CO2018011804A2 - Receptores quiméricos de flt3 y métodos de uso de los mismos - Google Patents

Receptores quiméricos de flt3 y métodos de uso de los mismos

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Publication number
CO2018011804A2
CO2018011804A2 CONC2018/0011804A CO2018011804A CO2018011804A2 CO 2018011804 A2 CO2018011804 A2 CO 2018011804A2 CO 2018011804 A CO2018011804 A CO 2018011804A CO 2018011804 A2 CO2018011804 A2 CO 2018011804A2
Authority
CO
Colombia
Prior art keywords
flt3
methods
chimeric receptors
bioengineering
antigen binding
Prior art date
Application number
CONC2018/0011804A
Other languages
English (en)
Inventor
Alice Bakker
Lawren Wu
Tara Arvedson
Jed J Wiltzius
Ruben Alvarez Rodriguez
Original Assignee
Amgen Inc
Kite Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc, Kite Pharma Inc filed Critical Amgen Inc
Publication of CO2018011804A2 publication Critical patent/CO2018011804A2/es

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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    • A61K39/464411—Immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/09—Recombinant DNA-technology
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12N2510/00—Genetically modified cells

Abstract

Se describen moléculas de unión a antígenos, receptores quiméricos y células inmunitarias producidas por bioingeniería para FLT3 de acuerdo con la invención. La invención se relaciona además con vectores, composiciones y métodos de tratamiento y/o detección usando las moléculas de unión a antígenos de FLT3 y células inmunitarias producidas por bioingeniería.
CONC2018/0011804A 2016-04-01 2018-10-31 Receptores quiméricos de flt3 y métodos de uso de los mismos CO2018011804A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662317219P 2016-04-01 2016-04-01
PCT/US2017/025613 WO2017173410A1 (en) 2016-04-01 2017-03-31 Chimeric receptors to flt3 and methods of use thereof

Publications (1)

Publication Number Publication Date
CO2018011804A2 true CO2018011804A2 (es) 2019-02-08

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CONC2018/0011804A CO2018011804A2 (es) 2016-04-01 2018-10-31 Receptores quiméricos de flt3 y métodos de uso de los mismos

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US (2) US20190183931A1 (es)
EP (1) EP3436479A1 (es)
JP (2) JP2019516352A (es)
KR (2) KR102389096B1 (es)
CN (1) CN109641956A (es)
AR (2) AR109626A1 (es)
AU (2) AU2017240801A1 (es)
BR (1) BR112018070187A8 (es)
CA (1) CA3019655A1 (es)
CL (1) CL2018002792A1 (es)
CO (1) CO2018011804A2 (es)
CR (1) CR20180518A (es)
EA (1) EA201892193A1 (es)
IL (2) IL262061B2 (es)
MA (1) MA44507A (es)
MY (1) MY201207A (es)
NZ (1) NZ746925A (es)
PE (1) PE20190201A1 (es)
PH (1) PH12018502118A1 (es)
SA (1) SA518400154B1 (es)
SG (2) SG11201808622SA (es)
TN (1) TN2018000337A1 (es)
TW (2) TW202313669A (es)
WO (1) WO2017173410A1 (es)

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