CN215641318U - Non-contact trace liquid transfer device and biochemical instrument - Google Patents
Non-contact trace liquid transfer device and biochemical instrument Download PDFInfo
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- CN215641318U CN215641318U CN202120330921.XU CN202120330921U CN215641318U CN 215641318 U CN215641318 U CN 215641318U CN 202120330921 U CN202120330921 U CN 202120330921U CN 215641318 U CN215641318 U CN 215641318U
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Abstract
The utility model discloses a non-contact micro-liquid transfer device and a biochemical analyzer.A sampling unit is connected with an injection unit through a first pipeline, so that the injection unit can provide a power source required by sampling and spitting of a sampling unit; and the first pipeline and the injection unit are respectively connected with the gas cleaning unit and the liquid cleaning unit. After the sampling unit spits a sample, the liquid cleaning unit inputs cleaning liquid into the first pipeline and the sampling unit and is matched with the injection unit to clean the sampling end; the inner wall is cleaned by injecting air into the first pipeline and the sampling unit by the gas cleaning unit, so that cleaning liquid in the first pipeline and the sampling unit is discharged, an air column is formed in the sampling unit, a next-time collected sample is separated from the cleaning liquid in the pipeline, cross infection with the previous collected sample or cleaning liquid is avoided, sampling and sample spitting precision is guaranteed, and the problem that cross contamination is easily caused by an existing sampling needle is solved.
Description
Technical Field
The utility model belongs to the technical field of in-vitro diagnosis, and particularly relates to a non-contact micro liquid transfer device and a biochemical analyzer.
Background
The full-automatic biochemical analyzer analyzes body fluid, measures various biochemical indexes, comprehensively analyzes measured results, and is beneficial to diagnosis, prejudgment and function evaluation of diseases. The precision of the sample adding system can most directly influence the measurement result, so that the precision requirement of the micro liquid transfer system is higher.
Along with the general improvement of the quality of life level, the attention degree of people to health is obviously improved, so the number of samples required to be measured in unit time is greatly increased, and the in-vitro reagent detection and analysis speed is also improved to a certain degree.
When the sample is added, if the sampling needle contacts the sample at the sample adding position, the accuracy of the sample adding amount of the sampling needle is reduced, and after the needle tip contacts the body fluid sample such as serum, if the sample is not completely cleaned, cross contamination may be caused to the reagent or the sample, and the accuracy degree of a sample adding system is seriously influenced.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the technical problem of providing a non-contact micro liquid transfer device and a biochemical analyzer so as to solve the problem that cross contamination is easily caused by the existing sampling needle.
In order to solve the problems, the technical scheme of the utility model is as follows:
the utility model discloses a non-contact micro-liquid transfer device, which comprises a sampling unit, an injection unit, a first pipeline, a liquid cleaning unit and a gas cleaning unit, wherein the sampling unit is connected with the injection unit;
the sampling unit is used for being connected with an external driving device and comprises a sampling end and a connecting end, and the connecting end is communicated with the head end of the first pipeline;
the output end of the injection unit is communicated with the tail end of the first pipeline and is used for providing a power source required by sampling and spitting of the sampling unit;
the output end of the liquid cleaning unit is communicated with the output end of the injection unit and is used for carrying out liquid cleaning on the first pipeline and the sampling unit;
the output end of the gas cleaning unit is communicated with the first pipeline and is used for injecting air to the sampling end to form an air column.
The non-contact type trace liquid transfer device comprises a liquid cleaning unit, a liquid transfer unit and a liquid transfer unit, wherein the liquid cleaning unit comprises a liquid pipeline, a water pump and a cleaning liquid accommodating container for accommodating cleaning liquid;
the head end of the liquid pipeline extends into the cleaning liquid accommodating container, and the tail end of the liquid pipeline is communicated with the output end of the injection unit;
the water pump is arranged on the liquid pipeline.
The non-contact micro liquid transfer device also comprises a first electromagnetic valve;
the first electromagnetic valve is arranged on the liquid pipeline and is positioned between the water pump and the tail end of the liquid pipeline;
the water pump is a magnetic circulating pump.
The non-contact micro-liquid transfer device also comprises a second electromagnetic valve, wherein the second electromagnetic valve is a three-way electromagnetic valve;
the first pipeline comprises a first connecting pipe and a second connecting pipe;
the head end of the first connecting pipe is communicated with the connecting end; the tail end of the second connecting pipe is communicated with the output end of the injection unit; the tail end of the first connecting pipe, the head end of the second connecting pipe and the output end of the gas cleaning unit are respectively communicated with three ports of the three-way electromagnetic valve.
The non-contact type trace liquid transfer device comprises a gas cleaning unit, a gas pump, an overflow valve and a gas pipeline, wherein the gas cleaning unit comprises a gas pump, an overflow valve and a gas pipeline;
the head end of the gas pipeline is communicated with the gas pump, and the tail end of the gas pipeline is communicated with the three-way electromagnetic valve;
the overflow valve is arranged on the gas pipeline and used for controlling the gas pressure in the gas pipeline.
According to the non-contact type trace liquid transfer device, the gas cleaning unit further comprises a gas storage tank; the gas storage tank is arranged on the gas pipeline and is positioned between the tail end of the gas pipeline and the overflow valve.
According to the non-contact type micro-liquid transfer device, the sampling unit is a sampling needle.
According to the non-contact micro-liquid transfer device, the injection unit is an injector; the injector comprises a piston cylinder and a piston, wherein the piston is connected in the piston cylinder in a sliding way and is matched with the piston cylinder to form a piston cavity; the piston cavity is respectively communicated with the tail end of the first pipeline and the output end of the liquid cleaning unit.
The biochemical analyzer comprises the non-contact micro-liquid transfer device.
Due to the adoption of the technical scheme, compared with the prior art, the utility model has the following advantages and positive effects:
according to the embodiment of the utility model, the sampling unit is connected with the injection unit through the first pipeline, so that the injection unit can provide a power source required by sampling and spitting of the sampling unit; and the first pipeline and the injection unit are respectively connected with the gas cleaning unit and the liquid cleaning unit. After the sampling unit spits a sample, the liquid cleaning unit inputs cleaning liquid into the first pipeline and the sampling unit so as to clean the sampling end; the inner wall is cleaned by injecting air into the first pipeline and the sampling unit by the gas cleaning unit, so that cleaning liquid in the first pipeline and the sampling unit is discharged, an air column is formed in the sampling unit, a next-time collected sample is separated from the cleaning liquid in the pipeline, cross infection with the previous collected sample or cleaning liquid is avoided, sampling and sample spitting precision is guaranteed, and the problem that cross contamination is easily caused by an existing sampling needle is solved.
Drawings
FIG. 1 is a schematic view of a non-contact micro-liquid transfer device according to the present invention.
Description of reference numerals: 1: a sampling unit; 2: an injection unit; 3: a water pump; 4: a first solenoid valve; 5: a cleaning liquid container; 6: a second solenoid valve; 7: an air pump; 8: an overflow valve; 9: an air storage tank.
Detailed Description
The non-contact micro-liquid transfer device and the biochemical analyzer according to the present invention will be described in detail with reference to the accompanying drawings and specific embodiments. Advantages and features of the present invention will become apparent from the following description and from the claims.
Example one
Referring to fig. 1, in one embodiment, a non-contact micro liquid transfer device includes a sampling unit 1, an injection unit 2, a first pipeline, a liquid cleaning unit, and a gas cleaning unit.
Wherein, sampling unit 1 is used for being connected with external drive device, including sampling end and link, the link communicates with the head end of first pipeline. The output end of the injection unit 2 is communicated with the tail end of the first pipeline and is used for providing a power source required by sampling and spitting of the sampling unit 1. The output end of the liquid cleaning unit is communicated with the output end of the injection unit 2 and is used for carrying out liquid cleaning on the first pipeline and the sampling unit 1. The output end of the gas cleaning unit is communicated with the first pipeline and used for injecting air to the sampling end to form an air column.
In the embodiment, the sampling unit 1 is connected with the injection unit 2 through the first pipeline, so that the injection unit 2 can provide a power source required by sampling and spitting of the sampling unit 1; and the first pipeline and the injection unit 2 are respectively connected with a gas cleaning unit and a liquid cleaning unit. After the sampling unit 1 spits a sample, the liquid cleaning unit inputs cleaning liquid into the first pipeline and the sampling unit 1 and is matched with the injection unit 2 to clean a sampling end; inject the air into by gas washing unit in to first pipeline and sampling unit 1 afterwards and clean the inner wall for the washing liquid in first pipeline and the sampling unit 1 is discharged, and forms the air column in sampling unit 1, separates with the washing liquid in next collection sample and the pipeline, avoids gathering sample or washing liquid cross infection with the previous, has guaranteed the precision of sampling and telling appearance, has solved the problem that current sampling needle easily causes cross contamination.
The following further describes the specific structure of the non-contact micro-liquid transfer device of the present embodiment:
in this embodiment, in order to facilitate the external driving device to drive the collecting unit to move, the first pipeline may be a hose.
In the present embodiment, the liquid cleaning unit may specifically include a liquid pipeline, a water pump 3, a first electromagnetic valve 4, and a cleaning liquid container 5 for containing a cleaning liquid.
The head end of the liquid pipeline extends into the cleaning liquid containing container 5, and the tail end of the liquid pipeline is communicated with the output end of the injection unit 2. The water pump 3 is arranged on the liquid pipeline. The first electromagnetic valve 4 is also arranged on the liquid pipeline and is positioned between the water pump 3 and the tail end of the liquid pipeline. The water pump 3 is used for pumping cleaning fluid into the liquid pipeline; the first solenoid valve 4 is used for controlling whether the liquid circulates in the liquid pipeline or not, so that the liquid can flow out to the first pipeline and the sampling unit 1 through the liquid pipeline at a required moment
Further, water pump 3 is the magnetic force circulating pump, and the magnetic force circulating pump can be when first solenoid valve 4 closes the liquid pipeline, carries out the pump income of liquid continuously, and can not destroy.
In this embodiment, the non-contact micro liquid transfer device further includes a second electromagnetic valve 6, and the second electromagnetic valve 6 is a three-way electromagnetic valve. The first pipeline includes a first connection pipe and a second connection pipe.
Wherein, the head end of the first connecting pipe is communicated with the connecting end. The tail end of the second connecting pipe is communicated with the output end of the injection unit 2. The tail end of the first connecting pipe, the head end of the second connecting pipe and the output end of the gas cleaning unit are respectively communicated with three ports of the three-way electromagnetic valve. The three-way electromagnetic valve can be normally opened between two ports communicated with the first connecting pipe and the second connecting pipe, and when ventilation is needed, the ports communicated with the gas cleaning unit are opened, so that gas can be input into the first connecting pipe and the second connecting pipe.
In this embodiment, the gas cleaning unit may specifically include a gas pump 7, an overflow valve 8, a gas storage tank 9, and a gas pipeline.
Wherein, the head end of the gas pipeline is communicated with the air pump 7, and the tail end is communicated with the three-way electromagnetic valve. The overflow valve 8 is arranged in the gas pipeline and used for controlling the gas pressure in the gas pipeline. The gas storage tank 9 is arranged on the gas pipeline and is positioned between the tail end of the gas pipeline and the overflow valve 8. The overflow valve 8 can make the surplus gas overflow from the overflow valve 8, and can not continuously pressurize the gas circuit and the gas storage tank 9.
In the present embodiment, the sampling unit 1 is a sampling needle. Of course, in other embodiments, the form of the sampling unit 1 may be various, and is not limited to the form of the sampling needle, and is not limited thereto.
In the present embodiment, the injection unit 2 is a syringe. The syringe may include a plunger barrel and a plunger slidably coupled within the barrel and cooperating to define a plunger cavity. The piston cavity is respectively communicated with the tail end of the first pipeline and the output end of the liquid cleaning unit.
The injector can also be an electric injector, and the sample sucking/air sucking operation can be quickly carried out at a reagent or sample sampling position by adopting an electric driving mode, and the sample can also be accurately spit at a high speed right above containers such as cuvettes.
Specifically, in consideration of the problem of return error, the sampling needle for sampling liquid such as serum and the like selects an injector or a plunger pump with a smaller volume as much as possible on the premise of meeting the sampling volume of a single sample, and the return error is reduced as much as possible; and selecting a syringe or a plunger pump with a proper measuring range according to the requirements.
The accuracy is mainly focused on the requirement of high accuracy on the sample discharge amount, that is, the sample suction amount is only required to be larger than the sample discharge amount. Therefore, when the sample is sucked, not less than (the sample volume is spitted and the maximum return error of the injector) sample/reagent is sucked, and the sample suction volume can be ensured to be larger than the required sample volume. At the moment, the sampling needle is only required to be accurately controlled to carry out accurate sampling at the sampling position, and the requirement of high-precision sample volume spitting can be met.
The injection unit 2 may also be other devices that can provide suction to the sampling unit 1, such as a plunger pump, and is not limited in particular.
Each sampling needle of the embodiment can achieve a plurality of functional actions of sucking and spitting a sample, sucking an air section, sucking cleaning liquid from the cleaning liquid accommodating container 5, washing the inner wall of the sampling needle, emptying residual liquid in the sampling needle and the like only by correspondingly using one injector 2, and the sampling effect is accurate.
In this embodiment, the non-contact micro-liquid transfer device may further include a liquid level detection device to detect whether the sampling needle reaches a position below the liquid level, and the device may prevent the sampling needle from striking the bottom of the sample container to damage the needle tip.
Furthermore, the liquid level detection device can be matched with a random tracking function, and the height of the needle tip descending during next sample suction after each sample suction of the sampling needle can be controlled according to the amount of the sucked samples, so that the normal operation of the liquid level detection device is ensured.
In this embodiment, the non-contact micro-liquid transferring device may further include a blocking needle module to detect a pressure variation signal in the whole pipeline system of the sampling needle, so as to determine whether a foreign object is in the pipeline, which may cause a blockage or a low flow rate.
The following describes specific steps of the non-contact micro-liquid transfer device of the present embodiment:
after the sampling needle is used for sampling, liquid with a certain volume can be quickly extracted from a cleaning liquid containing container 5 containing cleaning liquid or cleaning water under the condition that the first electromagnetic valve 4 is opened, and the liquid is pushed into an internal flow path of the sampling needle through an injector to be washed, so that the internal operation of the sampling needle is cleaned.
After liquid is cleaned or before sampling by a sampling needle, a port of a second electromagnetic valve 6 communicated with a gas pipeline is opened, so that the sampling needle absorbs an air column with a certain volume, the collected sample is separated from water or cleaning liquid in the pipeline, the sample liquid drop is not suspended at the tip of the needle, after the sampling needle finishes spitting, the gas in the gas storage tank 9 is rapidly discharged at the position of a cleaning pool, redundant samples, air and partial cleaning liquid/water in the sampling needle are rapidly discharged, and the inner wall of the sampling needle is cleaned.
Example two
A biochemical analyzer, comprising the non-contact micro-liquid transferring device in the first embodiment. The injection unit 2 provides a power source required by sampling and spitting of the sampling unit 1, and a gas cleaning unit and a liquid cleaning unit are arranged. The liquid cleaning unit inputs cleaning liquid into the sampling unit 1 and is matched with the injection unit 2 to clean the sampling end; gas cleaning unit injects the air in to sampling unit 1 and cleans the inner wall for the washing liquid is discharged, and forms the air column in sampling unit 1, separates with the washing liquid in next collection sample and the pipeline, avoids gathering sample or washing liquid cross infection with the previous, has guaranteed the precision of sampling with telling the appearance, has solved the problem that current sampling needle easily causes cross contamination.
It should be noted that, when the biochemical analyzer is installed, the syringe piston needs to perform the operations of sucking and spitting liquid for many times, and the air column and the air bubble in the syringe and the connecting liquid path thereof are completely discharged, so that the syringe is completely filled with water. If the demand of heat medium output exists, a small amount of heat medium sample adding can be carried out for multiple times, and multiple times of circulating pump switch operation are carried out, so that the circulating system is filled with the heat medium and is not blocked by bubbles. The pipeline for circulating the heat medium is prevented from being bent as much as possible, and the dead zone at the bent position is prevented from having bubble blockage.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the above embodiments. Even if various changes are made to the present invention, it is still within the scope of the present invention if they fall within the scope of the claims of the present invention and their equivalents.
