CO2017010149A2 - Construcciones de vectores virales adeno-asociados de glut1 recombinantes y métodos relacionados para restablecer la expresión de glut1 - Google Patents
Construcciones de vectores virales adeno-asociados de glut1 recombinantes y métodos relacionados para restablecer la expresión de glut1Info
- Publication number
- CO2017010149A2 CO2017010149A2 CONC2017/0010149A CO2017010149A CO2017010149A2 CO 2017010149 A2 CO2017010149 A2 CO 2017010149A2 CO 2017010149 A CO2017010149 A CO 2017010149A CO 2017010149 A2 CO2017010149 A2 CO 2017010149A2
- Authority
- CO
- Colombia
- Prior art keywords
- glut1
- certain embodiments
- relates
- present
- recombinant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a construcciones de vectores virales adeno-asociados (rAAV) de Glut1 recombinantes y métodos relacionados para restablecer la expresión de Glut1 en mamíferos con deficiencia de Glut1. En determinadas modalidades, el rAAV además comprende un promotor de β-actina de pollo, en donde el rAAV es capaz de cruzar la barrera hematoencefálica (BBB). En determinadas modalidades, la presente invención se refiere a una composición que comprende cualquiera de los AAV recombinantes descritos en la presente. En determinadas modalidades, la presente invención se refiere a un kit que comprende una cubierta de un recipiente que comprende la composición descrita en la presente. En determinadas modalidades, la presente invención se refiere a métodos para restablecer el transporte de Glut1 en la BBB de un sujeto, que comprende administrarle al sujeto una cantidad eficaz de cualquiera de los vectores AAV recombinantes descritos en la presente. En determinadas modalidades, la presente invención se refiere a un método para tratar el síndrome de deficiencia de Glut1 en un sujeto que lo necesita.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562130899P | 2015-03-10 | 2015-03-10 | |
PCT/US2016/021810 WO2016145217A1 (en) | 2015-03-10 | 2016-03-10 | Recombinant glut1 adeno-associated viral vector constructs and related methods for restoring glut1 expression |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2017010149A2 true CO2017010149A2 (es) | 2018-02-28 |
Family
ID=56879055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2017/0010149A CO2017010149A2 (es) | 2015-03-10 | 2017-10-05 | Construcciones de vectores virales adeno-asociados de glut1 recombinantes y métodos relacionados para restablecer la expresión de glut1 |
Country Status (20)
Country | Link |
---|---|
US (2) | US20180042991A1 (es) |
EP (1) | EP3268024B1 (es) |
JP (3) | JP2018509164A (es) |
KR (1) | KR20180016722A (es) |
CN (1) | CN107635575A (es) |
AU (1) | AU2016229000B2 (es) |
BR (1) | BR112017019294A2 (es) |
CA (1) | CA2978917A1 (es) |
CL (1) | CL2017002282A1 (es) |
CO (1) | CO2017010149A2 (es) |
DK (1) | DK3268024T3 (es) |
EA (1) | EA036051B1 (es) |
ES (1) | ES2836258T3 (es) |
HU (1) | HUE052577T2 (es) |
IL (2) | IL282053B2 (es) |
MX (2) | MX2017011615A (es) |
PT (1) | PT3268024T (es) |
SG (1) | SG11201707116QA (es) |
UA (1) | UA128249C2 (es) |
WO (1) | WO2016145217A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2017005834A (es) | 2014-11-05 | 2017-11-17 | Voyager Therapeutics Inc | Polinucleotidos aad para el tratamiento de la enfermedad de parkinson. |
JP6996728B2 (ja) * | 2016-01-07 | 2022-01-17 | 学校法人自治医科大学 | グルコーストランスポーター1発現用アデノ随伴ウイルスベクター |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
CA3098871A1 (en) * | 2018-05-08 | 2019-11-14 | Rutgers, The State University Of New Jersey | Aav-compatible laminin-linker polymerization proteins |
AU2019346655A1 (en) * | 2018-09-28 | 2021-05-06 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
AU2020274339C1 (en) | 2019-05-13 | 2023-08-31 | Dna Twopointo Inc. | Modifications of mammalian cells using artificial micro-RNA to alter their properties and the compositions of their products |
CN114555814A (zh) * | 2019-09-13 | 2022-05-27 | 罗特格斯新泽西州立大学 | Aav相容的层粘连蛋白-连接子聚合蛋白 |
