CO4850562A1 - Proceso para producir una preparacion concentrada de anticuerpos - Google Patents
Proceso para producir una preparacion concentrada de anticuerposInfo
- Publication number
- CO4850562A1 CO4850562A1 CO97028095A CO97028095A CO4850562A1 CO 4850562 A1 CO4850562 A1 CO 4850562A1 CO 97028095 A CO97028095 A CO 97028095A CO 97028095 A CO97028095 A CO 97028095A CO 4850562 A1 CO4850562 A1 CO 4850562A1
- Authority
- CO
- Colombia
- Prior art keywords
- antibody
- preparation according
- preparation
- concentration
- antibody preparation
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Una preparación de anticuerpos monoclonales para laadministración a un humano, caracterizada porque el anticuerpo en la preparación está en una concentración de 100 mg/ml o mayor. Una preparación de anticuerpos monoclonales para la administración a un humano caracterizada porque comprende el anticuerpo en una concentración de 100 mg/ml o mayor en donde la preparación está sustancialmente libre de agregados. Una preparación de anticuerpos de conformidad con la reivindicación 1 o 2, caracterizada porque el anticuerpo está presente en una concentración mayor que 100 mg/ml. Una preparación de anticuerpos de conformidad con cualquiera de las reivindicaciones anteriores, caracterizada porque el anticuerpo está presente en una concentración entre 100 y 350 mg/ml. Una preparación de anticuerpos de conformidad con cualquiera de las reivindicaciones anteriores, caracterizada porque el anticuerpo es del isotipo IgG. Una preparación de anticuerpos de conformidad con cualquiera de las reivindicaciones anteriores, caracterizada porque el anticuerpo es un anticuerpo recombinante. Una preparación de anticuerpos de conformidad con la reivindicación 6, caracterizada porque el anticuerpo es un anticuerpo alterado. Una preparación de anticuerpos de conformidad con la reivindicación 7, caracterizada porque el anticuerpo es un anticuerpo quimérico o un injertado de CDR. Una preparación de anticuerpos de conformidad con cualquiera de las reivindicaciones anteriores, caracterizada porque une a una célula T a un antígeno de cáncer. Una preparación de anticuerpos de conformidad con cualquiera de las reivindicaciones anteriores, caracterizada porque el pH de la preparación es diferente del pH del punto isoeléctrico del anticuerpo.1Una formulación farmacéutica, caracterizada porque comprende un anticuerpo monoclonal en una concentración de 100 mg/ml o mayor y un excipiente farmacéuticamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9610992.1A GB9610992D0 (en) | 1996-05-24 | 1996-05-24 | Concentrated antibody preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4850562A1 true CO4850562A1 (es) | 1999-10-26 |
Family
ID=10794316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO97028095A CO4850562A1 (es) | 1996-05-24 | 1997-05-22 | Proceso para producir una preparacion concentrada de anticuerpos |
Country Status (28)
Country | Link |
---|---|
US (1) | US6252055B1 (es) |
EP (1) | EP0907378B1 (es) |
JP (1) | JP3338060B2 (es) |
KR (1) | KR20000015935A (es) |
CN (1) | CN1219882A (es) |
AP (1) | AP9801392A0 (es) |
AR (1) | AR007249A1 (es) |
AT (1) | ATE318146T1 (es) |
AU (1) | AU731950B2 (es) |
BR (1) | BR9709267A (es) |
CA (1) | CA2254983A1 (es) |
CO (1) | CO4850562A1 (es) |
CZ (1) | CZ382498A3 (es) |
DE (1) | DE69735295T2 (es) |
EA (1) | EA001860B1 (es) |
ES (1) | ES2258277T3 (es) |
GB (1) | GB9610992D0 (es) |
ID (1) | ID16966A (es) |
IL (1) | IL126940A0 (es) |
IS (1) | IS4892A (es) |
NO (1) | NO985464L (es) |
NZ (1) | NZ332625A (es) |
