CN220308147U - Experimental device for be used for screening medicine that has effect of improving cognitive dysfunction - Google Patents
Experimental device for be used for screening medicine that has effect of improving cognitive dysfunction Download PDFInfo
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- CN220308147U CN220308147U CN202321936835.9U CN202321936835U CN220308147U CN 220308147 U CN220308147 U CN 220308147U CN 202321936835 U CN202321936835 U CN 202321936835U CN 220308147 U CN220308147 U CN 220308147U
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- 239000003814 drug Substances 0.000 title claims abstract description 92
- 208000010877 cognitive disease Diseases 0.000 title claims abstract description 30
- 230000000694 effects Effects 0.000 title claims abstract description 23
- 238000012216 screening Methods 0.000 title claims abstract description 20
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 36
- 239000001301 oxygen Substances 0.000 claims abstract description 36
- 208000028698 Cognitive impairment Diseases 0.000 claims abstract description 26
- 238000002474 experimental method Methods 0.000 claims abstract description 25
- 229940079593 drug Drugs 0.000 claims abstract description 22
- 238000004090 dissolution Methods 0.000 claims abstract description 7
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Abstract
The utility model relates to an experimental device for screening medicines with a function of improving cognitive impairment, which comprises a medicine experimental device body, wherein a crushing box is fixedly arranged on the left side of the medicine experimental device body, and an accelerating dissolution mechanism of the medicine experimental device is arranged on the left side of the medicine experimental device body. This an experimental apparatus for screening have medicine that improves cognitive impairment effect carries out the medicine experiment of cognitive impairment effect through medicine experimental apparatus body splendid attire zebra fish, firstly stirs the inside of smashing the case with the medicine pouring in when the medicine of cognitive impairment effect for the zebra fish, and No. two motor drive connecting plates drive the closure plate and left move and make the inside that makes the medicine fall into the oxygen tube afterwards, and the operation of oxygen generation pump produces oxygen and blows into the inside of medicine experimental apparatus body together with its inside medicine powder through the oxygen tube, and then accelerates the absorption cognitive impairment medicine of zebra fish to the effect of accelerating the propulsion experiment has been reached.
Description
Technical Field
The utility model relates to the technical field of experimental devices of medicines, in particular to an experimental device for screening medicines with a function of improving cognitive impairment.
Background
Zebra fish is used as model organism, the homology of the zebra fish with human genes is up to 85%, the biological structure and the physiological function are similar to those of mammals, the zebra fish has the advantages of small individuals, short development period, short experimental period, low cost, in vitro fertilization, transparency, higher single spawning number, small experimental dosage and the like, can perform targeted screening and pharmacodynamics evaluation on candidate compounds with definite action targets like in vitro experiments, can perform pharmacodynamics-based screening and evaluation on therapeutic drugs with unknown targets or diseases with complex pathogenesis like mammals, and is convenient to be used as experimental model animals for drug screening.
The utility model provides an experimental device for screening medicines with the effect of improving cognitive impairment, which belongs to the technical field of animal behavioural researches and comprises a glass jar, wherein the technical proposal of the experimental device for screening medicines with the effect of improving cognitive impairment is provided by Chinese patent publication No. CN217742781U, and the technical proposal provides the problem that the current experimental device for not improving cognitive impairment of zebra fish is difficult to intuitively and effectively screen medicines related to improving cognitive impairment through a zebra fish experimental model; the first glass plate separates the glass cylinder into a left space and a right space; the middle part of the first glass plate is provided with a through hole … …, and zebra fish can be induced to walk through forming an optical path; the electric shock device is used for giving proper current stimulation to the zebra fish to form a punishment type animal behavioural experimental method, a control experiment is carried out, and the effect of the drug on improving the cognitive impairment of the zebra fish is researched, so that the aim of researching the improvement of the cognitive impairment of the zebra fish is fulfilled, and the following defects exist in the scheme: the device for rapidly dissolving the medicine is not arranged, so that the medicine can not be rapidly absorbed by the experimental zebra fish, and the experimental process is delayed, and the experimental device for screening the medicine with the effect of improving the cognitive dysfunction is provided.
