CO2023001559A2 - Anticuerpos fgfr3 y métodos de uso - Google Patents
Anticuerpos fgfr3 y métodos de usoInfo
- Publication number
- CO2023001559A2 CO2023001559A2 CONC2023/0001559A CO2023001559A CO2023001559A2 CO 2023001559 A2 CO2023001559 A2 CO 2023001559A2 CO 2023001559 A CO2023001559 A CO 2023001559A CO 2023001559 A2 CO2023001559 A2 CO 2023001559A2
- Authority
- CO
- Colombia
- Prior art keywords
- methods
- fgfr3
- fgfr3 antibodies
- antigen binding
- antibodies
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 101150025764 FGFR3 gene Proteins 0.000 title 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 abstract 2
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000025171 antigen binding proteins Human genes 0.000 abstract 1
- 108091000831 antigen binding proteins Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se proporcionan proteínas de unión a antígeno anti-FGFR3 y fragmentos de unión a antígeno de las mismas. También se proporcionan métodos para inhibir la actividad de FGFR3 y métodos para tratar trastornos o enfermedades en las que interviene FGFR3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063068575P | 2020-08-21 | 2020-08-21 | |
PCT/US2021/046958 WO2022040560A1 (en) | 2020-08-21 | 2021-08-20 | Fgfr3 antibodies and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2023001559A2 true CO2023001559A2 (es) | 2023-02-16 |
Family
ID=77774991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2023/0001559A CO2023001559A2 (es) | 2020-08-21 | 2023-02-14 | Anticuerpos fgfr3 y métodos de uso |
Country Status (14)
Country | Link |
---|---|
US (2) | US11505611B2 (es) |
EP (1) | EP4200019A1 (es) |
JP (1) | JP2023538098A (es) |
KR (1) | KR20230052963A (es) |
CN (1) | CN116323666A (es) |
AR (1) | AR123306A1 (es) |
AU (1) | AU2021327387A1 (es) |
BR (1) | BR112023002455A2 (es) |
CA (1) | CA3189470A1 (es) |
CO (1) | CO2023001559A2 (es) |
IL (1) | IL300623A (es) |
MX (1) | MX2023002106A (es) |
TW (1) | TW202229343A (es) |
WO (1) | WO2022040560A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024104922A1 (en) | 2022-11-14 | 2024-05-23 | Ascendis Pharma Growth Disorders A/S | Method of improving skeletal muscle function |
US20240158515A1 (en) * | 2022-11-14 | 2024-05-16 | Regeneron Pharmaceuticals, Inc. | Anti-fgfr3 antibodies and antigen-binding fragments and methods of use thereof |
Family Cites Families (50)
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DK0481000T3 (da) | 1989-07-06 | 1999-11-15 | Univ California | Receptorer for fibroblastvækstfaktorer |
DE69304331T2 (de) | 1992-06-18 | 1997-01-16 | The Whittier Institute For Diabetes And Endocrinology, La Jolla, Calif. | Verfahren zur detektion neoplastischer erkrankungen |
WO1994021813A1 (en) | 1993-03-17 | 1994-09-29 | The Whittier Institute For Diabetes And Endocrinology | Monoclonal antibodies specific for fibroblast growth factor receptors, immunotoxins, and use thereof |
US6517872B1 (en) | 1995-06-12 | 2003-02-11 | Yeda Research And Development Co., Ltd. | FGFR3 as a marker for mesenchymal skeletal progenitor cells |
GB9524973D0 (en) | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
ZA200007412B (en) | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
US20030143676A1 (en) | 1999-03-25 | 2003-07-31 | Genesis Research And Development Corporation Limited | Fibroblast growth factor receptors and methods for their use |
CA2372990C (en) | 1999-05-05 | 2007-06-19 | Institut Curie | Means for detecting and treating pathologies linked to fgfr3 |
US7135311B1 (en) | 1999-05-05 | 2006-11-14 | Institut Curie | Means for detecting and treating pathologies linked to FGFR3 |
DE20023659U1 (de) | 1999-10-06 | 2005-07-07 | Tigenix N.V. | Molekulare Marker zum Testen der phänotypischen Stabilität von Zellpopulationen und Zellpopulationen für die autologe Transplantation |
WO2002102854A2 (en) | 2001-06-20 | 2002-12-27 | Morphosys Ag | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
WO2003063893A2 (en) | 2002-01-31 | 2003-08-07 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Fgfr agonists |
NZ537208A (en) | 2002-06-27 | 2009-02-28 | Adipogen Pharmaceuticals Pty Ltd | Differentiation modulating agents and uses therefor |
WO2004022095A1 (en) | 2002-09-04 | 2004-03-18 | Abtech | Anti-idiotypic antibodies as vegf or fgf agonists for bone therapy |
EP1579218A2 (en) | 2002-12-20 | 2005-09-28 | Enkam Pharmaceuticals A/S | Method of modulation of interaction between receptor and ligand |
WO2004074506A2 (en) | 2003-02-13 | 2004-09-02 | Mergen Ltd | Polynucleotide sequences and corresponding encoded polypeptides of particular secreted and membrane-bound proteins overexpressed in certain cancers |
WO2004085676A1 (en) | 2003-03-26 | 2004-10-07 | Progenika Biopharma, S.A. | In vitro method to detect bladder transitional cell carcinoma |
IL156495A0 (en) | 2003-06-17 | 2004-01-04 | Prochon Biotech Ltd | Use of fgfr3 antagonists for treating t cell mediated diseases |
WO2005066211A2 (en) | 2003-12-19 | 2005-07-21 | Five Prime Therapeutics, Inc. | Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention |
DE60319240D1 (de) | 2003-12-19 | 2008-04-03 | Charite Universitaetsmedizin | Verwendung von Liganden von CD52 Antigen zur Behandlung von soliden Tumoren und von Knochenkrebserkrankungen |
CA2558758C (en) | 2004-02-24 | 2015-06-23 | Allergan, Inc. | Botulinum toxin screening assays |
US7872016B2 (en) | 2004-05-25 | 2011-01-18 | Yale University | Method for treating skeletal disorders resulting from FGFR malfunction |
CA2595398A1 (en) | 2004-11-04 | 2006-05-11 | Fibron Limited | Treatment of b-cell malignancies |
EP1659175A1 (en) | 2004-11-18 | 2006-05-24 | Institut Curie | Alterations in seborrheic keratoses and their applications |
PL1772465T3 (pl) | 2005-01-05 | 2009-08-31 | F Star Biotechnologische Forschungs Und Entw M B H | Syntetyczne domeny immunoglobulinowe o właściwościach wiążących modyfikowane w regionach cząsteczki różnych od regionów determinujących komplementarność |
CA2601592A1 (en) | 2005-03-15 | 2006-09-28 | Allergan, Inc. | Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems |
US7678890B2 (en) | 2005-07-22 | 2010-03-16 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with FGFR fusion proteins |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
JP2009511613A (ja) | 2005-10-17 | 2009-03-19 | エンカム ファーマシューティカルズ アクティーゼルスカブ | 神経細胞接着分子l1のペプチド断片を含む新規fgf受容体結合化合物 |
EP1960547A2 (en) | 2005-12-08 | 2008-08-27 | Novartis AG | Effects of inhibitors of fgfr3 on gene transcription |
US8101721B2 (en) | 2006-06-15 | 2012-01-24 | Fibron Ltd. | Antibodies blocking fibroblast growth factor receptor activation and methods of use thereof |
WO2008127707A1 (en) | 2007-04-13 | 2008-10-23 | Dana Farber Cancer Institute, Inc. | Receptor tyrosine kinase profiling |
EP2190861A4 (en) | 2007-08-22 | 2011-03-30 | Univ California | ACTIVE BINDING POLYPEPTIDES AND METHOD FOR THEIR IDENTIFICATION AND USE |
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IN2012DN05017A (es) | 2010-01-14 | 2015-10-02 | Univ Yale | |
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TWI541022B (zh) | 2013-12-18 | 2016-07-11 | 應克隆公司 | 針對纖維母細胞生長因子受體-3(fgfr3)之化合物及治療方法 |
BR112017017700A2 (pt) | 2015-02-19 | 2018-07-31 | Bioclin Therapeutics Inc | métodos, composições e kits para tratamento do câncer |
SG11201906249PA (en) | 2017-02-06 | 2019-08-27 | Rainier Therapeutics Inc | Methods, compositions, and kits for treatment of cancer |
-
2021
- 2021-08-20 MX MX2023002106A patent/MX2023002106A/es unknown
- 2021-08-20 CA CA3189470A patent/CA3189470A1/en active Pending
- 2021-08-20 CN CN202180051281.1A patent/CN116323666A/zh active Pending
- 2021-08-20 EP EP21770357.8A patent/EP4200019A1/en active Pending
- 2021-08-20 WO PCT/US2021/046958 patent/WO2022040560A1/en active Application Filing
- 2021-08-20 TW TW110130895A patent/TW202229343A/zh unknown
- 2021-08-20 BR BR112023002455A patent/BR112023002455A2/pt unknown
- 2021-08-20 IL IL300623A patent/IL300623A/en unknown
- 2021-08-20 JP JP2023512280A patent/JP2023538098A/ja active Pending
- 2021-08-20 US US17/407,774 patent/US11505611B2/en active Active
- 2021-08-20 AR ARP210102356A patent/AR123306A1/es unknown
- 2021-08-20 AU AU2021327387A patent/AU2021327387A1/en active Pending
- 2021-08-20 KR KR1020237009493A patent/KR20230052963A/ko unknown
-
2022
- 2022-10-12 US US18/045,995 patent/US20230303704A1/en active Pending
-
2023
- 2023-02-14 CO CONC2023/0001559A patent/CO2023001559A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN116323666A (zh) | 2023-06-23 |
TW202229343A (zh) | 2022-08-01 |
US11505611B2 (en) | 2022-11-22 |
AU2021327387A1 (en) | 2023-05-04 |
KR20230052963A (ko) | 2023-04-20 |
CA3189470A1 (en) | 2022-02-24 |
JP2023538098A (ja) | 2023-09-06 |
BR112023002455A2 (pt) | 2023-03-28 |
AR123306A1 (es) | 2022-11-16 |
US20220056142A1 (en) | 2022-02-24 |
EP4200019A1 (en) | 2023-06-28 |
AU2021327387A9 (en) | 2023-07-06 |
WO2022040560A1 (en) | 2022-02-24 |
MX2023002106A (es) | 2023-03-15 |
US20230303704A1 (en) | 2023-09-28 |
IL300623A (en) | 2023-04-01 |
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