CO6270218A2 - Composicion de bicapas para la liberacion controlada de acetaminofeno y tramadol - Google Patents
Composicion de bicapas para la liberacion controlada de acetaminofeno y tramadolInfo
- Publication number
- CO6270218A2 CO6270218A2 CO10044379A CO10044379A CO6270218A2 CO 6270218 A2 CO6270218 A2 CO 6270218A2 CO 10044379 A CO10044379 A CO 10044379A CO 10044379 A CO10044379 A CO 10044379A CO 6270218 A2 CO6270218 A2 CO 6270218A2
- Authority
- CO
- Colombia
- Prior art keywords
- tramadol
- composition
- acetaminophen
- hour
- initial administration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invencion se refiere a una composicion de bicapas para la liberacion de acetaminofeno y tramadol en un periodo de tiempo de por lo menos doce horas después de la administracion inicial. Una administracion ·nica de la composicion de bicapas puede proveer analgesia comenzando en menos de media hora hasta aproximadamente una hora después de la administracion inicial, con una duracion de por lo menos doce horas después de la administracion inicial. 1.- Una composicion de bicapas para la liberacion de tramadol y acetaminofeno, en la cual, la composicion de bicapas comprende: a. una primera capa que define una porcion de liberacion rapida de la composicion y que comprende acetaminofeno. b. una segunda capa que define una porcion de liberacion sostenida de la composicion, y comprende acetaminofeno, tramadol y almidon de alto contenido de amilosa entrecruzado, donde, cuando se ensaya en un Aparato U.S.P. de Tipo III, con 20 inmersiones por minuto a 37° C, en una solucion de 250 mL de fosfato de potasio monobasico de pH 6,8 durante una hora, - después de lo cual la solucion es removida y reemplazada con 250 mL de fosfato de potasio monobasico fresco de pH 6,8 durante once horas - el acetaminofeno y el tramadol son liberados con la cinética siguiente:
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98020307P | 2007-10-16 | 2007-10-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6270218A2 true CO6270218A2 (es) | 2011-04-20 |
Family
ID=40566952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10044379A CO6270218A2 (es) | 2007-10-16 | 2010-04-16 | Composicion de bicapas para la liberacion controlada de acetaminofeno y tramadol |
Country Status (15)
Country | Link |
---|---|
US (1) | US8895066B2 (es) |
EP (1) | EP2203166B1 (es) |
JP (1) | JP5453280B2 (es) |
KR (1) | KR20100069685A (es) |
CN (1) | CN101827590A (es) |
AR (1) | AR068891A1 (es) |
AU (1) | AU2008314454A1 (es) |
BR (1) | BRPI0818762B8 (es) |
CA (1) | CA2678092C (es) |
CO (1) | CO6270218A2 (es) |
ES (1) | ES2541809T3 (es) |
MX (1) | MX336494B (es) |
RU (1) | RU2469718C2 (es) |
TW (1) | TW200927196A (es) |
WO (1) | WO2009049405A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090162431A1 (en) * | 2002-09-21 | 2009-06-25 | Shuyi Zhang | Sustained release formulations containing acetaminophen and tramadol |
CA2720108C (en) | 2008-03-11 | 2016-06-07 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
US8597681B2 (en) | 2009-12-22 | 2013-12-03 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
US20120015031A1 (en) | 2010-07-14 | 2012-01-19 | Grunenthal Gmbh | Novel gastro-retentive dosage forms |
CN102670542A (zh) * | 2011-03-17 | 2012-09-19 | 北京天衡药物研究院 | ***马多渗透泵控释片 |
US9050335B1 (en) | 2011-05-17 | 2015-06-09 | Mallinckrodt Llc | Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia |
US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
US10702485B2 (en) | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
EP2968182B8 (en) * | 2013-03-15 | 2018-07-25 | SpecGx LLC | Abuse deterrent solid dosage form for immediate release with functional score |
DE102013009114A1 (de) | 2013-05-29 | 2014-12-04 | Franz Gerstheimer | Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen |
KR101710792B1 (ko) * | 2015-07-14 | 2017-02-28 | 주식회사 유영제약 | 세레콕시브 및 트라마돌을 함유하는 약제학적 조성물 |
US9693949B1 (en) * | 2015-12-22 | 2017-07-04 | Revogenex Ireland Ltd | Intravenous administration of tramadol |
