CO4940482A1 - Composiciones farmaceuticas conteniendo 3-de-o-acylo lipido monofosforilo a y procedimiento de preparacion - Google Patents
Composiciones farmaceuticas conteniendo 3-de-o-acylo lipido monofosforilo a y procedimiento de preparacionInfo
- Publication number
- CO4940482A1 CO4940482A1 CO98018888A CO98018888A CO4940482A1 CO 4940482 A1 CO4940482 A1 CO 4940482A1 CO 98018888 A CO98018888 A CO 98018888A CO 98018888 A CO98018888 A CO 98018888A CO 4940482 A1 CO4940482 A1 CO 4940482A1
- Authority
- CO
- Colombia
- Prior art keywords
- monofosforilo
- lipido
- acylo
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una composición farmacéutica que comprende tirosina, un alergenoopcionalmente modificado, y lípido monofosforilo 3-de-O acilado A (3-DMPL). Un proceso para la preparación de una composición farmacéutica según la reivindicación 1 ó 2, el cual comprende (a) modificar (opcionalmente) un alergeno mediante reacción con un agente de enlazamiento cruzado, (b) mezclar una solución acuosa del alergeno opcionalmente modificado con una solución de tirosina en un ácido acuoso fuerte, (c) neutralizar la mezcla de soluciones precipitando de este modo la tirosina y el alergeno modificado (d) mezclar el producto con lípido monofosforilo 3-de-0 acilado A (3-DMPL), y (e) opcionalmente, agregar un vehículo fisiológicamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9706957.9A GB9706957D0 (en) | 1997-04-05 | 1997-04-05 | Formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4940482A1 true CO4940482A1 (es) | 2000-07-24 |
Family
ID=10810358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO98018888A CO4940482A1 (es) | 1997-04-05 | 1998-04-03 | Composiciones farmaceuticas conteniendo 3-de-o-acylo lipido monofosforilo a y procedimiento de preparacion |
Country Status (17)
Country | Link |
---|---|
US (2) | US7718178B2 (es) |
EP (1) | EP0975364B1 (es) |
JP (1) | JP4331798B2 (es) |
KR (1) | KR100549557B1 (es) |
AR (1) | AR011707A1 (es) |
AT (1) | ATE268607T1 (es) |
AU (1) | AU729631B2 (es) |
CA (1) | CA2285928C (es) |
CO (1) | CO4940482A1 (es) |
DE (1) | DE69824405T2 (es) |
ES (1) | ES2218819T3 (es) |
GB (1) | GB9706957D0 (es) |
NZ (1) | NZ337580A (es) |
PT (1) | PT975364E (es) |
TW (1) | TWI240628B (es) |
WO (1) | WO1998044947A1 (es) |
ZA (1) | ZA982851B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9706957D0 (en) * | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
GB9820525D0 (en) * | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
GB0000891D0 (en) | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
CN1775701B (zh) * | 2004-11-16 | 2010-05-26 | 鸿富锦精密工业(深圳)有限公司 | 具有超硬镀膜的模仁 |
GB201106802D0 (en) | 2011-04-21 | 2011-06-01 | Allergy Therapeutics Ltd | Process for preparing vaccine composition |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1128637A (en) | 1966-09-13 | 1968-09-25 | Beecham Group Ltd | Influenza vaccine |
US3541201A (en) | 1968-12-18 | 1970-11-17 | Ethan Alan Brown | Novel sodium chloride encapsulated injectionable substances |
GB1377074A (en) * | 1971-07-13 | 1974-12-11 | Beecham Group Ltd | Process for preparing injectable compositions |
GB1492973A (en) * | 1974-02-16 | 1977-11-23 | Beecham Group Ltd | Process for preparing injectable compositions |
