CR20140479A - Moduladores del receptor del estrogeno y sus usos - Google Patents

Moduladores del receptor del estrogeno y sus usos

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Publication number
CR20140479A
CR20140479A CR20140479A CR20140479A CR20140479A CR 20140479 A CR20140479 A CR 20140479A CR 20140479 A CR20140479 A CR 20140479A CR 20140479 A CR20140479 A CR 20140479A CR 20140479 A CR20140479 A CR 20140479A
Authority
CR
Costa Rica
Prior art keywords
modulators
strogen
receiver
compounds
estrogen receptor
Prior art date
Application number
CR20140479A
Other languages
English (en)
Inventor
Nicholas D Smith
Steven P Govek
Mehmet Kahraman
Jackaline D Julien
Johnny Y Nagasawa
Karensa L Douglas
Celine Bonnefous
Andiliy G Lai
Original Assignee
Seragon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seragon Pharmaceuticals Inc filed Critical Seragon Pharmaceuticals Inc
Publication of CR20140479A publication Critical patent/CR20140479A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Se describen en la presente compuestos que son moduladores del receptor de estrógeno.
CR20140479A 2012-03-20 2014-10-15 Moduladores del receptor del estrogeno y sus usos CR20140479A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261613442P 2012-03-20 2012-03-20
PCT/US2013/031507 WO2013142266A1 (en) 2012-03-20 2013-03-14 Estrogen receptor modulators and uses thereof

Publications (1)

Publication Number Publication Date
CR20140479A true CR20140479A (es) 2014-12-01

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CR20140479A CR20140479A (es) 2012-03-20 2014-10-15 Moduladores del receptor del estrogeno y sus usos

Country Status (18)

