CO4890854A1 - Formulaciones de peptido protico no acuoso - Google Patents

Formulaciones de peptido protico no acuoso

Info

Publication number
CO4890854A1
CO4890854A1 CO97037097A CO97037097A CO4890854A1 CO 4890854 A1 CO4890854 A1 CO 4890854A1 CO 97037097 A CO97037097 A CO 97037097A CO 97037097 A CO97037097 A CO 97037097A CO 4890854 A1 CO4890854 A1 CO 4890854A1
Authority
CO
Colombia
Prior art keywords
aqueous protic
peptide formulations
formulation
peptide compound
protic peptide
Prior art date
Application number
CO97037097A
Other languages
English (en)
Inventor
Cynthia L Stevenson
Sally A Tao
Steven J Prestrelski
James B Eckenhoff
Jeremy C Wright
Leonard Joe
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of CO4890854A1 publication Critical patent/CO4890854A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Una formulación no acuosa estable de un compuesto péptidocomprendiendo: a) al menos un compuesto péptido; y b) al menos un disolvente prótico no acuoso. La formulación de la reivindicación 1, la cual comprende al menos 10% (p/p) de compuesto péptido. La formulación de la reivindicación 1, la cual comprende al menos 30% (p/p) de compuesto péptido. La formulación de la reivindicación 1 en donde dicho compuesto péptido es un compuesto relacionado con LHRH.
CO97037097A 1996-07-03 1997-07-03 Formulaciones de peptido protico no acuoso CO4890854A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2112996P 1996-07-03 1996-07-03

Publications (1)

Publication Number Publication Date
CO4890854A1 true CO4890854A1 (es) 2000-02-28

Family

ID=21802501

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97037097A CO4890854A1 (es) 1996-07-03 1997-07-03 Formulaciones de peptido protico no acuoso

Country Status (27)