US9980900B2 (en) * | 2015-12-22 | 2018-05-29 | Revogenex Ireland Ltd | Intravenous administration of tramadol |
EP3694557B1 (en) * | 2017-10-13 | 2022-04-13 | Altus Formulation Inc. | Starch-based release modifying excipients and pharmaceutical compositions derived therefrom |
GB2567493B (en) * | 2017-10-13 | 2019-12-18 | Altus Formulation Inc | Starch-based release modifying excipients and pharmaceutical compositions derived therefrom |
US11000488B2 (en) | 2019-03-22 | 2021-05-11 | Syntrix Biosystems Inc. | Treating pain using desmetramadol |
DE102021210130A1 (de) * | 2021-09-14 | 2023-03-16 | Robert Bosch Gesellschaft mit beschränkter Haftung | Fluidleitvorrichtung für einen Scheibenwischer |
WO2024144258A1 (ko) * | 2022-12-28 | 2024-07-04 | 주식회사 삼양홀딩스 | 룩소리티닙의 다중 방출제어 정제 조성물 및 이의 제조 방법 |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
US4968509A (en) * | 1987-07-27 | 1990-11-06 | Mcneilab, Inc. | Oral sustained release acetaminophen formulation and process |
US5004613A (en) * | 1987-07-27 | 1991-04-02 | Mcneil-Ppc, Inc. | Oral sustained release pharmaceutical formulation and process |
US4820522A (en) * | 1987-07-27 | 1989-04-11 | Mcneilab, Inc. | Oral sustained release acetaminophen formulation and process |
US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
US5603956A (en) * | 1990-11-27 | 1997-02-18 | Labopharm Inc. | Cross-linked enzymatically controlled drug release |
CA2041774C (en) * | 1990-11-27 | 1994-04-19 | Mircea A. Mateescu | Use of cross-linked amylose as a matrix for the slow release of biologically active compounds |
ES2120451T7 (es) * | 1991-09-06 | 2009-11-05 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Composicion que comprende un compuesto de tramadol y acetaminofeno, y su uso. |
US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US5616343A (en) * | 1993-03-25 | 1997-04-01 | Labopharm, Inc. | Cross-linked amylose as a binder/disintegrant in tablets |
IL109460A (en) * | 1993-05-10 | 1998-03-10 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
IT1264696B1 (it) * | 1993-07-09 | 1996-10-04 | Applied Pharma Res | Forme farmaceutiche destinate alla somministrazione orale in grado di rilasciare sostanze attive a velocita' controllata e differenziata |
DE4329794C2 (de) * | 1993-09-03 | 1997-09-18 | Gruenenthal Gmbh | Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung |
US6210714B1 (en) * | 1993-11-23 | 2001-04-03 | Euro-Celtique S.A. | Immediate release tablet cores of acetaminophen having sustained-release coating |
GB9519363D0 (en) * | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
AUPN605795A0 (en) * | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
US5773031A (en) * | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
US5807575A (en) * | 1997-02-14 | 1998-09-15 | Rougier Inc. | Manufacture of cross-linked amylose useful as a excipient for control release of active compounds |
BE1011045A3 (fr) * | 1997-03-14 | 1999-04-06 | Ucb Sa | Compositions pharmaceutiques pour la liberation controlee de substances actives. |
FR2772615B1 (fr) * | 1997-12-23 | 2002-06-14 | Lipha | Comprime multicouche pour la liberation instantanee puis prolongee de substances actives |
US6284273B1 (en) * | 1998-02-24 | 2001-09-04 | Vincent Lenaerts | Cross-linked high amylose starch resistant to amylase as a matrix for the slow release of biologically active compounds |
US6245357B1 (en) * | 1998-03-06 | 2001-06-12 | Alza Corporation | Extended release dosage form |
US6156342A (en) * | 1998-05-26 | 2000-12-05 | Andex Pharmaceuticals, Inc. | Controlled release oral dosage form |
IT1301966B1 (it) * | 1998-07-30 | 2000-07-20 | Zambon Spa | Composizioni farmaceutiche ad attivita' analgesica |
US6245387B1 (en) * | 1998-11-03 | 2001-06-12 | Diamon-Fusion International, Inc. | Capped silicone film and method of manufacture thereof |
CA2371940C (en) * | 1999-03-31 | 2008-07-15 | Janssen Pharmaceutica N.V. | Pregelatinized starch in a controlled release formulation |
