CO4600682A1 - Protrombinas como antidoto para los inhibidores de la trom- bina - Google Patents

Protrombinas como antidoto para los inhibidores de la trom- bina

Info

Publication number
CO4600682A1
CO4600682A1 CO97006960A CO97006960A CO4600682A1 CO 4600682 A1 CO4600682 A1 CO 4600682A1 CO 97006960 A CO97006960 A CO 97006960A CO 97006960 A CO97006960 A CO 97006960A CO 4600682 A1 CO4600682 A1 CO 4600682A1
Authority
CO
Colombia
Prior art keywords
antidote
protocols
thrombin inhibitors
thrombin
inhibitors
Prior art date
Application number
CO97006960A
Other languages
English (en)
Inventor
Martin Raditsch
Claus Bollschweile
Wolgang Hans
Klaus Rubsamen
Thomas Friedrich
Jurgen Schweden
Martin Schmidt
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of CO4600682A1 publication Critical patent/CO4600682A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVAS TROMBIN MUTEINAS SU PREPARACION Y UTILIZACION COMO ANTIDOTO PARA LOS INHIBIDORES DE LA TROMBINA.
CO97006960A 1996-02-12 1997-02-11 Protrombinas como antidoto para los inhibidores de la trom- bina CO4600682A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19605126A DE19605126A1 (de) 1996-02-12 1996-02-12 Thrombinmuteine als Antidot für Thrombininhibitoren

Publications (1)

Publication Number Publication Date
CO4600682A1 true CO4600682A1 (es) 1998-05-08

Family

ID=7785198

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97006960A CO4600682A1 (es) 1996-02-12 1997-02-11 Protrombinas como antidoto para los inhibidores de la trom- bina

Country Status (18)

Country Link
US (1) US6060300A (es)
EP (1) EP0880591A1 (es)
JP (1) JPH11512621A (es)
KR (1) KR19990082479A (es)
CN (1) CN1211280A (es)
AR (1) AR005797A1 (es)
AU (1) AU1768497A (es)
BR (1) BR9707280A (es)
CA (1) CA2245546A1 (es)
CO (1) CO4600682A1 (es)
CZ (1) CZ247798A3 (es)
DE (1) DE19605126A1 (es)
HR (1) HRP970077A2 (es)
HU (1) HUP9900574A2 (es)
IL (1) IL125077A0 (es)
NO (1) NO983677D0 (es)
WO (1) WO1997029198A1 (es)
ZA (1) ZA971107B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000018933A (ko) * 1998-09-07 2000-04-06 김승수 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자
GB2355161B (en) * 1999-10-05 2001-09-12 3Com Corp Network device incorporating selective compression of stored data packets
KR20020008471A (ko) * 2000-07-20 2002-01-31 김승수 내피세포 성장 억제활성을 가지는 인간 프로트롬빈크링글, 그것의 재조합벡터 및 이를 발현하는 재조합 숙주
CN101501216B (zh) * 2006-03-06 2013-10-02 胡玛基因公司 制备重组人凝血酶的方法
HUE052423T2 (hu) 2007-09-28 2021-04-28 Alexion Pharma Inc Az XA faktor inhibitorok antidótumai és ezek alkalmazási módszerei
MX2011004907A (es) 2008-11-14 2011-07-29 Portola Pharm Inc Antidotos para inhibidores del factor xa y metodos para el uso de los mismos en combinacion con agentes de coagulacion de sangre.
WO2010117729A1 (en) 2009-03-30 2010-10-14 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
JP6163304B2 (ja) 2009-07-15 2017-07-12 ポートラ ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子インヒビターの解毒剤の単位用量処方物およびその使用方法
EP2316931B1 (de) 2009-10-30 2016-12-28 Senova Gesellschaft für Biowissenschaft und Technik mbH Polymergekoppelte Peptidasen
AR079944A1 (es) 2010-01-20 2012-02-29 Boehringer Ingelheim Int Anticuerpo neutralizante de la actividad de un anticoagulante
AP2013007046A0 (en) 2011-03-30 2013-08-31 Boehringer Ingelheim Int Anticoagulant antidotes
LT3149163T (lt) 2014-05-26 2020-09-25 Academisch Ziekenhuis Leiden Prohemostatiniai baltymai, skirti kraujavimo gydymui

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4203965A1 (de) * 1992-02-11 1993-08-12 Max Planck Gesellschaft Antidot fuer hirudin und synthetische thrombininhibitoren

Also Published As

Publication number Publication date
HRP970077A2 (en) 1998-04-30
NO983677L (no) 1998-08-11
KR19990082479A (ko) 1999-11-25
NO983677D0 (no) 1998-08-11
CZ247798A3 (cs) 1999-03-17
WO1997029198A1 (de) 1997-08-14
BR9707280A (pt) 1999-07-20
DE19605126A1 (de) 1997-08-14
US6060300A (en) 2000-05-09
IL125077A0 (en) 1999-01-26
ZA971107B (en) 1998-08-11
CN1211280A (zh) 1999-03-17
EP0880591A1 (de) 1998-12-02
HUP9900574A2 (hu) 1999-06-28
JPH11512621A (ja) 1999-11-02
CA2245546A1 (en) 1997-08-14
AR005797A1 (es) 1999-07-14
AU1768497A (en) 1997-08-28

Similar Documents

Publication Publication Date Title
HN1997000099A (es) Inhibidores de metaloproteasas matriciales basados en
HN1997000072A (es) Procedimiento para la preparacion de sildenafil
GT199900102A (es) Fenoxipropanolaminas, procedimiento para su preparacìon y composiciones farmacèuticasque las contienen.
HN1999000125A (es) Nuevos derivados sustituidos del pirazol
HN1997000058A (es) Derivados indolicos utiles para terapia
HN1997000023A (es) Derivados de lactama
HN1997000110A (es) Derivados del acido arilsulfoonilamino hidroxamico
HN1998000132A (es) Combinaciones terapeuticas
HN1998000139A (es) Pirimidin-4-ona y pirimidin-4-tiona novedosas como funguicidas
HN2001000217A (es) Nuevos tiadiazoles y oxadiazoles y su uso como inhibidores de fosfodiesterasa - 7
HN2002000300A (es) Nuevos derivados de piperazina
HN1996000101A (es) Terapia combinada para la osteoporosis
CO4600682A1 (es) Protrombinas como antidoto para los inhibidores de la trom- bina
BR0114903A (pt) 7-azaindóis, sua aplicação como inibidores da fosfodiesterase 4 e processos para a sua preparação
ES2154318T3 (es) Agentes antitromboticos.
HN2001000235A (es) Derivados puentes de piperazina
HN1998000158A (es) Isoquinolinas
HN1997000127A (es) Procedimiento e intermedios para preparar derivados de cromanol sustituidos.
HN1998000167A (es) Nuevo procedimiento para preparar una cetoimina
HN2002000278A (es) Tetrahidroquinolinas
HN1999000101A (es) Inhibidores de las fkbp.
HN2000000056A (es) Nuevas formas cristalinas de un antibiotico macrolido
ES2186989T3 (es) Cristales de maltitol de formas especificas, compuestos cristalinos que los contienen y procedimientos para su preparacion.
ES2174297T3 (es) Nuevos derivados de piranosidos.
UY26556A1 (es) Compuestos calcilíticos