US4070455A (en) | 1974-02-16 | 1978-01-24 | Beecham Group Limited | Process for preparing injectable desensitizing compositions and products thereof in microparticle form |
EP0182442B2 (en) | 1978-12-22 | 1996-04-03 | Biogen, Inc. | Recombinant DNA molecules and their method of production |
US4258029A (en) | 1979-04-23 | 1981-03-24 | Connaught Laboratories Limited | Synthetic adjuvants for stimulation of antigenic responses |
US4528029A (en) * | 1980-07-21 | 1985-07-09 | Board Of Control Of Michigan Technological University | Self-reducing iron oxide agglomerates |
US4987237A (en) | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5244663A (en) | 1987-01-28 | 1993-09-14 | Medibrevex | Therapeutic method against allergy |
FR2621916B1 (fr) | 1987-10-19 | 1990-03-09 | Bioeurope | Derives de la l-tyrosine solubles dans l'eau et procede pour leur preparation |
US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
GB9106048D0 (en) | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccines |
EP0640347A1 (en) | 1992-03-03 | 1995-03-01 | Daiichi Pharmaceutical Co., Ltd. | Oral vaccine |
ATE188613T1 (de) | 1992-06-25 | 2000-01-15 | Smithkline Beecham Biolog | Adjuvantien enthaltende impfstoffzusammensetzung |
HU219056B (hu) | 1993-03-23 | 2001-02-28 | Smithkline Beecham Biologicals Sa | 3-O-Dezacilezett monofoszforil-lipid A-t tartalmazó vakcinakészítmény |
US5723130A (en) | 1993-05-25 | 1998-03-03 | Hancock; Gerald E. | Adjuvants for vaccines against respiratory syncytial virus |
CA2167691A1 (en) | 1993-08-27 | 1995-03-02 | Martin J. Blaser | Campylobacter jejuni antigens, and methods for their production and use |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
US5997873A (en) | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
US5646115A (en) | 1994-10-07 | 1997-07-08 | Heska Corporation | Ectoparasite saliva proteins and apparatus to collect such proteins |
AU4977896A (en) | 1995-02-17 | 1996-09-04 | Immunotherapy, Inc. | Immunotherapy screening, prognosis, and treatment methods and compositions |
GB9508785D0 (en) * | 1995-04-29 | 1995-06-21 | Smithkline Beecham Plc | Novel compositions |
US5762943A (en) | 1996-05-14 | 1998-06-09 | Ribi Immunochem Research, Inc. | Methods of treating type I hypersensitivity using monophosphoryl lipid A |
US5973128A (en) | 1996-11-22 | 1999-10-26 | The Hospital For Sick Children Research And Development Lp | Glycolipid mimics and methods of use thereof |
US6491919B2 (en) | 1997-04-01 | 2002-12-10 | Corixa Corporation | Aqueous immunologic adjuvant compostions of monophosphoryl lipid A |
JP5019494B2 (ja) | 1997-04-01 | 2012-09-05 | コリクサ コーポレーション | モノホスホリルリピドaの水性免疫アジュバント組成物 |
GB9706957D0 (en) * | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
AU7983198A (en) | 1997-06-23 | 1999-01-04 | Ludwig Institute For Cancer Research | Improved methods for inducing an immune response |
GB9717953D0 (en) | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
GB9720585D0 (en) | 1997-09-26 | 1997-11-26 | Smithkline Beecham Biolog | Vaccine |
CA2319380A1 (en) | 1997-11-10 | 1999-05-20 | Statens Serum Institut | Nucleic acid fragments and polypeptide fragments derived from m. tuberculosis |
GB9812613D0 (en) | 1998-06-11 | 1998-08-12 | Smithkline Beecham Biolog | Vaccine |
EP1086228A1 (en) | 1998-06-12 | 2001-03-28 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Recombinant production of toxoplasma sag1 antigen |
