CO6280419A2 - 5-[(3,3,3-trifluoro-2-hidroxi-1-arilpropil)amino]-1h-quinolin-2-onas un proceso para su produccion y uso como agentes inflamatorios - Google Patents
5-[(3,3,3-trifluoro-2-hidroxi-1-arilpropil)amino]-1h-quinolin-2-onas un proceso para su produccion y uso como agentes inflamatoriosInfo
- Publication number
- CO6280419A2 CO6280419A2 CO10061149A CO10061149A CO6280419A2 CO 6280419 A2 CO6280419 A2 CO 6280419A2 CO 10061149 A CO10061149 A CO 10061149A CO 10061149 A CO10061149 A CO 10061149A CO 6280419 A2 CO6280419 A2 CO 6280419A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkyl
- nr6r7
- optionally substituted
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula I, a procesos para su producción y a su uso como agentes antiinflamatorios.1.- Compuestos que responden a la fórmula general 1R1 y R2 significan en forma independiente entre sí un átomo de hidrógeno, un grupo hidroxi, un átomo de halógeno, un grupo (C1-C10)-alquilo opcionalmente sustituido, un grupo (C1-C10)-alcoxi opcionalmente sustituido, un grupo (C1-C10)-alquiltio, un grupo (C1-C5)-perfluoroalquilo, un grupo ciano, un grupo nitro, o R1 y R2 juntos significan un grupo que se selecciona entre los grupos -O-(CH2)p-O-, -O-(CH2)p-(CH2)-, -O-CH=CH-, -(CH2)p+2-, -NH-(CH2)p+1, -N(C1-C3-alquil) - (CH2)p+1, y -NH-N=CH-, donde p = 1 o 2, y los átomos de oxígeno y/o átomos de carbono y/o átomos de nitrógeno terminales están unidos a átomos de carbono del anillo directamente adyacente, o NR6R7, donde R6 y R7, significan en forma independiente entre sí hidrógeno, C1-C5 alquilo o (CO) - (C1-C5) -alquilo, R3 significa un átomo de hidrógeno, un grupo hidroxi, un átomo de halógeno, un grupo ciano, un grupo (C1-C10)-alquilo opcionalmente sustituido, un grupo (C1-C10)-alcoxi, un grupo (C1-C10)-alquiltio, o un grupo (C1-C5)-perfluoroalquilo, R4 significa hidrógeno, halógeno, hidroxi, (C1-C5)-alquilo, (C1-C5)alcoxi, (C1-C5)-alquiltio, (C1-C5)-perfluoroalquilo, ciano, nitro, NR6R7, COOR9, (CO)NR6R7 o un grupo (C1-C5-alquilen)-O-(CO)-(C1-C5) alquilo ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07076019A EP2062880A1 (en) | 2007-11-22 | 2007-11-22 | 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6280419A2 true CO6280419A2 (es) | 2011-05-20 |
Family
ID=39575536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10061149A CO6280419A2 (es) | 2007-11-22 | 2010-05-21 | 5-[(3,3,3-trifluoro-2-hidroxi-1-arilpropil)amino]-1h-quinolin-2-onas un proceso para su produccion y uso como agentes inflamatorios |
Country Status (40)
| Country | Link |
|---|---|
| US (3) | US8394958B2 (es) |
| EP (2) | EP2062880A1 (es) |
| JP (1) | JP5559058B2 (es) |
| KR (1) | KR101580700B1 (es) |
| CN (2) | CN103396300A (es) |
| AR (1) | AR069400A1 (es) |
| AU (1) | AU2008328307C1 (es) |
| BR (1) | BRPI0819833B1 (es) |
| CA (1) | CA2705410C (es) |
| CL (1) | CL2008003472A1 (es) |
| CO (1) | CO6280419A2 (es) |
| CR (1) | CR11452A (es) |
| CU (1) | CU23889B1 (es) |
| CY (1) | CY1118173T1 (es) |
| DK (1) | DK2234979T3 (es) |
| DO (1) | DOP2010000152A (es) |
| EA (1) | EA017459B1 (es) |
| EC (1) | ECSP10010192A (es) |
| ES (1) | ES2588170T3 (es) |
| HK (1) | HK1144817A1 (es) |
| HN (1) | HN2010001060A (es) |
| HR (1) | HRP20161015T1 (es) |
| HU (1) | HUE028865T2 (es) |