AU2276801A (en) | 1999-12-20 | 2001-07-03 | Schering Corporation | Extended release oral dosage composition |
US6761895B2 (en) * | 2000-04-17 | 2004-07-13 | Yamanouchi Pharmaceutical Co., Ltd. | Drug delivery system for averting pharmacokinetic drug interaction and method thereof |
GB0009522D0 (en) * | 2000-04-19 | 2000-06-07 | Smithkline Beecham Plc | Composition |
US6955821B2 (en) * | 2000-04-28 | 2005-10-18 | Adams Laboratories, Inc. | Sustained release formulations of guaifenesin and additional drug ingredients |
US6607748B1 (en) * | 2000-06-29 | 2003-08-19 | Vincent Lenaerts | Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture |
JP2004513091A (ja) * | 2000-10-03 | 2004-04-30 | ペンウェスト ファーマシューティカルズ カンパニー | 異なる速度の複数の医薬活性成分の送達系 |
US20020106408A1 (en) * | 2000-12-01 | 2002-08-08 | Johnatan Bacon | Prolamin-based sustained-release compositions and delayed-onset compositions |
US6968551B2 (en) * | 2001-06-11 | 2005-11-22 | John Hediger | System and user interface for generation and processing of software application installation instructions |
US20030092724A1 (en) * | 2001-09-18 | 2003-05-15 | Huaihung Kao | Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic |
US8329217B2 (en) * | 2001-11-06 | 2012-12-11 | Osmotica Kereskedelmi Es Szolgaltato Kft | Dual controlled release dosage form |
KR100522239B1 (ko) | 2002-07-16 | 2005-10-18 | 주식회사 서울제약 | 아세트아미노펜을 함유하는 제어방출성의 경구용 제제 |
EP1555022B1 (en) * | 2002-09-21 | 2008-02-20 | Shuyi Zhang | Sustained release formulation of acetaminophen and tramadol |
US8487002B2 (en) * | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
RU2333745C2 (ru) * | 2002-10-25 | 2008-09-20 | Лабофарм Инк. | Композиции с контролируемым высвобождением |
TWI319713B (en) * | 2002-10-25 | 2010-01-21 | Sustained-release tramadol formulations with 24-hour efficacy | |
CA2419349A1 (en) * | 2003-02-20 | 2004-08-20 | Geoffrey Lambert | A modular display holder for a card |
US20080031901A1 (en) * | 2004-09-24 | 2008-02-07 | Abbott Laboratories | Sustained release monoeximic formulations of opioid and nonopioid analgesics |
NZ546148A (en) * | 2003-09-26 | 2009-05-31 | Alza Corp | Drug coating providing high drug loading and methods for providing the same |
US20060172006A1 (en) * | 2003-10-10 | 2006-08-03 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour clinical efficacy |
US20050157382A1 (en) * | 2004-01-07 | 2005-07-21 | Kafka James D. | Industrial directly diode-pumped ultrafast amplifier system |
US7622137B2 (en) * | 2004-05-21 | 2009-11-24 | Accu-Break Technologies, Inc. | Dosage forms contained within a capsule or sachet |
US8541026B2 (en) * | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
US20060257473A1 (en) * | 2005-05-11 | 2006-11-16 | Porranee Puranajoti | Extended release tablet |
ES2441766T3 (es) * | 2005-08-24 | 2014-02-06 | Endo Pharmaceuticals Inc. | Formulaciones de nalbufina de liberación sostenida |
ES2389666T3 (es) * | 2005-09-09 | 2012-10-30 | Angelini Labopharm, Llc | Composición de trazodona para una administración de una vez al día |
EA020867B1 (ru) * | 2006-03-06 | 2015-02-27 | Поузен Инк. | Лекарственные формы для введения комбинаций лекарственных средств |
US20070237816A1 (en) * | 2006-04-06 | 2007-10-11 | David Finkelstein | Acetaminophen formulation for joint pain relief |
-
2008
- 2008-10-15 MX MX2010004236A patent/MX336494B/es unknown
- 2008-10-15 KR KR1020107008205A patent/KR20100069685A/ko not_active Application Discontinuation
- 2008-10-15 RU RU2010119463/15A patent/RU2469718C2/ru not_active IP Right Cessation
- 2008-10-15 CA CA2678092A patent/CA2678092C/en active Active
- 2008-10-15 CN CN200880112295A patent/CN101827590A/zh active Pending
- 2008-10-15 AU AU2008314454A patent/AU2008314454A1/en not_active Abandoned
- 2008-10-15 WO PCT/CA2008/001799 patent/WO2009049405A1/en active Application Filing
- 2008-10-15 JP JP2010529201A patent/JP5453280B2/ja active Active
