CN86100903A - Winter aconite tooth paste - Google Patents
Winter aconite tooth paste Download PDFInfo
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- CN86100903A CN86100903A CN 86100903 CN86100903A CN86100903A CN 86100903 A CN86100903 A CN 86100903A CN 86100903 CN86100903 CN 86100903 CN 86100903 A CN86100903 A CN 86100903A CN 86100903 A CN86100903 A CN 86100903A
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- radix aconiti
- toothpaste
- brachypodi
- szechenyiani
- tooth paste
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Abstract
Winter aconite tooth paste.Be a kind of be the Chinese herbal medicine toothpaste of medicine with the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani).The present invention is according to various pharmacological test datas, determined to add in every toothpaste the safe and effective dosage of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani).Simultaneously, through test of many times, filtered out other composition of raw materials of mutual adaptation.Clinical practice shows that Winter aconite tooth paste has good antiinflammatory, hemostasis, analgesic activity, and oral cavity commonly encountered diseases marginal gingivitis and periodontitis are had obvious curative effects.
Description
The present invention is a kind of medicated toothpaste, more particularly be a kind of be the Chinese herbal medicine toothpaste of main medicine with Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani).
Toothpaste is indispensable cleaning agent for mouth cavity in people's daily life.The basic function of toothpaste is to remove the oral cavity dirt, reaches the oral cavity cleaning purpose.Toothpaste variety development both at home and abroad in recent years is very fast, becomes more diverse, diversification.People are also just taking place to change to the needs of toothpaste, select or buy toothpaste not only to the odor type or the taste requirement to some extent of toothpaste, and wish that this toothpaste has the effect of the odontopathy of preventing and treating.Therefore, the demand of high-quality medicated toothpaste constantly increases.Existing medicated toothpaste has numerous species, is the Chinese herbal medicine toothpaste of medicated premix with the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) but still do not have a kind of.
The purpose of this invention is to provide a kind of have antiinflammatory, hemostasis, analgesic activity, the Winter aconite tooth paste that oral cavity commonly encountered diseases marginal gingivitis and periodontitis are had obvious curative effects.
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) also is an aconitum brachypodum, perennial vertical herbage, and Ranunculaceae grows under the high mountain sparse woods of Dongchuan, Yunnan height above sea level more than 2,700 meters or on the cliff of mountain region, has wind-damp dispelling, the effect of reducing swelling and alleviating pain.Past is among the people to be widely used in treatment traumatic injury, rheumatic arthritis, diseases such as traumatic hemorrhage.Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) has recorded in " Chinese pharmacopoeia version in 1977,530～531 pages.Its active ingredient is the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) alkaloid, belongs to aconitine.Contain bullatine A, second element, third element, fourth element, penta element, oneself is plain, heptan is plain.Total alkaloid content is with the plain C of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) second
24H
39O
6N represents.By Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) total alkaloids basis pharmacological testing, acute toxicity test, measuring its LD50 ± 95CL value is 11.01 ± 0.86mg/Kg.Subacute toxicity test is the result show, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) does not have obvious influence to hepatic and renal function.By the long-pending coefficient determination method of Artemisia, with fixed dosage or ascending-dose method successive administration, dosage accumulative total is respectively greater than 6 LD50 or 8 LD50, and the animal dead rate is respectively 17.5 and 15.0 as a result, do not reach half death as yet, cumulative action is very weak in vivo to disclose this product.Recording its therapeutic index LD50/ED50 value again is 5.45.Various pharmacological test datas show that the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) therapeutic index is lower, and toxic and side effects is bigger, and safety range is less, but the long-pending effect of continuous use Artemisia in vivo is then very weak.In view of the above, the present invention has determined to add in every toothpaste the safe and effective dosage of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): the percentage by weight that adds Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) total alkaloid salt acid salt solution is 0.5～1.5%; The percentage by weight that adds the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) crude drug is 0.02～0.15%.Simultaneously, other raw material of considering adding should adapt with it, avoid producing mutually untoward reaction, so that destroy the stable of toothpaste or human body produced adverse effect, composition of raw materials is carried out test of many times, repeated screening, determined with Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) alkaloid salt hydrochlorate or Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) crude drug to serve as to add medicine, with strontium chloride, chlorophyll, glycerol, carboxymethyl cellulose, sodium benzoate or formaldehyde, glucide, sodium lauryl sulfate, toothpaste spice (containing a small amount of Oleum Ocimi Gratissimi and Borneolum Syntheticum) and water and powdery abrasive (as calcium carbonate) adopt traditional wet method paste manufacture process through glue for the rational formula of batching, mix, grind emulsifying, the degassing, several procedures of fill have been produced Winter aconite tooth paste.