EP4142775A1 (en) * | 2020-05-01 | 2023-03-08 | Atlas Biotechnology S.A. | Treatment and/or prevention of a disease or a syndrome related to a virus infection |
US20230248824A1 (en) * | 2020-07-09 | 2023-08-10 | The Board of Trutees of the Leland Stanford Junior University | Immune cells with increased glycolytic flux |
CA3184233A1 (en) * | 2020-08-05 | 2022-02-10 | Christopher Dean HERZOG | Adeno-associated viral vector for glut1 expression and uses thereof |
EP4192487A1 (en) | 2020-08-07 | 2023-06-14 | Spacecraft Seven, LLC | Plakophilin-2 (pkp2) gene therapy using aav vector |
US20230313187A1 (en) * | 2020-09-04 | 2023-10-05 | Dna Twopointo Inc. | Modifications of mammalian cells using artificial micro-rna to alter their properties and the compositions of their products |
WO2023154763A2 (en) * | 2022-02-08 | 2023-08-17 | Spacecraft Seven, Llc | Adeno-associated viral vector for glut1 expression and uses thereof |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
US6001650A (en) | 1995-08-03 | 1999-12-14 | Avigen, Inc. | High-efficiency wild-type-free AAV helper functions |
WO1998010088A1 (en) | 1996-09-06 | 1998-03-12 | Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
US6156303A (en) | 1997-06-11 | 2000-12-05 | University Of Washington | Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom |
NZ600121A (en) | 2001-11-13 | 2013-12-20 | Univ Pennsylvania | A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby |
EP2610265B1 (en) * | 2003-05-02 | 2016-11-16 | Centre National de la Recherche Scientifique (C.N.R.S.) | Glut-1 as a receptor for HTLV envelopes and its uses |
SI2292780T1 (sl) | 2003-09-30 | 2017-12-29 | The Trustees Of The University Of Pennsylvania | Genotipske skupine, zaporedja, vektorji, ki vsebujejo le-te z adenovirusi povezanega virusa (aav) in njihova uporaba |
ES2525143T3 (es) | 2005-04-07 | 2014-12-18 | The Trustees Of The University Of Pennsylvania | Cápsides de AAVrh.64 modificado, composiciones que las contienen y usos de las mismas |
WO2008134632A1 (en) * | 2007-04-26 | 2008-11-06 | President And Fellows Of Harvard College | Wnt ligands involved in blood-brain barrier development and uses therefor |
WO2010071832A1 (en) * | 2008-12-19 | 2010-06-24 | Nationwide Children's Hospital | Delivery of polynucleotides across the blood brain barrier using recombinant aav9 |
WO2010121010A2 (en) | 2009-04-16 | 2010-10-21 | President And Fellows Of Harvard College | Methods for inhibiting starvation of a cell |
CA3049237C (en) * | 2010-04-23 | 2024-06-11 | University Of Massachusetts | Cns targeting aav vectors and methods of use thereof |
EP2394667A1 (en) * | 2010-06-10 | 2011-12-14 | Laboratorios Del Dr. Esteve, S.A. | Vectors and sequences for the treatment of diseases |
-
2016
- 2016-03-10 IL IL282053A patent/IL282053B2/en unknown
- 2016-03-10 AU AU2016229000A patent/AU2016229000B2/en active Active
- 2016-03-10 JP JP2017548205A patent/JP2018509164A/ja active Pending
- 2016-03-10 KR KR1020177028554A patent/KR20180016722A/ko not_active Application Discontinuation
- 2016-03-10 CA CA2978917A patent/CA2978917A1/en active Pending
- 2016-03-10 EA EA201791936A patent/EA036051B1/ru unknown
- 2016-03-10 CN CN201680025266.9A patent/CN107635575A/zh active Pending
- 2016-03-10 BR BR112017019294A patent/BR112017019294A2/pt active Search and Examination
- 2016-03-10 UA UAA201709758A patent/UA128249C2/uk unknown
- 2016-03-10 MX MX2017011615A patent/MX2017011615A/es unknown
- 2016-03-10 PT PT167625300T patent/PT3268024T/pt unknown
- 2016-03-10 SG SG11201707116QA patent/SG11201707116QA/en unknown
- 2016-03-10 US US15/556,412 patent/US20180042991A1/en not_active Abandoned
- 2016-03-10 HU HUE16762530A patent/HUE052577T2/hu unknown
- 2016-03-10 ES ES16762530T patent/ES2836258T3/es active Active
- 2016-03-10 WO PCT/US2016/021810 patent/WO2016145217A1/en active Application Filing
- 2016-03-10 EP EP16762530.0A patent/EP3268024B1/en active Active
- 2016-03-10 DK DK16762530.0T patent/DK3268024T3/da active
-
2017
- 2017-09-03 IL IL254286A patent/IL254286B/en active IP Right Grant
