CO2019008783A2 - Compuestos dinucleotidos ciclicos para el tratamiento del cancer - Google Patents
Compuestos dinucleotidos ciclicos para el tratamiento del cancerInfo
- Publication number
- CO2019008783A2 CO2019008783A2 CONC2019/0008783A CO2019008783A CO2019008783A2 CO 2019008783 A2 CO2019008783 A2 CO 2019008783A2 CO 2019008783 A CO2019008783 A CO 2019008783A CO 2019008783 A2 CO2019008783 A2 CO 2019008783A2
- Authority
- CO
- Colombia
- Prior art keywords
- cancer
- treatment
- cyclic dinucleotide
- dinucleotide compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6587—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having two phosphorus atoms as ring hetero atoms in the same ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Abstract
En la presente se proveen compuestos útiles para el tratamiento deL cáncer
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762460562P | 2017-02-17 | 2017-02-17 | |
US201762479169P | 2017-03-30 | 2017-03-30 | |
US201762551647P | 2017-08-29 | 2017-08-29 | |
US201762551668P | 2017-08-29 | 2017-08-29 | |
US201762551645P | 2017-08-29 | 2017-08-29 | |
PCT/US2018/018556 WO2018152450A1 (en) | 2017-02-17 | 2018-02-17 | Cyclic di-nucleotides compounds for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2019008783A2 true CO2019008783A2 (es) | 2020-01-17 |
Family
ID=61521844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2019/0008783A CO2019008783A2 (es) | 2017-02-17 | 2019-08-13 | Compuestos dinucleotidos ciclicos para el tratamiento del cancer |
Country Status (31)
Country | Link |
---|---|
US (4) | US20200055883A1 (es) |
EP (3) | EP4008403A1 (es) |
JP (2) | JP6672532B2 (es) |
KR (1) | KR102645790B1 (es) |
CN (3) | CN110536719A (es) |
AU (1) | AU2018221170B2 (es) |
BR (1) | BR112019017084A2 (es) |
CA (1) | CA3053932A1 (es) |
CL (1) | CL2019002304A1 (es) |
CO (1) | CO2019008783A2 (es) |
DK (1) | DK3582853T3 (es) |
ES (1) | ES2906299T3 (es) |
HR (1) | HRP20220110T1 (es) |
HU (1) | HUE057665T2 (es) |
IL (1) | IL268721B (es) |
JO (1) | JOP20190194B1 (es) |
LT (1) | LT3582853T (es) |
MA (1) | MA47501A (es) |
MD (1) | MD3582853T2 (es) |
MX (1) | MX2019009796A (es) |
PE (1) | PE20191686A1 (es) |
PH (1) | PH12019501914A1 (es) |
PL (1) | PL3582853T3 (es) |
PT (1) | PT3582853T (es) |
RS (1) | RS62842B1 (es) |
SG (1) | SG11201907496RA (es) |
SI (1) | SI3582853T1 (es) |
TW (1) | TWI766948B (es) |
UA (1) | UA125310C2 (es) |
WO (2) | WO2018152450A1 (es) |
ZA (1) | ZA201906111B (es) |
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JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
KR102611446B1 (ko) | 2017-01-20 | 2023-12-06 | 아르커스 바이오사이언시즈 인코포레이티드 | 암-관련 장애의 치료를 위한 아졸로피리미딘 |
WO2019084060A1 (en) | 2017-10-24 | 2019-05-02 | Silverback Therapeutics, Inc. | CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS |
US11542293B2 (en) | 2017-11-10 | 2023-01-03 | Takeda Pharmaceutical Company Limited | Sting modulator compounds, and methods of making and using |
WO2019123340A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
CA3084582A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
KR20200121337A (ko) | 2018-02-16 | 2020-10-23 | 아르커스 바이오사이언시즈 인코포레이티드 | 아졸로피리미딘 화합물의 투여 |
JP7296398B2 (ja) | 2018-04-06 | 2023-06-22 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. | 3’3’-環状ジヌクレオチド |
TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
BR112020024605A2 (pt) * | 2018-06-01 | 2021-04-06 | Eisai R&D Management Co., Ltd. | Métodos para o tratamento de câncer de bexiga |
CN112041325B (zh) * | 2018-08-16 | 2023-10-24 | 卫材R&D管理有限公司 | 化合物的盐及其晶体 |
EP3849615A1 (en) | 2018-09-12 | 2021-07-21 | Silverback Therapeutics, Inc. | Compositions for the treatment of disease with immune stimulatory conjugates |
CN111655712B (zh) * | 2018-12-29 | 2021-02-05 | 上海济煜医药科技有限公司 | 作为肿瘤免疫类的化合物及其应用 |
US11787833B2 (en) | 2019-05-09 | 2023-10-17 | Aligos Therapeutics, Inc. | Modified cyclic dinucleoside compounds as sting modulators |
EP3972695A1 (en) * | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
US20220304982A1 (en) * | 2019-07-01 | 2022-09-29 | Eisai R&D Management Co., Ltd. | System for enhancing therapeutic compliance of the anti-cancer compound e7766 |