Disclosure of Invention
Aiming at the defects of the prior art, the utility model provides an experimental device for screening medicines with the function of improving cognitive impairment, which has the advantages of accelerating a propulsion experiment and the like.
In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides an experimental apparatus for screening have medicine that improves cognitive impairment effect, includes the medicine experimental apparatus body, the left side fixed mounting of medicine experimental apparatus body has crushing case, the left side of medicine experimental apparatus body is provided with the accelerating dissolution mechanism of medicine experimental apparatus.
The accelerating dissolution mechanism of the medicine experiment device comprises a motor I fixedly arranged at the top of a crushing box, a crushing knife penetrating into the inside of the crushing box is fixedly arranged at the output end of the motor I, a dosing pipe penetrating into the inside of the crushing box is fixedly arranged at the left side of the crushing box, a side bracket is fixedly arranged at the left side of the crushing box, a motor II is fixedly arranged at the left side of the side bracket, a screw rod penetrating into the right side of the motor II is fixedly arranged at the output end of the motor II, a connecting plate is arranged at the external thread of the screw rod, a sealing plate penetrating into the inside of the crushing box is fixedly arranged at the right side of the connecting plate, a floor located at the bottom of the crushing box is fixedly arranged at the left side of the medicine experiment device body, an oxygen generating pump is fixedly arranged at the top of the floor, an oxygen outlet pipe penetrating into the inside of the medicine experiment device body is fixedly arranged at the right side of the oxygen generating pump, and a one-way valve is fixedly arranged at the right side of the oxygen outlet pipe.
Further, smash the case and be located the one end that is close to medicine experimental apparatus body top, the output of motor No. one is towards the below, smash the sword rotation and install in the inside of smashing the case.
Further, the height of smashing the sword is less than the height of smashing the case, the medicine adding pipe is located the one end that is close to smashing the case top, the outside of side support is the "7" shape structure of empting.
Further, the side support is located the bottom of dosing tube, the output of No. two motors is towards the right side, the lead screw is rotated and is installed in the left side of smashing the case.
Further, the connecting plate slides in the bottom of side support side by side, the left side wall of closing plate and crushing case is left and right sliding connection, the closing plate is located crushing sword's bottom.
Further, the oxygen generation pump is located the left side of No. two motors, smash the case and run through to the inside of oxygen outlet pipe, oxygen outlet pipe fixed mounting is in the top on floor, the inside of one-way valve medicine experimental apparatus body.
Compared with the prior art, the technical scheme of the application has the following beneficial effects:
this an experimental apparatus for screening have medicine that improves cognitive impairment effect carries out the medicine experiment of cognitive impairment effect through medicine experimental apparatus body splendid attire zebra fish, firstly stirs the inside of smashing the case with the medicine pouring in when the medicine of cognitive impairment effect for the zebra fish, and No. two motor drive connecting plates drive the closure plate and left move and make the inside that makes the medicine fall into the oxygen tube afterwards, and the operation of oxygen generation pump produces oxygen and blows into the inside of medicine experimental apparatus body together with its inside medicine powder through the oxygen tube, and then accelerates the absorption cognitive impairment medicine of zebra fish to the effect of accelerating the propulsion experiment has been reached.
Drawings
FIG. 1 is a cross-sectional view of the structure of the present utility model;
FIG. 2 is a front elevational view of the structure of the present utility model;
FIG. 3 is an enlarged schematic view of the first embodiment of the present utility model.
