CO5280082A1 - Nueva vacuna - Google Patents
Nueva vacunaInfo
- Publication number
- CO5280082A1 CO5280082A1 CO00072097A CO00072097A CO5280082A1 CO 5280082 A1 CO5280082 A1 CO 5280082A1 CO 00072097 A CO00072097 A CO 00072097A CO 00072097 A CO00072097 A CO 00072097A CO 5280082 A1 CO5280082 A1 CO 5280082A1
- Authority
- CO
- Colombia
- Prior art keywords
- influenza
- vaccine
- preparation
- dose
- equal
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Otolaryngology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
1.- Preparación de antígeno del virus de la gripe muerto en la fabricación de una formulación de vacuna para vacunación intranasal de una dosis frente a la gripe, en la que la vacunación de una dosis genera una respuesta inmune que cumple los requisitos regulatorios para vacunas de la gripe.7.- Preparación de antígeno según la reivindicación 6, en el que el tensioactivo es al menos un tensioactivo no iónico seleccionado del grupo constituido por octilfenoxipolietoxietanoles (por ejemplo de la serie TritonTM comercialmente disponible), ésteres de polioxietilensorbitano (serie tweenTM) y éteres o ésteres de polioxietileno de fórmula general (I) HO(CH2CH2O)n-A-R en la que n es 1-50, A es un enlace o -C(O)-, R es alquilo C1-50 o fenilalquilo C1-50 y combinaciones de dos o más de estos. 23.- Vacuna de virus no vivo contra la gripe, administrable en una dosis sencilla a través de una superficie de mucosa para inducir una respuesta inmune que cumple al menos dos de los siguientes criterios para todas las ce pas de gripe presentes en la vacuna.(i) una tasa de conversión sérica mayor o igual al 40%,(ii) una tasa de protección sérica mayor o igual al 70%, y(iii) un factor de conversión mayor o igual a 2,5.30.- Un procedimiento de fabricación de una vacuna de la gripe para aplicación nasal, comprendiendo el procedimiento:(i) proporcionar una preparación del virus de la gripe fraccionado producido esencialmente como para una vacuna de la gripe inyectada convencional y que comprende al menos un tensioactivo no iónico.(ii) ajustar opcionalmente la concentración de hemaglutinina y/o concentración de tensioactivo no iónico en la preparación,(iii) rellenar un dispositivo de suministro intranasal con una dosis de vacuna a partir de la preparación del virus de la gripe fraccionado, siendo la citada dosis un volumen adecuado para administración intranasal, opcionalmente en un formato bidosis.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9922700.1A GB9922700D0 (en) | 1999-09-24 | 1999-09-24 | Vaccine |
GBGB9922703.5A GB9922703D0 (en) | 1999-09-24 | 1999-09-24 | Vaccine |
GB0016686A GB0016686D0 (en) | 2000-07-06 | 2000-07-06 | Novel vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5280082A1 true CO5280082A1 (es) | 2003-05-30 |
Family
ID=27255796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO00072097A CO5280082A1 (es) | 1999-09-24 | 2000-09-22 | Nueva vacuna |
Country Status (23)
Country | Link |
---|---|
US (2) | US20050201946A1 (es) |
EP (2) | EP1214054B1 (es) |
JP (1) | JP4763197B2 (es) |
KR (1) | KR20020038771A (es) |
CN (1) | CN1391463A (es) |
AR (2) | AR032597A1 (es) |
AT (1) | ATE376825T1 (es) |
AU (1) | AU764368B2 (es) |
BR (1) | BR0014281A (es) |
CA (1) | CA2383105C (es) |
CO (1) | CO5280082A1 (es) |
CZ (1) | CZ20021044A3 (es) |
DE (1) | DE60036952T2 (es) |
ES (1) | ES2293923T3 (es) |
HU (1) | HUP0202846A3 (es) |
IL (1) | IL148673A0 (es) |
MX (1) | MXPA02003069A (es) |
MY (1) | MY126588A (es) |
NO (1) | NO20021431L (es) |
NZ (1) | NZ517903A (es) |
PL (1) | PL355287A1 (es) |
TR (1) | TR200200776T2 (es) |
WO (1) | WO2001021151A1 (es) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9923176D0 (en) * | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
GB0024089D0 (en) * | 2000-10-02 | 2000-11-15 | Smithkline Beecham Biolog | Novel compounds |
PT1361890E (pt) | 2001-02-23 | 2011-06-07 | Glaxosmithkline Biolog Sa | Formulações vacinais de influenza para distribuição intradérmica |
MY134424A (en) * | 2001-05-30 | 2007-12-31 | Saechsisches Serumwerk | Stable influenza virus preparations with low or no amount of thiomersal |
JP5600375B2 (ja) | 2004-03-09 | 2014-10-01 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | インフルエンザウイルスワクチン |
EA014314B1 (ru) * | 2005-08-02 | 2010-10-29 | Новартис Вэксинес Энд Дайэгностикс Срл | Пониженная интерференция между маслосодержащими адъювантами и антигенами, содержащими поверхностно-активные вещества |
NZ567817A (en) | 2005-11-01 | 2012-01-12 | Novartis Vaccines & Diagnostic | Cell-derived viral vaccines with low levels of residual cell DNA by beta-propiolactone treatment |
US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
EA014028B1 (ru) | 2005-11-04 | 2010-08-30 | Новартис Вэксинс Энд Диагностикс Срл | Эмульсии, содержащие свободное поверхностно-активное вещество в водной фазе в качестве адъюванта сплит вакцин против гриппа |
CA2628152C (en) | 2005-11-04 | 2016-02-02 | Novartis Vaccines And Diagnostics S.R.L. | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
US20110180430A1 (en) | 2005-11-04 | 2011-07-28 | Novartis Vaccines And Diagnostics Srl | Adjuvanted influenza vaccines including cytokine-inducing agents |
NZ568211A (en) | 2005-11-04 | 2011-11-25 | Novartis Vaccines & Diagnostic | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
DK1976559T6 (da) | 2006-01-27 | 2020-04-06 | Seqirus Uk Ltd | Influenzavacciner indeholdende hæmagglutinin og matrixproteiner |
US20080038294A1 (en) * | 2006-03-22 | 2008-02-14 | Kersten Alexander J | Intranasal or inhalational administration of virosomes |
US8535683B2 (en) | 2006-03-22 | 2013-09-17 | Abbott Biologicals B.V. | Intranasal or inhalational administration of virosomes |
EP2004226A1 (en) | 2006-03-24 | 2008-12-24 | Novartis Vaccines and Diagnostics GmbH & Co. KG | Storage of influenza vaccines without refrigeration |
GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
CA2663196A1 (en) | 2006-09-11 | 2008-03-20 | Novartis Ag | Making influenza virus vaccines without using eggs |
CN101015691B (zh) * | 2006-11-14 | 2010-08-25 | 中国医学科学院医学生物学研究所 | 重组噬菌体流感疫苗 |
NZ577405A (en) | 2006-12-06 | 2012-08-31 | Novartis Ag | Vaccines including antigen from four strains of influenza virus |
EA201070066A1 (ru) | 2007-06-27 | 2010-06-30 | Новартис Аг | Вакцины против гриппа с низким содержанием добавок |
GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
CA2710480A1 (en) | 2007-12-24 | 2009-07-02 | Novartis Ag | Assays for adsorbed influenza vaccines |
US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
EP2268309B1 (en) * | 2008-03-18 | 2015-01-21 | Novartis AG | Improvements in preparation of influenza virus vaccine antigens |
US20110070574A1 (en) * | 2008-06-02 | 2011-03-24 | Ge Healthcare Bio-Sciences Ab | Method for virus detection |
US20110217330A1 (en) | 2008-11-05 | 2011-09-08 | Bruno Rene Andre | Novel method |
CU20080215A7 (es) | 2008-11-19 | 2012-06-21 | Inst Finlay | Vacunas unitemporales |
DK2396032T3 (en) | 2009-02-10 | 2016-12-19 | Seqirus Uk Ltd | Influenza vaccines with reduced amounts of squalene |
JP2012517416A (ja) | 2009-02-10 | 2012-08-02 | ノバルティス アーゲー | 増加した量のh3抗原を含むインフルエンザワクチン |
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EP2413962A1 (en) | 2009-03-30 | 2012-02-08 | Mount Sinai School of Medicine | Influenza virus vaccines and uses thereof |
DE102010018462A1 (de) | 2009-04-27 | 2011-04-07 | Novartis Ag | Impfstoffe zum Schutz gegen Influenza |
SI2401384T1 (sl) | 2009-05-21 | 2013-01-31 | Novartis Ag | Reverzna genetika z uporabo neendogenih pol i promotorjev |
AU2010254136B2 (en) | 2009-05-26 | 2016-09-29 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
JP5716297B2 (ja) | 2009-06-25 | 2015-05-13 | Jnc株式会社 | クロマトグラフィー用充填剤、その製造方法、およびそれを用いたウイルス用ワクチンの製造方法 |
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CA2769673A1 (en) | 2009-07-31 | 2011-02-03 | Novartis Ag | Reverse genetics systems |