| IL (1) | IL205117A (es) |
| LT (1) | LT2234979T (es) |
| MA (1) | MA31834B1 (es) |
| MX (1) | MX2010005528A (es) |
| MY (1) | MY151017A (es) |
| NZ (1) | NZ585495A (es) |
| PA (1) | PA8804601A1 (es) |
| PE (1) | PE20091066A1 (es) |
| PL (1) | PL2234979T3 (es) |
| PT (1) | PT2234979T (es) |
| RS (1) | RS55012B1 (es) |
| SI (1) | SI2234979T1 (es) |
| TN (1) | TN2010000219A1 (es) |
| TW (1) | TWI520736B (es) |
| UA (1) | UA100251C2 (es) |
| UY (1) | UY31479A1 (es) |
| WO (1) | WO2009065503A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1878717A1 (en) | 2006-07-14 | 2008-01-16 | Bayer Schering Pharma Aktiengesellschaft | Benzyl amines, a process for their production and their use as anti-inflammatory agents |
| WO2009151569A2 (en) * | 2008-06-09 | 2009-12-17 | Combinatorx, Incorporated | Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders |
| US20100016338A1 (en) * | 2008-07-21 | 2010-01-21 | Bayer Schering Pharma Aktiengesellschaft | 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents |
| JP6061373B2 (ja) * | 2012-07-24 | 2017-01-18 | 国立研究開発法人産業技術総合研究所 | ２−ヒドロキシベンズアルデヒド化合物、これを含有するコラーゲン細胞外分泌阻害剤及び医薬品組成物 |
| WO2017025371A1 (en) * | 2015-08-07 | 2017-02-16 | Bayer Pharma Aktiengesellschaft | Process for the preparation of 5-amino-quinolin-2(1h)-ones and their tautomer forms 5-amino-quinolin-2-ols |
| WO2017081044A1 (en) | 2015-11-13 | 2017-05-18 | Bayer Pharma Aktiengesellschaft | 4-(4-cyano-2-thioaryl)dihydropyrimidinones for treating chronic wounds |
| WO2017161518A1 (en) | 2016-03-23 | 2017-09-28 | Astrazeneca Ab | New physical form |
| WO2018046684A1 (en) | 2016-09-08 | 2018-03-15 | Bayer Pharma Aktiengesellschaft | Process for the preparation of substituted 5-{[2-(alkoxymethyl)-3,3,3-trifluoro-2-hydroxy-1-phenylpropyl]amino}quinolin-2(1h)-ones |
| WO2018046681A1 (en) | 2016-09-08 | 2018-03-15 | Bayer Pharma Aktiengesellschaft | Forms of 5-{[(1s,2s)-1-(2-chloro-3-fluoro-4-methoxyphenyl)-3,3,3-trifluoro-2-hydroxy-2-(methoxymethyl)propyl]amino}-7-fluoro-1h-quinolin-2-one |
| WO2018046678A1 (de) | 2016-09-08 | 2018-03-15 | Bayer Aktiengesellschaft | Glukokorticoid-rezeptor-agonisten enthaltende formulierungen |
| WO2018046685A1 (en) | 2016-09-08 | 2018-03-15 | Bayer Aktiengesellschaft | Quinoline derivatives for treatment of inflammatory skin diseases |
| AU2020211303A1 (en) * | 2019-01-22 | 2021-07-15 | Akribes Biomedical Gmbh | Selective Glucocorticoid Receptor Modifiers for treating impaired skin wound healing |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1045180A (en) * | 1963-09-20 | 1966-10-12 | Parke Davis & Co | Quinazoline derivatives |
| US4197209A (en) * | 1977-03-10 | 1980-04-08 | Ciba-Geigy Corporation | Lubricant compositions containing sulfur-containing esters of phosphoric acid |
| JPH06172321A (ja) | 1992-10-08 | 1994-06-21 | Agro Kanesho Co Ltd | 置換アミノピリミジン誘導体、その製造法及びそれを有効成分とする有害生物駆除剤 |
| UA57002C2 (uk) * | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
| AU5682299A (en) | 1998-08-21 | 2000-03-14 | Scripps Research Institute, The | Catalytic asymmetric aminohydroxylation with amino-substituted heterocycles |
| DE10038639A1 (de) | 2000-07-28 | 2002-02-21 | Schering Ag | Nichtsteroidale Entzündungshemmer |