Country Link
US (1) US9499538B2 (es)
EP (1) EP2828243B1 (es)
JP (1) JP6154887B2 (es)
KR (1) KR20140138296A (es)
CN (1) CN104220426B (es)
AU (1) AU2013235499A1 (es)
CA (1) CA2866891A1 (es)
CO (1) CO7170179A2 (es)
CR (1) CR20140479A (es)
EA (1) EA201491530A1 (es)
HK (1) HK1202535A1 (es)
IL (1) IL234487A0 (es)
MX (1) MX2014011217A (es)
NZ (1) NZ630124A (es)
PE (1) PE20142461A1 (es)
PH (1) PH12014502095A1 (es)
SG (1) SG11201405918XA (es)
WO (1) WO2013142266A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20142461A1 (es) 2012-03-20 2015-02-05 Seragon Pharmaceuticals Inc Moduladores del receptor de estrogeno y sus usos
EP2970130A4 (en) 2013-03-14 2016-08-03 Seragon Pharmaceuticals Inc MODULATORS OF POLYCYCLIC STROGEN RECEPTORS AND USES THEREOF
CA2906931C (en) 2013-03-15 2023-03-14 Epigen Biosciences, Inc. Heterocyclic compounds useful in the treatment of disease
JP6389517B2 (ja) 2013-06-19 2018-09-12 セラゴン ファーマシューティカルズ， インク． アゼチジンエストロゲン受容体調節因子及びその使用
SG11201509508YA (en) 2013-06-19 2015-12-30 Seragon Pharmaceuticals Inc Estrogen receptor modulator and uses thereof
CN105916501A (zh) 2013-12-06 2016-08-31 豪夫迈·罗氏有限公司 用于治疗局部晚期或转移性***受体阳性乳腺癌的***受体调节剂
CN106572990A (zh) 2014-03-13 2017-04-19 豪夫迈·罗氏有限公司 含有***受体调节剂的治疗性组合产品
MX2016011698A (es) 2014-03-13 2016-12-12 Hoffmann La Roche Metodos y composiciones para modular mutantes de receptor de estrogeno.
AU2015303297A1 (en) 2014-08-11 2016-12-01 F. Hoffmann-La Roche Ag Crystalline forms of an estrogen receptor modulator
WO2016189011A1 (en) 2015-05-26 2016-12-01 F. Hoffmann-La Roche Ag Heterocyclic estrogen receptor modulators and uses thereof
CN107847498B (zh) 2015-05-29 2021-04-13 卫材R&D管理有限公司 四取代的烯烃化合物及其用途
CN105061316B (zh) * 2015-07-17 2017-12-22 苏州大学 稠环类化合物、制备方法和用途
CN106518768B (zh) * 2015-09-15 2021-07-02 江苏恒瑞医药股份有限公司 丙烯酸类衍生物、其制备方法及其在医药上的应用
EP3359527A1 (en) * 2015-10-07 2018-08-15 H. Hoffnabb-La Roche Ag Process for the preparation of (e)-3-(4-((e)-2-(2-chloro-4-fluorophenyl)-1-(1h-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid
DK3386500T3 (da) 2015-12-09 2022-12-12 Univ Illinois Benzothiophen-baserede selektive østrogenreceptor ned-regulatorer
EP3434668B1 (en) 2016-03-25 2020-08-26 Luoxin Pharmaceutical (Shanghai) Co., Ltd. Indolo-substituted-piperidine compounds as estrogen receptor degrading agent
BR112018070161A2 (pt) 2016-04-01 2019-02-12 Zeno Royalties & Milestones, LLC moduladores de receptores de estrogênio
CN113912586B (zh) 2016-08-31 2023-04-07 江苏恒瑞医药股份有限公司 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用
WO2018081168A2 (en) 2016-10-24 2018-05-03 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective mixed estrogen receptor downregulators
WO2018098305A1 (en) * 2016-11-24 2018-05-31 Eisai R&D Management Co., Ltd. Tetrasubstituted alkene compounds and their use for the treatment of breast cancer
CA3041986A1 (en) 2016-11-28 2018-05-31 Eisai R&D Management Co., Ltd. Salts of indazole derivative and crystals thereof
CN110177554B (zh) 2017-01-06 2023-06-02 G1治疗公司 用于治疗癌症的组合疗法
KR20190117582A (ko) 2017-02-10 2019-10-16 쥐원 쎄라퓨틱스, 인크. 벤조티오펜 에스트로겐 수용체 조정제
CN108976187B (zh) * 2017-06-02 2021-11-26 上海青东生物科技有限公司 一种取代苯并呋喃衍生物及其制备与在制备抗肿瘤药物中的应用
JP6994698B2 (ja) 2017-08-28 2022-01-14 株式会社荏原製作所 単相誘導電動機
WO2019225552A1 (en) * 2018-05-22 2019-11-28 Eisai R&D Management Co., Ltd. Salts of indazole derivative and crystals thereof
CN113490850A (zh) 2018-08-17 2021-10-08 F·霍夫曼-拉罗氏股份公司 用于治疗乳腺癌的诊断和治疗方法
US20220033376A1 (en) * 2018-12-17 2022-02-03 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Estrogen receptor antagonist
AU2020326691A1 (en) 2019-08-06 2022-03-03 Recurium Ip Holdings, Llc Estrogen receptor modulators for treating mutants
JP2024502270A (ja) 2020-12-23 2024-01-18 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー エストロゲン受容体調節薬

