CN212547257U - Transplantation stent and transplantation stent delivery system - Google Patents

Abstract

A stent for transplantation and a stent delivery system for transplantation, the stent for transplantation comprising: a stent body woven from filaments and having an expanded configuration and a compressed configuration, wherein the stent body has a stent middle section in a middle portion in a longitudinal direction, and a proximal end portion and a distal end portion at both ends of the stent body; the stent body has a longitudinally extending internal passage therein, and the stent for transplantation further comprises: the degradable layer is coated on the outer surface of the stent body; the mucous membrane tissue layer is fixedly arranged on the outer surface of the degradable layer. The structure not only simplifies the delivery process, but also can effectively promote tissue regeneration, epithelialization and prevent postoperative restenosis and other complications.

Description

Transplantation stent and transplantation stent delivery system

Technical Field

The utility model relates to a medical bracket for transplantation, which belongs to a medical device used in a human body.

Background

Esophageal cancer is one of common malignant tumors in China, most patients with middle and late esophageal cancer are diagnosed with dysphagia, the survival rate of the patients after 5 years of comprehensive treatment is still less than 20%, and the survival rate of the patients with early esophageal cancer after 5 years of treatment can reach more than 95%, so that the early esophageal cancer treatment is a clinical problem which needs to be solved urgently. The main techniques for endoscopic treatment of early esophageal cancer include: endoscopic submucosal resectioning (EMR), endoscopic multi-ring ligation submucosal resectioning, Endoscopic Submucosal Dissection (ESD), etc. The literature reports that the traditional surgical operation and the ESD treatment can obtain good clinical effects on early esophageal cancer, and compared with the traditional surgical operation, the ESD treatment has the advantages of small wound, few complications, quick recovery, low cost and the like, so that the current endoscopic ESD treatment becomes one of the main treatment technologies for early esophageal cancer.

And the size, infiltration depth and damage of the inherent muscle layer of the esophagus of early esophageal cancer have larger influence on the postoperative stenosis of the esophageal ESD. Wherein, the excision range is more than 3/4 weeks, the muscle layer damage in the operation process is an independent risk factor for generating postoperative stenosis, the esophagus lesion ESD postoperative stenosis incidence rate is more than 90% in more than 3/4 weeks, and the esophagus full-week lesion ESD postoperative stenosis incidence rate is 100%. How to prevent and treat the esophageal stenosis is important, and the prevention and treatment means of the esophageal stenosis at present mainly comprise four methods:

1) the medicine can be used for preventing esophageal stenosis. For example, glucocorticoids, 5-fluorouracil, mitomycin C, etc., have been used in the prevention and treatment of esophageal strictures.

2) Polyglycolic acid film (PGA) prevents esophageal stenosis. The polyglycolic acid film is a biodegradable suture material and can be adhered to fibrin on the surface of a wound, so that the formation of esophageal stenosis is prevented. However, the effectiveness of the polyglycolic acid film in preventing esophageal strictures is not high, and the incidence of strictures is higher than that of glucocorticoid therapy, and a single application of the polyglycolic acid film is ineffective for the full-week resection.

3) The esophageal stenosis is prevented by autologous cell transplantation under an endoscope. The existing bracket with fixed mucosal tissue needs to be compressed in an endoscopic channel of 2.8-4.2 mm to realize a delivery process, so that the mucosal tissue is strongly squeezed and inactivated in the compression delivery process, and the promotion effect of the mucosal tissue on wound recovery is greatly reduced, so that how to effectively deliver autologous cells to a wound in clinic to combine with postoperative esophageal tissue and promote the directional growth of new tissue still has great technical difficulty.

4) And (4) esophageal stent treatment. Esophageal stents were originally used for minimally invasive treatment of esophageal malignant strictures and esophageal fistulas that could not be surgically removed. The advantage is that the strictured oesophagus can be constantly dilated and the oesophageal stent can be removed when there is a serious complication or significant relief of the oesophageal stricture. In recent years, with the repeated application of recyclable covered metal stents, drug eluting stents, anti-displacement stents, biodegradable stents and the like in clinic, stent implantation gradually becomes a new choice for treating benign stricture of esophagus. The existing single-layer tectorial membrane bracket does not show a better tissue healing effect in the process of promoting tissue healing, and has the technical problems of poor epithelial cell regeneration effect, easy restenosis and the like. In addition, the existing esophageal stent delivery system has a complex structure, the operation of doctors is relatively complex in the operation process, and particularly, the release operation of the stent in the release process is complicated, and the release position is not suitable to be adjusted.

SUMMERY OF THE UTILITY MODEL

Based on the technical problem that the mucosal tissue is difficult to directionally and effectively grow and the epithelial cell regeneration effect is not good in the existing stent treatment process, the utility model provides a stent for transplantation, include:

a stent body woven from filaments and having an expanded configuration and a compressed configuration, wherein the stent body has a stent middle section in a middle portion in a longitudinal direction, and a proximal end portion and a distal end portion at both ends of the stent body; the stent body is internally provided with an internal passage which extends longitudinally and is used for passing through an endoscope, and the stent body is provided with a film covering structure which is in a full film covering or partial film covering form.

The stent for transplantation further comprises: the degradable layer is coated on the outer surface of the stent body; the mucous membrane tissue layer is fixedly arranged on the outer surface of the degradable layer.

Preferably, the mucosal tissue layer comprises mucosal tissues distributed in any one or more of normal, dislocation, array, linearity and curve, the mucosal tissues comprise autologous mucosa and/or stem cell cultured mucosa, and the distribution mode on the outer surface of the degradable layer comprises normal, dislocation, array, linearity, curve (such as spiral curve, irregular curve and the like) and the like.

Preferably, the degradable layer is covered on the outer surface of the stent body by means of sewing and/or bonding; the mucous membrane tissue lattice is fixed to the outer surface of the degradable layer by one or more of sewing, bonding and nailing.

Preferably, the degradable layer is of a nearly rectangular structure, and the degradable layer is coated on the outer surface of the stent body through one or more of sewing, bonding and nailing.

Preferably, the degradable layer is of a nearly rectangular structure, one long edge of the degradable layer is longitudinally wrapped on the outer surface of the stent body through a suture, and the other long edge of the degradable layer is longitudinally fixed through an adhesion mode, so that the degradable layer is wrapped on the outer surface of the stent body.

Preferably, the stent body is woven by silk threads, the diameter of the stent is 12mm to 28mm, and the length of the stent is 4cm to 20 cm.

Preferably, the proximal portion and the distal portion of the two ends of the stent body are flange structures protruding from the middle section of the stent in the radial direction, and the flange structures are spherical, cup-shaped, ellipsoidal or cylindrical structures extending in the longitudinal direction.

Preferably, the distal end edge of the stent body is provided with a release structure;

the proximal end portion of support body is equipped with retrieves the line, retrieve the line including extending to external or keeping somewhere internal first receipts line to and set up in the second of proximal end portion edge and retrieve the line.

Preferably, the release structure is preferably a release ring having one end fixed at the distal edge of the stent body and the other end extending distally.

In order to overcome the technical problem that the stent delivery process is complicated and the stent is not easy to position in the prior art, the utility model also provides a stent delivery system for transplantation, which comprises the following structures:

a stent for transplantation;

an endoscope extending through an internal passage covered by a stent body in the stent for transplantation;

an outer sleeve sleeved outside the stent for transplantation;

and the minimally invasive surgical instrument is positioned in the endoscope clamping passage.

Preferably, the stent delivery system for transplantation has a stent structure for transplantation preferably used in the present invention.

Preferably, the minimally invasive surgical instrument comprises a minimally invasive surgical instrument with a clamping function, such as a biopsy forceps, a foreign body forceps or a clamp.

Through the technical scheme, the utility model discloses following technological effect has:

firstly, the utility model discloses with traditional supporting structure, degradable layer and active tissue mucous membrane integration innovatively, discover through the research and set up the degradable layer on the support, the degradable layer can induce epithelial regeneration's tissue mucous membrane well and transplant in patient's alimentary canal (preferred esophagus) excision department, active tissue mucous membrane can help to induce patient's alimentary canal epithelial cell regeneration, simultaneously the utility model discloses well preferred tissue mucous membrane layer structure set up the mode and can ensure that degradable layer furthest adheres to on the fibrin of the surface of a wound and the support body makes the multilayer structure who covers at its surface all hug closely on the alimentary canal wall through self expansion force, guarantee to transplant the mucous membrane survival, reduced the probability of mucous membrane unordered growth in the growth process simultaneously, effectively avoid along wound formation's alimentary canal narrow once more. In the clinical application process, after the wound of the digestive tract is epithelialized (after about 2-8 weeks), the degradable layer is automatically degraded, the epithelial of the digestive tract is successfully formed, and the stent is taken out to complete the whole stent operation treatment. According to different actual conditions of patients, the multilayer structure on the surface of the stent can be ensured to be tightly attached to the wall of the digestive tract through the optimal length and diameter of the stent, and the survival of transplanted mucous membrane is ensured.

Secondly, the utility model discloses an adopt specific support delivery system, transplant in the alimentary canal with the support whole and neither shift guaranteeing, under the prerequisite of too much oppression esophagus again, through arranging the scope outside in with the support ingeniously, the radial space of holding support has effectively been increased to overcome the defect of mucous membrane tissue excessive compression on the support, avoided causing on the support fixed tissue mucous membrane layer because of the oppression necrosis, mucous membrane tissue shift's the condition greatly reduced also simultaneously.

In addition, the fixed connection mode of degradable layer and support body is more simple convenient, can install according to actual conditions swiftly in the operation and form the utility model discloses support for transplantation, the conventional fixed knot constructs among the prior art relatively support for transplantation, the utility model provides a support for transplantation uses more in a flexible way, and is convenient, and firm connected mode can not influence the release and the recovery process of support moreover, can guarantee that the mucous membrane laminates completely in excision department all around simultaneously. The support structure is divided into a support middle section structure and flange structures at two ends, which is beneficial to fixing the support and preventing the support from shifting and falling off.

Drawings

FIG. 1 is a schematic view of the structure of a stent body in the stent for transplantation of the present invention;

FIG. 2 is an exploded view of the stent for transplantation of the present invention;

FIG. 3 is a schematic view showing the linear distribution of the mucosal tissue on the surface of the degradable layer in example 1 of the present invention;

FIG. 4 is a schematic diagram of the dislocation distribution of the mucosal tissue on the surface of the degradable layer of the present invention;

FIG. 5 is a schematic diagram of the distribution of the mucosal tissue array on the surface of the degradable layer of the present invention;

FIG. 6 is a schematic diagram of normal distribution of mucosal tissues on the surface of the degradable layer of the present invention;

FIG. 7 is a schematic view of the distribution of the mucosal tissue curve on the surface of the degradable layer of the present invention;

FIG. 8 is a schematic view of the connection between the degradable layer and the stent body in example 1 of the present invention;

fig. 9 is a schematic view of the connection between the degradable layer and the stent body in example 2 of the present invention;

fig. 10 is a schematic view of the connection between the degradable layer and the stent body in example 3 of the present invention;

FIG. 11 is a perspective view of the stent delivery system for implantation of the present invention before releasing the stent;

FIG. 12 is a perspective view of the stent delivery system for grafting in releasing the stent of the present invention;

fig. 13 is a perspective view of the stent delivery system for middle graft release stent of the present invention.

Description of reference numerals:

1-stent body, 2-stent middle section, 3-distal section, 4-proximal section, 5-distal release ring, 6-proximal second recovery line, 7-first recovery line, 8-degradable layer, 9-mucous membrane tissue, 10-suture line, 11-bonding material, 12-endoscope, 13-outer cannula, 14-minimally invasive surgical instrument, A-esophagus

Detailed Description

The technical contents of the present invention will be described in detail with reference to the accompanying drawings and specific embodiments.

Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will understand that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention.

Some terms referred to in the present invention will be explained. Proximal refers to the section near the operator outside the body, i.e., the buccal side; distal end refers to the end located in the body, i.e. the anal side; the longitudinal direction refers to the longitudinal extending direction of the stent for transplantation, can be non-linearly extended and generally corresponds to the extending direction of the digestive tract of a human body; radial refers to the direction extending perpendicular to the axial direction; circumferential means in a circumferential direction around the axial direction.

Example 1

As shown in fig. 1-3 and 8, the stent for transplantation in the first embodiment of the present invention comprises: the stent comprises a cylindrical stent body 1 extending longitudinally, wherein the stent body 1 is formed by weaving silk threads and has an expansion shape and a compression shape, wherein the stent body 1 is provided with a middle stent section 2 in the middle part in the longitudinal direction, and a distal end part 3 and a proximal end part 4 at two ends of the stent body 1; the stent body 1 is internally provided with a longitudinally extending internal passage, and the stent for transplantation also comprises a degradable layer 8 and a mucous membrane tissue layer 9. The structure of each part will be described in detail below.

As shown in fig. 1, the stent body 1 serving as a base support in this embodiment 1 is a full-covered wire mesh structure, and has good biocompatibility, the wire mesh is preferably woven by using an implantable flexible memory alloy wire, of course, the wire mesh material can be any existing implantable material besides alloy, and the wire mesh structure not only has good flexibility, but also helps release and recover the stent in the outer casing 13, and can effectively avoid excessive damage of the stent to human tissues. The utility model discloses the whole tectorial membrane structure of preferred silk screen, the silk screen is whole to be covered and is constructed, and the tectorial membrane structure on the support body 1 of course can also adopt current tectorial membrane structure, like form such as full tectorial membrane or partial tectorial membrane to reach the technological effect that effectively prevents granulation tissue to support ingrowth.

The utility model discloses in weave by the silk thread and form 2 diameters in support middle section are 12mm to 28mm to guarantee that the support neither can shift in the esophagus, can not excessively oppress esophagus A again simultaneously, cause transplantation mucous membrane blood supply insufficiency, necrosis. In addition, through the design repeatedly, the utility model discloses with 1 length control of support body in 4cm to 20cm within range, can make the support for the transplantation be suitable for different patients to can ensure that the mucous membrane transplantation is grown successfully.

In the present embodiment, the stent body 1 has a stent middle section 2 located in the middle in the longitudinal direction, and a distal end portion 3 and a proximal end portion 4 located at both ends of the stent body 1, and in the present embodiment, the distal end portion 3 and the proximal end portion 4 at both ends of the stent body 1 are flange structures protruding from the stent middle section 2 in the radial direction. The middle section 2 of the bracket is in a long tube shape, the tube body extends along the direction of a human body cavity in the treatment process, and the tube body structure of the middle section 1 of the bracket can be better attached to the wall surface of tissue in the human body; the distal end part 3 and the proximal end part 4 of the middle section 1 of the stent, which are provided with flange structures at two ends, are determined by the structure of human tissues, and the convex flange structures are arranged at two ends, so that the stent for transplantation is more firmly and stably positioned at the wound part in a human body cavity, and the displacement and falling of the stent are effectively prevented. As shown in fig. 1, in the present embodiment, the proximal portion 4 is a longitudinally extending cylinder-shaped structure which is easy to drag and not easy to deform, and the distal portion 3 is an ellipsoid which is less irritating to the body lumen. Of course, the flange structure may be any one of spherical, cup-shaped, ellipsoidal, or longitudinally extending cylindrical structures, depending on the actual treatment site.

As shown in fig. 1, the distal end portion 3 and the proximal end portion 4 of the stent body 1 are respectively fitted with first retrieval lines 7. The proximal end of the first retrieving line 7 can extend to the outside of the body or be detained in a body cavity such as the stomach, and the second retrieving line 6 is arranged at the proximal end of the edge of the proximal end portion 4, in this embodiment, the second retrieving line 6 can be two axially symmetrical wire rings, and can be arranged by 1 or a plurality of wire rings according to actual conditions, can extend towards the proximal end, and can also be wound in a wire mesh hole at the proximal end edge, so that the stent can be dragged out; the far end of the first rewinding line 7 is connected with the stent body 1 or connected with the near-end second rewinding line 6, after the wound is epithelialized, the degradable layer 8 is automatically degraded (after about 2-8 weeks), the esophagus A is successfully epithelialized, and the stent can be recovered through the first rewinding line 7 and the near-end second rewinding line 6, so that the stent treatment process is completed. The utility model discloses a set up the first time of two kinds of different structure functions at the near-end and receive line 7, realize effective, convenient support location, retrieve, improved the security and the success rate of operation.

Based on the idea that the release ring 5 is arranged on the distal end portion 3 of the stent body 1, the proximal end of the release ring 5 is connected with the wire mesh hole at the edge of the distal end portion, and the distal end extends to the distal end, the contact point of the minimally invasive surgical instrument 14 (such as a biopsy forceps, a foreign body forceps, a clamp and other minimally invasive instruments with a clamping function) which performs a clamping action in the release process and the release ring 5 is located at the distal end of the release ring 5, and the contact point preferably keeps a certain distance from the edge of the distal end portion of the stent body 1, so that the stability of the endoscope 12 and the minimally invasive surgical instrument 14 in the jaw channel for. In this embodiment, the release ring 5 may be two axially symmetric wire rings, and of course, 1 or more wire rings may be adopted according to actual situations. When the stent for transplantation is released, the endoscope 12 and the minimally invasive surgical instrument 14 in the forceps channel can move the surgical instrument dragging the release ring 5 from the internal passage of the stent for transplantation to the far end, drag the release ring 5 at the far end, drag the stent for transplantation out of the delivery system, and realize the release process of the stent.

As shown in fig. 2 and 8, in the embodiment 1, the degradable layer 8 serving as a supporting mucosal tissue layer 9 is coated on the outer surface of the stent body 1, and the degradable layer material may be made of a biodegradable material that can be used in a human body and has good biocompatibility. The degradable layer 9 can be coated on the outer surface of the stent body 1 by sewing and/or bonding. In this embodiment, the degradable layer 8 and the stent body 1 are fixed by sewing with a medical absorbable suture 10 (as shown in fig. 8). During the preparation, the degradable layer 8 circumference of approximate rectangle is around cladding to 1 outer peripheral face of support body, vertically sews up fixedly through stylolite 10 afterwards, and this fixed connection process can be accomplished before mucosa tissue layer 9 is fixed, also can be connected this degradable layer 8 and support body 1 after mucosa tissue layer 9 is fixed on degradable layer 8 again, the utility model discloses well fixed connection mode easy operation, and convenient nimble. The suture connection mode can ensure that the degradable layer 8 is not easy to fall off in the release process of the stent for transplantation, and the effectiveness of the operation is ensured.

The degradable layer 8 on the surface of the bracket body 1 of the utility model is used as a carrier for mucous membrane transplantation, and the mucous membrane tissue 9 is firmly attached to the surface of a wound under the action of the tension applied by the bracket body, so that the displacement is not easy to occur, the growth direction of the mucous membrane is controlled, and the absorption of human tissues is promoted; in addition, degradable layer 8 and support body 1's quick connect mode, easy operation, installation are swift, and at the operation scene, medical personnel can prepare required support for transplantation according to the actual operation condition completely, moreover the utility model discloses the connected mode not only firmly is difficult for droing and the connected mode can not influence the release and the recovery process of support yet, can guarantee simultaneously that the mucous membrane laminates completely in excision department all around.

As shown in fig. 3-7, in this embodiment 1, the mucosal tissue layer 9 closely attached to the esophagus a is fixedly disposed on the outer surface of the degradable layer 8, and the mucosal tissue layer 9 includes discrete mucosal tissues, and the mucosal tissues are distributed on the outer surface of the degradable layer 8 in a linear manner (as shown in fig. 3), a staggered manner (as shown in fig. 4), an array manner (as shown in fig. 5), a normal manner (as shown in fig. 6), a curve manner (as shown in fig. 7, the curve is a three-dimensional form after the mucosal layer is coated outside the degradable layer 8, such as a spiral form, or an irregular curve form), and the like. During the treatment process, the optimal distribution mode can be optimized according to the actual wound surface shape, the area size and the like, and the optimal diameter of the mucous membrane tissue element is selected so as to achieve the optimal treatment effect.

The mucosal tissue in the mucosal tissue layer 9 includes autologous mucosa and/or stem cell cultured mucosa, such as human body, other mammalian organisms, artificially cultured mucosal tissue, etc., and each mucosal tissue element may be in the shape of dot, sheet, strip, etc. The mucous membrane tissue layer 9 can better help to induce the regeneration of the epithelial cells of the esophagus A, the biodegradable layer 8 can be attached to the fibrin of the wound surface, and the metal bracket is tightly attached to the wall of the esophagus A, so that the mucous membrane can be prevented from disordered growth in the growth process to cause restenosis.

In the utility model, the mucous membrane tissue 9 is directly fixed to the outer surface of the degradable layer 8 through one or more modes of sewing, bonding and nailing, and the connection mode is convenient and firm. Furthermore, the mucosal tissue 9 may be placed in the open bag so that the open bag carries the mucosal tissue 9, or may be directly fixed to the outer surface of the degradable layer 8 by one or more of suturing, adhering, and stapling, which may avoid detachment, loss, deformation, and the like of the mucosal tissue 9 during the delivery process, which is not favorable for subsequent tissue healing.

As shown in fig. 11 to 13, a delivery system as a stent for transplantation shown in example 1 includes the following structure: the stent for transplantation in embodiment 1 includes an endoscope 12, a minimally invasive surgical instrument 14 (e.g., a minimally invasive surgical instrument having a holding function such as a biopsy forceps, a foreign body forceps, or a clip) extending through an internal passage covered with a stent body 1, and an outer sheath 13 fitted to an outer side of the stent for transplantation. Before release, the stent for transplantation is compressed and contained in the outer sleeve 13, the endoscope 12 penetrates through an internal passage in the stent to play roles of deflecting, positioning and supporting the stent, the minimally invasive surgical instrument 14 plays a role of releasing the stent for transplantation besides a surgical function, at least one minimally invasive surgical instrument 14 is adopted according to actual conditions, and the minimally invasive surgical instrument 14 comprises a biopsy forceps, a foreign body forceps or a clamp and other minimally invasive surgical instruments 14 with a clamping function. The utility model discloses a establish the support cover outside the scope, greatly increased the radial accommodation space of support, avoided the mucous membrane layer to receive excessive extrusion and necrosis. Through clinical practice, the utility model discloses well mucosa layer necrosis condition effectively reduces, and the survival rate of transplanting obviously improves.

The utility model discloses the concrete operation process of well transplantation with support delivery system specifically as follows.

As shown in fig. 11 and 12, the stent body 1 is firstly firmly connected with the degradable layer 8 and the mucous membrane tissue layer 9 (autologous mucous membrane and/or stem cell culture), the prepared stent for transplantation is compressed and then placed in the outer sleeve 13, and then the endoscope 12 is placed in the inner channel covered by the stent body 1. The endoscope 12 is extended into the esophagus A to observe the wound surface condition, the outer sleeve 13 and the bracket body 1 are extended to the neck of the esophagus, the endoscope 12 is retracted to enable the far end of the endoscope to be located near the far end of the outer sleeve 13, the minimally invasive surgical instrument 14 (biopsy forceps, foreign body forceps, clamps and the like) is conveyed to the far end of the endoscope along a forceps channel of the endoscope 12, the far end release ring 5 of the bracket body 1 is clamped by the minimally invasive surgical instrument 14, the bracket is dragged by pushing the endoscope 12 and the minimally invasive surgical instrument 14, and after the bracket for transplantation is completely released from the outer sleeve 13, the bracket for transplantation can be dragged by the endoscope 12 and the minimally invasive surgical instrument 14 to move in the esophagus A until the bracket reaches a complete circumferential resection part, so that the degradable layer 8 and the mucous membrane tissue layer 9 on the surface of the bracket are completely pasted on. The first retrieval line 7 fixed to the proximal end portion 4 of the stent for transplantation can be used to leave the proximal end in the stomach or in the outside of the body for subsequent retrieval of the stent for transplantation. After the stent for transplantation is released, the endoscope 12, the minimally invasive surgical instrument 14 and the outer sleeve 13 are withdrawn, and the stent treatment process is completed.

As shown in fig. 1 and 13, after about 2-8 weeks, the main stent 1 is recovered after the degradable layer 8 is automatically degraded and the esophagus a is epithelialized. Dragging a second recovery wire 6 at the near end of the bracket body 1 through a first recovery wire 7 in cooperation with an endoscope 12 and a minimally invasive surgical instrument 14 in a forceps channel; or the endoscope 12 and the minimally invasive surgical instrument 14 in the forceps channel drag the first retraction line 7 at the proximal end of the stent body 1 to complete the recovery process of the stent for transplantation.

Example 2

As shown in fig. 9, the degradable layer 8 and the stent body 1 in example 1 are sewn and fixed instead. In this embodiment, the stent body 1 and the degradable layer 8 are fixed by adhesion. The degradable layer 8 and the stent body 1 are fixedly connected through an adhesive material 11, and the adhesive material 11 can be a conventional medical adhesive used in a human body, such as an adhesive tape or a double-sided adhesive tape. When prepared, the degradable layer 8 with approximate rectangle is wrapped around the outer circumference of the stent body 1, and then the long sides of the degradable layer 8 with bilateral symmetry are fixed to the stent body 1 longitudinally through the bonding material 11. The fixing and connecting process can be completed before the mucosa tissue layer 9 is fixed, and the degradable layer 8 can be connected with the stent body 1 after the mucosa tissue layer 9 is fixed on the degradable layer 8. Compare with the connection mode of sewing up in embodiment 1, utilize prefabricated adhesive material 11 to fix degradable layer 8 and support body 1 and paste, it is more convenient fast to operate, saves artifical process of making up, improves preparation efficiency.

Example 3

As shown in fig. 10, the degradable layer 8 and the stent body 1 in example 1 are sewn and fixed instead. In this embodiment, the degradable layer 8 is of a nearly rectangular structure, one long edge of the degradable layer is longitudinally fixed to the outer surface of the stent body 1 by sewing, and the other long edge of the degradable layer is longitudinally fixed by adhesion, so that the degradable layer 8 covers the outer surface of the stent body 1. During preparation, the first long edge of the degradable layer 8 is longitudinally sewn with the stent body 1, then the degradable layer 8 is circumferentially wound for a circle around the outer circumferential surface of the stent body 1, and finally the second long edge of the degradable layer 8 is adhered and fixed with the first long edge sewn to the stent body 1 before through the adhesive material 11. This process of fixing and connecting can be performed before the fixing of the mucosa tissue layer 9, or the degradable layer 8 can be connected with the stent body 1 after the mucosa tissue layer 9 is fixed on the degradable layer 8. Compared with the connection mode in the embodiments 1 and 2, the embodiment has the advantages of both the fixing strength of the suture and the rapidness and convenience of the adhesion fixing mode, and improves the safety and the preparation efficiency of treatment.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention.

Claims (9)

1. A stent for transplantation, comprising:

a stent body woven from filaments and having an expanded form and a compressed form, wherein,

the stent body has a stent middle section in the middle in the longitudinal direction, and a proximal end portion and a distal end portion at both ends of the stent body;

the stent body is internally provided with a longitudinally extending internal passage,

the stent body is provided with a film covering structure which is in a full film covering or partial film covering form,

characterized in that, the stent for transplantation further comprises:

the degradable layer is coated on the outer surface of the stent body;

the mucous membrane tissue layer is fixedly arranged on the outer surface of the degradable layer.

2. The stent for transplantation according to claim 1, wherein:

the mucous membrane tissue layer comprises mucous membrane tissues distributed in any one or more of normal, dislocation, array, linearity and curve, and the mucous membrane tissues comprise autologous mucous membranes and/or stem cell cultured mucous membranes.

3. The stent for transplantation according to claim 1, wherein:

the degradable layer is coated on the outer surface of the stent body in a sewing and/or bonding mode;

the mucosal tissue is secured to the outer surface of the degradable layer by one or more of suturing, adhering, stapling.

4. The stent for transplantation according to claim 3, wherein:

the degradable layer is of a rectangular structure, one long edge is longitudinally fixed on the outer surface of the bracket body through sewing, and the other long edge is longitudinally fixed through an adhesion mode, so that the degradable layer is coated on the outer surface of the bracket body.

5. The stent for transplantation according to any one of claims 1 to 4, wherein:

the stent body is formed by weaving silk threads, the diameter of the stent is 12mm to 28mm, and the length of the stent is 4cm to 20 cm.

6. The stent for transplantation according to any one of claims 1 to 4, wherein:

the proximal end part and the distal end part of the two ends of the bracket body are flange structures protruding out of the middle section of the bracket in the radial direction, and the flange structures are spherical, cup-shaped, ellipsoidal or cylindrical structures extending along the longitudinal direction.

7. The stent for transplantation according to any one of claims 1 to 4, wherein:

the edge of the far end part of the bracket body is provided with a release structure;

the proximal end portion of support body is equipped with retrieves the line, retrieve the line including extending to external or keeping somewhere internal first receipts line to and set up in the second of proximal end portion edge and retrieve the line.

8. A stent delivery system for transplantation, comprising the following structure:

a stent for transplantation;

it is characterized in that the preparation method is characterized in that,

the stent delivery system for transplantation further comprises:

an endoscope extending through an internal passage covered by a stent body in the stent for transplantation;

an outer sleeve sleeved outside the stent for transplantation;

a minimally invasive surgical instrument positioned in the endoscopic forceps channel,

wherein the stent for transplantation has a stent structure for transplantation according to any one of claims 1 to 7.

9. The stent delivery system for transplantation according to claim 8, wherein:

the minimally invasive surgical instrument comprises a minimally invasive surgical instrument with a clamping function.

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