CN217505795U - Sample analyzer - Google Patents

Abstract

The embodiment of the application provides a sample analyzer, which comprises a reagent accommodating component, an accommodating component, a reagent providing component and an in-place detection component, wherein the reagent accommodating component is internally provided with an accommodating cavity with an opening at one end and used for accommodating a reagent container; the reagent supply assembly comprises a reagent pipeline and first power equipment connected to the reagent pipeline, one end of the reagent pipeline is used for being communicated with the first reagent outlet of the reagent container, and a second reagent outlet is formed at the other end of the reagent pipeline, so that the reagent in the reagent container is supplied to the accommodating assembly from the second reagent outlet under the action of the first power equipment; and the in-place detection assembly generates state change when the connection state of the first reagent outlet of the reagent container and the reagent pipeline is switched from disconnection to connection. Whether the reagent vessel is securely connected to the reagent holding assembly can be detected by the in-situ detection assembly.

Description

Sample analyzer

Technical Field

The application relates to the technical field of medical equipment, in particular to a sample analyzer.

Background

Sample analyzers, such as electrolyte analyzers, are generally composed of an instrument and a reagent, and the existing instruments on the market usually require manual clicking operations on a software interface when changing the reagent, and a user needs to spend great efforts to check whether a reagent pack is reliably connected to the instrument.

SUMMERY OF THE UTILITY MODEL

The present application provides a sample analyzer that aims to detect whether a reagent container is reliably connected to the instrument.

In a first aspect, an embodiment of the present application provides a sample analyzer, including:

the reagent accommodating component is internally provided with an accommodating cavity with one end opened and used for accommodating a reagent container;

an accommodating component;

the reagent supply assembly comprises a reagent pipeline and a first power device connected to the reagent pipeline, one end of the reagent pipeline is used for being communicated with the first reagent outlet of the reagent container, and the other end of the reagent pipeline is provided with a second reagent outlet, so that the reagent in the reagent container is supplied to the accommodating assembly from the second reagent outlet under the action of the first power device;

and the in-place detection assembly generates state change when the connection state of the first reagent outlet of the reagent container and the reagent pipeline is switched from disconnection to connection.

The embodiment of the application provides a sample analyzer, which comprises a reagent accommodating component, an accommodating component, a reagent providing component and an in-place detection component, wherein an accommodating cavity with one end opened and used for accommodating a reagent container is arranged in the reagent accommodating component; the reagent supply assembly comprises a reagent pipeline and first power equipment connected to the reagent pipeline, one end of the reagent pipeline is used for being communicated with the first reagent outlet of the reagent container, and a second reagent outlet is formed at the other end of the reagent pipeline, so that the reagent in the reagent container is supplied to the accommodating assembly from the second reagent outlet under the action of the first power equipment; and the in-place detection assembly generates state change when the connection state of the first reagent outlet of the reagent container and the reagent pipeline is switched from disconnection to connection. Whether the reagent vessel is securely connected to the reagent holding assembly may be detected by the in-situ detection assembly.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure of the embodiments of the present application.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

Fig. 1 is a schematic structural diagram of a sample analyzer provided in an embodiment of the present application;

FIG. 2 is a schematic block diagram of a sample analyzer in one embodiment;

FIG. 3 is a schematic block diagram of a sample analyzer in another embodiment;

FIG. 4 is a schematic view of one embodiment of a reagent container placed in a reagent containment assembly;

FIG. 5 is a schematic diagram of the structure of a reagent holding assembly according to one embodiment;

FIG. 6 is a schematic view of one embodiment of a reagent container placed in a reagent containment assembly;

FIG. 7 is a schematic view of a reagent container in one embodiment;

8-9 are schematic views of some embodiments of a first boss abutting a microswitch;

FIGS. 10-11 are schematic structural views of a reagent holding assembly according to some embodiments;

FIG. 12 is a schematic diagram of the structure of a sample analyzer in one embodiment;

fig. 13 is a schematic view of the structure of a sample analyzer according to another embodiment.

Description of reference numerals:

110. a reagent containment assembly; 101. an accommodating cavity; 111. a side plate; 1111. a guide structure; 112. a back plate; 113. a fixing member; 114. a guard; 120. an accommodating component; 130. a reagent supply assembly; 131. a reagent line; 131a, a first sub-reagent line; 131b, a second sub-reagent line; 1311. a second reagent outlet; 1311a, a first sub-reagent outlet; 1311b, a second sub-reagent outlet; 1312. a reagent inlet; 132. A first power plant; 132a, a first reagent pump; 132b, a second reagent pump; 140. an in-situ detection component; 150. a detection device; 160. a radio frequency identification component; 170. a sample dispensing assembly; 180. a drainage assembly; 181. a second power plant; 182. a liquid discharge port; 190. an indicator light;

200. a reagent container; 201. a first surface; 202. a second surface; 210. a first reagent outlet; 220. A hand-held portion; 230. a first boss portion; 240. a second boss;

10. a functional module; 11. a sample part; 12. a sample dispensing mechanism; 13. a reagent component; 14. a reagent dispensing mechanism; 15. a blending mechanism; 16. a reaction member; 17. a light measuring component; 20. an input module; 30. A display module; 40. a memory; 50. a processor; 60. and an alarm module.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some, but not all, embodiments of the present application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

The flow diagrams depicted in the figures are merely illustrative and do not necessarily include all of the elements and operations/steps, nor do they necessarily have to be performed in the order depicted. For example, some operations/steps may be decomposed, combined or partially combined, so that the actual execution sequence may be changed according to the actual situation.

Some embodiments of the present application will be described in detail below with reference to the accompanying drawings. The embodiments described below and the features of the embodiments can be combined with each other without conflict.

Referring to fig. 1, fig. 1 is a schematic structural diagram of a sample analyzer according to an embodiment of the present disclosure.

In some embodiments, the sample analyzer includes, but is not limited to, at least one of: electrolyte analyzer, biochemical analyzer, immunity analyzer, blood coagulation analyzer, urine analyzer. The electrolyte analyzer is, for example, an ISE (Ion Selective Electrode) analyzer.

Illustratively, the sample analyzer is an ISE analysis module in a biochemical analyzer, which may further comprise at least one of an immunoassay module, a coagulation analysis module, a urine analysis module, and the like.

Before explaining the present invention in detail, a description will be given of the structure of a sample analyzer in some embodiments.

Referring to fig. 2, one embodiment discloses a sample analyzer, which includes at least one functional module 10 (or one or more functional modules 10), an input module 20, a display module 30, a memory 40, a processor 50, and an alarm module 60, which are described below.

Each functional module 10 is used for performing at least one function required in the sample analysis process, and the functional modules 10 cooperate together to perform the sample analysis to obtain the result of the sample analysis. Referring to fig. 3, a sample analyzer according to an embodiment is shown, in which some examples are given to the functional module 10. For example, the functional module 10 may include a sample cell 11, a sample dispensing mechanism 12, a reagent cell 13, a reagent dispensing mechanism 14, a kneading mechanism 15, a reaction cell 16, an optical measurement cell 17, and the like.

The sample block 11 is used to carry a sample. In some examples, the Sample unit 11 may include a Sample Delivery Module (SDM) and a front end rail; in other examples, the sample section 10 may be a sample disk including a plurality of sample sites on which sample tubes, for example, can be placed, and the sample disk may be configured to rotate to dispatch the sample to a corresponding position, for example, a position where the sample is aspirated by the sample pipetting mechanism 12.

The sample dispensing mechanism 12 is used for sucking a sample and discharging the sample into a reaction cup to be loaded. For example, the sample dispensing mechanism 12 may include a sample needle that performs a two-dimensional or three-dimensional motion in space by a two-dimensional or three-dimensional driving mechanism, so that the sample needle can move to aspirate a sample carried by the sample member 11 and to a cuvette to be loaded and discharge the sample to the cuvette.

The reagent component 13 is used to carry reagents. In one embodiment, the reagent unit 13 may be a reagent disk, which is configured in a disk-shaped structure and has a plurality of positions for holding reagent containers, and the reagent unit 13 can rotate and drive the reagent containers held by the reagent unit to rotate to a specific position, for example, a position for sucking reagent by the reagent dispensing mechanism 14. The number of the reagent member 13 may be one or more.

The reagent dispensing mechanism 14 suctions and discharges a reagent into a reaction cuvette to be filled with the reagent. In one embodiment, the reagent dispensing mechanism 14 may include a reagent needle that performs a two-dimensional or three-dimensional motion in space by a two-dimensional or three-dimensional driving mechanism, so that the reagent needle can move to aspirate a reagent carried by the reagent unit 13 and to a cuvette to which the reagent is to be added and discharge the reagent to the cuvette.

The mixing mechanism 15 is used for mixing the reaction liquid to be mixed in the reaction cup. The number of the kneading mechanisms 15 may be one or more.

The reaction part 16 has at least one placing position for placing the cuvette and incubating the reaction solution in the cuvette. For example, the reaction component 16 may be a reaction tray, which is configured in a disc-shaped structure and has one or more placing positions for placing reaction cups, and the reaction tray can rotate and drive the reaction cups in the placing positions to rotate for scheduling the reaction cups in the reaction tray and incubating reaction liquid in the reaction cups.

The photometric unit 17 is used to perform photometric measurement on the reaction solution after completion of incubation, and to obtain reaction data of the sample. For example, the photodetector 17 detects the light emission intensity of the reaction solution to be measured, and calculates the concentration of the component to be measured in the sample from the calibration curve. In one embodiment, the photometric component 17 is separately disposed outside the reaction component 16.

While the above is some examples of the functional module 10, the following continues with a description of other components and structures in the sample analyzer.

