CN220056339U - Filling equipment for crosslinking sodium hyaluronate gel - Google Patents

Filling equipment for crosslinking sodium hyaluronate gel Download PDF

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Publication number
CN220056339U
CN220056339U CN202321356385.6U CN202321356385U CN220056339U CN 220056339 U CN220056339 U CN 220056339U CN 202321356385 U CN202321356385 U CN 202321356385U CN 220056339 U CN220056339 U CN 220056339U
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box body
filling
sodium hyaluronate
hyaluronate gel
conveyor belt
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CN202321356385.6U
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赵磊
徐罗鹏
杨加永
张宇杲
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Jiangsu Tianlaiya Biotechnology Co ltd
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Jiangsu Tianlaiya Biotechnology Co ltd
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Abstract

The utility model discloses filling equipment for crosslinking sodium hyaluronate gel, which comprises a box body, a support and a filling barrel, wherein an ultraviolet lamp is arranged on a top plate of the box body, a conveyor belt transversely penetrating through bottom ends of door frames on the left side and the right side is arranged at the lower end of the box body, the conveyor belt is tensioned on a plurality of rollers, a central shaft of one roller is fixedly connected with an output shaft of a driving motor, the support stretches over the conveyor belt, the filling barrel is arranged at the top of the support, a hose with one end connected with a compressed air source is arranged on the top plate of the box body in a penetrating way, the other end of the hose penetrates through a cover plate of the filling barrel and extends to the upper end of an inner cavity of the filling barrel, a peristaltic pump is arranged on the hose, an optical fiber sensor correspondingly facing to a space below a filling head is arranged at the lower end of a rear side plate of the box body, and the driving motor, the peristaltic pump, the ultraviolet lamp and the optical fiber sensor are all connected with a control system. The filling equipment provided by the utility model obviously improves the accuracy and the overall filling efficiency of the gel amount of the crosslinked sodium hyaluronate filled in the same batch of injection barrels, and reduces the labor cost.

