CN218666087U - Radioactive particle in-vitro cell irradiation experiment template based on 3D printing - Google Patents
Radioactive particle in-vitro cell irradiation experiment template based on 3D printing Download PDFInfo
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- CN218666087U CN218666087U CN202222993288.XU CN202222993288U CN218666087U CN 218666087 U CN218666087 U CN 218666087U CN 202222993288 U CN202222993288 U CN 202222993288U CN 218666087 U CN218666087 U CN 218666087U
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Abstract
The utility model discloses a radioactive particle in-vitro cell irradiation experiment template based on 3D printing, which comprises a template body, a particle storage mechanism and a culture dish supporting mechanism, wherein the particle storage mechanism and the culture dish supporting mechanism are positioned on the template body; the particle storage mechanism comprises a particle groove printing area located on the template body, a reference line which is located on the particle groove printing area and is arranged in parallel, particle grooves which are arranged along the length direction of the reference line, and particle grooves which are located on the same reference line are arranged at equal intervals. Through the integral type experiment template of 3D preparation, the particle is arranged in the particle recess, and the culture dish supports through the culture dish and supports, guarantees to shine evenly, can print the template of equidimension not simultaneously, change the interval between the particle recess, adjust the figure of particle recess according to different culture dish sizes, experiment dosage requirements. The template meets the experiment requirements, ensures that the irradiation rays received in the culture dish field are uniform, and meets different requirements of the tumor cell radioactive particle in-vitro irradiation experiment.
Description
Technical Field
The utility model relates to a medical science experiment equipment technical field, more specifically say, relate to a radioactive particle external cell irradiation experiment template based on 3D prints.
Background
The radioactive particle implantation is widely applied to clinical short-distance irradiation treatment at present, is mainly applied to solid tumor implantation treatment, and has obvious curative effect. However, fundamental studies on the mechanism of irradiation therapy within radioactive particles have not been intensively carried out, and the influence of the continuous gamma irradiation of radioactive particles on tumor cells and microenvironment has not been clarified. There is a great clinical need to develop relevant research to define the unique mechanism of radiation therapy in radioactive particles, so as to guide the clinical radiation therapy scheme and dose guidance, and promote the wide clinical application of radioactive particles. In vitro tumor cell irradiation is a common research method for discussing radiotherapy, and due to the influences of factors such as small volume, uneven irradiation and the like of radioactive particles, the experimental requirements of uniform distribution and equal-dose irradiation of the radioactive particles cannot be effectively simulated in the aspect of in vitro irradiation.
The related patents of the related radioactive particle experiment template which are applied at present are as follows: chinese patent CN212800387U is a radioactive irradiation device for cancer cells, the base and the cap are located in the radiation-proof housing, the base is provided with a plurality of culture dishes for placing cancer cells, the bottom of each culture dish is provided with an accommodating groove for accommodating radioactive particles, and the cap is located above the base and covers the culture dish. The design irradiates multiple cell culture dishes simultaneously, and the radioactive particle field areas of different culture dishes are crossed and mutually influenced. The radioactive particle grooves are designed unevenly, so that cells in an irradiation field can not be guaranteed to receive equal-dose ray irradiation, and meanwhile, adjustment can not be carried out according to different dose experiment requirements. The cap covers above the culture dish, can not guarantee effective ventilation, and is very big to cell culture, influences the experiment effect easily.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a radioactive particle external cell irradiation experiment template based on 3D prints for solve the technical problem who exists among the above-mentioned background art.
The utility model discloses a radioactive particle in vitro cell irradiation experiment template based on 3D printing, which comprises a template body, a particle storage mechanism and a culture dish supporting mechanism, wherein the particle storage mechanism and the culture dish supporting mechanism are positioned on the template body;
the particle storage mechanism comprises a particle groove printing area, a reference line and a particle groove, wherein the particle groove printing area is positioned on the template body, the reference line is positioned in the particle groove printing area and is arranged in parallel, the particle groove is arranged along the length direction of the reference line, and the particle grooves on the same reference line are arranged at equal intervals.
In a preferred embodiment, the particle recess regions are arranged in a circle, and the diameters of the particle recess regions are not unique.
In a preferred embodiment, the distance between two adjacent reference lines is 10mm.
In a preferred embodiment, the particle grooves have a length of 5mm and a width of 1mm, and the spacing of the particle grooves on the same reference line is not unique and is between 5-10 mm.
In a preferred embodiment, the culture dish supporting mechanisms are arranged at four corners of the template body and comprise supporting columns and supporting bars which are connected with the supporting columns and horizontally arranged, the bottom of each supporting bar is 5mm away from the upper surface of the template body, and the length of each supporting bar is 2mm.
In a preferred embodiment, the particle storage mechanism and the culture dish support mechanism are both made by 3D printing.
The utility model discloses technical scheme's beneficial effect is:
through the integral type experiment template of 3D preparation, the particle is arranged in the particle recess, and the culture dish supports through the culture dish and supports, requires according to different culture dish sizes, experiment dosage, and printable not template of equidimension changes interval, particle recess figure between the particle recess according to the demand simultaneously. The template meets the experiment requirements, ensures that the irradiation rays received in the culture dish field are uniform, and meets different requirements of the tumor cell radioactive particle in-vitro irradiation experiment.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention,
fig. 2 is an enlarged view of a portion a in fig. 1 according to the present invention.
Description of reference numerals: 1 template body, 2 particle storage mechanisms, 3 particle groove printing areas, 4 reference lines, 5 particle grooves, 6 culture dish supporting mechanisms, 7 supporting columns and 8 supporting strips.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments. The embodiments of the present invention have been presented for purposes of illustration and description, and are not intended to be exhaustive or limited to the invention in the form disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiment was chosen and described in order to best explain the principles of the invention and the practical application, and to enable others of ordinary skill in the art to understand the invention for various embodiments with various modifications as are suited to the particular use contemplated.
As shown in fig. 1-2, the utility model discloses a radioactive particle external cell irradiation experiment template based on 3D prints is disclosed to technical scheme, including template body 1, be located particle storage mechanism 2 and culture dish supporting mechanism 6 on template body 1, particle storage mechanism 2 is used for depositing radioactive particle, and the culture dish is located particle storage mechanism 2 top after supporting and supporting through culture dish supporting mechanism 6. The particle storage mechanism 2 and the culture dish support mechanism 6 are both made by 3D printing.
The particle storage mechanism 2 comprises a particle groove printing area 3 positioned on the template body 1, a reference line 4 which is positioned on the particle groove printing area 3 and is arranged in parallel, and particle grooves 5 which are arranged along the length direction of the reference line 4, wherein the particle grooves 5 positioned on the same reference line 4 are arranged at equal intervals. The size of the particle recess printing zone 3 is determined according to the diameter of the culture dish, for example, for a culture dish with a diameter of 100mm, the diameter of the particle recess printing zone 3 is also set to 100mm. The radioactive particles are stored in the particle recesses 5, and one particle recess 5 stores one radioactive particle correspondingly.
In order to adapt to the shape of the culture dish, the particle groove 5 area is usually set to be circular, and the diameter of the particle groove 5 area is not unique and can be printed to different diameters according to specific experimental requirements.
The length of the particle groove 5 is 5mm, the width is 1mm, and the standard of the radioactive particles commonly used in clinic is 0.8mm multiplied by 4.5mm, so the size of the particle groove 5 is set to be 1mm multiplied by 5mm, and the particles can be smoothly arranged in the particle groove 5 and fixed in position. The distance between two adjacent reference lines 4 is 10mm, and the distance between the particle grooves 5 on the same reference line 4 is not only 5-10 mm. The distance between the particles implanted into the tumor clinically is 5-10mm according to the effective irradiation radius (17 mm) of the radioactive particles, and the distance between the 5 value of the particle grooves can be adjusted by several money according to different metering requirements. The above arrangement can simulate clinical and TPS plans to require that the irradiation rays received in the culture dish field are uniform.
Culture dish supporting mechanism 6 sets up at four angles of template body 1, and culture dish supporting mechanism 6 includes support column 7 and the support bar 8 of being connected and the level setting with support column 7, and 8 bottom distances of support bar 5mm from 1 upper surface of template body, 8 length of support bar are 2mm. The culture dish passes through support bar 8 and supports, and 8 bottoms of support bar are apart from 1 upper surface 5mm of template body, and support bar 8 sets up to 2mm, accords with clinical and cell experiment conventional requirement, and guarantees that the culture dish is steady fixed and do not shelter from the ray. At the same time, the culture dish completely overlaps the circular radioactive particle placement area.
It is obvious that the described embodiments are only some of the embodiments of the present invention, and not all of them. Based on the embodiments in the present disclosure, all other embodiments obtained by a person of ordinary skill in the art and related fields without creative efforts shall fall within the protection scope of the present disclosure. The structures, devices, and methods of operation of the present invention, not specifically described and illustrated, are generally practiced by those of ordinary skill in the art without specific recitation or limitation.
Claims (6)
1. The utility model provides a radioactive particle in vitro cell irradiation experiment template based on 3D prints which characterized in that: the particle storage device comprises a template body, a particle storage mechanism and a culture dish supporting mechanism, wherein the particle storage mechanism and the culture dish supporting mechanism are positioned on the template body;
the particle storage mechanism comprises a particle groove printing area, a reference line and a particle groove, wherein the particle groove printing area is positioned on the template body, the reference line is positioned in the particle groove printing area and is arranged in parallel, the particle groove is arranged along the length direction of the reference line, and the particle grooves on the same reference line are arranged at equal intervals.
2. The radioactive particle in-vitro cell irradiation experiment template based on 3D printing as claimed in claim 1, wherein: the particle groove regions are arranged in a circle, and the diameters of the particle groove regions are not unique.
3. The radioactive particle in-vitro cell irradiation experiment template based on 3D printing as claimed in claim 1, wherein: the distance between two adjacent reference lines is 10mm.
4. The radioactive particle in-vitro cell irradiation experiment template based on 3D printing as claimed in claim 1, wherein: the particle grooves are 5mm long and 1mm wide, and the spacing between the particle grooves on the same reference line is not unique and is between 5 and 10mm.
5. The radioactive particle in-vitro cell irradiation experiment template based on 3D printing as claimed in claim 1, wherein: culture dish supporting mechanism sets up four angles of template body, culture dish supporting mechanism include the support column and with the support bar that the support column is connected and the level sets up, support bar bottom distance template body upper surface 5mm, support bar length are 2mm.
6. The radioactive particle in-vitro cell irradiation experiment template based on 3D printing as claimed in claim 1, wherein: the particle storage mechanism and the culture dish supporting mechanism are both manufactured through 3D printing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222993288.XU CN218666087U (en) | 2022-11-10 | 2022-11-10 | Radioactive particle in-vitro cell irradiation experiment template based on 3D printing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222993288.XU CN218666087U (en) | 2022-11-10 | 2022-11-10 | Radioactive particle in-vitro cell irradiation experiment template based on 3D printing |
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| Publication Number | Publication Date |
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| CN218666087U true CN218666087U (en) | 2023-03-21 |
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| CN202222993288.XU Active CN218666087U (en) | 2022-11-10 | 2022-11-10 | Radioactive particle in-vitro cell irradiation experiment template based on 3D printing |
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| CN (1) | CN218666087U (en) |
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2022
- 2022-11-10 CN CN202222993288.XU patent/CN218666087U/en active Active
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