CO2023004646A2 - Compuestos y composiciones como inhibidores de sppl2a - Google Patents
Compuestos y composiciones como inhibidores de sppl2aInfo
- Publication number
- CO2023004646A2 CO2023004646A2 CONC2023/0004646A CO2023004646A CO2023004646A2 CO 2023004646 A2 CO2023004646 A2 CO 2023004646A2 CO 2023004646 A CO2023004646 A CO 2023004646A CO 2023004646 A2 CO2023004646 A2 CO 2023004646A2
- Authority
- CO
- Colombia
- Prior art keywords
- inhibitors
- sppl2a
- compositions
- compounds
- protease
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 102100029083 Minor histocompatibility antigen H13 Human genes 0.000 abstract 1
- DHZYXWMZLAKTQV-UHFFFAOYSA-N diazepin-3-one Chemical group O=C1C=CC=CN=N1 DHZYXWMZLAKTQV-UHFFFAOYSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108010031009 signal peptide peptidase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a compuestos tricíclicos que comprenden un resto de diazepinona que son eficaces para inhibir Sppl2a (péptido señal peptidasa similar a la proteasa 2a), a composiciones farmacéuticas que contienen tales inhibidores y a métodos para usar tales inhibidores y composiciones.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063079604P | 2020-09-17 | 2020-09-17 | |
| PCT/IB2021/058398 WO2022058902A1 (en) | 2020-09-17 | 2021-09-15 | Compounds and compositions as sppl2a inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2023004646A2 true CO2023004646A2 (es) | 2023-07-21 |
Family
ID=77897680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2023/0004646A CO2023004646A2 (es) | 2020-09-17 | 2023-04-14 | Compuestos y composiciones como inhibidores de sppl2a |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20230365571A1 (es) |
| EP (1) | EP4214210A1 (es) |
| JP (1) | JP2023541475A (es) |
| KR (1) | KR20230069947A (es) |
| CN (1) | CN116615425A (es) |
| AU (1) | AU2021342783A1 (es) |
| CA (1) | CA3192763A1 (es) |
| CL (1) | CL2023000728A1 (es) |
| CO (1) | CO2023004646A2 (es) |
| CR (1) | CR20230142A (es) |
| DO (1) | DOP2023000055A (es) |
| EC (1) | ECSP23027092A (es) |
| IL (1) | IL300953A (es) |
| MX (1) | MX2023003122A (es) |
| PE (1) | PE20231099A1 (es) |
| WO (1) | WO2022058902A1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9612622D0 (en) | 1996-06-17 | 1996-08-21 | Zeneca Ltd | Chemical process |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| WO2015160772A1 (en) | 2014-04-15 | 2015-10-22 | Janssen Pharmaceutica Nv | Tetrahydro-benzoimidazolyl modulators of tgr5 |
-
2021
- 2021-09-15 JP JP2023517751A patent/JP2023541475A/ja active Pending
- 2021-09-15 PE PE2023001167A patent/PE20231099A1/es unknown
- 2021-09-15 EP EP21773886.3A patent/EP4214210A1/en active Pending
- 2021-09-15 AU AU2021342783A patent/AU2021342783A1/en active Pending
- 2021-09-15 CA CA3192763A patent/CA3192763A1/en active Pending
- 2021-09-15 MX MX2023003122A patent/MX2023003122A/es unknown
- 2021-09-15 US US18/044,455 patent/US20230365571A1/en active Pending
- 2021-09-15 IL IL300953A patent/IL300953A/en unknown
- 2021-09-15 CN CN202180074962.XA patent/CN116615425A/zh active Pending
- 2021-09-15 CR CR20230142A patent/CR20230142A/es unknown
- 2021-09-15 KR KR1020237011546A patent/KR20230069947A/ko unknown
- 2021-09-15 WO PCT/IB2021/058398 patent/WO2022058902A1/en active Application Filing
-
2023
- 2023-03-14 CL CL2023000728A patent/CL2023000728A1/es unknown
- 2023-03-16 DO DO2023000055A patent/DOP2023000055A/es unknown
- 2023-04-14 EC ECSENADI202327092A patent/ECSP23027092A/es unknown
- 2023-04-14 CO CONC2023/0004646A patent/CO2023004646A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR20230142A (es) | 2023-08-25 |
| CA3192763A1 (en) | 2022-03-24 |
| KR20230069947A (ko) | 2023-05-19 |
| CL2023000728A1 (es) | 2023-12-15 |
| EP4214210A1 (en) | 2023-07-26 |
| ECSP23027092A (es) | 2023-06-30 |
| DOP2023000055A (es) | 2023-06-15 |
| MX2023003122A (es) | 2023-03-22 |
| IL300953A (en) | 2023-04-01 |
| US20230365571A1 (en) | 2023-11-16 |
| AU2021342783A1 (en) | 2023-05-18 |
| CN116615425A (zh) | 2023-08-18 |
| PE20231099A1 (es) | 2023-07-18 |
| WO2022058902A1 (en) | 2022-03-24 |
| JP2023541475A (ja) | 2023-10-02 |
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