CN218629209U - Whole blood pretreatment device - Google Patents
Whole blood pretreatment device Download PDFInfo
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- CN218629209U CN218629209U CN202222822051.5U CN202222822051U CN218629209U CN 218629209 U CN218629209 U CN 218629209U CN 202222822051 U CN202222822051 U CN 202222822051U CN 218629209 U CN218629209 U CN 218629209U
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- whole blood
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Abstract
The utility model provides a whole blood pretreatment device, which comprises an ultrasonic unit and a water tank; the bearing frame is arranged in the water tank and is driven by the first driving unit to rotate; a plurality of bearing units are rotatably arranged on the bearing frame and are positioned in the water tank; the bearing unit is used for bearing a whole blood container; the second driving unit is used for driving the bearing unit to rotate on the bearing frame. The utility model has the advantages of automation, high treatment efficiency and the like.
Description
Technical Field
The utility model relates to a whole blood detects, in particular to whole blood pretreatment device.
Background
In the detection of a whole blood biological sample, the pretreatment of the sample for protein precipitation before mass spectrometry is required. The protein precipitation is carried out by adding a certain volume of organic solvent (methanol, acetonitrile) into whole blood, coagulating erythrocyte in the whole blood into agglomerate, and denaturing protein precipitation. However, this results in a partial encapsulation of the analyte and a lower analyte content.
In order to disperse the formed clot, the centrifuge tube containing the blood needs to be subjected to ultrasonic treatment to disperse the clot. In the experiment, the clot can be dispersed in a few seconds only when the centrifugal tube is placed at the four corners of the ultrasonic cleaning machine where the vortex ripples exist, and the clot at other places in the ultrasonic cleaning machine can not be uniformly dispersed for a long time.
Such a pretreatment scheme has disadvantages, such as:
1. dispersing 4 samples at a time with slow speed and other remaining samples left for a long time, makes the clot binding more firm and more difficult to disperse;
2. 4 samples are ultrasonically dispersed at one time, the samples are batched in large quantities, and the batch timing is needed, so that errors are easy to occur;
3. the sample is held by hand for ultrasound, which consumes manpower.
SUMMERY OF THE UTILITY MODEL
In order to solve the defects in the prior art, the utility model provides a whole blood pretreatment device.
The utility model aims at realizing through the following technical scheme:
the whole blood pretreatment device comprises an ultrasonic unit and a water tank; the whole blood pretreatment device further comprises:
the bearing frame is arranged in the water tank and driven by the first driving unit to rotate;
the bearing units are rotatably arranged on the bearing frame and are positioned in the water tank; the bearing unit is used for bearing a whole blood container;
the second driving unit is used for driving the bearing unit to rotate on the bearing frame.
Compared with the prior art, the utility model discloses the beneficial effect who has does:
1. the pretreatment efficiency is high;
a plurality of whole blood samples are carried by a rotatable carrier, and a plurality of whole blood samples, such as 3, 4 or more (depending on the number of corners of the ultrasonic water tank), are processed at a time, so that the pretreatment efficiency is improved;
the whole blood sample is not required to be manually prevented from being placed at the corner of the ultrasonic water tank, and the whole blood sample on the bearing frame is automatically placed at the corner of the ultrasonic water tank by placing a plurality of whole blood samples at one time, so that the pretreatment is completed, and the pretreatment efficiency is further improved;
2. the pretreatment effect is good;
when the whole blood sample at the corner of the ultrasonic water tank is subjected to pretreatment, all the whole blood samples on the bearing frame rotate in a standing mode, so that clot combination is prevented, and the pretreatment effect is improved.
Drawings
The disclosure of the present invention will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only intended to illustrate the technical solution of the present invention and are not intended to limit the scope of the present invention. In the figure:
fig. 1 is a schematic top view of a whole blood pretreatment device according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a whole blood pretreatment device according to an embodiment of the present invention.
Detailed Description
Fig. 1-2 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and reproduce the invention. For explaining the technical solution of the present invention, some conventional aspects have been simplified or omitted. Those skilled in the art will appreciate variations or substitutions from these embodiments that will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Accordingly, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.
Example 1:
fig. 1-2 schematically show a schematic structural diagram of a whole blood pretreatment device according to an embodiment of the present invention, and as shown in fig. 1-2, the whole blood pretreatment device includes:
a water tank 11 and an ultrasonic unit (not shown);
a carrier 21 and a first driving unit 22, wherein the carrier 21 is disposed in the sink 11 and is driven by the first driving unit 22 to rotate;
a plurality of bearing units 41, wherein the bearing units 41 are rotatably arranged on the bearing frame 21 and are positioned in the water tank 11; the carrying unit 41 is used for carrying a whole blood container 42, such as a test tube;
a second driving unit for driving the carrying unit 41 to rotate on the carriage 21.
In order to improve the pretreatment efficiency, the carrying units 41 are further uniformly distributed on a concentric circle, and the number of the carrying units is integral multiple of the number of corners of the water tank 11.
In order to drive the plurality of carrying units synchronously, further, the second driving unit includes:
the motor 32 drives the synchronous belt 31 to rotate, and the synchronous belt 31 is wound on the outer sides of the motor 32 and the bearing unit 41.
In order to reduce the structural complexity and cost, further, the carrier comprises:
a plurality of connecting rods connected with the links;
a link connecting the first driving unit.
In order to determine the position of the whole blood sample (carrier unit), further, the whole blood pretreatment apparatus further includes:
a position sensor 51, wherein the position sensor 51 is used for detecting the position of the bearing unit 41.
In order to firmly fix the whole blood sample, further, the carrying unit 41 includes:
a cradle that allows insertion of the container 42 and cradles the container 42 from the bottom;
the clamp spring 43, the clamp spring 43 sets up the inner wall of bracket.
Example 2:
according to the utility model discloses whole blood pretreatment device's of embodiment 1 application example.
In the present application, as shown in fig. 1-2, the water tank 11 has a quadrangular prism shape with four corners; the carrier 21 includes 8 connecting rods and 1 link, 8 connecting rods are connected with the link, the link is connected with the first driving unit 22, the first driving unit 22 adopts a motor, so that the connecting rods are driven by the first driving unit 22 to rotate;
8 carrier units 41, the carrier units 41 including a holder and a clamp spring 43, the holder allowing insertion of a test tube (whole blood container 42) and holding the container 42 from the bottom; the clamp spring 43 is arranged on the inner wall of the bracket and used for clamping the whole blood sample test tube inserted into the bracket; the 8 bearing units 41 are respectively arranged at the tail ends of the connecting rods through bearings 44 and are distributed in concentric circles;
the second driving unit comprises a motor 32 and a synchronous belt 31, the motor 32 drives the synchronous belt 31 to rotate, and the synchronous belt 31 is wound outside the motor 32 and the bearing unit 41;
the position sensor 51 employs an optical coupler for detecting the position of the bearing unit 41.
The whole blood pretreatment apparatus of the present embodiment operates as follows:
inserting 8 whole blood sample tubes into the holder;
the position sensor 51 detects the carrying unit 41, that is, determines the initial position of the carrying unit 41;
the first driving unit 22 drives the carrier 21 to rotate, i.e. revolve, so that the 4 carrier units 41 are located at the 4 corners of the sink 11, and the carrier 21 stops rotating; 4 whole blood samples in the corner of the water tank are subjected to ultrasonic treatment;
meanwhile, the second driving unit drives all 8 bearing units 41 to rotate, namely, to rotate, so as to prevent the coagulation blocks in the test tube from being combined;
after the pretreatment of the 4 whole blood samples is finished, the first driving unit 22 drives the carrier 21 to rotate by 45 degrees and then stops, so that the other 4 carrier units 41 are positioned at the corners of the water tank 11;
the whole blood samples in the other 4 bearing units 41 are subjected to ultrasonic treatment, and simultaneously, the second driving unit drives all 8 bearing units 41 to rotate, so that the coagulation blocks in the test tube are prevented from being combined;
after all the processing is completed, the first driving unit 22 drives the carriage 21 to rotate, and the position sensor 51 detects the rotation until each carriage unit 41 returns to the initial position.
Claims (8)
1. The whole blood pretreatment device comprises an ultrasonic unit and a water tank; it is characterized in that the whole blood pretreatment device further comprises:
the bearing frame is arranged in the water tank and driven by the first driving unit to rotate;
the bearing units are rotatably arranged on the bearing frame and are positioned in the water tank; the bearing unit is used for bearing a whole blood container;
the second driving unit is used for driving the bearing unit to rotate on the bearing frame.
2. The whole blood pretreatment device according to claim 1, wherein the carrier units are uniformly distributed on a concentric circle, and the number is an integral multiple of the number of the corners of the water tank.
3. The whole blood pretreatment device according to claim 1, wherein the second drive unit includes:
the motor drives the synchronous belt to rotate, and the synchronous belt is wound on the outer sides of the motor and the bearing unit.
4. The whole blood pretreatment device according to claim 1, wherein the carrier includes:
a plurality of connecting rods connected with the links;
a link connecting the first driving unit.
5. The whole blood pretreatment device according to claim 1, further comprising:
a position sensor for detecting a position of the carrying unit.
6. The whole blood pretreatment device according to claim 1, wherein the carrier unit includes:
a cradle that allows insertion of the container and cradles the container from the bottom;
the clamp spring is arranged on the inner wall of the bracket.
7. The whole blood pretreatment device according to claim 1, wherein the container is a test tube.
8. The whole blood pretreatment device according to claim 1, wherein the first drive unit includes a motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222822051.5U CN218629209U (en) | 2022-10-26 | 2022-10-26 | Whole blood pretreatment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222822051.5U CN218629209U (en) | 2022-10-26 | 2022-10-26 | Whole blood pretreatment device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218629209U true CN218629209U (en) | 2023-03-14 |
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ID=85472527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222822051.5U Active CN218629209U (en) | 2022-10-26 | 2022-10-26 | Whole blood pretreatment device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN218629209U (en) |
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2022
- 2022-10-26 CN CN202222822051.5U patent/CN218629209U/en active Active
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