CN217697546U

CN217697546U - Transnasal drug delivery device

Info

Publication number: CN217697546U
Application number: CN202221108977.1U
Authority: CN
Inventors: 刘静怡; 陈柱佗
Original assignee: Nasofide Shanghai Pharmaceutical Technology Co ltd
Current assignee: Nasofide Shanghai Pharmaceutical Technology Co ltd
Priority date: 2022-05-10
Filing date: 2022-05-10
Publication date: 2022-11-01
Anticipated expiration: 2032-05-10

Abstract

The utility model provides a medicine liquid device is released in intranasal delivery, include: the device comprises a nose entering device, a positioning device, a quantitative atomizing device and a driving device; the nose inlet device comprises a nose inlet part, a medicine inlet part and a positioning and mounting part, wherein the positioning and mounting part is connected between the nose inlet part and the medicine inlet part; the positioning and mounting part is provided with a plurality of mounting positions along the axial direction of the nose entering device, and the positioning device is detachably mounted on the mounting positions and forms a limiting structure which limits the depth of the nose entering part into the nasal cavity with the nasal opening; the output end of the atomization device is connected with the medicine feeding part, and the driving device is in driving connection with the atomization device. The utility model discloses a positioner adjusts into the nasal part and stretches into the inside degree of depth of nasal cavity, can put into the nasal cavity degree of depth to exploring and carry out accurate location, with the accurate delivery of liquid medicine to the nasal cavity smell district's position, improve the medicine absorption rate. Accurate output of the dosage can be realized through the quantitative atomizing device, and the condition of excessive or too little dosage is avoided.

Description

Transnasal drug delivery device

Technical Field

The utility model relates to a medical appliance, in particular to a device for delivering medicine liquid through the nose.

Background

The administration through the nasal mucosa has been regarded as a drug can be absorbed by the administration mode of high efficiency fast, has a lot of fine villi on the nasal mucosa cell, consequently greatly increased the absorptive effective area of medicine, has abundant blood vessel and lymphatic vessel under the mucosa cell, and the medicine can directly get into the systemic circulation after through the mucosa absorption, and in addition, the metabolic action of the interior enzyme of nasal cavity is less than intestines and stomach, and consequently, nasal cavity delivery system is receiving people's attention increasingly.

From a kinetic point of view, the nasal cavity is a complex organ, since the three different processes of drug administration (drug deposition, drug clearance and drug absorption) are performed in the nasal cavity. The medicine is absorbed from the nasal olfactory region, and an effective administration route is provided for treating certain central nervous system diseases. In addition, nasal administration of vaccines is also very attractive in terms of efficacy and patient acceptance. Therefore, it is desirable to provide a device that ensures delivery site accuracy by nasal delivery.

Common nasal cavity device of dosing is as shown in figure 1, and the user directly puts into the nasal cavity with the nozzle, because the user usually does not know the position that the nasal cavity needs to use medicine, think only need send into the medicine can, even professional medical staff helps the operation, also can only rely on its own experience to predict, be difficult to guarantee the accuracy of sending the medicine position, and absorption efficiency is also relatively lower, and simultaneously, the transport mode of manual push type leads to liquid medicine release amount repetition precision to be low.

SUMMERY OF THE UTILITY MODEL

Aiming at the defects in the prior art, the utility model aims at providing a transnasal drug delivery device.

According to the utility model provides a pair of intranasal delivers medicine liquid device, include: the device comprises a nose entering device 2, a positioning device 1, a quantitative atomizing device 3 and a driving device 4;

the nose-entering device 2 comprises a nose-entering part 21, a medicine feeding part 22 and a positioning and mounting part 23, wherein the positioning and mounting part 23 is connected between the nose-entering part 21 and the medicine feeding part 22;

the positioning and mounting part 23 is provided with a plurality of mounting positions along the axial direction of the nose-entering device 2, the positioning device 1 is detachably mounted on the mounting positions, and a limiting structure for limiting the depth of the nose-entering part 21 entering the nasal cavity is formed by the positioning device and the nasal opening;

the output end of the atomization device 3 is connected with the medicine feeding part 22, and the driving device 4 is in driving connection with the atomization device 3.

Preferably, the mounting location comprises an annular groove, in which the positioning device 1 is detachably connected.

Preferably, the positioning device 1 comprises a strip-shaped structure with a bent middle part, two ends of the strip-shaped structure extend outwards, and the length of the positioning device 1 is larger than the diameter of the nostril.

Preferably, the shape of the nose-in portion 21 is adapted to the inner space of the nasal cavity.

Preferably, the top of the quantitative atomizing device 3 is provided with a medicine bottle interface, and the mouth of the medicine bottle can be filled downwards in the medicine bottle interface.

Preferably, the quantitative atomizing device 3 comprises an atomizing plate, and the driving device 4 drives the atomizing plate to vibrate.

Preferably, the nose-entering portion 21 is of an arc-shaped circular tube structure.

Preferably, the end surface of the nose portion 21 is curved.

Preferably, a driving switch is arranged on the driving device 4.

Preferably, the medicine inlet portion 22 is in a funnel shape with a gradually decreasing diameter, and one end with a smaller diameter is connected to the positioning and mounting portion 23.

Compared with the prior art, the utility model discloses following beneficial effect has:

the utility model discloses a positioner adjusts into the nasal part and stretches into the inside degree of depth of nasal cavity, can put into the degree of depth of probing into the nasal cavity and carry out accurate location, with the accurate delivery of liquid medicine to the nasal cavity smell district's position, improve the medicine absorptivity.

The utility model discloses a quantitative atomizing device can realize the accurate output of dose, avoids using medicine excessive or the condition too little.

Drawings

Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:

FIG. 1 is a schematic view of a nasal delivery device of the prior art;

FIG. 2 is a perspective view of the drug delivery device of the present invention through the nose;

FIG. 3 is a perspective view of the nasal device;

figure 4 is a side view of the nasal device.

Detailed Description

The present invention will be described in detail with reference to the following embodiments. The following examples will assist those skilled in the art in further understanding the present invention, but are not intended to limit the invention in any way. It should be noted that various changes and modifications can be made by one skilled in the art without departing from the spirit of the invention. These all belong to the protection scope of the present invention.

As shown in figure 2, the utility model provides a drug delivery device through nose, which comprises: the nasal device 2, the positioning device 1, the quantitative atomizing device 3 and the driving device 4. The front end of the nasal device 2 is used for probing into the nasal cavity to deliver medicine, the rear end of the nasal device is used for being connected with the output end of the quantitative atomization device 3 to obtain the liquid medicine delivered by the medicine delivery device, and the nasal device 2 and the positioning device 1 are internally provided with medicine delivery pipelines which are communicated with each other. Go into nose portion 21's shape and nasal cavity inner space looks adaptation, avoid going into the outer wall touch damage nasal cavity inner wall of nose portion 21, guarantee simultaneously to deliver liquid medicine position directional nasal cavity and smell the district. Drive arrangement 4 is connected with atomizing device 3 drive for drive 3 work of ration atomizing device, ration atomizing device 3's top is provided with the medicine bottle interface, and the bottleneck of medicine bottle 5 can the flip-chip down in the medicine bottle interface, and the liquid medicine gets into the cavity in the ration atomizing device 3 through self gravity.

As shown in fig. 3, the nasal device 2 includes a nasal portion 21, a medicament delivery portion 22, and a locator-mounting portion 23, the locator-mounting portion 23 being connected between the nasal portion 21 and the medicament delivery portion 22. The nose portion 21 is a portion for inserting into the nasal cavity to deliver the medicine, and the medicine inlet portion 22 is a portion for attaching a medicine delivery device. Wherein, go into nose part 21 and adopt the flexible material of food level safety material, simultaneously, go into nose part 21 and be the arc pipe structure, the terminal surface of going into nose part 21 is the cambered surface to guarantee the health after getting into the nasal cavity and avoid stabbing. The medicine inlet part 22 is in a funnel shape with gradually decreasing diameter, one end with small diameter is connected with the positioning installation part 23, the other end with large diameter is connected with the medicine conveying device, and the medicine liquid is conveyed into the medicine inlet part 22, so that the conveyed medicine liquid has a certain distance.

As shown in fig. 4, the positioning and mounting portion 23 includes a plurality of mounting positions arranged along the axial direction of the nose-entering device 2, and the positioning device 1 is detachably mounted on the mounting positions to form a limiting structure with the nostril for limiting the depth of the nose-entering portion 21 entering the nasal cavity. The mounting position is an annular groove, and the positioning device 1 is partially connected in the annular groove and extends towards the outside of the annular groove. The positioning device 1 is a strip-shaped structure with a bent middle part, the size and the shape of the bent part are matched with the groove, the bending part can be clamped in the groove in an interference manner, and the length of the strip-shaped structure is larger than the diameter of the nostril.

The quantitative atomizer 3 adopts a commercially available quantitative atomizer, generally based on the ultrasonic atomization principle, and comprises an atomization sheet inside, and the atomization sheet drives the atomization sheet to vibrate through the driving device 4, so that liquid medicine atomization is realized. The driving device 4 is provided with a driving switch, and a user controls the driving device 4 to work by pressing the driving switch.

The use method of the transnasal drug delivery device is as follows:

step 1: the depth of the nasal sniff region of the target is detected using an endoscope.

Step 2: the medicine bottle is inserted into the medicine bottle interface at the top of the quantitative atomizing device 3, so that the medicine liquid enters the quantitative atomizing device 3.

And step 3: the positioning device 1 is pressed and fixed in the groove of the corresponding positioning installation part 23, so that the length from the end part of the nose part 21 to the positioning device 1 is equal to the measured depth of the nasal cavity olfactory region.

And 4, step 4: the nose-entering portion 21 is extended into the target nasal cavity until the positioning device 1 is stopped at the nostril.

And 5: the drive means 4 is activated to deliver the liquid medicine to the nasal olfactory region.

In the description of the present application, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, merely for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and therefore, are not to be construed as limiting the present application.

The foregoing description of the specific embodiments of the invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by those skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.

Claims

1. A device for transnasally delivering a medicament, comprising: the nasal cavity device comprises a nasal inlet device (2), a positioning device (1), a quantitative atomizing device (3) and a driving device (4);

the nose-entering device (2) comprises a nose-entering part (21), a medicine-feeding part (22) and a positioning and mounting part (23), wherein the positioning and mounting part (23) is connected between the nose-entering part (21) and the medicine-feeding part (22);

the positioning and mounting part (23) is provided with a plurality of mounting positions along the axial direction of the nose-entering device (2), and the positioning device (1) is detachably mounted on the mounting positions and forms a limiting structure with the nostrils for limiting the depth of the nose-entering part (21) entering the nasal cavity;

the output end of the atomization device (3) is connected with the medicine feeding part (22), and the driving device (4) is in driving connection with the atomization device (3).

2. A device for transnasally delivering medicament release according to claim 1, wherein the mounting location comprises an annular groove, the retainer (1) being removably attached within the annular groove.

3. A device for transnasally delivering drug delivery solution according to claim 1, wherein the positioning device (1) comprises a bar-shaped structure with a curved middle part, both ends of the bar-shaped structure extending outwards, and the length of the positioning device (1) is greater than the diameter of the nostril.

4. A device according to claim 1, wherein the nose portion (21) is shaped to fit the internal space of the nasal cavity.

5. A device for transnasally delivering medicament according to claim 1, characterized in that the quantitative atomizing device (3) is provided at the top with a vial socket in which the mouth of a vial can be fitted upside down.

6. Device according to claim 1, wherein the metered dose atomization device (3) comprises an atomization patch and the drive means (4) drives the patch to vibrate.

7. A device for transnasally delivering medicament delivery according to claim 1, wherein the nose portion (21) has an arcuate round tube configuration.

8. A device for delivery of drug substances through the nose according to claim 1, wherein the end face of the nose portion (21) is cambered.

9. A device for transnasally delivering medicament according to claim 1, wherein the actuating means (4) is provided with an actuating switch.

10. A device for transnasally delivering medicament release according to claim 1, wherein the inlet portion (22) is funnel-shaped with a gradually decreasing diameter, and one end with a smaller diameter is connected to the positioning and mounting portion (23).