WO2021067644A1 (en) | 2019-10-01 | 2021-04-08 | Silverback Therapeutics, Inc. | Combination therapy with immune stimulatory conjugates |
JP2022177332A (ja) * | 2019-10-24 | 2022-12-01 | 日東電工株式会社 | オリゴヌクレオチドを製造する方法 |
WO2021168274A1 (en) | 2020-02-21 | 2021-08-26 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
EP4134098A4 (en) | 2020-04-10 | 2024-05-15 | Ono Pharmaceutical Co | CANCER THERAPY METHODS |
WO2021252904A1 (en) | 2020-06-11 | 2021-12-16 | Massachusetts Institute Of Technology | Ribonucleoprotein approach to boost the sting signaling for cancer immunotherapy |
AU2021300362A1 (en) | 2020-07-01 | 2023-02-23 | ARS Pharmaceuticals, Inc. | Anti-ASGR1 antibody conjugates and uses thereof |
CN111909223A (zh) * | 2020-07-17 | 2020-11-10 | 清华大学 | 环二核苷酸共价修饰物及其制备方法和应用 |
EP4228681A1 (en) | 2020-10-14 | 2023-08-23 | Boehringer Ingelheim International GmbH | Combination of a sting agonist and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist |
MX2023005381A (es) | 2020-11-09 | 2023-05-23 | Takeda Pharmaceuticals Co | Conjugados de anticuerpo y farmaco. |
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CN102199183B (zh) | 2010-03-26 | 2013-12-18 | 北京大学 | 环二鸟苷酸及其类似物和制备方法 |
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BR112015027327B1 (pt) * | 2013-04-29 | 2022-08-02 | Rutgers, The State University Of New Jersey | Composto, modulador de cgas, composição farmacêutica compreendendo o referido composto ou modulador |
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-
2018
- 2018-02-16 US US16/486,954 patent/US20200055883A1/en not_active Abandoned
- 2018-02-17 UA UAA201909860A patent/UA125310C2/uk unknown
- 2018-02-17 PT PT187080320T patent/PT3582853T/pt unknown
- 2018-02-17 WO PCT/US2018/018556 patent/WO2018152450A1/en unknown
- 2018-02-17 MX MX2019009796A patent/MX2019009796A/es unknown
- 2018-02-17 PL PL18708032T patent/PL3582853T3/pl unknown
- 2018-02-17 JO JOP/2019/0194A patent/JOP20190194B1/ar active
- 2018-02-17 DK DK18708032.0T patent/DK3582853T3/da active
- 2018-02-17 WO PCT/US2018/018561 patent/WO2018152453A1/en unknown
- 2018-02-17 CA CA3053932A patent/CA3053932A1/en active Pending
- 2018-02-17 MD MDE20200009T patent/MD3582853T2/ro unknown
- 2018-02-17 EP EP21208462.8A patent/EP4008403A1/en not_active Withdrawn
- 2018-02-17 CN CN201880025317.7A patent/CN110536719A/zh active Pending
- 2018-02-17 JP JP2019544817A patent/JP6672532B2/ja active Active
- 2018-02-17 CN CN202410024195.7A patent/CN117866030A/zh active Pending
- 2018-02-17 EP EP18709835.5A patent/EP3582854A1/en not_active Withdrawn
- 2018-02-17 KR KR1020197027073A patent/KR102645790B1/ko active IP Right Grant
- 2018-02-17 RS RS20220079A patent/RS62842B1/sr unknown
- 2018-02-17 SI SI201830553T patent/SI3582853T1/sl unknown
- 2018-02-17 SG SG11201907496RA patent/SG11201907496RA/en unknown
- 2018-02-17 LT LTEPPCT/US2018/018556T patent/LT3582853T/lt unknown
- 2018-02-17 JP JP2019544725A patent/JP2020510638A/ja active Pending
- 2018-02-17 EP EP18708032.0A patent/EP3582853B1/en active Active
- 2018-02-17 HU HUE18708032A patent/HUE057665T2/hu unknown
- 2018-02-17 CN CN201880021349.XA patent/CN110461416B/zh active Active
- 2018-02-17 ES ES18708032T patent/ES2906299T3/es active Active
- 2018-02-17 MA MA047501A patent/MA47501A/fr unknown
- 2018-02-17 AU AU2018221170A patent/AU2018221170B2/en active Active
- 2018-02-17 US US15/898,533 patent/US10246480B2/en active Active
- 2018-02-17 PE PE2019001715A patent/PE20191686A1/es unknown
- 2018-02-17 BR BR112019017084A patent/BR112019017084A2/pt unknown
- 2018-02-17 HR HRP20220110TT patent/HRP20220110T1/hr unknown
- 2018-02-21 TW TW107105846A patent/TWI766948B/zh active
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2019
- 2019-02-15 US US16/277,522 patent/US10618930B2/en active Active
- 2019-08-13 CO CONC2019/0008783A patent/CO2019008783A2/es unknown
- 2019-08-14 CL CL2019002304A patent/CL2019002304A1/es unknown
- 2019-08-15 IL IL268721A patent/IL268721B/en unknown
- 2019-08-16 PH PH12019501914A patent/PH12019501914A1/en unknown
- 2019-09-16 ZA ZA2019/06111A patent/ZA201906111B/en unknown
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2020
- 2020-02-04 US US16/781,352 patent/US11339188B2/en active Active
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