CN212568090U - A sample needle sample and cleaning system for chemiluminescence immunoassay appearance - Google Patents
A sample needle sample and cleaning system for chemiluminescence immunoassay appearance Download PDFInfo
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- CN212568090U CN212568090U CN202021338413.8U CN202021338413U CN212568090U CN 212568090 U CN212568090 U CN 212568090U CN 202021338413 U CN202021338413 U CN 202021338413U CN 212568090 U CN212568090 U CN 212568090U
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Abstract
The utility model discloses a sample needle sample and cleaning system for chemiluminescence immunoassay appearance, including the sample needle, plunger pump and lotion bucket, it has first pressure sensor to establish ties on the sample acquisition pipeline between sample needle and the plunger pump, and it has scavenging pump and solenoid valve to establish ties on the scavenge pipe way between lotion bucket and the plunger pump, and the scavenge pipe way that is located between scavenging pump and the solenoid valve has shunt piping in parallel, and the exit end on shunt piping extends to in the lotion bucket, and interval series connection has second pressure sensor and overflow valve on the shunt piping. The utility model discloses effectively avoid breaking or revealing the phenomenon because of the pipeline that pipeline pressure arouses unusually, whether take place to block up through the accurate judgement sampling needle of first pressure sensor, wash the flow through the accurate control of second pressure sensor, the sampling needle cleaning performance is good, avoids the sample to adhere to the cross contamination who arouses at the sampling needle inner wall, guarantees quantitative precision, improves the success rate of sample sampling, guarantees the reliability of the luminous testing result of sample.
Description
Technical Field
The utility model relates to a tube-line system of chemiluminescence immunoassay appearance especially relates to a sample needle sample and cleaning system for chemiluminescence immunoassay appearance.
Background
According to statistics, more than 80% of the reasons of the detection failure of the current chemiluminescence immunoassay analyzer are a sample sampling link, wherein the quantitative preparation of the sample needle extraction is a main factor influencing the sample within the detection limit range, and the cleanliness of the sample needle is a main factor avoiding cross contamination among samples. Thus, the sampling needle sampling system is an important part for ensuring the accuracy of the sample detection result. The existing sample needle sampling system utilizes the speed of a plunger pump and the pressure on a cleaning pipeline to jointly judge whether a sample needle is blocked or not, but because the suction speed of the plunger pump amplifies the error of sampling quantity, the system still has the situation of sample quantitative failure; and because the flow of the sample needle is uncontrollable, whether the sample needle is washed clean or not cannot be confirmed, namely the system still has the condition of sample cross contamination. Therefore, how to design a sample needle sampling system capable of accurately judging whether a sample needle is cleaned or not and ensuring accurate quantification is a key problem for the research of the technicians in the field.
Disclosure of Invention
An object of the utility model is to provide a sample needle sample and cleaning system for chemiluminescence immunoassay appearance effectively guarantees that the sample ration is accurate, avoids appearing cross contamination between the different samples completely, and then guarantees sample testing result's accuracy and reliability.
In order to achieve the above purpose, the utility model adopts the following technical proposal:
the utility model discloses a sample needle sample and cleaning system for chemiluminescence immunoassay appearance, including sample needle, plunger pump and lotion bucket, the sample needle with establish ties on the sample acquisition pipeline between the plunger pump has first pressure sensor, establish ties on the washing pipeline between lotion bucket and the plunger pump has the scavenging pump, establish ties on the washing pipeline between scavenging pump and the plunger pump has the solenoid valve, and the washing pipeline between scavenging pump and solenoid valve has parallelly connected the reposition of redundant personnel pipeline, the exit end of reposition of redundant personnel pipeline extends to in the lotion bucket, and interval series has second pressure sensor and overflow valve on the reposition of redundant personnel pipeline; the signal output ends of the first pressure sensor and the second pressure sensor are electrically connected with the signal output end of the programmable controller, and the control input ends of the plunger pump, the cleaning pump, the control valve and the overflow valve are respectively electrically connected with the control output end of the programmable controller.
And a liquid level sensor is arranged in the washing liquid barrel, the signal output end of the liquid level sensor is electrically connected with the signal input end of the programmable controller, and the signal output end of the programmable controller is electrically connected with the signal input end of the alarm.
The cleaning pump is a diaphragm pump.
The utility model has the advantages of simple structure, not only guaranteed the accurate nature of sample extraction volume, avoided sample ration failure and sample cross contamination, improved the success rate of sample sampling. Specifically, the pressure is monitored by the first pressure sensor and the second pressure sensor, so that the phenomenon of pipeline breakage or leakage caused by abnormal pipeline pressure is avoided, whether the sampling needle is blocked or not is accurately judged by the pressure value of the first pressure sensor, further, cross contamination of different samples or reagents is avoided, and the success rate of sampling the samples is improved; the accurate control of the pressure value that detects through second pressure sensor washes the flow, and the sampling needle cleaning performance is good, avoids the sample to adhere to at the sampling needle inner wall, avoids cross contamination, improves the degree of accuracy of the luminous testing result of sample.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a schematic block diagram of the novel circuit of the present invention.
Detailed Description
As shown in fig. 1 and fig. 2, the sample needle sampling and cleaning system for a chemiluminescence immunoassay analyzer of the present invention comprises a sample needle 1, a plunger pump 2 and a washing liquid barrel 3, wherein a waste liquid pool is arranged below the sample needle 1 for containing waste liquid flowing out from the sample needle 1; a first pressure sensor 5.1 is connected in series on a sample collecting pipeline 4 between the sample needle 1 and the plunger pump 2, a cleaning pump 7 is connected in series on a cleaning pipeline 6 between the washing barrel 3 and the plunger pump 2, an electromagnetic valve 8 (the electromagnetic valve 8 is a two-position two-way electromagnetic valve) is connected in series on the cleaning pipeline 6 between the cleaning pump 7 and the plunger pump 2, a shunt pipeline 9 is connected in parallel on the cleaning pipeline 6 between the cleaning pump 7 (the cleaning pump 7 is a diaphragm pump) and the electromagnetic valve 8, the outlet end of the shunt pipeline 9 extends into the washing barrel 3, and a second pressure sensor 5.2 and an overflow valve 10 are connected in series on the shunt pipeline 9 at intervals; the signal output ends of the first pressure sensor 5.1 and the second pressure sensor 5.2 are electrically connected with the signal output end of a programmable controller (namely a singlechip), and the control input ends of the plunger pump 2, the cleaning pump 7, the control valve and the overflow valve 10 are respectively and electrically connected with the control output end of the programmable controller.
Be provided with level sensor 11 in the lotion bucket 3, level sensor 11's signal output part with programmable controller's signal input part electricity is connected, and programmable controller's signal output part is connected with the signal input part electricity of alarm, and level sensor 11 gives programmable controller with the liquid level signal transmission who inhales the liquid bucket, and when the washing liquid in the lotion bucket 3 was less than minimum predetermined volume, programmable controller sent the signal to the alarm, reminds the staff to add the washing liquid, ensures that the instrument normally works, avoids leading to sample needle 1 to wash thoroughly because of the washing liquid is not enough.
When the device works, the sample needle 1 is moved into the sample container, the electromagnetic valve 8 is ensured to be in a power-off state, the single chip microcomputer controls the plunger pump 2 to work to enable the sample collection pipeline 4 to generate negative pressure, the sample needle 1 extracts a preset amount of samples, and then the single chip microcomputer controls the sample needle 1 through the plunger pump 2 to discharge the samples into a specified reaction cup; after the sampling is finished, the electromagnetic valve 8 is electrified to enable the cleaning pipeline 6 and the plunger pump 2 to be in a communicated state, the cleaning pump 7 is started, and the inner cavity of the plunger pump 2, the sample collecting pipeline 4 and the inner wall of the sample needle 1 are sequentially cleaned until the pressure value detected by the first pressure sensor 5.1P A And stopping cleaning when the pressure is within the preset pressure range.
The clogging judgment process of the sample needle 1 is as follows: the first pressure sensor 5.1 monitors the pressure on the sample collection pipe 4 in real timeP A The single chip computer presets the sample collection amount toA n Pressure corresponding toP A The ranges are shown in Table 1.
TABLE 1 sample Collection volume and pressureP A The relationship between
When the sample is collected in an amount ofA n When pressure is appliedP A When the size of the sample needle is within a preset range, the sample needle 1 is not blocked, otherwise, the sample needle 1 is blocked, when the sample needle 1 is blocked, the single chip starts the cleaning pump 7, the electromagnetic valve 8 is powered on, and the sample needle 1 and the sample collection pipeline 4 are cleaned until the pressure is reachedP A And when the size is within the preset range, the cleaning is stopped, so that the quantitative accuracy is ensured.
