-02-10 CL CL2021000362A patent/CL2021000362A1/es unknown
- 2021-02-11 PH PH12021500013A patent/PH12021500013A1/en unknown
- 2021-02-24 CO CONC2021/0002382A patent/CO2021002382A2/es unknown
-
2022
- 2022-05-20 US US17/749,496 patent/US11802133B2/en active Active
-
2023
- 2023-09-26 US US18/475,065 patent/US20240150373A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2019322538A1 (en) | 2021-01-07 |
EP3837263A1 (en) | 2021-06-23 |
AU2019322538B2 (en) | 2021-09-30 |
US20240150373A1 (en) | 2024-05-09 |
PE20211089A1 (es) | 2021-06-14 |
TW202021970A (zh) | 2020-06-16 |
RU2769507C1 (ru) | 2022-04-01 |
MA53219A (fr) | 2021-11-17 |
AR116666A1 (es) | 2021-06-02 |
JP2021534139A (ja) | 2021-12-09 |
CO2021002382A2 (es) | 2021-03-08 |
KR20210045992A (ko) | 2021-04-27 |
TWI812770B (zh) | 2023-08-21 |
CL2021000362A1 (es) | 2021-07-09 |
US20200308190A1 (en) | 2020-10-01 |
SG11202013064WA (en) | 2021-01-28 |
IL279173A (en) | 2021-01-31 |
CA3104928A1 (en) | 2020-02-20 |
UA127629C2 (uk) | 2023-11-08 |
US20230050901A1 (en) | 2023-02-16 |
CN112867720A (zh) | 2021-05-28 |
PH12021500013A1 (en) | 2021-09-13 |
MX2021001433A (es) | 2021-04-12 |
US11802133B2 (en) | 2023-10-31 |
BR112021002298A2 (pt) | 2021-05-04 |
WO2020035424A1 (en) | 2020-02-20 |
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