CO2019007409A2 - Derivados de la pirimidin enona tricíclica para la inhibición de rorγ y otros usos - Google Patents
Derivados de la pirimidin enona tricíclica para la inhibición de rorγ y otros usosInfo
- Publication number
- CO2019007409A2 CO2019007409A2 CONC2019/0007409A CO2019007409A CO2019007409A2 CO 2019007409 A2 CO2019007409 A2 CO 2019007409A2 CO 2019007409 A CO2019007409 A CO 2019007409A CO 2019007409 A2 CO2019007409 A2 CO 2019007409A2
- Authority
- CO
- Colombia
- Prior art keywords
- rorγ
- compounds
- tricyclic enone
- inhibition
- pyrimidin derivatives
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 108091008773 RAR-related orphan receptors γ Proteins 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
En la presente, se describen compuestos de las fórmulas: (I) así como análogos de estos, donde las variables se definen en la presente. También se proporcionan composiciones farmacéuticas de estos. En algunos aspectos, los compuestos y las composiciones que se proporcionan en la presente pueden usarse para inhibir RORγ y/o reducir la expresión de la IL-17. También se proporcionan métodos de administración de compuestos y la composición que se proporcionan en la presente a un paciente que lo necesite, por ejemplo, para el tratamiento o la prevención de enfermedades o trastornos asociados a trastornos autoinmunitarios o inflamación.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662435588P | 2016-12-16 | 2016-12-16 | |
PCT/US2017/000094 WO2018111315A1 (en) | 2016-12-16 | 2017-12-16 | PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF RORγ AND OTHER USES |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2019007409A2 true CO2019007409A2 (es) | 2019-07-31 |
Family
ID=61028153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2019/0007409A CO2019007409A2 (es) | 2016-12-16 | 2019-07-10 | Derivados de la pirimidin enona tricíclica para la inhibición de rorγ y otros usos |
Country Status (20)
Country | Link |
---|---|
US (2) | US11292781B2 (es) |
EP (1) | EP3555062A1 (es) |
JP (1) | JP7177059B2 (es) |
KR (2) | KR20190110089A (es) |
CN (1) | CN110248932B (es) |
AU (1) | AU2017377852B2 (es) |
BR (1) | BR112019012271A2 (es) |
CA (2) | CA3223645A1 (es) |
CL (1) | CL2019001658A1 (es) |
CO (1) | CO2019007409A2 (es) |
EA (1) | EA201991387A1 (es) |
IL (1) | IL267274B2 (es) |
MX (1) | MX2019007088A (es) |
NZ (1) | NZ754764A (es) |
PE (1) | PE20191490A1 (es) |
PH (1) | PH12019501371A1 (es) |
TW (1) | TWI831738B (es) |
UA (1) | UA127376C2 (es) |
WO (1) | WO2018111315A1 (es) |
ZA (1) | ZA201904227B (es) |
Families Citing this family (7)
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LT2276493T (lt) | 2008-04-18 | 2019-01-10 | Reata Pharmaceuticals, Inc. | Antioksidaciniai uždegimo moduliatoriai: oleanolio rūgšties dariniai su amino ir kitomis modifikacijomis c-17 |
ME02926B (me) | 2012-04-27 | 2018-04-20 | Reata Pharmaceuticals Inc | 2,2-difluoropropionamidni derivati bardoksolon metila, polimorfni oblici i postupci za njihovu upotrebu |
LT3640251T (lt) | 2016-10-24 | 2022-03-10 | Astrazeneca Ab | 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f]izochinolino dariniai, tinkami vėžio gydymui |
BR112019015389A2 (pt) | 2017-01-30 | 2020-03-10 | Astrazeneca Ab | Moduladores de receptores de estrogênio |
KR20200128531A (ko) | 2018-01-29 | 2020-11-13 | 카풀루스 테라퓨틱스, 엘엘씨 | 6원 중심 고리를 포함하는 srebp 억제제 |
US20210147380A1 (en) * | 2018-06-20 | 2021-05-20 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
BR112023001832A2 (pt) * | 2020-08-07 | 2023-02-23 | Taiho Pharmaceutical Co Ltd | Composto cicloalquenona ou sal do mesmo |
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CA2430454A1 (en) | 2000-11-28 | 2002-06-20 | Board Of Regents, The University Of Texas System | Cddo-compounds and combination therapies thereof |
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EP1465615B1 (en) | 2002-01-15 | 2012-08-01 | Trustees of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