- 2008-10-15 BR BRPI0818762A patent/BRPI0818762B8/pt active IP Right Grant
- 2008-10-15 EP EP20080839570 patent/EP2203166B1/en active Active
- 2008-10-15 US US12/252,117 patent/US8895066B2/en active Active
- 2008-10-15 ES ES08839570.2T patent/ES2541809T3/es active Active
- 2008-10-16 AR ARP080104506A patent/AR068891A1/es not_active Application Discontinuation
- 2008-10-16 TW TW097139684A patent/TW200927196A/zh unknown
-
2010
- 2010-04-16 CO CO10044379A patent/CO6270218A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BRPI0818762B1 (pt) | 2019-07-02 |
AU2008314454A1 (en) | 2009-04-23 |
CA2678092C (en) | 2013-07-30 |
WO2009049405A1 (en) | 2009-04-23 |
MX336494B (es) | 2016-01-21 |
BRPI0818762A8 (pt) | 2017-09-19 |
CN101827590A (zh) | 2010-09-08 |
ES2541809T3 (es) | 2015-07-24 |
KR20100069685A (ko) | 2010-06-24 |
JP2011500607A (ja) | 2011-01-06 |
RU2010119463A (ru) | 2011-11-27 |
MX2010004236A (es) | 2010-09-07 |
US20090130183A1 (en) | 2009-05-21 |
AR068891A1 (es) | 2009-12-16 |
EP2203166A4 (en) | 2012-07-04 |
JP5453280B2 (ja) | 2014-03-26 |
BRPI0818762A2 (pt) | 2015-04-07 |
US8895066B2 (en) | 2014-11-25 |
BRPI0818762B8 (pt) | 2021-05-25 |
EP2203166B1 (en) | 2015-05-06 |
RU2469718C2 (ru) | 2012-12-20 |
TW200927196A (en) | 2009-07-01 |
EP2203166A1 (en) | 2010-07-07 |
CA2678092A1 (en) | 2009-04-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6270218A2 (es) | Composicion de bicapas para la liberacion controlada de acetaminofeno y tramadol | |
NZ580226A (en) | Dimer compounds as inhibitors of iap | |
BRPI0419348B8 (pt) | métodos para produzir o conjugado de maitansinóide-agente de ligação celular | |
WO2005086860A3 (en) | Methods for generating insulin-producing cells | |
UA86699C2 (ru) | Отверждающаяся композиция, способ ее получения и способ уплотнения | |
TW200621313A (en) | Pharmaceutical compositions | |
NO20076284L (no) | Vannsvellbart hybridmateriale med uorganiske tilsetningsstoffer, og fremgangsmate for fremstilling av dette | |
BRPI0512347B8 (pt) | preparação da pregabalina e compostos relacionados | |
GT200800184A (es) | Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevencion de diabetes. | |
BRPI0515684A (pt) | formulações de cristais injetáveis ativas de longa duração de metabólitos de estradiol, e métodos de utilização das mesmas | |
AR066395A1 (es) | Reovirus que tienen secuencias modificadas | |
TW200716628A (en) | Novel compounds | |
WO2007061939A3 (en) | Metabolite derivatives of the hdac inhibitor fk228 | |
MXPA06012500A (es) | Compuestos para el tratamiento de la enfermedad de alzheimer y para la inhibicion de la produccion del peptido beta-amiloideo. | |
WO2007143607A3 (en) | Method of treating atrophic vaginitis | |
UA92894C2 (ru) | Способ приготовления и применения композиции адсорбента фосфата, адсорбент фосфата, композиция адсорбента фосфата | |
TW200731987A (en) | Cytotoxicity mediation of cells evidencing surface expression of CD44 | |
WO2008075192A3 (en) | Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds | |
MX2010001574A (es) | Ligandos del receptor cannabinoide. | |
MX2009005148A (es) | Aptamero contra midcina, y uso del mismo. | |
CL2008001393A1 (es) | Compuestos derivados de dihidroquinonas y dihidronaftiridinas, inhibidores de jnk; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar artritis reumatoide, asma, diabetes tipo 2, alzheimer, enfermedad de parkinson, hiperproliferacion celular. | |
MX2009008511A (es) | Reduccion de efectos secundarios de tramadol. | |
DK1530628T3 (da) | Fremgangsmåde til fremstilling af temperaturinducerede tumorcellelysater til anvendelse som immunogene forbindelser | |
BR112012007991B8 (pt) | uso de inibidores de cxcr1/2 como adjuvantes no transplante de ilhotas pancreáticas | |
BRPI0815050A8 (pt) | Avidina oxidada com tempo de permanência elevado em tecidos tratados, complexo compreendendo a referida avidina e uso dos mesmos, composição farmacêutica, kit, bem como processo de oxidação de avidina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |