CN220490764U - Gradient leaching liquid mixing device - Google Patents
Gradient leaching liquid mixing device Download PDFInfo
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- CN220490764U CN220490764U CN202322357391.XU CN202322357391U CN220490764U CN 220490764 U CN220490764 U CN 220490764U CN 202322357391 U CN202322357391 U CN 202322357391U CN 220490764 U CN220490764 U CN 220490764U
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- 239000007788 liquid Substances 0.000 title claims abstract description 51
- 238000002386 leaching Methods 0.000 title claims abstract description 22
- 238000000605 extraction Methods 0.000 claims abstract description 40
- 238000010828 elution Methods 0.000 claims description 16
- 238000002347 injection Methods 0.000 claims description 15
- 239000007924 injection Substances 0.000 claims description 15
- 239000000243 solution Substances 0.000 claims description 11
- 239000003480 eluent Substances 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000001802 infusion Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000003817 vacuum liquid chromatography Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/20—Recycling
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- Extraction Or Liquid Replacement (AREA)
Abstract
The utility model discloses a gradient leaching and mixing device, which relates to the field of low-pressure gradient leaching and comprises a plurality of multi-way devices and a plurality of groups of double-way extraction devices, wherein each group of double-way extraction devices comprises a plurality of double-way extractors, each double-way extractor is provided with an extraction flow mark, the double-way extraction devices are used for circularly extracting mobile phase liquid in a plurality of leaching liquid bottles under normal pressure, a plurality of input ends of each multi-way device are connected with output ends of the plurality of double-way extractors of each group of double-way extraction devices, and the output ends of each multi-way device are connected with a mixing device, so that the concentration ratio of mobile phase with any gradient change can be realized, and the mobile phase liquid is easier to realize.
Description
Technical Field
The utility model relates to the field of low-pressure gradient elution, in particular to a gradient elution mixed liquid device.
Background
The gradient elution of the high performance liquid chromatograph aims at changing the polarity of a mobile phase by changing the proportion of components of the mobile phase, so that each flowing component has a proper capacity factor k', all components of a sample can be optimally separated in the shortest time, the gradient elution comprises high-pressure gradient elution and low-pressure gradient elution, the high-pressure gradient elution adopts two high-pressure infusion pumps to respectively convey two solutions A and B to a mixer according to a set proportion, the two solutions are mixed in a high-pressure state after the mixer is pumped, the low-pressure gradient elution only needs one high-pressure infusion pump, the proportional valve is arranged in front of the pump, the solutions are mixed at low pressure, the high-pressure gradient elution adopts the high-pressure infusion pump, the proportion control difficulty of the mobile phase liquid is high, the proportion control precision is not high, the random proportion of various mobile phase liquids cannot be mixed, the low-pressure gradient elution adopts the proportional valve, the control proportion is fixed, and the random proportion of various mobile phase liquids cannot be mixed.
The patent with application number 201510167811.5 discloses an automatic vacuum liquid chromatography separation device and a control method thereof, and specifically discloses a connection relation of the vacuum liquid chromatography separation device, which comprises the following steps: the outlet of the 10 liquid storage tanks is respectively connected with the inlet of 1 multi-inlet 1 pneumatic control valve, the outlet of the multi-inlet 1 pneumatic control valve is connected with the inlet of 1 multi-inlet 1 pneumatic control valve, the outlet of the 1 multi-inlet 3 pneumatic control valve is respectively connected with three chromatographic columns with different diameters, the outlet of each chromatographic column is respectively connected with the 3 inlets of the 1 multi-inlet 1 pneumatic control valve, the outlet of the 3 multi-inlet 1 pneumatic control valve is connected with the inlet of the 1 multi-inlet multi-outlet pneumatic control valve, the outlet of the 1 multi-inlet multi-outlet pneumatic control valve is respectively connected with the collector of 10 eluents, the outlet of the multi-inlet 1 pneumatic control valve is connected with the vacuum pump, and the automatic switching of the multi-inlet 1 pneumatic control valve and the 1 multi-inlet multi-outlet pneumatic control valve is realized through controlling the problems that the cost is higher, the control process is complex and the accuracy is not high.