CN102695523A (zh) | 2009-09-10 | 2012-09-26 | 诺华有限公司 | 针对呼吸道疾病的组合疫苗 |
AU2010309404B2 (en) | 2009-10-20 | 2015-07-09 | Seqirus UK Limited | Improved reverse genetics methods for virus rescue |
GB0918830D0 (en) | 2009-10-27 | 2009-12-09 | Glaxosmithkline Biolog Niederl | Process |
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EP2571520B1 (en) | 2010-05-21 | 2018-04-04 | Seqirus UK Limited | Influenza virus reassortment method |
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JP5976639B2 (ja) | 2010-06-01 | 2016-08-23 | ノバルティス アーゲー | インフルエンザワクチン抗原の濃縮および凍結乾燥 |
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CN101899101B (zh) * | 2010-07-21 | 2012-07-25 | 中国检验检疫科学研究院 | 一种用于流感病毒亚单位疫苗研究的合成多肽 |
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AU2013270793A1 (en) | 2012-06-04 | 2014-12-11 | Novartis Ag | Improved safety testing |
GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
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UY34506A (es) * | 2012-12-10 | 2014-06-30 | Fernando Amaury Ferreira Chiesa | Adyuvante de vacunación, preparación y vacunas que lo contienen |
AU2013362935B2 (en) | 2012-12-18 | 2018-10-04 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
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AT407958B (de) * | 1999-02-11 | 2001-07-25 | Immuno Ag | Inaktivierte influenza-virus-vakzine zur nasalen oder oralen applikation |
US6506803B1 (en) * | 1999-04-28 | 2003-01-14 | Regents Of The University Of Michigan | Methods of preventing and treating microbial infections |
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EP1361889A1 (en) * | 2001-02-23 | 2003-11-19 | GlaxoSmithKline Biologicals S.A. | Novel vaccine |
MY134424A (en) * | 2001-05-30 | 2007-12-31 | Saechsisches Serumwerk | Stable influenza virus preparations with low or no amount of thiomersal |
US20090028903A1 (en) * | 2005-03-23 | 2009-01-29 | Glaxosmithkline Biologicals, S.A. | Novel use |
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2000
- 2000-09-22 PL PL00355287A patent/PL355287A1/xx not_active Application Discontinuation
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- 2000-09-22 KR KR1020027003833A patent/KR20020038771A/ko not_active Application Discontinuation
- 2000-09-22 HU HU0202846A patent/HUP0202846A3/hu unknown
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- 2000-09-22 EP EP07119192A patent/EP1878424A3/en not_active Withdrawn
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- 2000-09-22 WO PCT/EP2000/009367 patent/WO2001021151A1/en active IP Right Grant
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- 2000-09-22 NZ NZ517903A patent/NZ517903A/en not_active IP Right Cessation
- 2000-09-22 CN CN00815945A patent/CN1391463A/zh active Pending
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EP1878424A3 (en) | 2008-04-09 |
EP1214054B1 (en) | 2007-10-31 |
DE60036952T2 (de) | 2008-08-07 |
HUP0202846A2 (hu) | 2002-12-28 |
ATE376825T1 (de) | 2007-11-15 |
MXPA02003069A (es) | 2002-09-30 |
JP4763197B2 (ja) | 2011-08-31 |
AU764368B2 (en) | 2003-08-14 |
IL148673A0 (en) | 2002-09-12 |
EP1214054A1 (en) | 2002-06-19 |
AR032597A1 (es) | 2003-11-19 |
CA2383105C (en) | 2010-01-26 |
PL355287A1 (en) | 2004-04-05 |
BR0014281A (pt) | 2002-05-21 |
CZ20021044A3 (cs) | 2002-08-14 |
ES2293923T3 (es) | 2008-04-01 |
HUP0202846A3 (en) | 2003-12-29 |
US20090155309A1 (en) | 2009-06-18 |
US20050201946A1 (en) | 2005-09-15 |
CN1391463A (zh) | 2003-01-15 |
NO20021431D0 (no) | 2002-03-21 |
MY126588A (en) | 2006-10-31 |
KR20020038771A (ko) | 2002-05-23 |
NO20021431L (no) | 2002-04-24 |
EP1878424A2 (en) | 2008-01-16 |
AU7782500A (en) | 2001-04-24 |
WO2001021151A1 (en) | 2001-03-29 |
TR200200776T2 (tr) | 2002-06-21 |
NZ517903A (en) | 2003-10-31 |
JP2003509451A (ja) | 2003-03-11 |
DE60036952D1 (de) | 2007-12-13 |
AR025750A1 (es) | 2002-12-11 |
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