PE (1) | PE69098A1 (es) |
PL (1) | PL330111A1 (es) |
TR (1) | TR199802423T2 (es) |
WO (1) | WO1997045140A1 (es) |
YU (1) | YU53098A (es) |
ZA (1) | ZA974486B (es) |
Families Citing this family (83)
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DE3272680D1 (en) * | 1981-05-01 | 1986-09-25 | Miles Lab | Oral pharmaceutical composition containing immune globulin |
JPH01268646A (ja) * | 1988-04-20 | 1989-10-26 | Meiji Milk Prod Co Ltd | 抗腫瘍剤 |
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-
1996
- 1996-05-24 GB GBGB9610992.1A patent/GB9610992D0/en active Pending
-
1997
- 1997-05-21 AR ARP970102171A patent/AR007249A1/es not_active Application Discontinuation
- 1997-05-22 JP JP54155397A patent/JP3338060B2/ja not_active Expired - Fee Related
- 1997-05-22 PL PL97330111A patent/PL330111A1/xx unknown
- 1997-05-22 CO CO97028095A patent/CO4850562A1/es unknown
- 1997-05-22 AT AT97923962T patent/ATE318146T1/de not_active IP Right Cessation
- 1997-05-22 WO PCT/EP1997/002595 patent/WO1997045140A1/en active IP Right Grant
- 1997-05-22 BR BR9709267A patent/BR9709267A/pt not_active IP Right Cessation
- 1997-05-22 YU YU53098A patent/YU53098A/sh unknown
- 1997-05-22 TR TR1998/02423T patent/TR199802423T2/xx unknown
- 1997-05-22 KR KR1019980709489A patent/KR20000015935A/ko not_active Application Discontinuation
- 1997-05-22 DE DE69735295T patent/DE69735295T2/de not_active Expired - Lifetime
- 1997-05-22 EA EA199800946A patent/EA001860B1/ru not_active IP Right Cessation
- 1997-05-22 EP EP97923962A patent/EP0907378B1/en not_active Revoked
- 1997-05-22 NZ NZ332625A patent/NZ332625A/xx unknown
- 1997-05-22 ES ES97923962T patent/ES2258277T3/es not_active Expired - Lifetime
- 1997-05-22 CA CA002254983A patent/CA2254983A1/en not_active Abandoned
- 1997-05-22 CN CN97194891A patent/CN1219882A/zh active Pending
- 1997-05-22 CZ CZ983824A patent/CZ382498A3/cs unknown
- 1997-05-22 US US09/180,485 patent/US6252055B1/en not_active Expired - Lifetime
- 1997-05-22 AP APAP/P/1998/001392A patent/AP9801392A0/en unknown
- 1997-05-22 ZA ZA974486A patent/ZA974486B/xx unknown
- 1997-05-22 IL IL12694097A patent/IL126940A0/xx unknown
- 1997-05-22 AU AU29589/97A patent/AU731950B2/en not_active Ceased
- 1997-05-23 PE PE1997000415A patent/PE69098A1/es not_active Application Discontinuation
- 1997-05-23 ID IDP971722A patent/ID16966A/id unknown
-
1998
- 1998-11-10 IS IS4892A patent/IS4892A/is unknown
- 1998-11-23 NO NO985464A patent/NO985464L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20000015935A (ko) | 2000-03-15 |
ES2258277T3 (es) | 2006-08-16 |
PL330111A1 (en) | 1999-04-26 |
GB9610992D0 (en) | 1996-07-31 |
ATE318146T1 (de) | 2006-03-15 |
JP3338060B2 (ja) | 2002-10-28 |
AP9801392A0 (en) | 1998-12-31 |
BR9709267A (pt) | 1999-08-10 |
AU731950B2 (en) | 2001-04-05 |
IS4892A (is) | 1998-11-10 |
NO985464L (no) | 1999-01-18 |
YU53098A (sh) | 2000-03-21 |
US6252055B1 (en) | 2001-06-26 |
IL126940A0 (en) | 1999-09-22 |
NZ332625A (en) | 2000-04-28 |
EA199800946A1 (ru) | 1999-06-24 |
DE69735295D1 (de) | 2006-04-27 |
TR199802423T2 (xx) | 1999-02-22 |
ZA974486B (en) | 1998-11-23 |
PE69098A1 (es) | 1998-12-02 |
CZ382498A3 (cs) | 1999-05-12 |
CN1219882A (zh) | 1999-06-16 |
EP0907378A1 (en) | 1999-04-14 |
DE69735295T2 (de) | 2006-10-05 |
EP0907378B1 (en) | 2006-02-22 |
ID16966A (id) | 1997-11-27 |
JPH11512753A (ja) | 1999-11-02 |
CA2254983A1 (en) | 1997-12-04 |
AR007249A1 (es) | 1999-10-27 |
WO1997045140A1 (en) | 1997-12-04 |
EA001860B1 (ru) | 2001-10-22 |
NO985464D0 (no) | 1998-11-23 |
AU2958997A (en) | 1998-01-05 |
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