CN114602046A

CN114602046A - Device for delivering liquid medicine to nasal cavity olfactory region and using method thereof

Info

Publication number: CN114602046A
Application number: CN202210500673.8A
Authority: CN
Inventors: 刘静怡; 陈柱佗
Original assignee: Nasofide Shanghai Pharmaceutical Technology Co ltd
Current assignee: Nasofide Shanghai Pharmaceutical Technology Co ltd
Priority date: 2022-05-10
Filing date: 2022-05-10
Publication date: 2022-06-10

Abstract

The invention provides a device for delivering liquid medicine to nasal cavity olfactory region and a using method thereof, comprising the following steps: a nose-entering device and a positioning device; the nose inlet device comprises a nose inlet part and a positioning and mounting part, one end of the positioning and mounting part is connected with the nose inlet part, and the other end of the positioning and mounting part is used as an input end to be connected with an external liquid medicine source; the locating and mounting part is provided with a plurality of mounting positions along the axial direction, the locating device is sleeved with the locating and mounting part in a sliding mode, the locating and mounting part can be limited in the mounting positions and forms a limiting structure with nostrils for limiting the depth of the nasal cavity entering the nasal cavity. According to the invention, the depth of the nose part extending into the nasal cavity is adjusted by the positioning device, so that the device can be accurately positioned when the nose part extends into the nasal cavity, and the liquid medicine is accurately delivered to the olfactory region of the nasal cavity.

Description

Device for delivering liquid medicine to nasal cavity olfactory region and using method thereof

Technical Field

The invention relates to the field of medical equipment, in particular to a device for delivering liquid medicine to nasal cavity olfactory region and a using method thereof.

Background

The administration through the nasal mucosa has been regarded as a drug can be absorbed by the administration mode of high efficiency fast, has a lot of fine villi on the nasal mucosa cell, consequently greatly increased the absorptive effective area of medicine, has abundant blood vessel and lymphatic vessel under the mucosa cell, and the medicine can directly get into the systemic circulation after through the mucosa absorption, and in addition, the metabolic action of the interior enzyme of nasal cavity is less than intestines and stomach, and consequently, nasal cavity delivery system is receiving people's attention increasingly.

From a kinetic point of view, the nasal cavity is a complex organ, because the three different processes of drug administration (drug deposition, drug clearance and drug absorption) are all performed in the nasal cavity. The medicine is absorbed from the nasal olfactory region, and an effective administration route is provided for treating certain central nervous system diseases. In addition, nasal administration of vaccines is also very attractive in terms of efficacy and patient acceptance. Therefore, it is desirable to provide a device that ensures delivery site accuracy by nasal delivery.

A conventional nasal cavity administration device, such as one disclosed in patent document CN204723587U, is used by a user to directly place the device in the nasal cavity, and the user usually does not know the position of the nasal cavity to be administered, so that the user only needs to send the drug into the nasal cavity.

Disclosure of Invention

In view of the deficiencies in the prior art, it is an object of the present invention to provide a device for delivering a liquid drug to the nasal olfactory region and a method of using the same.

According to the present invention there is provided a device for delivering a liquid medicament to the olfactory region of the nasal cavity, comprising: a nose-entering device 2 and a positioning device 1;

the nose-entering device 2 comprises a nose-entering part 21 and a positioning and mounting part 23, one end of the positioning and mounting part 23 is connected with the nose-entering part 21, and the other end of the positioning and mounting part 23 is used as an input end to be connected with an external liquid medicine source;

the positioning and mounting part 23 is provided with a plurality of mounting positions along the axial direction, the positioning device 1 is slidably sleeved on the positioning and mounting part 23 and can be limited in the mounting positions to form a limiting structure for limiting the depth of the nose entering part 21 into the nasal cavity with the nostril.

Preferably, a plurality of axially distributed projections are symmetrically arranged on two sides of the positioning and mounting portion 23, and a space between every two adjacent projections constitutes the mounting position.

Preferably, the positioning device 1 comprises an annular structure and an extension part connected with the annular structure and extending radially outwards, and the inner side surface of the annular structure can be in interference fit with two lugs in opposite positions.

Preferably, the shape of the nose-in portion 21 is adapted to the inner space of the nasal cavity.

Preferably, the nose portion 21 is in a funnel shape with a gradually decreasing diameter, and one end with a larger diameter is connected to the positioning and mounting portion 23.

Preferably, the length of the positioning device 1 is greater than the diameter of the nostril.

Preferably, the nose inlet portion 21 and the positioning and mounting portion 23 have drug delivery lines therein that communicate with each other.

Preferably, the nose-entering portion 21 is of an arc-shaped circular tube structure.

Preferably, the end surface of the nose-in portion 21 is curved.

According to the invention, the use method of the device for delivering the liquid medicine to the nasal olfactory region comprises the following steps:

step 1: detecting a nasal olfactory depth of a target using an endoscope;

step 2: mounting the positioning device 1 on a corresponding mounting position, and enabling the length from the end part of the nose inlet part 21 to the positioning device 1 to be equal to the measured depth of the nasal cavity olfactory region;

and step 3: the nose-entering portion 21 is extended into the target nasal cavity until the positioning device 1 is stopped at the nostril.

Compared with the prior art, the invention has the following beneficial effects:

according to the invention, the depth of the nose part extending into the nasal cavity is adjusted by the positioning device, so that the device can be accurately positioned when the nose part extends into the nasal cavity, and the liquid medicine is accurately delivered to the olfactory region of the nasal cavity.

Drawings

Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:

FIG. 1 is a perspective view of the present invention;

fig. 2 is a perspective view from another perspective of the present invention.

Detailed Description

The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that it would be obvious to those skilled in the art that various changes and modifications can be made without departing from the spirit of the invention. All falling within the scope of the present invention.

As shown in figures 1 and 2, the device for delivering liquid medicine to the nasal olfactory region comprises a nasal device 2 and a positioning device 1. The front end of the nasal device 2 is used for extending into the nasal cavity to deliver medicine, and the rear end is used for connecting an external medicine liquid source to obtain medicine liquid.

In the present invention, the nose-inlet device 2 includes a nose-inlet portion 21 and a positioning and mounting portion 23, and one end of the positioning and mounting portion 23 is connected to the nose-inlet portion 21. The nose portion 21 is a portion for penetrating into the nasal cavity to deliver the medicine. Wherein, go into nose part 21 and adopt the flexible material of food level safety material, simultaneously, go into nose part 21 and be the arc pipe structure, the terminal surface of going into nose part 21 is the cambered surface to guarantee the health after getting into the nasal cavity and avoid stabbing. The nose portion 21 is in a funnel shape with gradually decreasing diameter, and one end with larger diameter is connected with the positioning and mounting portion 23. The nasal device 2 is internally provided with drug delivery pipelines which are communicated with each other. The shape of the nose part 21 is matched with the inner space of the nasal cavity, so that the outer wall of the nose part 21 is prevented from touching and damaging the inner wall of the nasal cavity, and meanwhile, the position of delivering the liquid medicine is ensured to point to the nasal cavity olfactory region.

The positioning and mounting part 23 comprises a plurality of mounting positions arranged along the axial direction of the nose-entering device 2, and the positioning device 1 is slidably sleeved on the positioning and mounting part 23 and forms a limiting structure with the nostril for limiting the depth of the nose-entering part 21 entering the nasal cavity.

A plurality of axially distributed projections 24 are symmetrically arranged on both sides of the positioning and mounting portion 23, and the space between every two adjacent projections constitutes the mounting position 25. The positioning device 1 comprises an annular structure and an extension part which is connected with the annular structure and extends outwards and radially, and the inner side surface of the annular structure can be in interference fit with two lugs in opposite positions.

The use method of the device for delivering the liquid medicine to the nasal cavity olfactory region comprises the following steps:

step 1: the depth of the nasal olfactory region of the subject is probed using an endoscope.

Step 2: the positioning device 1 is mounted in the corresponding mounting position 25 such that the length of the end of the nose portion 21 to the positioning device 1 is equal to the measured nasal olfactory depth.

And 4, step 4: the drug delivery device is activated to deliver the liquid drug to the nasal olfactory region.

In the description of the present application, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present application.

The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.

Claims

1. A device for delivering a liquid to the nasal olfactory region, comprising: a nose-entering device (2) and a positioning device (1);

the nose inlet device (2) comprises a nose inlet part (21) and a positioning and mounting part (23), one end of the positioning and mounting part (23) is connected with the nose inlet part (21), and the other end of the positioning and mounting part (23) is used as an input end to be connected with an external liquid medicine source;

the positioning and mounting part (23) is provided with a plurality of mounting positions along the axial direction, the positioning device (1) is sleeved on the positioning and mounting part (23) in a sliding way and can be limited in the mounting positions, and a limiting structure for limiting the depth of the nose entering part (21) into the nasal cavity is formed between the positioning device and the nasal opening;

a plurality of axially distributed convex blocks are symmetrically arranged on two sides of the positioning and mounting part (23), and the space between every two adjacent convex blocks forms the mounting position;

the positioning device (1) comprises an annular structure and an extension part which is connected with the annular structure and extends outwards and radially, and the inner side surface of the annular structure can be in interference fit with two lugs in opposite positions;

the length of the positioning device (1) is larger than the diameter of the nostril;

the shape of the nose inlet part (21) is matched with the inner space of the nasal cavity.

2. A device for delivering liquid medicine to the nasal cavity and olfactory region as claimed in claim 1 wherein the nose-in portion (21) is funnel shaped with gradually decreasing diameter and the larger end is connected to the positioning and mounting portion (23).

3. Device for delivering medical liquids to the nasal olfactory region as claimed in claim 1, characterized in that the nasal inlet portion (21) and the positioning and mounting portion (23) have inside them mutually communicating delivery conduits.

4. The device for delivering a liquid medicine to the nasal olfactory region as claimed in claim 1 wherein the nose-entering portion (21) is of an arcuate tubular configuration.

5. A device for delivering medicinal liquids to the nasal olfactory region as claimed in claim 1 wherein the end face of the nose-entering portion (21) is cambered.

6. A method of using a device for delivering a liquid to the nasal olfactory region as claimed in claim 1 comprising:

step 1: detecting a nasal olfactory depth of a target using an endoscope;

step 2: mounting the positioning device (1) on a corresponding mounting position, and enabling the length from the end part of the nose inlet part (21) to the positioning device (1) to be equal to the measured depth of the nasal cavity olfactory region;

and step 3: the nose-entering part (21) is extended into the target nasal cavity until the positioning device (1) is limited at the nasal orifice.