CN211877862U - Ionization analysis system - Google Patents
Ionization analysis system Download PDFInfo
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- CN211877862U CN211877862U CN202020385978.5U CN202020385978U CN211877862U CN 211877862 U CN211877862 U CN 211877862U CN 202020385978 U CN202020385978 U CN 202020385978U CN 211877862 U CN211877862 U CN 211877862U
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Abstract
The utility model provides an ionization analysis system, which comprises an ion detector; the sampling probe is suitable for being inserted into the cavity; the adsorption substance is arranged on the outer wall of the part of the sampling probe, which is suitable for extending into the cavity; the two opposite ends of the cavity are provided with a first opening and a second opening, the sampling probe penetrates through the first opening to enter the cavity, and the interior of the cavity is communicated with the ion detector through the second opening; the medium barrier layer is arranged on the inner wall of the cavity; the discharge electrode is arranged on the outer side of the cavity; the gas channel is formed on the outer side of the sampling probe and extends along the length direction of the sampling probe; the gas channel has an inlet. The utility model has the advantages of high efficiency of sampling and ionization, wide application range, etc.
Description
Technical Field
The present invention relates to ionization, and more particularly to ionization analysis systems.
Background
Pretreatment is an essential step for complicated sample analysis, but the time consumed by pretreatment often accounts for more than two-thirds of the analysis process. With the continuous development of the instrument level and the analysis technology, the sample pretreatment becomes a bottleneck restricting the rapid analysis and detection.
Solid Phase Microextraction (SPME) is a relatively new sample pretreatment technique that is based on the partitioning of target compounds between the extraction coating (stationary phase) and the solution. Compared with the traditional sample pretreatment technology such as liquid-liquid extraction, Soxhlet extraction and the like, the method has the advantages of less sample consumption, simple and convenient operation, no secondary pollution and the like. Currently, SPME is commonly used in conjunction with GC or LC for analysis of volatile or thermally labile substances. The disadvantages are that: the combination of GC or LC increases the complexity of the instrument to a certain extent, and is not suitable for rapid detection or in-situ detection.
Currently, researchers have attempted to use SPME directly in conjunction with an in situ ionization ion source. The patent TWI488215B proposes a mass spectrometry system based on a solid phase microextraction probe, wherein a heating unit instantaneously vaporizes a substance to be detected on the solid phase microextraction probe, and a charge generating unit sprays charged liquid drops to fuse with the vaporized substance to be detected, so as to form ions of the substance to be detected to enter mass spectrometry. However, the ionization process is in an open environment, the fusion of the vaporized to-be-detected object and the charged liquid drop is easily interfered by the environment, and experimental errors are caused.
SUMMERY OF THE UTILITY MODEL
For solving the not enough among the above-mentioned prior art scheme, the utility model provides a sample and ionization high efficiency, wide ionization analytic system of range of application.
The utility model aims at realizing through the following technical scheme:
an ionization analysis system comprising an ion detector; the ionization analysis system further comprises:
a sampling probe adapted to be inserted into a cavity;
an adsorbent material disposed on an outer wall of a portion of the sampling probe adapted to extend into the cavity;
the sampling probe penetrates through the first opening to enter the cavity, and the interior of the cavity is communicated with the ion detector through the second opening;
the medium barrier layer is arranged on the inner wall of the cavity;
the discharge electrode is arranged on the outer side of the cavity;
a gas channel formed outside the sampling probe and extending in a length direction of the sampling probe; the gas channel has an inlet.
Compared with the prior art, the utility model discloses the beneficial effect who has does:
1. the ionization is efficient;
in the application, gas in the gas channel is firstly ionized by the discharge electrode to form plasma, and the plasma is used as a sample on the sampling probe, so that the ionization process is more efficient;
the heated gas is more beneficial to the desorption of a sample on the sampling probe, and the ionization process is more efficient;
2. sampling is efficient;
the operation can be completed only by inserting the sample probe stained with the sample into an analysis system, so that the operation is efficient and rapid;
3. the application range is wide;
the method can be freely switched between dielectric barrier discharge and proton transfer reaction, so that the application range of the sample is expanded;
the discharge, ionization and transmission are all completed in a closed cavity, the environmental interference is small, and the method is suitable for various analysis occasions.
Drawings
The disclosure of the present invention will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only intended to illustrate the technical solution of the present invention and are not intended to limit the scope of the present invention. In the figure:
FIG. 1 is a simplified schematic diagram of an ionization analysis system according to an embodiment of the present invention;
fig. 2 is another schematic diagram of an ionization analysis system according to an embodiment of the present invention.
Detailed Description
Fig. 1-2 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and reproduce the invention. For the purpose of teaching the present invention, some conventional aspects have been simplified or omitted. Those skilled in the art will appreciate variations or substitutions from these embodiments that will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Accordingly, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.
Example 1:
fig. 1 schematically shows a schematic view of an ionization analysis system according to embodiment 1 of the present invention, and as shown in fig. 1, the ionization analysis system includes:
a sampling probe 12, for example in a tubular configuration, said sampling probe 12 being adapted to be inserted into the cavity 2;
an adsorbent (not shown) disposed on an outer wall of a portion of the sampling probe adapted to protrude into the cavity, the adsorbent adapted to adsorb a sample to be measured;
the cavity 2 is in a cylindrical structure, two opposite ends of the cavity 2 are provided with a first opening and a second opening, the sampling probe 12 penetrates through the first opening to enter the cavity 2, and the interior of the cavity 2 is communicated with the ion detector 3 through the second opening;
the dielectric barrier layer 21, the said dielectric barrier layer 21 is set up in the inboard wall of the said cavity 2;
the discharge electrode 22, the said discharge electrode 22 is set up in the outside of the said cavity 2;
a gas channel formed outside the sampling probe and extending in a length direction of the sampling probe; the gas channel has an inlet such that gas within the gas channel flows along the outer wall of the sampling probe towards the end having the adsorbent material.
To form a stable gas flow, further, the ionization analysis system further comprises:
a sleeve 11, wherein the sleeve 11 is fixed on the outer side of the sampling probe 12 and enters the cavity 2 along with the sampling probe 12 passing through the first opening; or the sleeve 11 is fixed in the cavity 2, and the sampling probe 12 passes through the first opening and enters the sleeve 11;
the gas passage forms a space between the sampling probe and the sleeve.
In order to increase the intensity of the detection signal, the chamber has a steam inlet 31 through which steam such as water vapor or methanol is introduced as needed.
To evacuate the effects of the sleeve on ionization, further, one end of the sampling probe within the cavity extends outside the sleeve.
In order to reduce the influence of the external environment on the ionization in the cavity, further, the ionization system further comprises:
a seal 4, 24 arranged at the first and/or second opening.
In order to improve the desorption capability of the gas in the gas channel on the sample on the sampling probe, further, the ionization analysis system further comprises:
a heating unit for increasing the temperature within the gas passage within the cavity.
In order to improve the ionization efficiency of the sample, further, the sampling probe adopts a hollow tube with a closed end, and the adsorption substance is arranged on the outer wall of the closed end.
In order to adapt to various samples to be detected, the adsorption substance is any one of polydimethylsiloxane, polydimethylsiloxane/divinylbenzene, acrylamide, polyethylene glycol/polydimethylsiloxane, molecularly imprinted polymer or carbon nanotube, mesoporous material and graphene.
The ionization analysis system of the present embodiment works in the following manner:
one end of the sampling probe extends into the sample solution, and the adsorption substance adsorbs the sample;
one end of the sampling probe with the adsorbed substances passes through the first opening to enter the cavity;
the gas enters the gas channel and flows out of the cavity to purge the sample on the sampling probe;
the discharge electrode discharges, the sample is ionized, and the ions pass through the second opening into the ion detector.
Example 2:
an application example of the ionization analysis system according to embodiment 1 of the present invention.
In the present application example, as shown in fig. 1, the sampling probe 12 is a hollow tube with one end closed, the hollow tube is made of insulating materials such as glass, quartz, and ceramics, and the closed end has an adsorbing substance such as polydimethylsiloxane; the sleeve 11 is fixed on the outer side of the sampling probe 12, a gas channel is formed between the sampling probe 12 and the sleeve 11, a gas inlet 13 and a gas outlet 14 are formed in the sleeve, and the gas inlet 13 and the gas outlet 14 are far away from the closed end; the closed end of the sampling probe 12 extends out of the casing 11;
the hollow cavity 2 is provided with a medium barrier layer 21, and an annular discharge electrode 22 is arranged on the outer side of the medium barrier layer 21; the steam inlet 31 is arranged on the medium barrier layer 21 and communicated with the inside of the cavity 2; a sealing gasket 24 is arranged at the first opening of the cavity, and the sleeve 11 is inserted into the cavity 2 through the sealing gasket 24; the annular electrode 22 is connected with an alternating current high-voltage power supply, the power of the alternating current is 5-30W, the voltage is 1-20kV, and the frequency is 10-1000 Hz; the second opening of the cavity 2 is provided with a sealing element 4, the ion detector 3 is connected with the sealing element 4 and is provided with a vacuum pumping system, the internal pressure of the vacuum pumping system is far less than the internal pressure of the cavity 2, most of the gas entering from the gas inlet 13 enters the cavity 2 under the action of pressure difference, and a small part of the gas is discharged through the gas outlet 14.
The utility model discloses ionization analytic system's working method does:
the sampling probe 12 is immersed in the sample solution for a period of time while the solution is stirred to accelerate the two phases to reach equilibrium;
the closed end of the sampling probe 12 passes through the sealing washer 24, and part of the sampling probe and the sleeve are inserted into the cavity 2;
introducing gas such as nitrogen, helium, argon and the like into the gas inlet 13, wherein the flow rate of the gas is 0.03-5L/min; part of gas enters a gas channel between the sleeve 11 and the sampling probe due to the low-pressure environment in the cavity 2, flows towards the closed end of the sampling probe 12 and takes away a sample adsorbed on the sampling probe;
the discharge electrode 22 is connected with an alternating current high voltage power supply and discharges the gas flow carrying the sample at the closed end of the sampling probe 12, thereby forming an ion beam;
under the action of the pressure difference, the ion beam enters the ion detector 3 through the sealing piece 4 for analysis;
when the detection signal is weak, the steam passes through H from the steam inlet 312And the detection signal intensity is improved by O or methanol and other steam (which is ionized by plasma and converted into ionization by proton transfer reaction).
Example 3:
an application example of the ionization analysis system according to the embodiment 1 of the present invention in detecting caffeine is shown in fig. 2, which is different from the embodiment 2:
1. the sleeve 11 is fixed in the cavity 2, when the sampling probe 12 is inserted into the cavity 2, the sampling probe is positioned in the sleeve 11, and the closed end of the sampling probe 12 inserted into the cavity 2 extends out of the sleeve 11; the gas inlet 13 of the sleeve 11 extends out of the cavity 2;
2. a heating element 23 is arranged in the cavity 2 to increase the temperature of the gas between the sleeve 11 and the sampling probe 12.
Claims (8)
1. An ionization analysis system comprising an ion detector; the method is characterized in that: the ionization analysis system further comprises:
a sampling probe adapted to be inserted into a cavity;
an adsorbent material disposed on an outer wall of a portion of the sampling probe adapted to extend into the cavity;
the sampling probe penetrates through the first opening to enter the cavity, and the interior of the cavity is communicated with the ion detector through the second opening;
the medium barrier layer is arranged on the inner wall of the cavity;
the discharge electrode is arranged on the outer side of the cavity;
a gas channel formed outside the sampling probe and extending in a length direction of the sampling probe; the gas channel has an inlet.
2. The ionization analysis system of claim 1, wherein: the ionization analysis system further comprises:
the sleeve is fixed on the outer side of the sampling probe and enters the cavity along with the sampling probe passing through the first opening; or the sleeve is fixed in the cavity, and the sampling probe passes through the first opening and enters the sleeve;
the gas passage forms a space between the sampling probe and the sleeve.
3. The ionization analysis system of claim 2, wherein: one end of the sampling probe in the cavity extends out of the sleeve.
4. The ionization analysis system of claim 1, wherein: the ionization system further comprises:
a seal disposed at the first opening and/or the second opening.
5. The ionization analysis system of claim 1, wherein: the cavity has a steam inlet.
6. The ionization analysis system of claim 2, wherein: the ionization analysis system further comprises:
a heating unit for increasing the temperature within the gas passage within the cavity.
7. The ionization analysis system of claim 1, wherein: the sampling probe adopts a hollow pipe with a closed end, and the adsorption substance is arranged on the outer wall of the closed end.
8. The ionization analysis system of claim 1, wherein: the adsorption substance is any one of polydimethylsiloxane, polydimethylsiloxane/divinylbenzene, acrylamide, polyethylene glycol/polydimethylsiloxane, molecularly imprinted polymer or carbon nanotube, mesoporous material and graphene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020385978.5U CN211877862U (en) | 2020-03-24 | 2020-03-24 | Ionization analysis system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202020385978.5U CN211877862U (en) | 2020-03-24 | 2020-03-24 | Ionization analysis system |
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| CN211877862U true CN211877862U (en) | 2020-11-06 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111370289A (en) * | 2020-03-24 | 2020-07-03 | 宁波大学 | Ionization analysis system and method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111370289A (en) * | 2020-03-24 | 2020-07-03 | 宁波大学 | Ionization analysis system and method |
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