The input module 20 is used for receiving input of a user. The input module 20 may be a mouse, a keyboard, or the like, as is common, and in some cases, may be a touch-sensitive display screen that provides a function for a user to input and display content, and thus in this example, the input module 20 and the display module 30 are integrated. Of course, in some instances, the input module 20 may even be a voice input device or the like that facilitates recognizing speech.

The display module 30 may be used to display information. In some embodiments, the sample analyzer itself may be integrated with the display module, and in some embodiments, the sample analyzer may also be connected to a computer device (e.g., a computer) to display information through a display unit (e.g., a display screen) of the computer device, which are all within the scope of the present disclosure as defined and protected by the display module 30.

For convenience of explanation, the following description will be made mainly taking a sample analyzer as an electrolyte analyzer, such as an ISE analyzer, as an example. Compared with other ion detection devices, such as an atomic absorption spectrophotometer, an ICP (Inductively Coupled Plasma) mass spectrometer, an ion chromatograph and the like, the electrolyte analysis instrument has the advantages of high precision, good accuracy, high speed, simple operation and the like.

As shown in fig. 1, the sample analyzer includes a reagent holding assembly 110, a holding assembly 120, a reagent providing assembly 130, and an in-situ detection assembly 140.

The reagent accommodating assembly 110 is provided with an accommodating cavity 101 with an opening at one end for accommodating the reagent container 200; the reagent in the reagent container 200 includes, for example, an internal standard solution, a cleaning solution, a diluent, a reference solution, and the like, but is not limited thereto. The reagent container 200 is, for example, a reagent pack, and the reagent holding assembly 110 may be referred to as a reagent cartridge.

Specifically, the reagent container 200 may be placed in the accommodating chamber 101 of the reagent accommodating assembly 110, or may be taken out of the accommodating chamber 101. It will be appreciated that after removal of the reagent vessel 200, another reagent vessel 200 may be placed in the receiving chamber 101 of the reagent holding assembly 110.

As shown in fig. 1, the reagent supplying assembly 130 includes a reagent pipeline 131 and a first power device 132 connected to the reagent pipeline 131, one end of the reagent pipeline 131 is used for communicating with the first reagent outlet 210 of the reagent container 200, and the other end is formed with a second reagent outlet 1311, so that the reagent in the reagent container 200 is supplied from the second reagent outlet 1311 to the accommodating assembly 120 by the first power device 132.

For example, the reagent provided to the containment assembly 120 may be used to clean the containment assembly 120 and/or used for testing to obtain parameters of the reagent, such as electrolyte information.

Illustratively, as shown in fig. 4 and 5, one end of the reagent line 131 for communicating with the first reagent outlet 210 of the reagent vessel 200 is formed with a reagent inlet 1321. Optionally, the reagent inlet 1321 is, for example, a female head, and the first reagent outlet 210 is a male head. The female connector is, for example, a rubber female connector, and is used to communicate the male connector behind the reagent container 200 with the reagent line 131 inside the instrument. When the reagent inlet 1321 is connected to the first reagent outlet 210, reagent transfer between the reagent container 200 and the reagent line 131 and the like can be performed.

Specifically, the in-place detecting assembly 140 is used for detecting the connection state of the first reagent outlet 210 of the reagent container 200 and the reagent line 131.

Specifically, the presence detection module 140 generates a state change when the connection state of the first reagent outlet 210 of the reagent container 200 and the reagent line 131 is switched from off to on.

Alternatively, when the reagent vessel 200 is placed in the accommodating chamber 101 of the reagent holding assembly 110, the first reagent outlet 210 of the reagent vessel 200 can be connected to the reagent line 131 and generate a state change in the presence detection assembly 140.

In some embodiments, as shown in fig. 4, the reagent accommodating assembly 110 includes a side plate 111 and a back plate 112 connected to the side plate 111, the side plate 111 and the back plate 112 form an accommodating chamber 101 for accommodating the reagent container 200, and the back plate 112 is disposed opposite to an opening of the accommodating chamber 101. Illustratively, the side plate 111 and the back plate 112 are main structures of the reagent holding assembly 110, and may provide a mounting base for other components. For example, an opening may be provided on the side plate 111 and/or the back plate 112, and the reagent inlet 1321, the in-situ detection module 140, and the like may be provided at the opening of the side plate 111 and/or the back plate 112.

The reagent holding unit 110 and the reagent container 200 are not limited to a rectangular parallelepiped shape, and may be, for example, a cylindrical shape or another columnar structure.

Alternatively, as shown in fig. 4, the reagent inlet 1321 of the reagent pipeline 131 may be fixed on the back plate 112 of the reagent accommodating component 110 by a fixing member 113, such as on the side of the back plate 112 away from the accommodating chamber 101, or may be referred to as the back of the reagent accommodating component 110. When the reagent container 200 is pushed a distance from the opening of the accommodating chamber 101, the first reagent outlet 210 of the reagent container 200 is connected to the reagent inlet 1321 of the reagent line 131.

In some embodiments, in-situ detection assembly 140 may be disposed on housing chamber 101 of reagent holding assembly 110, for example, on back plate 112 of reagent holding assembly 110, on side plate 111 of reagent holding assembly 110, or may also be disposed on a cover plate of reagent holding assembly 110. The cover plate is arranged opposite to the back plate 112, the side plate 111 is perpendicular to the back plate 112 to form an accommodating cavity 101 for accommodating the reagent container 200, and the cover plate is used for closing or opening the accommodating cavity 101; nor may the cover plate be included. One end of the accommodating cavity 101 is open, the reagent container 200 enters the accommodating cavity 101 through the opening, and the opening of the accommodating cavity 101 is opposite to the back plate 112;

illustratively, as shown in fig. 4 and 5, the presence detection assembly 140 is disposed on the backplane 112. When the reagent container 200 is pushed in a certain distance from the opening of the housing chamber 101, the first reagent outlet 210 of the reagent container 200 is connected to the reagent inlet 1321 of the reagent line 131, and the in-place detecting unit 140 provided on the back plate 112 can detect the approach or abutment of the reagent container 200.

In some embodiments, the presence detection component 140 is a switch component, and the state change of the presence detection component 140, i.e. the on state change, can be represented by the output signal or level.

Illustratively, the presence detection assembly 140 includes a micro-switch. When the reagent container 200 is placed in the accommodating chamber 101 and the first reagent outlet 210 of the reagent container 200 is communicated with the reagent pipeline 131, the conduction state of the micro switch changes, and the state change of the on-site detection assembly 140 includes the change of the conduction state of the micro switch.

For example, the micro switch is disposed on the back plate 112 of the reagent accommodating component 110, when the reagent container 200 is placed in the accommodating chamber 101 and the first reagent outlet 210 of the reagent container 200 is communicated with the reagent pipeline 131, one side of the reagent container 200 facing the back plate 112 abuts against the micro switch, and the conduction state of the micro switch is changed.

For example, when the reagent container 200 is placed in the accommodating chamber 101 and the first reagent outlet 210 of the reagent container 200 is communicated with the reagent pipeline 131, the micro switch is in a closed state, and when the first reagent outlet 210 of the reagent container 200 is disconnected from the reagent pipeline 131, the micro switch is in an open state; the switching of the micro-switch from the open state to the closed state may be referred to as a state change. Or when the reagent container 200 is placed in the accommodating chamber 101 and the first reagent outlet 210 of the reagent container 200 is communicated with the reagent pipeline 131, the microswitch is in an off state, and when the first reagent outlet 210 of the reagent container 200 is disconnected from the reagent pipeline 131, the microswitch is in a closed state; the switching of the micro-switch from the closed state to the open state may be referred to as a state change.

Referring to fig. 6 and 7, the reagent container 200 includes a first surface 201 and a second surface 202 opposite to each other, the first surface 201 is provided with a handle portion 220, and the second surface 202 is provided with a first protrusion portion 230 at a position corresponding to the micro switch. The hand-held portion 220 may facilitate the user to take the reagent vessel 200.

In some examples, referring to fig. 8 and 9, when the reagent container 200 is placed in the accommodating chamber 101 and the first reagent outlet 210 of the reagent container 200 is communicated with the reagent pipeline 131, the first protrusion 230 of the reagent container 200 abuts against the micro switch to change the micro switch from closed to open. It will be appreciated that the structures in the right circle in fig. 8 and 9 are enlarged illustrations of the structures in the left circle.

In other examples, when the reagent container 200 is placed in the accommodating chamber 101 and the first reagent outlet 210 of the reagent container 200 is communicated with the reagent pipeline 131, the first protrusion 230 of the reagent container 200 abuts against the micro switch to change the micro switch from open to closed.

Referring to fig. 8 and 9, in the process of the medical staff placing the reagent container 200 into the accommodating cavity 101 of the reagent containing assembly 110, the male end of the second surface 202 of the reagent container 200 can be inserted into the rubber female end of the back plate 112 of the reagent containing assembly 110; when the depth D of the male plug inserted into the rubber female plug is greater than or equal to the minimum liquid-tight depth Dmin, the first protrusion 230 of the second surface 202 of the reagent container 200 enters into the trigger stroke of the micro switch, and the micro switch is triggered to generate the change of the conducting state.

The first protruding part 230 behind the back of the reagent container 200 triggers the change of the conducting state of the microswitch, and the microswitch can be arranged behind the reagent containing assembly 110 and away from the opening of the containing cavity 101, so that the influence of splashing of liquid in the containing cavity 101 on the microswitch under the unexpected condition can be avoided.

Optionally, as shown in fig. 7, the second surface 202 of the reagent container 200 is further provided with a second protrusion 240, the second protrusion 240 is disposed adjacent to the first protrusion 230, and the height of the second protrusion 240 is smaller than that of the first protrusion 230. During the process of placing the reagent container 200 into the accommodating cavity 101, the distance between the first protruding portion 230 and the back plate 112 is smaller than the distance between the second protruding portion 240 and the back plate 112. When the reagent container 200 continues to move toward the back plate 112 of the reagent holding module 110 after the microswitch is triggered and the on state changes, the second protrusion 240 of the second surface 202 of the reagent container 200 may abut against the back plate 112 to restrict the reagent container 200 from continuing to be inserted; the micro switch is prevented from being shortened due to the fact that the motion of the micro switch exceeds the travel limit of the micro switch, and therefore the micro switch is protected.

It will be appreciated that the presence detection assembly 140 is not limited to a micro switch, and other types of position sensors, such as an opto-electric coupled sensor, may be used, for example. For example, the photoelectric coupling sensor is a reflective photoelectric coupler, the reflective photoelectric coupler is disposed on the back plate 112 of the reagent container assembly 110, when the reagent container 200 is placed in the accommodating chamber 101 and the first reagent outlet 210 of the reagent container 200 is communicated with the reagent pipeline 131, one side of the reagent container 200 facing the back plate 112 is close to the reflective photoelectric coupler, light emitted by the reflective photoelectric coupler can be reflected back to the reflective photoelectric coupler by the reagent container 200, and the reflective photoelectric coupler senses the reflected light and changes to the conducting state.

In other embodiments, the in-situ detection assembly 140 may be disposed at the front of the reagent holding assembly 110, triggered by structure at the front of the reagent container 200. Wherein the front portion refers to a portion near the opening of the receiving cavity 101.

Illustratively, the reagent holding assembly 110 includes a cover (not shown) that can be disposed at an opening of the accommodating chamber 101; the in-place detection assembly 140 is disposed on the cover body, and when the reagent container 200 is placed in the accommodating chamber 101, such that the first reagent outlet 210 of the reagent container 200 is communicated with the reagent pipeline 131, and the cover body closes the opening of the accommodating chamber 101, the in-place detection assembly 140 generates a state change.

In some other embodiments, the position detection assembly 140 may be disposed on the reagent line 131, for example, a micro switch may be disposed on the reagent inlet 1321 of the reagent line 131, and when the first reagent outlet 210 of the reagent container 200 is connected to the reagent line 131, the corresponding position on the first reagent outlet 210 may abut against the micro switch of the reagent inlet 1321, so as to change the conduction state of the micro switch.

Optionally, as shown in fig. 10, a guide structure 1111 is disposed on the side plate 111 of the reagent accommodating module 110, and the guide structure 1111 extends from the opening of the accommodating chamber 101 to the direction of the back plate 112. For example, the guiding structure 1111 includes a groove or a guiding rib formed on the side plate 111, and the groove or the guiding rib extends from the opening of the accommodating cavity 101 to the direction of the back plate 112. The guiding structure of the reagent accommodating component 110 can ensure that the first reagent outlet 210 of the second surface 202 of the reagent container 200 can be accurately connected with the reagent pipeline 131, such as the reagent inlet 1321 of the reagent pipeline 131, when the reagent container 200 is placed in the accommodating cavity 101.

Optionally, as shown in fig. 11, the sample analyzer further includes a guard 114 covering the in-place detection assembly 140. The protection member 114 is, for example, a waterproof protection member 114. The protection member 114 covering the presence detecting assembly 140 can prevent the reagent leaking from the reagent pipeline 131 or other components from damaging the presence detecting assembly 140, such as short-circuiting a micro-switch. For example, the shield 114 is disposed between the reagent inlet 1321 of the reagent line 131 and the on-site detecting component 140, and the reagent inlet 1321 is located at a higher position than the on-site detecting component 140.

Illustratively, the shielding member 114 is a transparent and bendable waterproof cover, the upper portion of which can be connected to the fixing member 113 of the reagent tube 131 and is of a flexible structure that can be opened; not only can prevent the reagent accidentally leaked from the reagent pipeline 131 from damaging the micro switch and the radio frequency identification assembly 160, but also can facilitate the wiring and the maintenance of the micro switch and the radio frequency identification assembly 160.

In some embodiments, referring to fig. 4, the sample analyzer further includes a Radio Frequency Identification (RFID) component 160. The rfid assembly 160 may obtain information such as the reagent balance of the reagent container 200. For example, the reagent container 200 is provided with an electronic tag, and when the reagent container 200 is placed in the accommodating cavity 101 of the reagent accommodating component 110, the electronic tag is adjacent to the position of the rfid component 160 on the reagent accommodating component 110, and the rfid component 160 can read the reagent information stored in the electronic tag. Optionally, the reagent information includes, but is not limited to, at least one of: manufacturer of reagent, production date, shelf life, reagent type, ion concentration, and reagent amount.

Illustratively, the rfid component 160 is disposed on the reagent holding component 110, such as on the backing plate 112 of the reagent holding component 110; optionally, the in-situ detection assembly 140 is disposed below the shielding member 114 to prevent damage caused by leaked reagents.

In some embodiments, upon the presence detection assembly 140 detecting that the connection state of the first reagent outlet 210 of the reagent container 200 to the reagent line 131 is switched from off to on, the first power assembly operates to prime the reagent in the reagent container 200 to the reagent line 131.

Optionally, in the process of controlling the first power device 132 to operate to fill the reagent in the reagent container 200 into the reagent pipeline 131, a part of the reagent enters the accommodating component 120 through the reagent pipeline 131, so as to ensure that the reagent pipeline 131 is full; while also allowing for the discharge of reagents into the containment assembly 120.

By detecting the connection state of the first reagent outlet 210 of the reagent container 200 and the reagent line 131 by the in-place detecting assembly 140, and filling the reagent in the reagent container 200 into the reagent line 131 after the connection state of the first reagent outlet 210 and the reagent line 131 is switched from off to on, the efficiency of reagent replacement can be improved.

For example, it is not necessary for the user to check the connection state of the first reagent outlet 210 and the reagent line 131, and it is also possible to omit the operation of the user to start the sample analyzer to load the reagent from the reagent container 200 on the software interface; it is possible to prevent inaccurate test results or reagent leakage caused by the start of reagent loading from the reagent container 200 when the first reagent outlet 210 is not connected to the reagent line 131.

In some embodiments, as shown in fig. 12, the sample analyzer further comprises a sample dispensing assembly 170, a detection device 150, and a drain assembly 180. The sample dispensing assembly 170 is used for adding a sample into the accommodating device, the detection device 150 is used for detecting a reagent or a sample in the accommodating assembly 120 to obtain a detection result, and the liquid discharging assembly 180 is used for discharging liquid in the accommodating assembly 120.

Illustratively, as shown in fig. 12, the liquid discharge assembly 180 includes a second power device 181 and a liquid discharge port 182 disposed on the accommodating assembly 120, the liquid discharge port 182 is communicated with the second power device 181, so that the liquid in the accommodating assembly 120 is discharged through the liquid discharge port 182 to flow through the detection apparatus 150 under the action of the second power device 181.

Illustratively, the sample analyzer is an electrolyte analyzer and/or the detection device 150 is an electrolyte detection device 150.

Illustratively, the sample analyzer is an electrolyte analyzer and/or the detection device 150 is an electrolyte detection device 150. When the liquid in the housing assembly 120 is an electrolyte containing ions, such as a serum sample, when flowing through the detecting device 150, an electrode potential difference, i.e., a potential, is formed between the indicator electrode and the reference electrode of the detecting device 150, and the ion concentration of the sample can be determined according to the detected potential of the sample. Alternatively, the ion concentration of the sample may be determined from the potential of the detected sample and the potential of a reagent of known ion concentration, which may be referred to as direct method; or the sample is a sample diluted by a diluent, and the ion concentration of the sample before dilution is determined according to the potential of the diluted sample and the potential of the diluent, which can be called indirect method.

Optionally, the indicating electrode is an ion selective electrode, and the concentrations of different ions, such as potassium ions, sodium ions, and chloride ions, can be measured by different ion selective electrodes.

Optionally, the first power device 132 operates to supply the reagent in the reagent container 200 to the accommodating component 120, and the second power device 181 operates to discharge the reagent in the accommodating component 120 through the liquid outlet 182 and the detecting device 150, so that the accommodating component 120 and the detecting device 150 can be cleaned by the reagent in the reagent container 200, for example, to remove the residual sample in the accommodating component 120 and the detecting device 150.

Illustratively, after the housing assembly 120 and the detection device 150 are cleaned, the sample dispensing assembly 170 adds a sample to the housing device, the second power device 181 operates to discharge the liquid in the housing assembly 120 through the liquid discharge port 182 to flow through the detection device 150, and the detection device 150 detects the sample to obtain a detection result.

In some embodiments, as shown in fig. 4, the sample analyzer further comprises an indicator light 190; when the presence detection module 140 detects that the connection state of the first reagent outlet 210 of the reagent container 200 and the reagent line 131 is switched from off to on, the indicator lamp 190 is switched from on to off, or from off to on. So that the user determines the connection state of the first reagent outlet 210 of the reagent vessel 200 to the reagent piping 131 according to the state of the indicator lamp 190.

Optionally, the indicator light 190 may be disposed at an opening of the accommodating chamber 101 of the reagent accommodating assembly 110, so that a user can know whether the reagent container 200 is in place when the user puts the reagent container.

Illustratively, when the reagent container 200 is placed in the accommodating chamber 101 and the first reagent outlet 210 of the reagent container 200 is communicated with the reagent pipeline 131, the indicator light 190 is turned off, for example, the indicator light 190 is turned off after the reagent container 200 is mounted in place; when the reagent container 200 is taken out of the accommodating chamber 101 and the first reagent outlet 210 of the reagent container 200 is disconnected from the reagent line 131, the indicator lamp 190 is turned on.

Optionally, the indicator light 190 is connected to the presence detection assembly 140, and the indicator light 190 has different states when the presence detection assembly 140 is in different states, such as when the micro switch is closed or opened.

Optionally, when the time length of disconnection between the first reagent outlet 210 and the reagent pipeline 131 is greater than or equal to the preset time length, the indicator lamp 190 flashes to enhance the prompt effect.

In other embodiments, the indicator light 190 may be replaced with other types of audible and visual devices, such as a vibrating device, but not limited thereto.

In some embodiments, the first power assembly is further configured to stop operation when the connection state of the first reagent outlet 210 of the reagent vessel 200 to the reagent line 131 is switched off, to prevent the reagent from flowing into the open environment.

In some embodiments, as shown in fig. 13, the second reagent outlet 1311 includes a first sub-reagent outlet 1311a and a second sub-reagent outlet 1311b, the reagent line 131 includes a first sub-reagent line 131a and a second sub-reagent line 131b, the first power plant 132 includes a first reagent pump 132a and a second reagent pump 132b, the first sub-reagent outlet 1311a communicates with the first reagent pump 132a and the reagent container 200 through the first sub-reagent line 131a, and the second sub-reagent outlet 1311b communicates with the second reagent pump 132b and the reagent container 200 through the second sub-reagent line 131 b. For example, the first reagent pump 132a and the second reagent pump 132b are peristaltic pumps.

Illustratively, the first reagent pump 132a is used to inject a first reagent in the reagent vessel 200 into the holding device through the first sub-reagent line 131a, and the second reagent pump 132b is used to inject a second reagent in the reagent vessel 200 into the holding device through the second sub-reagent line 131b, the second reagent being different from the first reagent. Illustratively, the ion concentration of the second reagent is lower than the ion concentration of the first reagent. For example, the second reagent and the first reagent are standard solutions of known concentrations. Optionally, the sample analyzer is an electrolyte analyzer and/or the detection device 150 is an electrolyte detection device 150, the first reagent may be referred to as an a standard solution, and the second reagent may be referred to as a B standard solution.

In some embodiments, during the operation of the reagent container 200 by the medical staff, such as the insertion of a reagent pack into the reagent holding assembly 110, i.e. the reagent compartment, under the action of the guiding rib of the reagent holding assembly 110, the male head at the back of the reagent container 200 can be just inserted into the rubber female head at the back of the reagent holding assembly 110, and when the depth D of the male head inserted into the female head is greater than the minimum liquid-tight depth Dmin, the middle protrusion at the back of the reagent container 200, i.e. the first protrusion 230, enters into the micro switch triggering stroke, and the micro switch is triggered, at this time, the reagent container 200 has been effectively inserted, and the first power assembly, such as a peristaltic pump, works to realize the reagent transmission between the reagent container 200 and the instrument; because the micro-gap switch has the stroke limit, after exceeding the stroke limit, the life-span can reduce, when the micro-gap switch is close the stroke limit, the depth D that the public head inserted female head is at this moment is Dmax, and the both sides behind the back of the reagent container 200 are protruding, and second bellying 240 contacts the chamber bottom of reagent holding assembly 110 promptly, and restriction reagent container 200 continues to insert, protects the micro-gap switch, and pilot lamp 190 lights the suggestion user simultaneously.

In the process that the medical staff operates the reagent container 200 to pull out the cavity of the reagent accommodating component 110, the depth D of the male head behind the reagent container 200 inserted into the female head behind the reagent accommodating component 110 is reduced, when the depth D of the male head inserted into the female head is smaller than the minimum liquid-tight depth Dmin, the middle bulge behind the reagent container 200 leaves the trigger stroke of the micro switch, the micro switch resets, the reagent container 200 stops working like a peristaltic pump, the reagent between the reagent container 200 and an instrument stops transmission, the reagent leakage is guaranteed not to occur, and meanwhile the indicator light 190 is turned off to prompt a user.

The sample analyzer comprises a reagent accommodating component, an accommodating component, a reagent providing component and an in-place detection component, wherein an accommodating cavity with one end opened and used for accommodating a reagent container is arranged in the reagent accommodating component; the reagent supply assembly comprises a reagent pipeline and first power equipment connected to the reagent pipeline, one end of the reagent pipeline is used for being communicated with the first reagent outlet of the reagent container, and a second reagent outlet is formed at the other end of the reagent pipeline, so that the reagent in the reagent container is supplied to the accommodating assembly from the second reagent outlet under the action of the first power equipment; and the in-place detection assembly generates state change when the connection state of the first reagent outlet of the reagent container and the reagent pipeline is switched from disconnection to connection. Whether the reagent vessel is securely connected to the reagent holding assembly may be detected by the in-situ detection assembly.

In some embodiments, the guiding ribs in the reagent holding assembly ensure that the male tip of the reagent container can be accurately inserted into the rubber female tip of the reagent pipeline after the reagent container is inserted into the reagent holding assembly.

In some embodiments, the second surface of the reagent container, namely the back plate, is used for triggering the micro switch, and whether the depth of the male head of the reagent container inserted into the rubber female head meets the requirement is detected, namely the male head is effectively inserted into the female head, so that the reagent is ensured not to be leaked.

In some embodiments, the back plate of the reagent container is used for triggering and resetting the micro switch to drive the peristaltic pump to work and stop, so that convenience in operation of a user is realized.

In some embodiments, the micro switch is triggered by a protrusion in the middle of the reagent container back plate, i.e. the first protrusion, and the micro switch may be designed behind the reagent holding assembly, so that the influence of splashing of liquid in the reagent holding assembly on the micro switch in an accidental situation may be avoided.

In some embodiments, the second protrusion part, which is a protrusion on both sides of the reagent container back plate, is used to limit the over-insertion of the reagent container, preventing the micro switch from being damaged.

In some embodiments, the transparent soft waterproof cover is of a soft structure capable of being opened, so that not only can the damage of a reagent accidentally leaked from a reagent pipeline to the microswitch and the card reader be prevented, but also the wiring and the maintenance of the microswitch and the card reader can be facilitated.

In some embodiments, the indicator light may visually indicate to the user whether the reagent container is inserted securely, without the user having to go to a software page on the display.

In some embodiments, the user is not required to check the connection state of the first reagent outlet and the reagent pipeline, and the operation of loading the reagent from the reagent container by the sample analyzer started by the user on the software interface can be omitted; it is possible to prevent inaccurate test results or reagent leakage caused by the start of reagent loading from the reagent container when the first reagent outlet is not connected to the reagent line.

It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

It should also be understood that the term "and/or" as used in this application and the appended claims refers to and includes any and all possible combinations of one or more of the associated listed items.

While the invention has been described with reference to specific embodiments, the scope of the invention is not limited thereto, and those skilled in the art can easily conceive various equivalent modifications or substitutions within the technical scope of the invention. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims (10)

1. A sample analyzer, comprising:

the reagent accommodating component is internally provided with an accommodating cavity with one end opened and used for accommodating a reagent container;

an accommodating component;

the reagent supply assembly comprises a reagent pipeline and a first power device connected to the reagent pipeline, one end of the reagent pipeline is used for being communicated with the first reagent outlet of the reagent container, and the other end of the reagent pipeline is provided with a second reagent outlet, so that the reagent in the reagent container is supplied to the accommodating assembly from the second reagent outlet under the action of the first power device;

and the in-place detection assembly generates state change when the connection state of the first reagent outlet of the reagent container and the reagent pipeline is switched from disconnection to connection.

2. The sample analyzer of claim 1 wherein the reagent holding assembly comprises a side plate and a back plate connected to the side plate, the side plate and the back plate form the holding cavity, the back plate is disposed opposite to the opening of the holding cavity, and the in-situ detection assembly is disposed on the back plate.

3. The sample analyzer of claim 2, wherein the in-place detection assembly comprises a micro switch, the reagent container comprises a first surface and a second surface which are oppositely arranged, the first surface is provided with a handheld portion, and the second surface is provided with a first protruding portion at a position corresponding to the micro switch;

when a reagent container is placed in the accommodating cavity and a first reagent outlet of the reagent container is communicated with the reagent pipeline, a first bulge of the reagent container is abutted against the microswitch so that the microswitch is changed from being closed to being opened; or

When a reagent container is placed in the accommodating cavity and a first reagent outlet of the reagent container is communicated with the reagent pipeline, the first protruding part of the reagent container is abutted to the microswitch so that the microswitch is changed from being opened to being closed.

4. The sample analyzer of claim 3, wherein the second surface of the reagent container is further provided with a second raised portion, the second raised portion being disposed adjacent to the first raised portion, and the second raised portion having a height less than the first raised portion;

in the process that the reagent container is placed in the accommodating cavity, the distance between the first protruding portion and the back plate is smaller than the distance between the second protruding portion and the back plate.

5. The sample analyzer of any of claims 2-4, wherein the side plate has a guide structure extending from the opening of the receiving cavity toward the back plate.

6. The sample analyzer of claim 5, wherein the guide structure comprises a groove or a rib formed on the side plate, and the groove or the rib extends from the opening of the receiving cavity toward the back plate.

7. The sample analyzer of claim 1, wherein the reagent containment assembly includes a cover disposed at an opening of the containment chamber;

the in-place detection assembly is arranged on the cover body, when the reagent container is placed into the accommodating cavity, the first reagent outlet of the reagent container is communicated with the reagent pipeline, and the cover body closes the opening of the accommodating cavity, the in-place detection assembly generates state change.

8. The sample analyzer of any of claims 1-4 further comprising a guard covering the in-place detection assembly.

9. The sample analyzer of any of claims 1-4, wherein the first motive assembly is configured to operate to prime the reagent in the reagent container to the reagent line upon a change in state of the in-place detection assembly.

10. The sample analyzer of any of claims 1-4, further comprising an indicator light;

when the status of the in-place detection assembly changes, the indicator lamp is switched from being turned on to being turned off, or from being turned off to being turned on.

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