| ES2270955T3 (es) | 2000-12-22 | 2007-04-16 | Smithkline Beecham Plc | Sal mesilato de 5-(4-(2-(n-metil-n-(2-piridil)amino)etoxi)bencil)tiazolidina-2,4-diona. |
| EP1490317A1 (en) * | 2002-03-26 | 2004-12-29 | Boehringer Ingelheim Pharmaceuticals Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US20050090559A1 (en) * | 2003-07-01 | 2005-04-28 | Markus Berger | Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents |
| EA200600148A1 (ru) | 2003-07-01 | 2006-08-25 | Шеринг Акциенгезельшафт | Гетероциклически замещённые производные пентанола, способ их получения и их применение в качестве ингибиторов воспаления |
| US20050009109A1 (en) * | 2003-07-08 | 2005-01-13 | Stanford University | Fluorophore compounds and their use in biological systems |
| DE10347385A1 (de) | 2003-10-08 | 2005-05-12 | Schering Ag | Umgelagerte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
| EP1878717A1 (en) * | 2006-07-14 | 2008-01-16 | Bayer Schering Pharma Aktiengesellschaft | Benzyl amines, a process for their production and their use as anti-inflammatory agents |
| US20100016338A1 (en) * | 2008-07-21 | 2010-01-21 | Bayer Schering Pharma Aktiengesellschaft | 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents |
-
2007
- 2007-11-22 EP EP07076019A patent/EP2062880A1/en not_active Withdrawn
-
2008
- 2008-11-08 WO PCT/EP2008/009440 patent/WO2009065503A1/en active Application Filing
- 2008-11-08 CA CA2705410A patent/CA2705410C/en not_active Expired - Fee Related
- 2008-11-08 LT LTEP08852223.0T patent/LT2234979T/lt unknown
- 2008-11-08 PT PT88522230T patent/PT2234979T/pt unknown
- 2008-11-08 MY MYPI20101676 patent/MY151017A/en unknown
- 2008-11-08 BR BRPI0819833A patent/BRPI0819833B1/pt not_active IP Right Cessation
- 2008-11-08 MX MX2010005528A patent/MX2010005528A/es active IP Right Grant
- 2008-11-08 EA EA201000814A patent/EA017459B1/ru not_active IP Right Cessation
- 2008-11-08 SI SI200831665A patent/SI2234979T1/sl unknown
- 2008-11-08 CN CN2013101575656A patent/CN103396300A/zh active Pending
- 2008-11-08 ES ES08852223.0T patent/ES2588170T3/es active Active
- 2008-11-08 DK DK08852223.0T patent/DK2234979T3/en active
- 2008-11-08 PL PL08852223.0T patent/PL2234979T3/pl unknown
- 2008-11-08 KR KR1020107011067A patent/KR101580700B1/ko active IP Right Grant
- 2008-11-08 CN CN2008801173301A patent/CN101868448B/zh not_active Expired - Fee Related
- 2008-11-08 JP JP2010534394A patent/JP5559058B2/ja not_active Expired - Fee Related
- 2008-11-08 UA UAA201007264A patent/UA100251C2/uk unknown
- 2008-11-08 AU AU2008328307A patent/AU2008328307C1/en not_active Ceased
- 2008-11-08 HU HUE08852223A patent/HUE028865T2/en unknown
- 2008-11-08 RS RS20160676A patent/RS55012B1/sr unknown
- 2008-11-08 EP EP08852223.0A patent/EP2234979B1/en active Active
- 2008-11-08 NZ NZ585495A patent/NZ585495A/en not_active IP Right Cessation
- 2008-11-19 PE PE2008001948A patent/PE20091066A1/es active IP Right Grant
- 2008-11-20 UY UY31479A patent/UY31479A1/es not_active Application Discontinuation
- 2008-11-20 PA PA20088804601A patent/PA8804601A1/es unknown
- 2008-11-20 TW TW097144922A patent/TWI520736B/zh not_active IP Right Cessation
- 2008-11-21 CL CL2008003472A patent/CL2008003472A1/es unknown
- 2008-11-21 US US12/275,392 patent/US8394958B2/en not_active Expired - Fee Related
- 2008-11-21 AR ARP080105069A patent/AR069400A1/es active IP Right Grant