The sample needle 1 flushing flow rate is as follows: the pipeline flow and the pipeline pressure are positively correlated, and the relationship between the pipeline flow and the pipeline pressure is as follows:
in the formula (I), the compound is shown in the specification,Q-the flow rate of the liquid to be treated,μ-the flow coefficient of the gas flow,A-the cross-sectional area of the pipe,P-the pressure in the line, and,ρthe density of the fluid, and the cleaning flow of the cleaning pipeline 6 calculated by the pressure of the cleaning pipeline 6 all meet the cleaning requirement of the sample needle 1, which is as follows: a second pressure sensor 5.2 for detecting the pressure in the bypass line 9 at the outlet of the washing pumpP B When pressure is appliedP B When the pressure is in the range preset by the singlechip, the cleaning flow can meet the cleaning requirement of the sample needle 1, and when the pressure is in the range preset by the singlechipP B When the flow rate of the bypass pipeline 9 is larger than the maximum value of the preset range, the flow rate of the bypass pipeline 9 is over large, the flow rate of the cleaning pipeline 6 is smaller, and the overflow valve 10 regulates the flow rate of the bypass pipeline 9 in a throttling mode until the pressure is reachedP B Reducing the flow rate of the shunt pipeline 9 to be within a preset range, and relatively increasing the flow rate of the cleaning pipeline 6; when pressure is appliedP B When the flow rate is smaller than the minimum value of the preset range, the flow rate of the shunt pipeline 9 is too small, the flow rate of the cleaning pipeline 6 is larger, and the pressure is enabled to be larger by the overflow valve 10 in an overflow modeP B Increasing the flow rate of the shunt pipeline 9 and the flow rate of the cleaning pipeline 6 to be relatively reduced within a preset range.
Claims (3)
1. A sample needle sampling and cleaning system for a chemiluminescent immunoassay analyzer, comprising a sample needle (1), a plunger pump (2) and a washing liquid barrel (3), characterized in that: a first pressure sensor (5.1) is connected in series on a sample collecting pipeline (4) between the sample needle (1) and the plunger pump (2), a cleaning pump (7) is connected in series on a cleaning pipeline (6) between the cleaning barrel (3) and the plunger pump (2), an electromagnetic valve (8) is connected in series on the cleaning pipeline (6) between the cleaning pump (7) and the plunger pump (2), a shunt pipeline (9) is connected in parallel on the cleaning pipeline (6) between the cleaning pump (7) and the electromagnetic valve (8), the outlet end of the shunt pipeline (9) extends into the cleaning barrel (3), and a second pressure sensor (5.2) and an overflow valve (10) are connected in series on the shunt pipeline (9) at intervals; the signal output ends of the first pressure sensor (5.1) and the second pressure sensor (5.2) are electrically connected with the signal output end of a programmable controller, and the control input ends of the plunger pump (2), the cleaning pump (7), the control valve and the overflow valve (10) are respectively electrically connected with the control output end of the programmable controller.
2. The sample needle sampling and cleaning system for a chemiluminescent immunoassay analyzer of claim 1, wherein: a liquid level sensor (11) is arranged in the liquid washing barrel (3), the signal output end of the liquid level sensor (11) is electrically connected with the signal input end of the programmable controller, and the signal output end of the programmable controller is electrically connected with the signal input end of the alarm.
3. The sample needle sampling and cleaning system for a chemiluminescent immunoassay analyzer of claim 1, wherein: the cleaning pump (7) is a diaphragm pump.
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| CN202021338413.8U CN212568090U (en) | 2020-07-09 | 2020-07-09 | A sample needle sample and cleaning system for chemiluminescence immunoassay appearance |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112858593A (en) * | 2021-02-22 | 2021-05-28 | 广州科方生物技术股份有限公司 | Detection system and detection method for sample needle, reagent needle suction and needle blockage |
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2020
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112858593A (en) * | 2021-02-22 | 2021-05-28 | 广州科方生物技术股份有限公司 | Detection system and detection method for sample needle, reagent needle suction and needle blockage |
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