AU2003303128A1 (en) | 2002-05-13 | 2004-08-13 | Trustees Of Dartmouth College | Inhibitors and methods of use thereof |
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BRPI0911208B1 (pt) | 2008-04-18 | 2021-05-25 | Reata Pharmaceuticals, Inc | Compostos moduladores inflamatórios antioxidantes, seu uso, e composição farmacêutica |
NZ588711A (en) | 2008-04-18 | 2012-10-26 | Reata Pharmaceuticals Inc | C-17 homologated oleanolic acid derivatives for treating cancer |
LT2276493T (lt) | 2008-04-18 | 2019-01-10 | Reata Pharmaceuticals, Inc. | Antioksidaciniai uždegimo moduliatoriai: oleanolio rūgšties dariniai su amino ir kitomis modifikacijomis c-17 |
JP5564490B2 (ja) | 2008-04-18 | 2014-07-30 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗炎症性ファルマコアを含む化合物および使用法 |
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WO2010053817A1 (en) | 2008-11-04 | 2010-05-14 | Trustees Of Dartmouth College | Betulinic acid derivatives and methods of use thereof |
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2017
- 2017-12-15 TW TW106144248A patent/TWI831738B/zh active
- 2017-12-16 EA EA201991387A patent/EA201991387A1/ru unknown
- 2017-12-16 US US16/468,054 patent/US11292781B2/en active Active
- 2017-12-16 UA UAA201908085A patent/UA127376C2/uk unknown
- 2017-12-16 KR KR1020197018696A patent/KR20190110089A/ko not_active IP Right Cessation
- 2017-12-16 KR KR1020247003600A patent/KR20240019389A/ko not_active Application Discontinuation
- 2017-12-16 WO PCT/US2017/000094 patent/WO2018111315A1/en unknown
- 2017-12-16 AU AU2017377852A patent/AU2017377852B2/en active Active
- 2017-12-16 EP EP17835730.7A patent/EP3555062A1/en active Pending
- 2017-12-16 NZ NZ754764A patent/NZ754764A/en unknown
- 2017-12-16 CA CA3223645A patent/CA3223645A1/en active Pending
- 2017-12-16 CN CN201780085431.4A patent/CN110248932B/zh active Active
- 2017-12-16 JP JP2019531921A patent/JP7177059B2/ja active Active
- 2017-12-16 MX MX2019007088A patent/MX2019007088A/es unknown
- 2017-12-16 PE PE2019001274A patent/PE20191490A1/es unknown
- 2017-12-16 CA CA3046183A patent/CA3046183C/en active Active
- 2017-12-16 IL IL267274A patent/IL267274B2/en unknown
- 2017-12-16 BR BR112019012271A patent/BR112019012271A2/pt active Search and Examination
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2019
- 2019-06-14 PH PH12019501371A patent/PH12019501371A1/en unknown
- 2019-06-14 CL CL2019001658A patent/CL2019001658A1/es unknown
- 2019-06-27 ZA ZA2019/04227A patent/ZA201904227B/en unknown
- 2019-07-10 CO CONC2019/0007409A patent/CO2019007409A2/es unknown
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2022
- 2022-01-18 US US17/577,456 patent/US20220135534A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
TWI831738B (zh) | 2024-02-11 |
JP2020512289A (ja) | 2020-04-23 |
CA3223645A1 (en) | 2018-06-21 |
EP3555062A1 (en) | 2019-10-23 |
TW201835051A (zh) | 2018-10-01 |
AU2017377852A1 (en) | 2019-07-11 |
CN110248932A (zh) | 2019-09-17 |
NZ754764A (en) | 2023-04-28 |
CA3046183C (en) | 2024-02-20 |
CN110248932B (zh) | 2023-03-10 |
MX2019007088A (es) | 2019-10-15 |
JP7177059B2 (ja) | 2022-11-22 |
PH12019501371A1 (en) | 2019-10-28 |
EA201991387A1 (ru) | 2019-12-30 |
CA3046183A1 (en) | 2018-06-21 |
WO2018111315A8 (en) | 2019-07-11 |
KR20240019389A (ko) | 2024-02-14 |
US20200131148A1 (en) | 2020-04-30 |
WO2018111315A1 (en) | 2018-06-21 |
PE20191490A1 (es) | 2019-10-21 |
UA127376C2 (uk) | 2023-08-02 |
US11292781B2 (en) | 2022-04-05 |
IL267274B2 (en) | 2024-03-01 |
ZA201904227B (en) | 2024-02-28 |
IL267274A (en) | 2019-08-29 |
KR20190110089A (ko) | 2019-09-27 |
US20220135534A1 (en) | 2022-05-05 |
CL2019001658A1 (es) | 2019-09-27 |
BR112019012271A2 (pt) | 2019-12-03 |
AU2017377852B2 (en) | 2022-02-17 |
IL267274B1 (en) | 2023-11-01 |
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