CO6670521A2 - Vacuna y m´todos para reducir una infección por campylobacter - Google Patents

Vacuna y m´todos para reducir una infección por campylobacter

Info

Publication number
CO6670521A2
CO6670521A2 CO13003443A CO13003443A CO6670521A2 CO 6670521 A2 CO6670521 A2 CO 6670521A2 CO 13003443 A CO13003443 A CO 13003443A CO 13003443 A CO13003443 A CO 13003443A CO 6670521 A2 CO6670521 A2 CO 6670521A2
Authority
CO
Colombia
Prior art keywords
polypeptide
vector
campylobacter
methods
vaccine
Prior art date
Application number
CO13003443A
Other languages
English (en)
Inventor
Billy Hargis
Neil R Pumford
Young-Min Kwon
Sherryl Layton
Original Assignee
Univ Arkansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arkansas filed Critical Univ Arkansas
Publication of CO6670521A2 publication Critical patent/CO6670521A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención aborda el campo farmacéutico, en particular, el desarrollo de vacunas seguras y efectivas en cuanto al costo para la generación de inmunidad de mucosas contra enfermedades gastrointestinales humanas causadas por bacterias. Por lo tanto, se proveen vectores de vacuna y métodos para mejorar la resistencia a una infección por Campylobacter o para mejorar la respuesta inmune a Campylobacter. Los vectores de vacuna incluyen un primer polinucleótido que codifica un polipéptido antigénico seleccionado de las SEQ ID NO: 7-9 o un fragmento del mismo. El vector también puede incluir un segundo polipéptido inmunoestimulante, por ejemplo, un polipéptido CD154 o HMGBI. El polipéptido antigénico y el polipéptido inmunoestimulante se expresan sobre la superficie del vector, el cual puede ser una bacteria del género, por ejemplo, Salmonella, Escherichia, Bacillus o Lactobacillus.Finalmente, la presente invención provee el uso del vector para proteger a un sujeto vacunado contra una subsiguiente infección con Campylobacter spp.
CO13003443A 2010-06-09 2013-01-09 Vacuna y m´todos para reducir una infección por campylobacter CO6670521A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35303910P 2010-06-09 2010-06-09

Publications (1)

Publication Number Publication Date
CO6670521A2 true CO6670521A2 (es) 2013-05-15

Family

ID=45098670

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13003443A CO6670521A2 (es) 2010-06-09 2013-01-09 Vacuna y m´todos para reducir una infección por campylobacter

Country Status (22)

Country Link
US (2) US8961990B2 (es)
EP (2) EP2579901B1 (es)
JP (1) JP5746333B2 (es)
KR (3) KR102008120B1 (es)
CN (1) CN102971008B (es)
AR (1) AR081856A1 (es)
AU (3) AU2011264772B2 (es)
BR (1) BR112012031211A2 (es)
CA (1) CA2800830C (es)
CL (1) CL2012003458A1 (es)
CO (1) CO6670521A2 (es)
DK (1) DK2579901T3 (es)
EA (1) EA030793B1 (es)
ES (1) ES2753142T3 (es)
HU (1) HUE046858T2 (es)
MX (1) MX350306B (es)
NZ (3) NZ702839A (es)
PL (1) PL2579901T3 (es)
PT (1) PT2579901T (es)
UA (2) UA116915C2 (es)
WO (1) WO2011156619A2 (es)
ZA (1) ZA201209411B (es)

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ES2968398T3 (es) 2013-02-14 2024-05-09 Univ Arkansas Composiciones y métodos para potenciar las respuestas inmunitarias a Eimeria o limitar la infección por Eimeria
EP3578190A1 (en) * 2013-03-15 2019-12-11 The Board of Trustees of the University of Arkansas Compositions and methods of enhancing immune responses to enteric pathogens
US20150044698A1 (en) * 2013-08-06 2015-02-12 Techlab, Inc. Outer membrane protein 18 as a diagnostic marker for campylobacter
SG11201609965XA (en) * 2014-06-05 2016-12-29 Univ Arkansas Antibody guided vaccines and methods of use for generation of rapid mature immune responses
CN105223362B (zh) * 2015-09-10 2016-08-31 上海慧耘生物科技有限公司 空肠弯曲菌酶联免疫检测试剂盒
SG11201809686SA (en) * 2016-05-03 2018-11-29 Univ Arkansas Yeast vaccine vector including immunostimulatory and antigenic polypeptides and methods of using the same
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria

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Also Published As

Publication number Publication date
WO2011156619A3 (en) 2012-02-16
CL2012003458A1 (es) 2013-04-05
US10960068B2 (en) 2021-03-30
NZ604412A (en) 2015-01-30
AR081856A1 (es) 2012-10-24
US8961990B2 (en) 2015-02-24
AU2011264772A1 (en) 2013-01-24
KR102008120B1 (ko) 2019-08-07
JP2013537401A (ja) 2013-10-03
CN102971008B (zh) 2015-11-25
PT2579901T (pt) 2019-11-05
AU2015243062B2 (en) 2017-05-04
CA2800830A1 (en) 2011-12-15
JP5746333B2 (ja) 2015-07-08
NZ702839A (en) 2016-04-29
PL2579901T3 (pl) 2020-02-28
DK2579901T3 (da) 2019-11-04
AU2011264772B2 (en) 2015-07-16
AU2015243062A1 (en) 2015-11-12
ES2753142T3 (es) 2020-04-07
EP2579901A2 (en) 2013-04-17
BR112012031211A2 (pt) 2018-01-30
AU2017202104A1 (en) 2017-04-20
EP2579901A4 (en) 2013-11-06
US20150190496A1 (en) 2015-07-09
MX350306B (es) 2017-09-04
AU2017202104B2 (en) 2018-08-23
CA2800830C (en) 2020-09-08
UA116915C2 (uk) 2018-05-25
KR20180126618A (ko) 2018-11-27
EP2579901B1 (en) 2019-08-07
KR20180085064A (ko) 2018-07-25
MX2012014395A (es) 2013-02-26
EA030793B1 (ru) 2018-09-28
UA113496C2 (xx) 2017-02-10
HUE046858T2 (hu) 2020-03-30
AU2011264772A2 (en) 2013-02-14
CN102971008A (zh) 2013-03-13
EA201291373A1 (ru) 2013-05-30
KR101881611B1 (ko) 2018-07-25
NZ718006A (en) 2017-06-30
KR102007132B1 (ko) 2019-08-05
US20130084304A1 (en) 2013-04-04
ZA201209411B (en) 2015-05-27
KR20130088122A (ko) 2013-08-07
EP3556397A1 (en) 2019-10-23
WO2011156619A2 (en) 2011-12-15

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