Description

Filling equipment for crosslinking sodium hyaluronate gel
Technical Field
The utility model relates to the technical field of aseptic filling of crosslinked sodium hyaluronate gel, in particular to filling equipment for crosslinked sodium hyaluronate gel.
Background
Hyaluronic Acid (HA), also known as Hyaluronic Acid, is a mucopolysaccharide formed by alternately connecting glucuronic Acid and N-acetamido glucosamine as disaccharide units. Hyaluronic acid is widely present in connective, epithelial and nervous tissues. Commercially available hyaluronic acid will be present in its sodium salt form, known as sodium hyaluronate.
The sodium hyaluronate gel subjected to the crosslinking reaction exhibits swelling and insolubilization due to the formation of a covalent crosslinked network. Because of the large amount of hydrophilic groups in the hydrogel, a large amount of water can be absorbed and stored, so that the weight and the volume of the hydrogel are obviously increased. The crosslinked sodium hyaluronate gel has the advantages of excellent biocompatibility, biodegradability, easy synthesis and the like, overcomes the defect of high degradation speed of uncrosslinked sodium hyaluronate gel, has the advantages of high mechanical strength, good viscoelasticity, water insolubility, long degradation time and the like, greatly improves the application range and performance of the sodium hyaluronate gel, and can better meet the clinical use requirement.
With the progress of society, people pay more attention to self-maintenance, pursue younger and more advanced, and the medical and cosmetic industries are growing and developing rapidly. With the continuous development of the medical cosmetology industry, the hyaluronic acid gel subjected to crosslinking modification becomes a popular clinical tissue filling material due to excellent biocompatibility and controllable degradation time.
For ease of use, the crosslinked sodium hyaluronate gel product is typically filled into a syringe for vending. At present, most of crosslinked sodium hyaluronate gel is filled in a syringe manually, and the specific operation process is as follows: firstly, sterilizing the injection cylinder and the rubber plug; secondly, filling the crosslinked sodium hyaluronate gel into the injection cylinder in a manual mode, and additionally installing a rubber plug at the upper end of the injection cylinder to realize the sealing of the injection cylinder; and finally, carrying out terminal sterilization and encapsulation on the filled crosslinked sodium hyaluronate gel product. The problem with this filling mode is that: (1) The amount of the crosslinked sodium hyaluronate gel filled in each injection cylinder is difficult to control accurately, so that the amount of the crosslinked sodium hyaluronate gel filled in different injectors of the same batch is large in difference, and inconvenience is brought to later use; (2) The filling step is long in time consumption, the labor participation is large, the integral filling efficiency of the crosslinked sodium hyaluronate gel product is seriously influenced, and the labor cost is high.
Disclosure of Invention
The utility model aims to overcome the defects in the prior art, and provides a filling device for crosslinking sodium hyaluronate gel, which controls the cooperative coordination of an optical fiber sensor, a peristaltic pump and a driving motor through a control system, quantitatively inputs compressed air to the upper end of the inner part of a cavity of a filling barrel each time through the peristaltic pump, and extrudes and fills quantitative crosslinking sodium hyaluronate gel into the injection barrel by utilizing the quantitatively input compressed air, thereby remarkably improving the accuracy of the amount of the crosslinking sodium hyaluronate gel filled in the injection barrel of the same batch, greatly reducing the workload of manual participation, remarkably improving the overall filling efficiency of the crosslinking sodium hyaluronate gel and reducing the labor cost; the whole structure is simple in design, low in cost, high in preparation and implementation feasibility and high in practicability.
In order to achieve the above purpose, the technical scheme of the utility model is to design filling equipment for crosslinking sodium hyaluronate gel, which comprises a box body, a bracket, a filling barrel and a control system, wherein a door frame is correspondingly arranged on the left side plate and the right side plate of the box body, a box door capable of sliding along the vertical direction is arranged in the door frame, an ultraviolet lamp which faces the inside of the box body is arranged on the top plate of the box body, a conveyor belt which transversely passes through the bottom ends of the door frames on the left side and the right side is arranged at the lower end of the box body, the conveyor belt is tensioned on a plurality of rollers which are rotatably arranged at the front side plate and the lower end of the rear side plate of the box body, the rear end of a central shaft of one roller movably passes through the rear side plate of the box body and is fixedly connected with an output shaft of a driving motor, a plurality of rollers are in transmission connection through a sprocket chain component, the bracket spans over the upper part of the conveyor belt, the filling barrel is arranged at the top of the bracket, one end of the top plate of the box body is connected with a compressed air source, the other end of the hose passes through a through hole in the cover plate of the box body and extends to the inside a cavity of the box body, and the corresponding peristaltic pump is arranged at the upper end of the pump and the peristaltic pump is arranged at the lower end of the pump.
According to the filling equipment for the crosslinked sodium hyaluronate gel, the optical fiber sensor, the peristaltic pump and the driving motor are controlled to cooperatively cooperate through the control system, compressed air is quantitatively input to the upper end of the inner part of the cavity of the filling barrel by the peristaltic pump each time, the quantitatively input compressed air is utilized to extrude and fill the quantitatively crosslinked sodium hyaluronate gel into the injection barrel, the accuracy of the amount of the filled crosslinked sodium hyaluronate gel in the injection barrel in the same batch is obviously improved, meanwhile, the workload of manual participation is greatly reduced, the overall filling efficiency of the crosslinked sodium hyaluronate gel is obviously improved, and the labor cost is reduced; the whole structure is simple in design, low in cost, high in preparation and implementation feasibility and high in practicability.
