CO2020005226A2 - Production method of an intermediate compound to synthesize a drug - Google Patents

Production method of an intermediate compound to synthesize a drug

Info

Publication number
CO2020005226A2
CO2020005226A2 CONC2020/0005226A CO2020005226A CO2020005226A2 CO 2020005226 A2 CO2020005226 A2 CO 2020005226A2 CO 2020005226 A CO2020005226 A CO 2020005226A CO 2020005226 A2 CO2020005226 A2 CO 2020005226A2
Authority
CO
Colombia
Prior art keywords
synthesize
drug
production method
intermediate compound
increase
Prior art date
Application number
CONC2020/0005226A
Other languages
Spanish (es)
Inventor
Seok Ju Lee
Bongchan Kim
Ae Ri Park
In Ae Ryu
Jongwon Park
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/KR2018/011565 external-priority patent/WO2019066578A1/en
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Publication of CO2020005226A2 publication Critical patent/CO2020005226A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un método para la preparación de un compuesto de fórmula química 2 que es un producto intermedio usado para sintetizar agentes antidiabéticos que inhiben la enzima dipeptidil peptidasa IV, que 1) puede producirlo con alta pureza a través de una ciclación y desciclación de oxazolidinona que la convierte en una amida, 2) puede aumentar el rendimiento y aumentar la productividad a través de la estabilización del procedimiento de preparación, y 3) puede lograr un efecto de mejora tal como la reducción del coste de materias primas, etc. usando un material de partida de una muestra económica.The present invention relates to a method for the preparation of a compound of chemical formula 2 which is an intermediate product used to synthesize antidiabetic agents that inhibit the enzyme dipeptidyl peptidase IV, which 1) can produce it in high purity through cyclization and Decyclization of oxazolidinone which converts it to an amide, 2) it can increase the yield and increase the productivity through stabilization of the preparation process, and 3) it can achieve an improvement effect such as reducing the cost of raw materials, etc. . using a starting material from an inexpensive sample.

CONC2020/0005226A 2017-09-28 2020-04-27 Production method of an intermediate compound to synthesize a drug CO2020005226A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20170126119 2017-09-28
KR1020180115838A KR102152445B1 (en) 2017-09-28 2018-09-28 Production method of intermediate compound for synthesizing medicament
PCT/KR2018/011565 WO2019066578A1 (en) 2017-09-28 2018-09-28 Process for preparing intermediate compound for pharmaceutical synthesis

Publications (1)

Publication Number Publication Date
CO2020005226A2 true CO2020005226A2 (en) 2020-06-09

Family

ID=66104057

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0005226A CO2020005226A2 (en) 2017-09-28 2020-04-27 Production method of an intermediate compound to synthesize a drug

Country Status (8)

Country Link
KR (1) KR102152445B1 (en)
CN (1) CN111164071A (en)
BR (1) BR112020006063B1 (en)
CL (1) CL2020000807A1 (en)
CO (1) CO2020005226A2 (en)
PE (1) PE20201169A1 (en)
PH (1) PH12020550170A1 (en)
RU (1) RU2742765C1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6267097A (en) * 1985-09-18 1987-03-26 Nippon Kayaku Co Ltd Novel process for production of alpha-aspartyl-phenylalanine ester
IT1248486B (en) * 1990-05-24 1995-01-19 Roberto Pellicciari THERAPEUTIC AGENT ACTIVITIES ON THE CENTRAL NERVOUS SYSTEM
EP1745784A1 (en) * 2005-06-27 2007-01-24 Ferrer Internacional, S.A. Oxazolidinone derivatives and use thereof as antibiotics
US8741927B2 (en) * 2010-09-03 2014-06-03 Lg Life Sciences Ltd. Production method of intermediate compound for synthesizing medicament
US8524936B2 (en) * 2011-05-18 2013-09-03 Milan Soukup Manufacturing process for sitagliptin from L-aspartic acid

Also Published As

Publication number Publication date
PE20201169A1 (en) 2020-10-28
PH12020550170A1 (en) 2021-03-01
BR112020006063A2 (en) 2020-09-29
RU2742765C1 (en) 2021-02-10
CL2020000807A1 (en) 2020-08-07
BR112020006063B1 (en) 2024-01-16
CN111164071A (en) 2020-05-15
KR20190037172A (en) 2019-04-05
KR102152445B1 (en) 2020-09-04

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