In the figure: 1. a drug testing device body; 2. a crushing box; 3. a motor I; 4. a crushing knife; 5. a dosing tube; 6. a side bracket; 7. a motor II; 8. a screw rod; 9. a connecting plate; 10. a closing plate; 11. a floor; 12. an oxygen generating pump; 13. an oxygen outlet pipe; 14. a one-way valve.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Referring to fig. 1-3, an experimental device for screening drugs with cognitive impairment improving effects in this embodiment includes a drug experimental device body 1, wherein the drug experimental device body 1 is used for carrying out drug experiments by holding fish, a crushing box 2 is fixedly mounted on the left side of the drug experimental device body 1, the crushing box 2 is located at one end close to the top of the drug experimental device body 1, and an accelerating dissolution mechanism of the drug experimental device is arranged on the left side of the drug experimental device body 1.
The accelerating dissolution mechanism of the medicine experiment device comprises a motor 3 fixedly arranged at the top of a crushing box 2, the output end of the motor 3 faces downwards, a crushing cutter 4 penetrating into the crushing box 2 is fixedly arranged at the output end of the motor 3, the crushing cutter 4 is rotatably arranged in the crushing box 2, the crushing cutter 4 is smaller than the crushing box 2 in height, the crushing cutter 4 is driven to rotate in the crushing box 2 through the motor 3, a medicine adding pipe 5 penetrating into the crushing box 2 is fixedly arranged at the left side of the crushing box 2, the medicine adding pipe 5 is positioned at one end close to the top of the crushing box 2, experimental medicines are added into the crushing box 2 through the medicine adding pipe 5 for crushing, a side bracket 6 is fixedly arranged at the left side of the crushing box 2, the outside of the side bracket 6 is of a toppling 7-shaped structure, the side bracket 6 is positioned at the bottom of the medicine adding pipe 5, a motor 7 is fixedly arranged at the left side of the side bracket 6, the output end of the motor 7 faces right, the output end of the motor 7 is fixedly arranged at the left side of the side bracket 6, a screw rod 8 penetrating into the right side of the crushing box 2 is rotatably arranged at the left side of the screw rod 2.
The connecting plate 9 is installed to the external screw thread of lead screw 8, connecting plate 9 side by side slides in the bottom of side stand 6, the right side fixed mounting of connecting plate 9 has the closure plate 10 that runs through to smashing the incasement portion 2, closure plate 10 and the left side wall of smashing case 2 are left and right sliding connection, closure plate 10 is located the bottom of smashing sword 4, drive lead screw 8 positive and negative rotation through No. two motor 7 forces connecting plate 9 to drive closure plate 10 and control the removal in smashing the inside of case 2, the floor 11 that is located smashing the bottom of case 2 is fixed to the left side fixed mounting of medicine experimental apparatus body 1, the top fixed mounting of floor 11 has the oxygen pump 12, support the oxygen pump 12 through floor 11 and fix in the left side of medicine experimental apparatus body 1, oxygen pump 12 is located the left side of No. two motor 7, the right side outlet end fixed mounting of oxygen pump 12 has the oxygen pipe 13 that runs through to the inside of medicine experimental apparatus body 1, the inside of the medicine experimental apparatus body is prevented to go back to the oxygen pipe 13 through the operation of oxygen pump 12, the inside of oxygen pipe 13 is fixed mounting of inside the inside experiment body 1, the inside experiment body is prevented from flowing back to the inside of medicine experimental apparatus body 1 is provided with the check valve 14.