Claims (9)
1. A non-contact micro liquid transfer device is characterized by comprising a sampling unit, an injection unit, a first pipeline, a liquid cleaning unit and a gas cleaning unit;
the sampling unit is used for being connected with an external driving device and comprises a sampling end and a connecting end, and the connecting end is communicated with the head end of the first pipeline;
the output end of the injection unit is communicated with the tail end of the first pipeline and is used for providing a power source required by sampling and spitting of the sampling unit;
the output end of the liquid cleaning unit is communicated with the output end of the injection unit and is used for carrying out liquid cleaning on the first pipeline and the sampling unit;
the output end of the gas cleaning unit is communicated with the first pipeline and used for injecting air to the sampling end to form an air column.
2. The non-contact micro liquid transfer device according to claim 1, wherein the liquid cleaning unit comprises a liquid pipeline, a water pump and a cleaning liquid containing container for containing a cleaning liquid;
the head end of the liquid pipeline extends into the cleaning liquid accommodating container, and the tail end of the liquid pipeline is communicated with the output end of the injection unit;
the water pump is arranged on the liquid pipeline.
3. The non-contact micro liquid transfer device according to claim 2, further comprising a first solenoid valve;
the first electromagnetic valve is arranged on the liquid pipeline and is positioned between the water pump and the tail end of the liquid pipeline;
the water pump is a magnetic circulating pump.
4. The non-contact micro liquid transfer device according to claim 1, further comprising a second solenoid valve, wherein the second solenoid valve is a three-way solenoid valve;
the first pipeline comprises a first connecting pipe and a second connecting pipe;
the head end of the first connecting pipe is communicated with the connecting end; the tail end of the second connecting pipe is communicated with the output end of the injection unit; the tail end of the first connecting pipe, the head end of the second connecting pipe and the output end of the gas cleaning unit are respectively communicated with three ports of the three-way electromagnetic valve.
5. The non-contact micro liquid transfer device according to claim 4, wherein the gas purge unit comprises a gas pump, an overflow valve and a gas line;
the head end of the gas pipeline is communicated with the gas pump, and the tail end of the gas pipeline is communicated with the three-way electromagnetic valve;
the overflow valve is arranged on the gas pipeline and used for controlling the gas pressure in the gas pipeline.
6. The non-contact micro liquid transfer device according to claim 5, wherein the gas purge unit further comprises a gas tank; the gas storage tank is arranged on the gas pipeline and is positioned between the tail end of the gas pipeline and the overflow valve.
7. The non-contact micro liquid transfer device according to claim 1, wherein the sampling unit is a sampling needle.
8. The non-contact micro liquid transfer device according to claim 1, wherein the injection unit is a syringe; the injector comprises a piston cylinder and a piston, wherein the piston is connected in the piston cylinder in a sliding way and is matched with the piston cylinder to form a piston cavity; the piston cavity is respectively communicated with the tail end of the first pipeline and the output end of the liquid cleaning unit.
9. A biochemical analyzer, comprising the non-contact micro liquid transfer device according to any one of claims 1 to 8.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202120330921.XU CN215641318U (en) | 2021-02-05 | 2021-02-05 | Non-contact trace liquid transfer device and biochemical instrument |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202120330921.XU CN215641318U (en) | 2021-02-05 | 2021-02-05 | Non-contact trace liquid transfer device and biochemical instrument |
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| CN215641318U true CN215641318U (en) | 2022-01-25 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023241020A1 (en) * | 2022-06-13 | 2023-12-21 | 深圳市帝迈生物技术有限公司 | Cleaning method for sample analyzer and sample analyzer |
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2021
- 2021-02-05 CN CN202120330921.XU patent/CN215641318U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023241020A1 (en) * | 2022-06-13 | 2023-12-21 | 深圳市帝迈生物技术有限公司 | Cleaning method for sample analyzer and sample analyzer |
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