CO2019013047A2 - Composiciones sólidas para administración oral - Google Patents
Composiciones sólidas para administración oralInfo
- Publication number
- CO2019013047A2 CO2019013047A2 CONC2019/0013047A CO2019013047A CO2019013047A2 CO 2019013047 A2 CO2019013047 A2 CO 2019013047A2 CO 2019013047 A CO2019013047 A CO 2019013047A CO 2019013047 A2 CO2019013047 A2 CO 2019013047A2
- Authority
- CO
- Colombia
- Prior art keywords
- oral administration
- solid compositions
- glp
- derivative
- sglt2
- Prior art date
Links
- 239000008247 solid mixture Substances 0.000 title abstract 2
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 2
- JVHXJTBJCFBINQ-ADAARDCZSA-N Dapagliflozin Chemical compound C1=CC(OCC)=CC=C1CC1=CC([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=C1Cl JVHXJTBJCFBINQ-ADAARDCZSA-N 0.000 abstract 1
- 108091006269 SLC5A2 Proteins 0.000 abstract 1
- 102000058081 Sodium-Glucose Transporter 2 Human genes 0.000 abstract 1
- 229940123518 Sodium/glucose cotransporter 2 inhibitor Drugs 0.000 abstract 1
- 229960003834 dapagliflozin Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
RESUMEN La presente invención se refiere a composiciones sólidas para administración oral que comprenden (i) un derivado de GLP-1 y el inhibidor de SGLT2 dapagliflozina o (ii) un derivado de GLP-1 y una sal de NAC en combinación con un inhibidor de SGLT2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17175131 | 2017-06-09 | ||
PCT/EP2018/065266 WO2018224689A2 (en) | 2017-06-09 | 2018-06-11 | Solid compositions for oral administration |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2019013047A2 true CO2019013047A2 (es) | 2020-04-01 |
Family
ID=59070439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2019/0013047A CO2019013047A2 (es) | 2017-06-09 | 2019-11-22 | Composiciones sólidas para administración oral |
Country Status (28)
Country | Link |
---|---|
US (2) | US11167014B2 (es) |
EP (1) | EP3634468B1 (es) |
JP (1) | JP7239495B2 (es) |
KR (1) | KR20200015564A (es) |
CN (1) | CN110769846A (es) |
AR (1) | AR112015A1 (es) |
AU (1) | AU2018280875A1 (es) |
BR (1) | BR112019025769A2 (es) |
CA (1) | CA3064677A1 (es) |
CL (1) | CL2019003402A1 (es) |
CO (1) | CO2019013047A2 (es) |
DK (1) | DK3634468T3 (es) |
ES (1) | ES2938050T3 (es) |
FI (1) | FI3634468T3 (es) |
HR (1) | HRP20230075T1 (es) |
HU (1) | HUE060962T2 (es) |
IL (1) | IL270812B2 (es) |
MA (1) | MA49253A (es) |
MX (1) | MX2019013965A (es) |
MY (1) | MY197488A (es) |
PE (1) | PE20200606A1 (es) |
PH (1) | PH12019550249A1 (es) |
PL (1) | PL3634468T3 (es) |
PT (1) | PT3634468T (es) |
RS (1) | RS64045B1 (es) |
SI (1) | SI3634468T1 (es) |
TW (1) | TWI797133B (es) |
WO (1) | WO2018224689A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2013234496B2 (en) | 2012-03-22 | 2017-07-27 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
IL275778B2 (en) | 2018-02-02 | 2023-12-01 | Novo Nordisk As | Solid compounds that make up glp-1 agonist n-8-2-hydroxybenzoyl salt |
TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
KR102376009B1 (ko) * | 2018-12-21 | 2022-03-18 | (주)휴온스 | 엠파글리플로진 및 시타글립틴을 포함하는 약학적 조성물 |
CA3144611A1 (en) * | 2019-08-07 | 2021-02-11 | Betty Lomstein PEDERSEN | Solid compositions comprising a glp-1 agonist, an sglt2 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
US20220395559A1 (en) * | 2019-11-07 | 2022-12-15 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, an sglt2 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
WO2023065231A1 (en) * | 2021-10-21 | 2023-04-27 | Guangzhou Dazhou Biomedicine Ltd. | Oral delivery of therapeutic agents |
WO2023123063A1 (en) * | 2021-12-29 | 2023-07-06 | Guangzhou Dazhou Biomedicine Ltd. | Oral delivery |
EP4299052A1 (en) * | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and a permeation enhancer |
CN114984191B (zh) * | 2022-07-04 | 2022-10-25 | 北京惠之衡生物科技有限公司 | 一种多肽类药物口服递送组合物 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
AU3357800A (en) | 1999-02-05 | 2000-08-25 | Emisphere Technologies, Inc. | Method of preparing alkylated salicylamides |
US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
US7262325B2 (en) | 2000-06-02 | 2007-08-28 | Emisphere Technologies, Inc. | Method of preparing salicylamides |
US6936590B2 (en) | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
AR056195A1 (es) | 2005-09-15 | 2007-09-26 | Boehringer Ingelheim Int | Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos |
US7745414B2 (en) | 2006-02-15 | 2010-06-29 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture |
WO2007121318A2 (en) | 2006-04-12 | 2007-10-25 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
US7919598B2 (en) | 2006-06-28 | 2011-04-05 | Bristol-Myers Squibb Company | Crystal structures of SGLT2 inhibitors and processes for preparing same |
CA2662080C (en) | 2006-09-07 | 2012-07-17 | F. Hoffmann-La Roche Ag | A process for the manufacture of snac (salcaprozate sodium) |
TW200904405A (en) | 2007-03-22 | 2009-02-01 | Bristol Myers Squibb Co | Pharmaceutical formulations containing an SGLT2 inhibitor |
WO2008144346A2 (en) | 2007-05-18 | 2008-11-27 | Bristol-Myers Squibb Company | Crystal structures of sglt2 inhibitors and processes for their preparation |
EP2679597A1 (en) | 2007-09-05 | 2014-01-01 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
JP2012528170A (ja) | 2009-05-27 | 2012-11-12 | ブリストル−マイヤーズ スクイブ カンパニー | 別の抗糖尿病薬を用いた先の治療に抵抗性を有する2型糖尿病患者をsglt2阻害剤およびその組成物を用いて治療する方法 |
SI2498759T1 (sl) | 2009-11-13 | 2018-12-31 | Astrazeneca Ab | Formulacije tablet s takojšnjim sproščanjem |
DK2513140T3 (en) | 2009-12-16 | 2016-01-18 | Novo Nordisk As | Double-acylated GLP-1 derivatives |
DK3326620T3 (da) | 2010-12-16 | 2020-05-25 | Novo Nordisk As | Faste sammensætninger omfattende en glp-1-agonist og et salt af n-(8-(2- hydroxybenzoyl)amino)caprylsyre |
US20130035281A1 (en) | 2011-02-09 | 2013-02-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
MX355361B (es) * | 2011-04-12 | 2018-04-17 | Novo Nordisk As | Derivados de peptido 1 tipo glucagon (glp-1) doblemente acilados. |
US20130224300A1 (en) | 2011-08-26 | 2013-08-29 | Edward T. Maggio | Compositions and methods thereof for oral administration of drugs |
AU2013234496B2 (en) | 2012-03-22 | 2017-07-27 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
EP4331667A2 (en) | 2012-03-22 | 2024-03-06 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