GB9820525D0 (en) | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
US6734172B2 (en) | 1998-11-18 | 2004-05-11 | Pacific Northwest Research Institute | Surface receptor antigen vaccines |
SI1031347T1 (en) | 1999-01-27 | 2002-10-31 | Idea Ag | Transnasal transport/immunisation with highly adaptable carriers |
ATE481108T1 (de) | 1999-02-26 | 2010-10-15 | Novartis Vaccines & Diagnostic | Verwendung von bioadhaesiven und adjuvantien für die mukosale anwendung von antigenen |
GB9909077D0 (en) | 1999-04-20 | 1999-06-16 | Smithkline Beecham Biolog | Novel compositions |
EE200100552A (et) | 1999-04-23 | 2002-12-16 | Pharmexa A/S | Meetod kasvuteguri IL-5 aktiivsuse in vivo mahasurumiseks, IL-5 analoog, seda kodeeriv nukleiinhappefragment ning kasutamine immunogeense kompositsiooni valmistamiseks |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
GB9924529D0 (en) | 1999-10-15 | 1999-12-15 | Smithkline Beecham Biolog | Novel compounds |
GB0000891D0 (en) | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
-
1997
- 1997-04-05 GB GBGB9706957.9A patent/GB9706957D0/en active Pending
-
1998
- 1998-04-02 AR ARP980101508A patent/AR011707A1/es active IP Right Grant
- 1998-04-03 AU AU72160/98A patent/AU729631B2/en not_active Expired
- 1998-04-03 KR KR1019997008719A patent/KR100549557B1/ko not_active IP Right Cessation
- 1998-04-03 CA CA002285928A patent/CA2285928C/en not_active Expired - Lifetime
- 1998-04-03 PT PT98919258T patent/PT975364E/pt unknown
- 1998-04-03 NZ NZ337580A patent/NZ337580A/en not_active IP Right Cessation
- 1998-04-03 ZA ZA9802851A patent/ZA982851B/xx unknown
- 1998-04-03 WO PCT/EP1998/002138 patent/WO1998044947A1/en active IP Right Grant
- 1998-04-03 AT AT98919258T patent/ATE268607T1/de active
- 1998-04-03 CO CO98018888A patent/CO4940482A1/es unknown
- 1998-04-03 JP JP54240898A patent/JP4331798B2/ja not_active Expired - Lifetime
- 1998-04-03 DE DE69824405T patent/DE69824405T2/de not_active Expired - Lifetime
- 1998-04-03 EP EP98919258A patent/EP0975364B1/en not_active Expired - Lifetime
- 1998-04-03 ES ES98919258T patent/ES2218819T3/es not_active Expired - Lifetime
- 1998-04-07 TW TW087105161A patent/TWI240628B/zh not_active IP Right Cessation
-
2005
- 2005-01-21 US US11/040,952 patent/US7718178B2/en not_active Expired - Fee Related
-
2010
- 2010-03-29 US US12/749,326 patent/US8105605B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AR011707A1 (es) | 2000-08-30 |
AU7216098A (en) | 1998-10-30 |
PT975364E (pt) | 2004-09-30 |
ES2218819T3 (es) | 2004-11-16 |
ATE268607T1 (de) | 2004-06-15 |
EP0975364B1 (en) | 2004-06-09 |
JP2001519797A (ja) | 2001-10-23 |
US20100183659A1 (en) | 2010-07-22 |
KR100549557B1 (ko) | 2006-02-08 |
DE69824405T2 (de) | 2004-10-07 |
AU729631B2 (en) | 2001-02-08 |
KR20010005651A (ko) | 2001-01-15 |
NZ337580A (en) | 2001-04-27 |
US8105605B2 (en) | 2012-01-31 |
GB9706957D0 (en) | 1997-05-21 |
ZA982851B (en) | 1999-10-04 |
CA2285928A1 (en) | 1998-10-15 |
US20050123570A1 (en) | 2005-06-09 |
TWI240628B (en) | 2005-10-01 |
EP0975364A1 (en) | 2000-02-02 |
JP4331798B2 (ja) | 2009-09-16 |
US7718178B2 (en) | 2010-05-18 |
CA2285928C (en) | 2008-07-08 |
WO1998044947A1 (en) | 1998-10-15 |
DE69824405D1 (de) | 2004-07-15 |
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