The working principle of the embodiment is as follows:
when the device is used, medicine is firstly contained in the medicine experiment device body 1 for experiments, when the medicine with cognitive impairment effect is required to be put into the medicine experiment device body 1, the medicine is firstly poured into the crushing box 2 from the medicine adding pipe 5, then the first motor 3 drives the crushing knife 4 to rotate in the crushing box 2 to crush the medicine, then the second motor 7 drives the lead screw 8 to rotate forward to force the connecting plate 9 to drive the sealing plate 10 to move leftwards, at the moment, the medicine in the crushing box 2 is not blocked and falls into the oxygen pipe 13, then the second motor 7 drives the lead screw 8 to rotate reversely to force the connecting plate 9 to push the sealing plate 10 to move rightwards to block the bottom of the crushing box 2, and then the oxygen making pump 12 operates to generate oxygen to blow medicine powder in the medicine experiment device body 1 together through the oxygen pipe 13, so that the medicine experiment fish in the medicine experiment device body 1 can absorb the cognitive impairment medicine.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. An experimental device for be used for screening to have medicine that improves cognitive dysfunction effect, includes medicine experimental device body (1), its characterized in that: the left side of the medicine experiment device body (1) is fixedly provided with a crushing box (2), and the left side of the medicine experiment device body (1) is provided with an accelerating dissolution mechanism of the medicine experiment device;
the accelerating dissolution mechanism of the medicine experiment device comprises a motor (3) fixedly arranged at the top of a crushing box (2), a crushing knife (4) penetrating into the crushing box (2) is fixedly arranged at the output end of the motor (3), a dosing pipe (5) penetrating into the crushing box (2) is fixedly arranged at the left side of the crushing box (2), a side bracket (6) is fixedly arranged at the left side of the crushing box (2), a motor No. two (7) is fixedly arranged at the left side of the side bracket (6), a lead screw (8) penetrating into the right side of the motor No. two (7) is fixedly arranged at the output end of the motor No. two (7), a connecting plate (9) is arranged at the external thread of the lead screw (8), a sealing plate (10) penetrating into the crushing box (2) is fixedly arranged at the right side of the connecting plate (9), a floor (11) located at the bottom of the crushing box (2) is fixedly arranged at the left side of the medicine experiment device body (1), an oxygen pump (12) is fixedly arranged at the top of the floor (11), and an oxygen pump (13) is fixedly arranged at the right side of the oxygen pump (12) and an oxygen pump (13) penetrates into the air outlet pipe (13).
2. An experimental set-up for screening for drugs having an effect of improving cognitive impairment according to claim 1, wherein: the crushing box (2) is located the one end that is close to medicine experimental apparatus body (1) top, the output of motor No. one (3) is towards the below, smash sword (4) rotation and install in the inside of crushing box (2).
3. An experimental set-up for screening for drugs having an effect of improving cognitive impairment according to claim 1, wherein: the height of the crushing cutter (4) is smaller than that of the crushing box (2), the dosing pipe (5) is positioned at one end close to the top of the crushing box (2), and the outer part of the side support (6) is of a toppling 7-shaped structure.
4. An experimental set-up for screening for drugs having an effect of improving cognitive impairment according to claim 1, wherein: the side support (6) is located the bottom of adding pencil (5), the output of No. two motor (7) is towards the right side, lead screw (8) rotate install in the left side of smashing case (2).
5. An experimental set-up for screening for drugs having an effect of improving cognitive impairment according to claim 1, wherein: the connecting plate (9) slides left and right at the bottom of the side bracket (6), the sealing plate (10) is in left and right sliding connection with the left side wall of the crushing box (2), and the sealing plate (10) is positioned at the bottom of the crushing knife (4).
6. An experimental set-up for screening for drugs having an effect of improving cognitive impairment according to claim 1, wherein: the oxygen generation pump (12) is located the left side of No. two motors (7), smash case (2) run through to the inside of oxygen outlet pipe (13), oxygen outlet pipe (13) fixed mounting is in the top on floor (11), check valve (14) are located the inside of medicine experimental apparatus body (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321936835.9U CN220308147U (en) | 2023-07-22 | 2023-07-22 | Experimental device for be used for screening medicine that has effect of improving cognitive dysfunction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321936835.9U CN220308147U (en) | 2023-07-22 | 2023-07-22 | Experimental device for be used for screening medicine that has effect of improving cognitive dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220308147U true CN220308147U (en) | 2024-01-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321936835.9U Active CN220308147U (en) | 2023-07-22 | 2023-07-22 | Experimental device for be used for screening medicine that has effect of improving cognitive dysfunction |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220308147U (en) |
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2023
- 2023-07-22 CN CN202321936835.9U patent/CN220308147U/en active Active
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