Country Link
EP (1) EP0909175B1 (es)
JP (3) JP2001504802A (es)
CN (1) CN1231256C (es)
AR (1) AR008060A1 (es)
AT (1) ATE241997T1 (es)
AU (1) AU737664B2 (es)
BR (1) BR9710130A (es)
CA (1) CA2259403A1 (es)
CO (1) CO4890854A1 (es)
CZ (1) CZ433898A3 (es)
DE (1) DE69722620T2 (es)
DK (1) DK0909175T3 (es)
ES (1) ES2201306T3 (es)
HU (1) HUP9903942A3 (es)
ID (1) ID19165A (es)
IL (1) IL127769A (es)
MY (1) MY121684A (es)
NO (1) NO323933B1 (es)
NZ (1) NZ333580A (es)
PL (1) PL189402B1 (es)
PT (1) PT909175E (es)
RO (1) RO119862B1 (es)
RU (1) RU2203085C2 (es)
SK (1) SK284490B6 (es)
TW (1) TW491703B (es)
WO (1) WO1998000152A1 (es)
ZA (1) ZA975942B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK284490B6 (sk) * 1996-07-03 2005-05-05 Alza Corporation Stabilná nevodná formulácia a spôsob jej prípravy
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
ES2298378T3 (es) 2001-06-28 2008-05-16 Novo Nordisk A/S Formulacion estable de glp-1 modificado.
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
ATE494885T1 (de) * 2003-04-25 2011-01-15 Boston Scient Scimed Inc Feste arzneimittelformulierung und vorrichtung zu ihrer aufbewahrung und kontrollierten abgabe
HUE043210T2 (hu) * 2003-11-20 2019-08-28 Novo Nordisk As Injekciós eszközök elõállítására optimális propilénglikol-tartalmú peptidkészítmények
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
ES2351527T3 (es) 2006-05-30 2011-02-07 Intarcia Therapeutics, Inc Modulador de flujo en dos piezas con conducto interno para un sistema osmótico de administración.
PL2359808T3 (pl) 2006-08-09 2013-10-31 Intarcia Therapeutics Inc Osmotyczne systemy dostawcze i zespoły tłokowe
US20080275030A1 (en) 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
AU2013203271B2 (en) * 2007-01-19 2016-05-12 Hananja Ehf Methods and compositions for the delivery of a therapeutic agent
CN101678112B (zh) * 2007-01-19 2016-08-31 哈南亚有限公司 用于递送治疗剂的方法和组合物
AU2008244523B2 (en) 2007-04-23 2012-02-16 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
US8968786B2 (en) 2007-06-22 2015-03-03 Board Of Regents, The University Of Texas System Formation of stable submicron peptide or protein particles by thin film freezing
WO2009102467A2 (en) 2008-02-13 2009-08-20 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US20100015240A1 (en) 2008-07-16 2010-01-21 Danielle Biggs Process for preparing microparticles containing bioactive peptides
HRP20200512T2 (hr) 2008-08-15 2024-05-24 Ironwood Pharmaceuticals, Inc. Formulacije koje sadrže linaklotid za oralnu primjenu
KR20110103961A (ko) 2008-11-16 2011-09-21 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 저점도 고농축 현탁액
CA2770077A1 (en) 2009-08-06 2011-02-10 Ironwood Pharmaceuticals, Inc. Formulations comprising linaclotide
KR102093612B1 (ko) 2009-09-28 2020-03-26 인타르시아 세라퓨틱스 인코포레이티드 실질 항정상태 약물 전달의 신속 확립 및/또는 종결
ES2638589T3 (es) 2010-02-17 2017-10-23 Ironwood Pharmaceuticals, Inc. Tratamientos para trastornos intestinales
JP5921545B2 (ja) 2010-08-11 2016-05-24 アイアンウッド ファーマシューティカルズ インコーポレイテッド リナクロチドの安定な製剤
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9708371B2 (en) 2011-08-17 2017-07-18 Ironwood Pharmaceuticals, Inc. Treatments for gastrointestinal disorders
US20130288968A1 (en) * 2012-04-30 2013-10-31 Sun Pharmaceutical Industries Ltd. Leuprolide injection
US9956287B2 (en) 2013-02-06 2018-05-01 Perosphere Inc. Stable glucagon formulations
EP2823808A1 (en) * 2013-07-09 2015-01-14 Ipsen Pharma S.A.S. Pharmaceutical composition for a sustained release of lanreotide
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
KR20240042548A (ko) 2015-06-03 2024-04-02 인타르시아 세라퓨틱스 인코포레이티드 임플란트 배치 및 제거 시스템들
TWI814219B (zh) 2016-05-16 2023-09-01 美商因塔希亞治療公司 升糖素受體選擇性多肽和彼之使用方法
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
IL267736B2 (en) 2017-01-03 2024-03-01 Intarcia Therapeutics Inc Methods involving continuous administration of a GLP-1 receptor agonist and co-administration of a drug
EP3372224A1 (en) 2017-03-07 2018-09-12 Alrise Biosystems GmbH New controlled drug delivery system using water miscible solvents for production of drug loaded micro- and nanoparticles
AU2018321157B2 (en) 2017-08-24 2024-03-28 Novo Nordisk A/S GLP-1 compositions and uses thereof
IL294521A (en) 2020-02-18 2022-09-01 Novo Nordisk As glp-1 compounds and their uses

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897256A (en) * 1986-11-25 1990-01-30 Abbott Laboratories LHRH analog formulations
ES2061591T3 (es) * 1987-10-15 1994-12-16 Syntex Inc Administracion intranasal de polipeptidos en forma pulverizada.
IT1237197B (it) * 1989-11-16 1993-05-26 Sclavo Spa Formulazioni farmaceutiche anidre e forme di dosaggio per la somministrazione rettale di calcitonina.
ATE156361T1 (de) * 1992-09-21 1997-08-15 Upjohn Co Proteinhaftige arzneimittel mit verzögerter wirkstoffabgabe
AU685784B2 (en) * 1993-02-23 1998-01-29 Genentech Inc. Excipient stabilization of polypeptides treated with organic solvents
US5955430A (en) * 1993-09-24 1999-09-21 University Of Southern California Use of angiotensin II fragments and analogs thereof in tissue repair
JP3597233B2 (ja) * 1993-10-21 2004-12-02 久光製薬株式会社 経鼻組成物及びそれを含有する経鼻製剤
SK284490B6 (sk) * 1996-07-03 2005-05-05 Alza Corporation Stabilná nevodná formulácia a spôsob jej prípravy