-
2010
- 2010-04-15 IL IL205117A patent/IL205117A/en active IP Right Grant
- 2010-05-05 MA MA32817A patent/MA31834B1/fr unknown
- 2010-05-20 TN TN2010000219A patent/TN2010000219A1/fr unknown
- 2010-05-21 CR CR11452A patent/CR11452A/es unknown
- 2010-05-21 EC EC2010010192A patent/ECSP10010192A/es unknown
- 2010-05-21 CU CUP2010000099A patent/CU23889B1/es active IP Right Grant
- 2010-05-21 DO DO2010000152A patent/DOP2010000152A/es unknown
- 2010-05-21 HN HN2010001060A patent/HN2010001060A/es unknown
- 2010-05-21 CO CO10061149A patent/CO6280419A2/es active IP Right Grant
- 2010-12-09 HK HK10111461.5A patent/HK1144817A1/xx not_active IP Right Cessation
-
2012
- 2012-09-13 US US13/614,161 patent/US8680117B2/en not_active Ceased
-
2016
- 2016-03-24 US US15/080,187 patent/USRE47047E1/en active Active
- 2016-08-16 HR HRP20161015TT patent/HRP20161015T1/hr unknown
- 2016-08-19 CY CY20161100820T patent/CY1118173T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO6280419A2 (es) | 5-[(3,3,3-trifluoro-2-hidroxi-1-arilpropil)amino]-1h-quinolin-2-onas un proceso para su produccion y uso como agentes inflamatorios | |
| CO6150135A2 (es) | Bencilaminas un proceso para su produccion y su uso como agentes antiinflamatorios | |
| ES2568009T3 (es) | Procedimiento para la absorción de CO2 a partir de una mezcla gaseosa con un medio de absorción que contiene aminas | |
| AR070479A1 (es) | Derivado heterociclico fusionado y su uso | |
| UY29742A1 (es) | Procedimiento para la preparación de betamimeticos | |
| CO6210751A2 (es) | Derivados de indolinona y procedimiento para su fabricacion | |
| BRPI0915692B8 (pt) | compostos derivados de 1,2,5-oxadiazóis, sua forma sólida, sua composição, bem como seus usos | |
| ECSP10010271A (es) | Derivados de tiazol usados como inhibidores de pi 3-cinasa | |
| DOP2010000047A (es) | Compuestos de pirazol y su uso como inhibidores de raf | |
| DOP2011000237A (es) | Inhibidores de poli (adp-ribosa) polimerasa (parp) | |
| ECSP078060A (es) | 2,4-diamino-pirimidinas como inhibidores de aurora | |
| CR20140091A (es) | Nuevos derivados dihidroquinolina-2-ona | |
| DOP2011000217A (es) | Nuevas bencenosulfonamidas como bloqueadores de canales de calcio | |
| BRPI0812222A2 (pt) | Compostos ciclobutenodiona substituídos anti-inflamatórios. | |
| ECSP11011244A (es) | Nuevos herbicidas. | |
| PA8779101A1 (es) | "compuestos tricíclicos como inhibidores de metaloproteinasas matriciales" | |
| CR10671A (es) | Compuestos azabiciclicos como inhibidores de la recaptacion de monoaminas | |
| UY32395A (es) | Compuesto con anillo fusionado y su uso | |
| CO6362013A2 (es) | Derivados de rifamicina | |
| UY32635A (es) | Derivados de bis-(sulfonilamino) en terapia 735 | |
| CL2023003154A1 (es) | Compuestos heterocíclicos | |
| CO6290665A2 (es) | Derivados de oxindol sustituido y su uso para el tratamiento de enfermedades dependientes de la vasopresina | |
| AR070874A1 (es) | Compuesto heterociclico fusionado, una composicion farmaceutica que lo comprende y su uso en el tratamiento del cancer. | |
| UY33179A (es) | Derivados de ácido carboxílico que comprenden un anillo de oxazolopirimidina 2,5-sustituido. | |
| EA201200150A1 (ru) | Новые гербициды |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |