CO2017011534A2 - Formas sólidas de quinasas que modulan un compuesto - Google Patents

Formas sólidas de quinasas que modulan un compuesto

Info

Publication number
CO2017011534A2
CO2017011534A2 CONC2017/0011534A CO2017011534A CO2017011534A2 CO 2017011534 A2 CO2017011534 A2 CO 2017011534A2 CO 2017011534 A CO2017011534 A CO 2017011534A CO 2017011534 A2 CO2017011534 A2 CO 2017011534A2
Authority
CO
Colombia
Prior art keywords
compound
solid forms
kinases
modulate
pyridin
Prior art date
Application number
CONC2017/0011534A
Other languages
English (en)
Inventor
Prabha N Ibrahim
Gary Conrad Visor
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of CO2017011534A2 publication Critical patent/CO2017011534A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Abstract

Las formas sólidas del compuesto, sal HCl de [5-(5-cloro-1H-pirrolo[2,3-b]piridin-3-ilmetil)-piridin-2-il]-(6-trifluorometil-piridin-3-ilmetil)amina (Compuesto I) y su base libre, activa en las proteínas quinasas del receptor de c-Kit y/o c-Fms y/o Flt3, se preparan y se caracterizan. También se proporcionan métodos para usar las formas sólidas.
CONC2017/0011534A 2015-05-06 2017-11-10 Formas sólidas de quinasas que modulan un compuesto CO2017011534A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562157902P 2015-05-06 2015-05-06
PCT/US2016/031027 WO2016179415A1 (en) 2015-05-06 2016-05-05 Solid forms of a compound modulating kinases

Publications (1)

Publication Number Publication Date
CO2017011534A2 true CO2017011534A2 (es) 2018-01-31

Family

ID=56008880

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CONC2017/0011534A CO2017011534A2 (es) 2015-05-06 2017-11-10 Formas sólidas de quinasas que modulan un compuesto

Country Status (28)

Country Link
US (4) US9802932B2 (es)
EP (2) EP3757104A1 (es)
JP (1) JP6946194B2 (es)
KR (1) KR102630889B1 (es)
CN (1) CN107548394B (es)
AU (1) AU2016258027B2 (es)
BR (1) BR112017023490B1 (es)
CA (1) CA2984910C (es)
CO (1) CO2017011534A2 (es)
CY (1) CY1123796T1 (es)
DK (1) DK3292123T3 (es)
ES (1) ES2820827T3 (es)
HR (1) HRP20201383T1 (es)
HU (1) HUE050506T2 (es)
IL (1) IL255313A0 (es)
LT (1) LT3292123T (es)
MX (1) MX2017013975A (es)
MY (1) MY192352A (es)
NZ (1) NZ737616A (es)
PH (1) PH12017501995A1 (es)
PT (1) PT3292123T (es)
RS (1) RS60731B1 (es)
RU (1) RU2730506C2 (es)
SG (1) SG10201912355TA (es)
SI (1) SI3292123T1 (es)
TW (1) TWI727949B (es)
WO (1) WO2016179415A1 (es)
ZA (1) ZA201708007B (es)

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