Also Published As

Publication number Publication date
EP0909175A1 (en) 1999-04-21
IL127769A (en) 2006-10-31
AU3407397A (en) 1998-01-21
HUP9903942A2 (hu) 2000-04-28
RU2203085C2 (ru) 2003-04-27
SK284490B6 (sk) 2005-05-05
BR9710130A (pt) 1999-08-10
AR008060A1 (es) 1999-12-09
RO119862B1 (ro) 2005-05-30
CA2259403A1 (en) 1998-01-08
AU737664B2 (en) 2001-08-30
SK179998A3 (en) 1999-05-07
NO323933B1 (no) 2007-07-23
DE69722620D1 (de) 2003-07-10
DE69722620T2 (de) 2004-04-29
PT909175E (pt) 2003-10-31
WO1998000152A1 (en) 1998-01-08
TW491703B (en) 2002-06-21
ATE241997T1 (de) 2003-06-15
PL330869A1 (en) 1999-06-07
JP2008195739A (ja) 2008-08-28
CN1224356A (zh) 1999-07-28
MY121684A (en) 2006-02-28
PL189402B1 (pl) 2005-08-31
CZ433898A3 (cs) 1999-04-14
HUP9903942A3 (en) 2000-07-28
CN1231256C (zh) 2005-12-14
ES2201306T3 (es) 2004-03-16
NZ333580A (en) 2000-06-23
IL127769A0 (en) 1999-10-28
NO986209D0 (no) 1998-12-30
ZA975942B (en) 1998-04-16
JP2001504802A (ja) 2001-04-10
DK0909175T3 (da) 2003-09-29
NO986209L (no) 1998-12-30
JP2010043105A (ja) 2010-02-25
EP0909175B1 (en) 2003-06-04
ID19165A (id) 1998-06-28

Similar Documents

Publication Publication Date Title
CO4890854A1 (es) Formulaciones de peptido protico no acuoso
CO4870762A1 (es) Formulaciones de peptido aprotico polar no acuoso
CO4890855A1 (es) Formulaciones acuosas de peptidos
RS50485B (sr) Terapeutske kombinacije koje sadrže amplodipin i atorvastatin
CA2284468A1 (en) Anti-inflammatory compounds
NO2007004I1 (no) Mycofenolsyre = (E)-6-(1,3-dihydro-4-hydroksy-6-metoksy-7-metyl-3-oksajsobenzofuran-5-yl)-4-, metylheks-4-ensyre
ES2131781T3 (es) Formulacion estable liofilizada que comprende una proteina, equipo de dosificacion.
FR2689312B1 (fr) Cathode à émission de champ.
NO994266L (no) Hydrofile binære systemer for administrasjon av cyklosporin
ITRM920476A0 (it) Formulazioni galeniche contenenti ciclosporina.
CA2163003A1 (en) Solubilizer and external preparations containing the same
EP1074243A3 (en) Cosmetic compositions
CA2253747A1 (en) Switched current delta-sigma modulator
AU1843397A (en) Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
WO1998010786A3 (en) Pharmaceutical composition for the treatment of syndrome x of reaven
EA200400041A1 (ru) Сочетание действующих ингредиентов, используемое в качестве вызывающего привыкание фармакологического средства или для интоксикационной терапии
AU9669398A (en) Walking beam compressor
BR9712078A (pt) Composto polim-rico compreendendo um ou mais lcoois ativos
TR199901209T2 (xx) B�cek �ld�r�c� ve mitisidal kompozisyonlar
AU4607397A (en) Glyoxylic compound comprising one or more active ingredient
ZA978638B (en) Antimycotic agents having high active compound release.
ZA977809B (en) New pharmaceutically active compounds.
RU96124294A (ru) Стабилизированная водорастворимая композиция трийодидов 1,2,3- триалкилбензимидазолия
FI990032A0 (fi) Okulaarisia hypotensiivisiä aktiivisia yhdisteitä
RU2000106182A (ru) Средство для лечения поражения кожи различной этиологии