- 2017-09-08 MX MX2023001213A patent/MX2023001213A/es unknown
- 2017-09-08 CL CL2017002282A patent/CL2017002282A1/es unknown
- 2017-10-05 CO CONC2017/0010149A patent/CO2017010149A2/es unknown
-
2020
- 2020-11-19 US US16/952,801 patent/US20210069292A1/en active Pending
-
2021
- 2021-03-01 JP JP2021032174A patent/JP2021097689A/ja active Pending
-
2023
- 2023-08-17 JP JP2023133147A patent/JP2023144087A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EA036051B1 (ru) | 2020-09-18 |
JP2018509164A (ja) | 2018-04-05 |
CL2017002282A1 (es) | 2018-04-13 |
WO2016145217A1 (en) | 2016-09-15 |
AU2016229000B2 (en) | 2021-11-04 |
KR20180016722A (ko) | 2018-02-19 |
EP3268024A1 (en) | 2018-01-17 |
JP2023144087A (ja) | 2023-10-06 |
BR112017019294A2 (pt) | 2018-05-02 |
UA128249C2 (uk) | 2024-05-22 |
IL282053B2 (en) | 2023-03-01 |
MX2023001213A (es) | 2023-03-03 |
HUE052577T2 (hu) | 2021-05-28 |
IL282053B (en) | 2022-11-01 |
IL254286A0 (en) | 2017-10-31 |
ES2836258T3 (es) | 2021-06-24 |
IL254286B (en) | 2021-04-29 |
US20180042991A1 (en) | 2018-02-15 |
AU2016229000A1 (en) | 2017-09-21 |
IL282053A (en) | 2021-05-31 |
MX2017011615A (es) | 2018-04-11 |
EA201791936A8 (ru) | 2018-11-30 |
DK3268024T3 (da) | 2020-12-07 |
SG11201707116QA (en) | 2017-09-28 |
EP3268024B1 (en) | 2020-09-09 |
US20210069292A1 (en) | 2021-03-11 |
JP2021097689A (ja) | 2021-07-01 |
EP3268024A4 (en) | 2018-08-01 |
PT3268024T (pt) | 2020-12-09 |
EA201791936A1 (ru) | 2018-01-31 |
CA2978917A1 (en) | 2016-09-15 |
CN107635575A (zh) | 2018-01-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2017010149A2 (es) | Construcciones de vectores virales adeno-asociados de glut1 recombinantes y métodos relacionados para restablecer la expresión de glut1 | |
AR093355A1 (es) | Composiciones y metodos para tratar proteinopatias | |
AR100419A1 (es) | Vectores de virus adenoasociados para el tratamiento de trastornos de almacenamiento lisosómico | |
CL2018000587A1 (es) | Adenovirus oncolítico que codifica una proteína b7 (divisional de sol. n° 2731-2017) | |
CO2017000506A2 (es) | Receptor quimérico de antígeno cll-1 | |
PE20160769A1 (es) | Vectores del factor viii del virus adeno-asociado | |
NZ761655A (en) | Cellular models of and therapies for ocular diseases | |
ECSP17059343A (es) | ARNi VARIANTE | |
CL2018000515A1 (es) | Virus de la enfermedad de newcastle y usos de los mismos (divisional sol. 2532-2015) | |
CO2017000510A2 (es) | Constructos de car | |
AR091735A1 (es) | Complejo de factor viii con xten y proteina factor de von willebrand (vwf) y usos del mismo | |
CO2018007203A2 (es) | Focalización de péptidos para dirigir virus adenoasociados (aavs) | |
BR112017002781A2 (pt) | cassete de expressão aprimorado para acondicionamento e expressão de variantes do fator viii para o tratamento de distúrbios de hemostasia | |
CO6470858A2 (es) | Composición tensioactiva reconstituida mejorada que contiene análogos de la proteína tensioactiva b (sp-b) y de la proteína tensioactiva c (sp-c) | |
CL2017000647A1 (es) | Proteínas de fusión, bacterias recombinantes y métodos de uso de las bacterias recombinantes | |
CL2020001262A1 (es) | Plataforma de presentación en endosporas basadas en paenibacillus, productos y métodos relacionados. | |
BR112018008766A2 (pt) | variantes, composições e métodos e utilizações do fator viii reduzido cpg para o tratamento de transtornos hemostásicos | |
EA201790378A1 (ru) | Заключенное в липосому аффинное лекарственное средство | |
EA201791134A1 (ru) | Полипептиды химерного фактора viii и их применение | |
BR112014005144A2 (pt) | preparação e composições de enxofre com valência zero altamente biodisponíveis e seus usos | |
BR112018071200A2 (pt) | terapia genética para o tratamento da hemofilia a | |
BR112014024751A2 (pt) | antígenos de clostridium difficile | |
BR112017008962A2 (pt) | proteínas de fusão inibidoras de c1 esterase e usos das mesmas | |
AR093569A1 (es) | Tensioactivos pulmonares reconstituidos | |
AR113134A1 (es) | Arni variante |