Winter aconite tooth paste provided by the invention detects through Chinese toothpaste industrial technology research center, and eight physical and chemical indexs all reach ministry standard.Drug regimen and mastic proportioning are safe and effective.Through unming Medical College's department of stomatology, the Dongchuan City the People's Hospital department of stomatology, the clinical 365 routine clinical verifications of the Dongchuan City institute of traditional Chinese medicine department of stomatology, this product is to the main malignant bacteria in oral cavity, lactobacillus, staphylococcus aureus, Streptococcus mutans has bacteriostasis preferably.Inhibition zone is all between 18 millimeters to 24 millimeters.The pain that oral disease is caused has analgesic effect, and effective percentage is 80.98%, to gingivitis, periodontitis cause hemorrhage, have anastalsis, effective percentage is 86.4%.Especially more obvious to the therapeutic effect of marginal gingivitis, effective percentage reaches 96.7%.Clinical practice shows that Winter aconite tooth paste has good antiinflammatory, hemostasis, analgesic activity, is a kind of medicated toothpaste new varieties that are worth of widely use.
Working of an invention:
Embodiment 1
Adopt the combination formula of calcium carbonate 50%, glycerol 10%, carboxymethyl cellulose 1.8%, sodium benzoate 0.05%, glucide 0.2%, strontium chloride 0.3%, chlorophyll 0.02% Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) total alkaloid salt acid salt solution 0.5%, sodium lauryl sulfate 2.5%, toothpaste spice (containing a small amount of Oleum Ocimi Gratissimi and Borneolum Syntheticum) 1.0%, water 33.63%, through glue, mixing, grinding emulsifying, the degassing, several procedures of fill, can make Winter aconite tooth paste.
Embodiment 2
Adopt the combination formula of calcium carbonate 49%, glycerol 17%, carboxymethyl cellulose 1.6%, strontium chloride 0.3%, formaldehyde 0.05%, glucide 0.2%, chlorophyll 0.02%, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) crude drug 0.1%, sodium lauryl sulfate 2.5%, toothpaste spice (containing a small amount of Oleum Ocimi Gratissimi and Borneolum Syntheticum) 1.0%, water 28.23%, through glue, mixing, grinding emulsifying, the degassing, several procedures of fill, promptly produce Winter aconite tooth paste.
Embodiment 3
Can make Winter aconite tooth paste safely and effectively with calcium carbonate 50%, glycerol 20%, carboxymethyl cellulose 1.4%, sodium benzoate 0.05%, strontium chloride 0.3%, glucide 0.2%, chlorophyll 0.02% Herba Achilleae alkaloid salt acid salt solution 1.5%, sodium lauryl sulfate 2.0%, toothpaste spice 1.0% and water 23.53%.
Claims (4)
1, a kind of toothpaste is characterized in that having added Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) total alkaloids hydrochlorate or Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) crude drug.
2, medicated toothpaste as claimed in claim 1, the percentage by weight that it is characterized in that Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) total alkaloid salt acid salt solution is 0.5～1.5%.
3, medicated toothpaste as claimed in claim 1, the percentage by weight that it is characterized in that the Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) crude drug is 0.02～0.15%.
4,, it is characterized in that other raw material composition is calcium carbonate, glycerol, carboxymethyl cellulose, sodium benzoate or formaldehyde, glucide, strontium chloride, chlorophyll, sodium lauryl sulfate, toothpaste spice and water as claim 1,2,3 described medicated toothpaste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 86100903 CN86100903A (en) | 1986-01-03 | 1986-01-03 | Winter aconite tooth paste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 86100903 CN86100903A (en) | 1986-01-03 | 1986-01-03 | Winter aconite tooth paste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN86100903A true CN86100903A (en) | 1987-10-28 |
Family
ID=4801243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 86100903 Pending CN86100903A (en) | 1986-01-03 | 1986-01-03 | Winter aconite tooth paste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN86100903A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102051275A (en) * | 2010-12-31 | 2011-05-11 | 乌鲁木齐一枝好生物科技有限公司 | Novel application of Artemisia rupestris L extract |
| CN103655301A (en) * | 2013-11-26 | 2014-03-26 | 乌鲁木齐一枝好生物科技有限公司 | Tooth paste containing artemisia rupestris extract and preparation method thereof |
| CN108403519A (en) * | 2016-12-28 | 2018-08-17 | 张可池 | Chinese medicinal herb essence toothpaste fluid |
-
1986
- 1986-01-03 CN CN 86100903 patent/CN86100903A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102051275A (en) * | 2010-12-31 | 2011-05-11 | 乌鲁木齐一枝好生物科技有限公司 | Novel application of Artemisia rupestris L extract |
| CN102051275B (en) * | 2010-12-31 | 2012-05-23 | 乌鲁木齐一枝好生物科技有限公司 | Novel application of Artemisia rupestris L extract |
| CN103655301A (en) * | 2013-11-26 | 2014-03-26 | 乌鲁木齐一枝好生物科技有限公司 | Tooth paste containing artemisia rupestris extract and preparation method thereof |
| CN108403519A (en) * | 2016-12-28 | 2018-08-17 | 张可池 | Chinese medicinal herb essence toothpaste fluid |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |