CO5690598A2 - 6-[(sustituido)fenil]triazolopirimidinas como agentes anticancer - Google Patents

6-[(sustituido)fenil]triazolopirimidinas como agentes anticancer

Info

Publication number
CO5690598A2
CO5690598A2 CO06038133A CO06038133A CO5690598A2 CO 5690598 A2 CO5690598 A2 CO 5690598A2 CO 06038133 A CO06038133 A CO 06038133A CO 06038133 A CO06038133 A CO 06038133A CO 5690598 A2 CO5690598 A2 CO 5690598A2
Authority
CO
Colombia
Prior art keywords
alkyl
independently
triazolopirimidinas
phenyl
replaced
Prior art date
Application number
CO06038133A
Other languages
English (en)
Inventor
Nan Zhang
Kaloustian Semiramis Ayral
Thai Hiep Nguyen
Yanzhong Wu
Wei Tong
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CO5690598A2 publication Critical patent/CO5690598A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Abstract

1.- Un compuesto de la Fórmula (I): caracterizado porque:R1 se selecciona deR2 es un radical del grupo n es un entero de 2, 3 ó 4;X es CI o Br;Y es O, S, CH2 o NR4;Q se selecciona de -NR6R7 y -OH;L1 y L2 son cada uno independientemente H, F, Cl, Br o CF3;R3 es CF3 o C2F5;R4 y R5 son cada uno independientemente H o alquilo C1-C3;R6 y R7 son cada uno independientemente H o alquilo C1-C3; o R6 y R7 cuando se toman opcionalmente juntos con el átomo de nitrógeno al que cada uno se enlaza forman un anillo heterocíclico saturado de 4 a 6 miembros que tiene 1-2 átomos de nitrógeno y 0-1 átomos de oxigeno ó 0-1 átomos de azufre y se sustituyen opcionalmente con R8;R8 es alquilo C1-C3;o una sal farmacéuticamente aceptable de los mismos.
CO06038133A 2003-09-24 2006-04-21 6-[(sustituido)fenil]triazolopirimidinas como agentes anticancer CO5690598A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24

Publications (1)

Publication Number Publication Date
CO5690598A2 true CO5690598A2 (es) 2006-10-31

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06038133A CO5690598A2 (es) 2003-09-24 2006-04-21 6-[(sustituido)fenil]triazolopirimidinas como agentes anticancer

Country Status (31)

Country Link
US (1) US7507739B2 (es)
EP (1) EP1680425B1 (es)
JP (1) JP2007506744A (es)
KR (1) KR20060098368A (es)
CN (1) CN100519559C (es)
AR (1) AR045810A1 (es)
AU (1) AU2004276240A1 (es)
BR (1) BRPI0414700A (es)
CA (1) CA2539252A1 (es)
CO (1) CO5690598A2 (es)
CR (1) CR8288A (es)
CY (1) CY1106392T1 (es)
DE (1) DE602004004295T8 (es)
DK (1) DK1680425T3 (es)
EC (1) ECSP066458A (es)
ES (1) ES2279452T3 (es)
GT (1) GT200400190A (es)
HK (1) HK1090374A1 (es)
IL (1) IL174281A0 (es)
MX (1) MXPA06003206A (es)
NO (1) NO20061318L (es)
PA (1) PA8613301A1 (es)
PE (1) PE20050433A1 (es)
PL (1) PL1680425T3 (es)
PT (1) PT1680425E (es)
RU (1) RU2006107579A (es)
SA (1) SA04250302A (es)
SI (1) SI1680425T1 (es)
TW (1) TW200512211A (es)
WO (1) WO2005030775A1 (es)
ZA (1) ZA200602387B (es)

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AU7306201A (en) * 2000-06-30 2002-01-14 American Home Prod Substituted-triazolopyrimidines as anticancer agents
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
KR20060098368A (ko) 2003-09-24 2006-09-18 와이어쓰 홀딩스 코포레이션 항암제로서의 6-[(치환된)페닐]트리아졸로피리미딘
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
WO2006138180A1 (en) * 2005-06-13 2006-12-28 Wyeth Tubulin inhibitor and process for its preparation
WO2007000412A1 (de) * 2005-06-27 2007-01-04 Basf Aktiengesellschaft Verfahren zur herstellung von substituierten phenylmalonestern, zwischenverbindungen sowie deren verwendung zur herstellung von 5 , 7-dihydr0xy-6- (2,4, 6-trifluorphenyl) -(1,2 , 4) triazolo (1 , 5-a) pyrimidinen
WO2007075452A2 (en) * 2005-12-16 2007-07-05 Wyeth Lyophilized compositions of a triazolopyrimidine compound
EP1963330A1 (en) * 2005-12-16 2008-09-03 Wyeth a Corporation of the State of Delaware Dimers and adducts of 6-[substituted) phenyl] triazolopyrimidines useful as anticancer agents
JP2010515669A (ja) * 2007-01-08 2010-05-13 ビーエーエスエフ ソシエタス・ヨーロピア 有害な植物病原菌類を防除するためのアゾロピリミジンの使用
EP3219207A1 (en) * 2012-09-19 2017-09-20 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
EP3758696A4 (en) * 2018-03-02 2021-12-08 The Trustees of the University of Pennsylvania [1,2,4] TRIAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AND USE OF THESE IN THE STABILIZATION OF MICROTUBULES
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种***并嘧啶醇类化合物及其制备方法和应用

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Also Published As

Publication number Publication date
PA8613301A1 (es) 2005-11-25
AU2004276240A1 (en) 2005-04-07
ES2279452T3 (es) 2007-08-16
EP1680425A1 (en) 2006-07-19
CN1867569A (zh) 2006-11-22
US20050090508A1 (en) 2005-04-28
RU2006107579A (ru) 2007-10-27
DE602004004295T2 (de) 2007-06-06
CN100519559C (zh) 2009-07-29
CA2539252A1 (en) 2005-04-07
JP2007506744A (ja) 2007-03-22
PT1680425E (pt) 2007-02-28
KR20060098368A (ko) 2006-09-18
GT200400190A (es) 2005-05-02
CR8288A (es) 2006-10-04
SI1680425T1 (sl) 2007-04-30
WO2005030775A1 (en) 2005-04-07
DK1680425T3 (da) 2007-03-19
CY1106392T1 (el) 2011-10-12
DE602004004295T8 (de) 2007-09-20
US7507739B2 (en) 2009-03-24
DE602004004295D1 (de) 2007-02-22
IL174281A0 (en) 2006-08-01
EP1680425B1 (en) 2007-01-10
PE20050433A1 (es) 2005-07-21
BRPI0414700A (pt) 2006-11-14
ECSP066458A (es) 2006-09-18
NO20061318L (no) 2006-04-21
AR045810A1 (es) 2005-11-16
TW200512211A (en) 2005-04-01
MXPA06003206A (es) 2006-06-23
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
ZA200602387B (en) 2008-11-26
HK1090374A1 (en) 2006-12-22

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