The preferable technical scheme is that the outer side surface of the conveyor belt is provided with a circumferential object placing groove, and the circumferential object placing groove corresponds to the filling head. During filling, the storage cylinder is inserted on the base, and the base is placed inside the annular storage groove on the conveyor belt, so that the stability of the base inserted with the injection cylinder on the conveyor belt is remarkably improved, and the phenomenon that the crosslinked sodium hyaluronate gel falls to the outside of the injection cylinder due to displacement of the injection cylinder is effectively avoided.
In order to ensure the sterilization sufficiency of the inner wall surface of the circumferential storage groove, a further preferable technical scheme is that the ultraviolet lamp is of a strip-shaped structure, the ultraviolet lamp is correspondingly positioned above the circumferential storage groove, and the length direction of the ultraviolet lamp is consistent with the length direction of the circumferential storage groove. ,
further preferable technical scheme is that the hose is also provided with an electromagnetic valve connected with the control system. When the peristaltic pump fails, the electromagnetic valve is closed, so that the tightness of the inside of the filling barrel is ensured, and the phenomenon that compressed air enters the inside of the filling barrel to extrude the crosslinked sodium hyaluronate gel is effectively avoided.
In order to facilitate the opening and closing of the box door, a further preferable technical scheme is that the lower end of the box door is provided with a handle facing the outside of the box body.
Further preferable technical scheme is that the frame and the box door of the box body are made of stainless steel materials, and the front side plate of the box body is made of transparent glass materials. The frame and the box door of the box body are made of stainless steel, so that the pollution problem of the injection cylinder caused by the corrosion of the box body or the box door is effectively avoided; the front side plate of the box body is made of transparent glass, so that an operator can observe the filling process of the filling head in real time, and the safety of the filling process is ensured.
The utility model has the advantages and beneficial effects that:
1. according to the filling equipment for the crosslinked sodium hyaluronate gel, the optical fiber sensor, the peristaltic pump and the driving motor are controlled to cooperatively cooperate through the control system, compressed air is quantitatively input to the upper end of the inner part of the cavity of the filling barrel by the peristaltic pump each time, the quantitatively input compressed air is utilized to extrude and fill the quantitatively crosslinked sodium hyaluronate gel into the injection barrel, the accuracy of the amount of the filled crosslinked sodium hyaluronate gel in the injection barrel in the same batch is obviously improved, meanwhile, the workload of manual participation is greatly reduced, the overall filling efficiency of the crosslinked sodium hyaluronate gel is obviously improved, and the labor cost is reduced; the whole structure is simple in design, low in cost, high in preparation and implementation feasibility and high in practicability.
2. The outer side surface of the conveyor belt is provided with a circumferential storage groove, and the circumferential storage groove corresponds to the filling head. During filling, the storage cylinder is inserted on the base, and the base is placed inside the annular storage groove on the conveyor belt, so that the stability of the base inserted with the injection cylinder when placed on the conveyor belt is remarkably improved, and the phenomenon that the crosslinked sodium hyaluronate gel falls outside the injection cylinder due to displacement of the injection cylinder is effectively avoided.
3. The hose is also provided with an electromagnetic valve connected with a control system. When the peristaltic pump fails, the electromagnetic valve is closed, so that the tightness of the inside of the filling barrel is ensured, and the phenomenon that compressed air enters the inside of the filling barrel to extrude the crosslinked sodium hyaluronate gel is effectively avoided.
4. The frame and the box door of the box body are made of stainless steel, so that the pollution problem of the injection cylinder caused by the corrosion of the box body or the box door is effectively avoided; the front side plate of the box body is made of transparent glass, so that an operator can observe the filling process of the filling head in real time, and the safety of the filling process is ensured.
Drawings
FIG. 1 is a front left side perspective view of a filling apparatus for cross-linking sodium hyaluronate gel of the present utility model;
FIG. 2 is a top view of a filling apparatus for cross-linking sodium hyaluronate gel of the present utility model;
fig. 3 is a longitudinal cross-sectional view of the filling apparatus for cross-linking sodium hyaluronate gel of fig. 2 along the direction A-A.
In the figure: 1. a case; 2. a door; 3. a conveyor belt; 4. a roller; 5. a driving motor; 6. a bracket; 7. filling a barrel; 8. a hose; 9. a peristaltic pump; 10. an ultraviolet lamp; 11. an optical fiber sensor; 12. an electromagnetic valve; 2-1, a handle; 3-1, a circumferential object placing groove; 7-1, cover plate; 7-2, filling heads.
Detailed Description
The following describes the embodiments of the present utility model further with reference to the drawings and examples. The following examples are only for more clearly illustrating the technical aspects of the present utility model, and are not intended to limit the scope of the present utility model.
Examples