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002097B1 (en) 1977-08-22 1981-08-05 Imperial Chemical Industries Plc Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
US4229447A (en) 1979-06-04 1980-10-21 American Home Products Corporation Intraoral methods of using benzodiazepines
US4596795A (en) 1984-04-25 1986-06-24 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
EP0230654B1 (en) 1985-12-28 1992-03-18 Sumitomo Pharmaceuticals Company, Limited Sustained pulsewise release pharmaceutical preparation
US4755386A (en) 1986-01-22 1988-07-05 Schering Corporation Buccal formulation
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5739136A (en) 1989-10-17 1998-04-14 Ellinwood, Jr.; Everett H. Intraoral dosing method of administering medicaments
US5017381A (en) 1990-05-02 1991-05-21 Alza Corporation Multi-unit pulsatile delivery system
US5229135A (en) 1991-11-22 1993-07-20 Prographarm Laboratories Sustained release diltiazem formulation
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
JP3409366B2 (ja) 1993-06-18 2003-05-26 東洋インキ製造株式会社 有機エレクトロルミネッセンス素子
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US5837284A (en) 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
DE19807760A1 (de) 1997-02-27 1998-09-03 Fuji Electric Co Ltd Elektrofotografischer Fotoleiter
US5840329A (en) 1997-05-15 1998-11-24 Bioadvances Llc Pulsatile drug delivery system
CZ300929B6 (cs) 1997-08-15 2009-09-16 Duke University Sloucenina pro použití pri lécení nebo prevenci estrogenem stimulované rakoviny
DE19801598C2 (de) 1998-01-17 2000-05-11 Aventis Res & Tech Gmbh & Co Katalytische Synthese von N-alkylierten Anilinen aus Olefinen und Anilinen
DE19801597C2 (de) 1998-01-17 2001-05-03 Aventis Res & Tech Gmbh & Co Basenkatalysierte Synthese von 1-Aryl-4-(arylethyl)piperazinen aus aromatischen Olefinen und 1-Arylpiperazinen
TW593256B (en) 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
GB9929988D0 (en) 1999-12-17 2000-02-09 Celltech Therapeutics Ltd Chemical compounds
US6528681B2 (en) * 2000-04-05 2003-03-04 Bristol-Meyers Squibb Pharma Company Halogenated triphenylethylene derivatives as selective estrogen receptor modulators
AU2002323098A1 (en) 2001-08-11 2003-03-03 Bristol-Myers Squibb Pharma Company Selective estrogen receptor modulators
AU2003248630A1 (en) 2002-06-06 2003-12-22 Smithkline Beecham Corporation Thrombopoietin mimetics
ES2307068T3 (es) * 2003-10-08 2008-11-16 Smithkline Beecham Corporation Compuestos de trifeniletileno como modularores selectivos de receptores de estrogenos.
DE102004028862A1 (de) * 2004-06-15 2005-12-29 Merck Patent Gmbh 3-Aminoindazole
US20070292545A1 (en) 2005-10-18 2007-12-20 Aaron Monte Anti-infective agents and methods of use
JP4804480B2 (ja) * 2005-01-26 2011-11-02 シェーリング コーポレイション 癌の処置のためのプロテインキナーゼインヒビターとしての、３−（インダゾール−５−イル）−（１，２，４）トリアジン誘導体、および関連する化合物
JP2009504872A (ja) 2005-08-15 2009-02-05 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド 印刷可能な材料
EP2099767A1 (en) 2006-11-01 2009-09-16 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- b activity and use thereof
JP2008156313A (ja) 2006-12-26 2008-07-10 Fyuuensu:Kk アミロイド疾患の治療およびモニタリングのための薬剤
GB0704407D0 (en) 2007-03-07 2007-04-18 Glaxo Group Ltd Compounds
DE102007049451A1 (de) * 2007-10-16 2009-04-23 Merck Patent Gmbh 5-Cyano-thienopyridine
JP5223362B2 (ja) 2008-02-07 2013-06-26 コニカミノルタビジネステクノロジーズ株式会社 光電変換素子及び太陽電池
WO2009131654A2 (en) 2008-04-21 2009-10-29 North Carolina State University Inhibition and dispersion of bacterial biofilms with imidazole-triazole derivatives
EP2362775B1 (en) 2008-11-20 2015-08-05 GlaxoSmithKline LLC Chemical compounds
WO2010077603A1 (en) 2008-12-08 2010-07-08 North Carolina State University Inhibition and dispersion of biofilms in plants with imidazole-triazole derivatives
WO2010107474A1 (en) 2009-03-16 2010-09-23 The Research Foundation Of State University Of New York Antiestrogens for breast cancer therapy
WO2010144959A1 (en) 2009-06-18 2010-12-23 Fibrotech Therapeutics Pty Ltd Analogues of anti-fibrotic agents
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
PE20142461A1 (es) 2012-03-20 2015-02-05 Seragon Pharmaceuticals Inc Moduladores del receptor de estrogeno y sus usos
JP6126562B2 (ja) * 2014-08-27 2017-05-10 三星ダイヤモンド工業株式会社 光ファイバ装置

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