HUE042757T2 (hu) | 2012-03-22 | 2019-07-29 | Novo Nordisk As | Szállító szert tartalmazó készítmények és elõállításuk |
ES2871328T3 (es) * | 2012-06-20 | 2021-10-28 | Novo Nordisk As | Formulación de comprimido que comprende un péptido y un agente de suministro |
JP6755175B2 (ja) | 2013-03-20 | 2020-09-16 | ノヴォ ノルディスク アー/エス | インスリン投薬レジメン |
ES2741507T3 (es) | 2014-04-07 | 2020-02-11 | Novo Nordisk As | Compuestos de glp-1 acilados doblemente |
JP2018519313A (ja) * | 2015-07-02 | 2018-07-19 | ラニ セラピューティクス, エルエルシー | 嚥下可能な薬物送達デバイスを使用する腸管の管腔中への送達のための治療剤製剤 |
WO2018096163A1 (en) | 2016-11-28 | 2018-05-31 | Novo Nordisk A/S | Insulin degludec for improvement of glycaemic control and reduction of acute and long-term diabetes complications |
WO2018096164A1 (en) | 2016-11-28 | 2018-05-31 | Novo Nordisk A/S | Insulin degludec for treating diabetes |
EP3544683A1 (en) | 2016-11-28 | 2019-10-02 | Novo Nordisk A/S | Insulin degludec in cardiovascular conditions |
CA3144611A1 (en) * | 2019-08-07 | 2021-02-11 | Betty Lomstein PEDERSEN | Solid compositions comprising a glp-1 agonist, an sglt2 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
-
2018
- 2018-06-08 AR ARP180101556A patent/AR112015A1/es unknown
- 2018-06-08 TW TW107119869A patent/TWI797133B/zh active
- 2018-06-11 KR KR1020197037131A patent/KR20200015564A/ko unknown
- 2018-06-11 ES ES18730344T patent/ES2938050T3/es active Active
- 2018-06-11 PE PE2019002460A patent/PE20200606A1/es unknown
- 2018-06-11 MX MX2019013965A patent/MX2019013965A/es unknown
- 2018-06-11 IL IL270812A patent/IL270812B2/en unknown
- 2018-06-11 MY MYPI2019006851A patent/MY197488A/en unknown
- 2018-06-11 HR HRP20230075TT patent/HRP20230075T1/hr unknown
- 2018-06-11 FI FIEP18730344.1T patent/FI3634468T3/fi active
- 2018-06-11 US US16/620,363 patent/US11167014B2/en active Active
- 2018-06-11 EP EP18730344.1A patent/EP3634468B1/en active Active
- 2018-06-11 PL PL18730344.1T patent/PL3634468T3/pl unknown
- 2018-06-11 SI SI201830839T patent/SI3634468T1/sl unknown
- 2018-06-11 RS RS20230103A patent/RS64045B1/sr unknown
- 2018-06-11 AU AU2018280875A patent/AU2018280875A1/en not_active Withdrawn
- 2018-06-11 BR BR112019025769-1A patent/BR112019025769A2/pt not_active Application Discontinuation
- 2018-06-11 CA CA3064677A patent/CA3064677A1/en not_active Withdrawn
- 2018-06-11 HU HUE18730344A patent/HUE060962T2/hu unknown
- 2018-06-11 CN CN201880038208.9A patent/CN110769846A/zh not_active Withdrawn
- 2018-06-11 MA MA049253A patent/MA49253A/fr unknown
- 2018-06-11 PT PT187303441T patent/PT3634468T/pt unknown
- 2018-06-11 JP JP2019567972A patent/JP7239495B2/ja active Active
- 2018-06-11 WO PCT/EP2018/065266 patent/WO2018224689A2/en active Application Filing
- 2018-06-11 DK DK18730344.1T patent/DK3634468T3/da active
-
2019
- 2019-11-22 CL CL2019003402A patent/CL2019003402A1/es unknown
- 2019-11-22 CO CONC2019/0013047A patent/CO2019013047A2/es unknown
- 2019-11-22 PH PH12019550249A patent/PH12019550249A1/en unknown
-
2021
- 2021-10-08 US US17/496,831 patent/US20220016216A1/en not_active Abandoned
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