As shown in fig. 1-3, the utility model relates to a filling device for crosslinking sodium hyaluronate gel, which comprises a box body 1, a bracket 6, a filling barrel 7 and a control system, wherein door frames are correspondingly arranged on a left side plate and a right side plate of the box body 1, a box door 2 capable of sliding along the vertical direction is arranged in the door frames, an ultraviolet lamp 10 facing the inside of the box body 1 is arranged on a top plate of the box body 1, a conveyor belt 3 transversely penetrating through the bottom ends of the door frames on the left side and the right side is arranged at the lower end of the box body 1, the conveyor belt 3 is tensioned on a plurality of rollers 4 rotatably arranged at the lower ends of the front side plate and the rear side plate of the box body 1, the rear end of a central shaft of one roller 4 movably penetrates through the rear side plate of the box body 1 and is fixedly connected with an output shaft of a driving motor 5, A plurality of rollers 4 between through sprocket chain subassembly transmission connection, support 6 span and erect in the top of conveyer belt 3, filling barrel 7 install in the top of support 6, the roof of box 1 on wear to be equipped with the hose 8 that one end and compressed air source are connected, the hose 8 other end pass the through-hole on the apron 7-1 of filling barrel 7 and extend in the upper end of filling barrel 7 internal cavity, hose 8 on be equipped with peristaltic pump 9, the posterior lateral plate lower extreme of box 1 be equipped with the corresponding orientation filling head 7-2 below space optical fiber sensor 11, driving motor 5, peristaltic pump 9, ultraviolet lamp 10 and optical fiber sensor 11 all be connected with control system.
Preferably, a circumferential storage groove 3-1 is arranged on the outer side surface of the conveyor belt 3, and the circumferential storage groove 3-1 corresponds to the filling head 7-2.
Further preferably, the ultraviolet lamp 10 has a strip structure, the ultraviolet lamp 10 is correspondingly located above the circumferential storage groove 3-1, and the length direction of the ultraviolet lamp 10 is consistent with the length direction of the circumferential storage groove 3-1.
It is further preferred that the hose 8 is further provided with a solenoid valve 12 connected to a control system.
Further preferably, the lower end of the box door 2 is provided with a handle 2-1 facing the outside of the box body 1.
Further preferably, the frame of the case 1 and the case door 2 are made of stainless steel, and the front side plate of the case 1 is made of transparent glass.
The utility model relates to a filling device for crosslinking sodium hyaluronate gel, which adopts the use principle that:
(1) Before the filling operation starts, the ultraviolet lamp 10 is started by the control system to irradiate for more than 30 minutes to sterilize the inside of the box body 1;
(2) After sterilization is completed, the ultraviolet lamp 10 is closed, the box doors 2 on the left side and the right side are opened, the crosslinked sodium hyaluronate gel is filled in the filling barrel 7, then the filling barrel 7 containing the crosslinked sodium hyaluronate gel is placed at the top of the bracket 6, and the lower end of the hose 8 passes through the through hole on the cover plate 7-1 and extends to the upper end of the inner cavity of the filling barrel 7 (above the liquid level of the crosslinked sodium hyaluronate gel);
(3) The working switch is started through the control system, the output shaft of the driving motor 5 drives the rollers 4 to rotate, the rollers 4 drive the conveyor belt 3 to start running, a plurality of sterilized injection barrels are inserted into the groove body on the base (the groove bodies on the base are arranged at intervals along the length direction of the base), and then the base inserted with the injection barrels is placed in the annular storage groove 3-1 on the conveyor belt 3;
(4) When the injection cylinder runs right below the filling head 7-2, the optical fiber sensor 11 recognizes the position information of the injection cylinder and transmits the position information to the control system, the control system sends a stop instruction to the driving motor 5 and a start instruction to the peristaltic pump 9, the peristaltic pump 9 drives a part of compressed air to enter the inside of the filling barrel 7, a certain amount of crosslinked sodium hyaluronate gel is filled in the corresponding injection cylinder through the filling head 7-2, and then the control system sends a start instruction to the driving motor 5 and a stop instruction to the peristaltic pump 9;
(5) And (3) repeating the step (4) until the next injection cylinder runs right below the filling head 7-2, taking down the injection cylinder from the right end of the conveyor belt 3 after all the injection cylinders on the same base are filled, and transferring to the next packaging procedure.
According to the filling equipment for the crosslinked sodium hyaluronate gel, the optical fiber sensor, the peristaltic pump and the driving motor are controlled to cooperatively cooperate through the control system, compressed air is quantitatively input to the upper end of the inner part of the cavity of the filling barrel by the peristaltic pump each time, the quantitatively input compressed air is utilized to extrude and fill the quantitatively crosslinked sodium hyaluronate gel into the injection barrel, the accuracy of the amount of the filled crosslinked sodium hyaluronate gel in the injection barrel in the same batch is obviously improved, meanwhile, the workload of manual participation is greatly reduced, the overall filling efficiency of the crosslinked sodium hyaluronate gel is obviously improved, and the labor cost is reduced; the whole structure is simple in design, low in cost, high in preparation and implementation feasibility and high in practicability.
The foregoing is merely a preferred embodiment of the present utility model, and it should be noted that it will be apparent to those skilled in the art that several modifications and variations can be made without departing from the technical principle of the present utility model, and these modifications and variations should also be regarded as the scope of the utility model.

Claims (6)

1. The filling equipment for crosslinking sodium hyaluronate gel is characterized by comprising a box body (1), a bracket (6), a filling barrel (7) and a control system, wherein a door frame is correspondingly arranged on a left side plate and a right side plate of the box body (1), a box door (2) capable of sliding along the vertical direction is arranged in the door frame, an ultraviolet lamp (10) facing the inside of the box body (1) is arranged on a top plate of the box body (1), a conveyor belt (3) transversely penetrating through the bottom ends of the door frame on the left side and the right side is arranged at the lower end of the box body (1), the conveyor belt (3) is tensioned on a plurality of rollers (4) rotatably arranged on the front side plate and the lower end of the rear side plate of the box body (1), the rear end of a central shaft of one roller (4) movably penetrates through the rear side plate of the box body (1) and is fixedly connected with an output shaft of a driving motor (5), a plurality of rollers (4) are in transmission connection through sprocket chain components, the bracket (6) stretches across the top of the conveyor belt (3), the conveyor belt (3) is tensioned on the bottom end of the box body (1) and is provided with a hose (7) and penetrates through the top plate (8) of the air source (7), the peristaltic pump (9) is arranged on the hose (8), the optical fiber sensor (11) which faces the space below the filling head (7-2) is arranged at the lower end of the rear side plate of the box body (1), and the driving motor (5), the peristaltic pump (9), the ultraviolet lamp (10) and the optical fiber sensor (11) are connected with the control system.
2. The filling device for cross-linked sodium hyaluronate gel according to claim 1, wherein the outer side surface of the conveyor belt (3) is provided with a circumferential storage groove (3-1), and the circumferential storage groove (3-1) corresponds to the filling head (7-2).
3. The filling equipment for cross-linked sodium hyaluronate gel according to claim 2, wherein the ultraviolet lamp (10) has a strip-shaped structure, the ultraviolet lamp (10) is correspondingly positioned above the circumferential storage groove (3-1), and the length direction of the ultraviolet lamp (10) is consistent with the length direction of the circumferential storage groove (3-1).
4. A filling device for cross-linked sodium hyaluronate gel as in claim 3, characterized in that said hose (8) is further provided with a solenoid valve (12) connected to a control system.
5. The filling apparatus for cross-linked sodium hyaluronate gel as set forth in claim 4, wherein the lower end of the door (2) is provided with a handle (2-1) facing the outside of the case (1).
6. The filling equipment for cross-linked sodium hyaluronate gel according to claim 5, wherein the frame and the door (2) of the case (1) are made of stainless steel materials, and the front side plate of the case (1) is made of transparent glass materials.
CN202321356385.6U 2023-05-31 2023-05-31 Filling equipment for crosslinking sodium hyaluronate gel Active CN220056339U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202321356385.6U CN220056339U (en) 2023-05-31 2023-05-31 Filling equipment for crosslinking sodium hyaluronate gel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202321356385.6U CN220056339U (en) 2023-05-31 2023-05-31 Filling equipment for crosslinking sodium hyaluronate gel

Publications (1)

Publication Number Publication Date
CN220056339U true CN220056339U (en) 2023-11-21

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ID=88768426

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202321356385.6U Active CN220056339U (en) 2023-05-31 2023-05-31 Filling equipment for crosslinking sodium hyaluronate gel

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CN (1) CN220056339U (en)

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