Disclosure of Invention
The embodiment of the utility model provides a gradient leaching liquid mixing device, which can solve the problems that in the prior art, a high-pressure infusion pump is used for high-pressure gradient leaching, the proportion control difficulty of mobile phase liquid is high, the proportion control precision is low, the mixing of multiple mobile phase liquids in any proportion cannot be carried out, a proportional valve is used for low-pressure gradient leaching, the control proportion is fixed, and the mixing of multiple mobile phase liquids in any proportion cannot be carried out.
The embodiment of the utility model provides a gradient leaching mixed liquor device, which comprises the following components:
a plurality of groups of two-way extraction devices; each group of double-way extraction devices comprises a plurality of double-way extractors, each double-way extractor is provided with an extraction flow mark, and the double-way extraction devices are used for circularly extracting mobile phase liquid in a plurality of eluent bottles under normal pressure;
and the output ends of the multi-way devices are connected with the liquid mixer.
Optionally, the multiple sets of two-way extraction devices are two sets of two-way extraction devices, and each set of two-way extraction devices includes two-way extractors.
Optionally, the plurality of multi-way devices are two first three-way pipes.
Optionally, each two-way decimator includes:
the two sliding tables are movably provided with sliding blocks;
the injection device comprises two injectors, injection barrels of the two injectors are respectively and fixedly arranged on two sliding tables, one end part of an injection push rod of each injector is slidably arranged in the injection barrel, and the other end part of the injection push rod of each injector is fixedly connected with a sliding block;
one end of the second three-way pipe is communicated with the leaching solution bottle;
the two three-way electromagnetic valves are respectively connected with two first output ends of the proportional controller, two first ends of the two three-way electromagnetic valves are respectively and movably connected with the remaining two ends of the second three-way pipe, two second ends of the two three-way electromagnetic valves are respectively and movably connected with the output ends of the two injection cylinders, the third ends of the two three-way electromagnetic valves are respectively connected with the two ends of the third three-way pipe, and the output end of the third three-way pipe is connected with the liquid mixer;
and the two driving devices are respectively connected with two second output ends of the proportional controller by input.
Optionally, a plurality of output ends of each set of two-way extraction devices are connected with the liquid mixer.
Compared with the prior art, the gradient leaching liquid mixing device provided by the embodiment of the utility model has the following beneficial effects:
compared with low-pressure gradient elution using a proportional valve, the gradient elution of mixing before pumping by a plurality of groups of double-way extraction devices has higher gradient control precision, can realize the concentration ratio of mobile phase liquid with any gradient change, and is easier to realize.
Drawings
Fig. 1 is a schematic diagram of the overall structure of a medium-pressure gradient leaching device according to an embodiment of the present utility model;
fig. 2 is a schematic diagram of a mixing device of a medium-pressure gradient elution device according to an embodiment of the present utility model.
Detailed Description
The following detailed description of embodiments of the utility model is, therefore, to be taken in conjunction with the accompanying drawings, and it is to be understood that the scope of the utility model is not limited to the specific embodiments.
It is to be understood that the terms "center," "longitudinal," "transverse," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are directional or positional relationships as indicated based on the drawings, merely to facilitate describing the utility model and simplify the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus are not to be construed as limiting the utility model. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second", etc. may explicitly or implicitly include one or more such feature. In the description of the present utility model, unless otherwise indicated, the meaning of "a plurality" is two or more.
It should be noted that, unless explicitly stated or limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art in a specific case.
Referring to fig. 1, a gradient elution mixing device, connected to a ratio controller, comprises:
a plurality of groups of two-way extraction devices; each group of double-way extraction devices comprises a plurality of double-way extractors, each double-way extractor is provided with an extraction flow mark, and the double-way extraction devices are used for circularly extracting mobile phase liquid in a plurality of eluent bottles under normal pressure;
and the output ends of the multi-way devices are connected with the liquid mixer.
It should be noted that the marks of the two-way extraction devices can be any visible marks, including centimeter marks, millimeter marks and marks which are set empirically, and the purpose of the two-way extraction devices is to make the output quantity of each time be constant, and simultaneously control the output speed of the two-way extraction devices, so that the different mobile phase liquids in the multiple different leaching solution bottles are output to the liquid mixer according to the preset proportion in the two aspects of the volume and the flow speed of the mobile phase liquid, and the purpose of the two-way extraction devices is to make one way extraction device unable to immediately supplement the mobile phase liquid after extracting the mobile phase liquid to cause the interruption of the liquid, so that the proportion is uneven, when the first way is outputting the liquid, the second way is sucking the liquid, and when the first way is outputting the liquid, the liquid in the second way is outputting the liquid in time, so that the stability of the mixing proportion is ensured.
In the embodiment of the utility model, each group of double-way extraction device comprises a plurality of double-way extractors, the plurality of double-way extractors extract liquid from a plurality of leaching solution bottles, the plurality of double-way extractors are arranged according to classification of the leaching solution bottles, the plurality of double-way extractors in each class are used as backup of one main double-way extractor in the class, the backup is arranged to improve redundancy and prevent individual double-way extractors from being broken, the input ends of the plurality of double-way extractors in the class are inserted into one leaching solution bottle, the plurality of types of double-way extractors are subjected to primary mixing through a multi-way valve, and the output ends of the plurality of multi-way valves are subjected to secondary mixing in a mixer.
The utility model belongs to a low-pressure gradient leaching device, compared with a conventional low-pressure gradient leaching device, the utility model is characterized in that a proportional valve is not provided, a plurality of groups of double-way extraction devices are used for continuously extracting mobile phase liquid in a plurality of leaching solution bottles, and the extracted multiple paths of mobile phase liquid are output to a liquid mixer in proportion, so that the concentration ratio of each mobile phase can be controlled more accurately.
In one possible embodiment, the plurality of sets of two-way extraction devices comprises two sets of two-way extraction devices, each set of two-way extraction devices comprising two-way extraction devices.
In an embodiment of the present utility model, as shown in fig. 1, fig. 1 is a schematic view of the whole present utility model, wherein the first set of two-way extractor devices 14 comprises two-way extractors, the two-way extractor input ends of which are inserted into different leaching solution bottles a and B, respectively, and in fig. 1 there is no backup two-way extractor.
In one possible embodiment, the plurality of multipass devices comprises two first tee 11.
In the embodiment of the present utility model, as shown in fig. 1, two output ends of two-way extractors of the first set of two-way extraction devices 14 are respectively connected with two input ends of the first three-way pipe 11, two output ends of the second set of two-way extraction devices are respectively connected with two input ends of the other first three-way pipe 11, the output ends of the two first three-way pipes 11 are connected with the input ends of the liquid mixer 12, the output ends of the liquid mixer 12 are connected with the input ends of the deaerator 13, the outlet of the deaerator 13 is connected to the buffer bottle 15, and the outlet of the buffer bottle 15 is connected to the inlet of the HPLC high-pressure pump.
In one possible embodiment, each two-way extraction device comprises:
the two sliding tables 4 are movably provided with sliding blocks 3.
The two syringes 5, the injection barrels of the two syringes 5 are respectively fixedly arranged on the two sliding tables 4, one end part of the injection push rod of each syringe 5 is slidably arranged in the injection barrel, and the other end part is fixedly connected with the sliding block 3.
And one end of the second tee pipe 7 is communicated with the leaching liquid bottle 8.
The two three-way electromagnetic valves 6 are respectively connected with two first output ends of the proportional controller 9, two first ends of the two three-way electromagnetic valves 6 are respectively and movably connected with the remaining two ends of the second three-way pipe, two second ends of the two three-way electromagnetic valves 6 are respectively and movably connected with the output ends of the two injection barrels, the third ends of the two three-way electromagnetic valves 6 are respectively connected with the two ends of the third three-way pipe 7, and the output end of the third three-way pipe 7 is connected with the first three-way pipe 11.
The two driving devices have their inputs respectively connected to two second outputs of the proportional controller 9.
In the embodiment of the present utility model, as shown in fig. 2, fig. 2 is a partial schematic diagram of the present utility model, the driving device includes a driving circuit 1 and a motor 2, the two driving circuits 1 are respectively connected with two second output ends of a proportional controller 9, the proportional controller 9 is connected with an upper computer 10, according to a script program set by the upper computer 10, the proportional controller 9 is used to control a three-way electromagnetic valve 6, so that one path of syringes 5 with liquid stored on two sliding tables 4 is conducted with an input end of a third three-way pipe 7 and is cut off with an output end of the second three-way valve, so that the syringes 5 output mobile phase liquid to the first three-way pipe 11, meanwhile, the upper computer 10 controls another three-way electromagnetic valve 6 according to the set script program, and uses the proportional controller 9 to conduct the syringes 5 with an output end of the second three-way valve and cut off with an input end of the third three-way pipe 7, so that the liquid discharged by the same speed is extracted, the two syringes 5 are alternately extracted and discharged under the control of the proportional controller 9, so that the liquid in the drip washing bottle B is extracted uninterruptedly, the syringe is more evenly, the syringe is replaced with a lower cost, and the syringe is not required to be replaced by a special person.
The two driving devices are commonly used stepping motors, servo motors and the like of the same type.
In one possible embodiment, the plurality of outputs of each set of two-way extraction devices are connected to a mixer.
In the embodiment of the utility model, not shown in the figure, the output end of each double-way extraction device is directly connected with the liquid mixer 12, the outlet of the liquid mixer 12 is connected with the inlet of the degasser 13, the outlet of the degasser 13 is connected with the buffer bottle 15, the outlet of the buffer bottle 15 is connected with the inlet of the high-pressure HPLC pump for direct proportional mixing, and the operation is simpler.
The foregoing disclosure is merely illustrative of specific embodiments of the utility model, but the embodiments are not limited thereto and variations within the scope of the utility model will be apparent to those skilled in the art.
Claims (4)
1. A gradient drip washing liquid mixing device connected with a proportion controller, which is characterized by comprising:
each set of double-path extraction device comprises a plurality of double-path extractors, each double-path extractor is provided with an extraction flow mark, and the double-path extraction devices are used for circularly extracting mobile phase liquid in a plurality of eluent bottles under normal pressure;
the multiple input ends of each multiple-pass device are connected with the output ends of the multiple double-way extractors of each double-way extractor, and the output ends of each multiple-pass device are connected with the liquid mixer.
2. A gradient elution mixing unit as claimed in claim 1, wherein said plurality of sets of two-way extraction units are two sets of two-way extraction units, each set of two-way extraction units comprising two of said two-way extractors.
3. A gradient elution mix as claimed in claim 1, wherein said plurality of multipass devices are two first tee.
4. A gradient drip mix apparatus as claimed in claim 1, wherein each of said two-way extractors comprises:
the two sliding tables are movably provided with sliding blocks;
the injection barrels of the two injectors are respectively and fixedly arranged on the two sliding tables, one end part of an injection push rod of each injector is slidably arranged in the injection barrel, and the other end part of the injection push rod of each injector is fixedly connected with the sliding blocks;
one end of the second three-way pipe is communicated with the leaching solution bottle;
the two three-way electromagnetic valves are respectively connected with the two first output ends of the proportional controller, the two first ends of the two three-way electromagnetic valves are respectively and movably connected with the remaining two ends of the second three-way pipe, the two second ends of the two three-way electromagnetic valves are respectively and movably connected with the output ends of the two injection barrels, the third ends of the two three-way electromagnetic valves are respectively connected with the two ends of a third three-way pipe, and the output end of the third three-way pipe is connected with the liquid mixer;
and the two driving devices are respectively connected with two second output ends of the proportional controller by input.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322357391.XU CN220490764U (en) | 2023-08-31 | 2023-08-31 | Gradient leaching liquid mixing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322357391.XU CN220490764U (en) | 2023-08-31 | 2023-08-31 | Gradient leaching liquid mixing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220490764U true CN220490764U (en) | 2024-02-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322357391.XU Active CN220490764U (en) | 2023-08-31 | 2023-08-31 | Gradient leaching liquid mixing device |
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| CN (1) | CN220490764U (en) |
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2023
- 2023-08-31 CN CN202322357391.XU patent/CN220490764U/en active Active
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