CO5160254A1 - DERIVATIVES OF CICLOBUTEN-3,4-DIONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS - Google Patents

DERIVATIVES OF CICLOBUTEN-3,4-DIONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Info

Publication number
CO5160254A1
CO5160254A1 CO00015525A CO00015525A CO5160254A1 CO 5160254 A1 CO5160254 A1 CO 5160254A1 CO 00015525 A CO00015525 A CO 00015525A CO 00015525 A CO00015525 A CO 00015525A CO 5160254 A1 CO5160254 A1 CO 5160254A1
Authority
CO
Colombia
Prior art keywords
carbon atoms
group
jpeg
cycloalkyl
alkyl
Prior art date
Application number
CO00015525A
Other languages
Spanish (es)
Inventor
Philippe R Bovy
Gerard Defosse
Claudie Gautier
Gilbert Marciniak
Christophe Philipppio
Viviane Van Dorsselaer
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of CO5160254A1 publication Critical patent/CO5160254A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuesto de fórmula general (I):<EMI FILE="00015525_1" ID="1" IMF=JPEG >en la cual:R1 y R2 representan, independientemente entre sí, un átomo de hidrógeno, un grupo alquilo de 1 a 6 átomos de carbono, alquenilo de 2 a 6 átomos de carbono, -(CH2)n-C3-6 cicloalquilo, R3 representa un átomo de hidrógeno, un grupo alquilo de 1 a 6 átomos de carbono, -(CH2)n-C3-6 cicloalquilo o -CH2-CO2C1-3 alquilo o -CH2COOH, W representa un grupo NR4R5 para el cual R4 y R5 representan, independientemente entre sí, un átomo de hidrógeno, un grupo alquilo de 1 a 6 átomos de carbono, alquenilo de 2 a 6 átomos de carbono, alquinilo de 2 a 6 átomos de carbono, -(CH2)n-C3-6 cicloalquilo, C1-4 alcoxi-C1-4 alquilo, fluoroalquilo de 1 a 6 átomos de carbono, perfluoroalquilo de 1 a 2 átomos de carbono, -(CH2)m-piridilo o un grupo<EMI FILE="00015525_2" ID="2" IMF=JPEG >ó R4 y R5 juntos forman una cadena alquileno de 3 a 7 átomos de carbono o representan un grupo <EMI FILE="00015525_3" ID="3" IMF=JPEG >n representa 0, 1 o 2, m representa 1 o 2 y p y p´ representan 1, 2, ó 3 y sus sales.Compound of general formula (I): <EMI FILE = "00015525_1" ID = "1" MFI = JPEG> in which: R1 and R2 independently represent each other a hydrogen atom, an alkyl group of 1 to 6 atoms carbon, alkenyl of 2 to 6 carbon atoms, - (CH2) n-C3-6 cycloalkyl, R3 represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, - (CH2) n-C3-6 cycloalkyl or -CH2-CO2C1-3 alkyl or -CH2COOH, W represents an NR4R5 group for which R4 and R5 independently represent each other a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, - (CH2) n-C3-6 cycloalkyl, C1-4 alkoxy-C1-4 alkyl, fluoroalkyl of 1 to 6 carbon atoms, perfluoroalkyl of 1 to 2 atoms carbon, - (CH2) m-pyridyl or a group <EMI FILE = "00015525_2" ID = "2" IMF = JPEG> or R4 and R5 together form an alkylene chain of 3 to 7 carbon atoms or represent a group < EMI FILE = "00015525_3" ID = "3" MFI = JPEG> n represents 0, 1 or 2, m represents 1 or 2 and p and p´ represent 1, 2, or 3 and their salts.

CO00015525A 1999-03-04 2000-03-03 DERIVATIVES OF CICLOBUTEN-3,4-DIONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS CO5160254A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9902679A FR2790472B1 (en) 1999-03-04 1999-03-04 DERIVATIVES OF CYCLOBUTENE-3, 4-DIONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
CO5160254A1 true CO5160254A1 (en) 2002-05-30

Family

ID=9542807

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00015525A CO5160254A1 (en) 1999-03-04 2000-03-03 DERIVATIVES OF CICLOBUTEN-3,4-DIONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Country Status (6)

Country Link
AR (1) AR022809A1 (en)
AU (1) AU2922700A (en)
CO (1) CO5160254A1 (en)
FR (1) FR2790472B1 (en)
PE (1) PE20001494A1 (en)
WO (1) WO2000051973A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548508B2 (en) 2000-10-20 2003-04-15 Pfizer, Inc. Use of PDE V inhibitors for improved fecundity in mammals
US6495576B2 (en) 2001-02-07 2002-12-17 Abbott Laboratories Aminal diones as potassium channel openers
AR068509A1 (en) * 2007-09-19 2009-11-18 Jerini Ag BRADIQUININE B1 RECEIVER ANTAGOSNIST

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312210D0 (en) * 1993-06-14 1993-07-28 Smithkline Beecham Plc Chemical compounds

Also Published As

Publication number Publication date
PE20001494A1 (en) 2001-03-04
AU2922700A (en) 2000-09-21
AR022809A1 (en) 2002-09-04
WO2000051973A1 (en) 2000-09-08
FR2790472A1 (en) 2000-09-08
FR2790472B1 (en) 2001-04-06

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