CN210090485U - Multi-parameter high-flux fluorescence immunoassay device - Google Patents

Multi-parameter high-flux fluorescence immunoassay device Download PDF

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Publication number
CN210090485U
CN210090485U CN201920906114.0U CN201920906114U CN210090485U CN 210090485 U CN210090485 U CN 210090485U CN 201920906114 U CN201920906114 U CN 201920906114U CN 210090485 U CN210090485 U CN 210090485U
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assembly
card
reagent card
module
fluorescence immunoassay
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CN201920906114.0U
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Inventor
梁桂彬
黄炜中
王振刚
吴涛
赵明建
刘波
李静
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Gua Teng Biotechnology Shenzhen Co ltd
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Guateng Technology (shenzhen) Co Ltd
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Abstract

The embodiment of the utility model discloses a multi-parameter high-flux fluorescence immunoassay device, which comprises a mainframe box, wherein a card storage box is arranged in the mainframe box, a reagent card cartridge clip is arranged in the card storage box, a card loading assembly is correspondingly arranged below the reagent card cartridge clip, and an optical detection assembly A, an incubation assembly and an optical detection assembly B are sequentially arranged on one side of the reagent card cartridge clip corresponding to the card discharging direction; one end of the reagent card cartridge clip is provided with a test tube rack assembly, and the other end is correspondingly provided with a reagent card recovery box; the mainframe box is also correspondingly provided with a liquid transfer assembly, and a bar code scanning assembly is also arranged in the mainframe box. The utility model discloses type, process such as application of sample, dilution, mixing, incubation, optical detection from the sample code, all realized full-automatic, can improve detection efficiency, reduce error and mistake that the people was brought for participating in.

Description

Multi-parameter high-flux fluorescence immunoassay device
Technical Field
The utility model relates to the technical field of automatic detection of biology and medical instruments, in particular to a multi-parameter high-flux fluorescence immunoassay device.
Background
At present, the quantitative detection of fluorescence immunity is relatively mature. In the existing fluorescence immunoassay quantitative analyzer, a part of reagent cards of the fluorescence immunoassay quantitative analyzer are put in, and samples are sampled and mixed uniformly, wherein the sample adding needs human participation. The main problems of the method are high labor cost, low detection efficiency and poor measurement stability and accuracy. The main reason for the low efficiency of detection is that most of them require human to complete. The measurement stability and accuracy are poor, some reasons are also artificial, and due to the inconsistency of the sample adding and sampling methods of each detector, the amount of the sample finally added to the reagent card is different, and particularly, the required amount of the sample is relatively small (less than 5 ul).
The other part of fluorescence immunoassay quantitative analyzer has the defects of large instrument volume, few detection items, large environmental influence on detection and the like. The instrument with larger volume occupies large space, is not only not beneficial to placement, but also has relatively higher production cost. Currently there are few instruments that can detect more than three reagent cards simultaneously. The common fluorescent card only has one detection parameter, which means that the common instrument can only detect three parameters simultaneously. Because the fluorescence quantitative analyzer is sensitive to temperature and light, the fluorescence quantitative analyzer is easily influenced by the temperature and the illumination outside or inside the analyzer.
SUMMERY OF THE UTILITY MODEL
The embodiment of the utility model provides a technical problem that will solve provides a multi-parameter high flux fluorescence immunoassay device to make the realization under comparatively complicated operational environment, accomplish the quantitative high flux detection of fluorescence immunity to multiple parameter.
In order to solve the technical problem, the embodiment of the utility model provides a multi-parameter high-flux fluorescence immunoassay device, which comprises a mainframe box, wherein a card storage box is arranged in the mainframe box, a reagent card cartridge clip is arranged in the card storage box, a card loading assembly is correspondingly arranged below the reagent card cartridge clip, and an optical detection assembly A, an incubation assembly and an optical detection assembly B are sequentially arranged on one side of the reagent card cartridge clip corresponding to the card discharging direction; one end of the reagent card cartridge clip is provided with a test tube rack assembly, and the other end is correspondingly provided with a reagent card recovery box; the mainframe box is also correspondingly provided with a liquid transfer assembly, and a bar code scanning assembly is also arranged in the mainframe box.
Furthermore, one end of the mainframe box corresponding to the test tube rack assembly is provided with a consumable replacing assembly and a position self-calibration assembly.
Furthermore, the upper clamping assembly comprises a linear motor module, a shifting piece and a shifting piece mounting frame, wherein the shifting piece is arranged on the shifting piece mounting frame, and the shifting piece mounting frame is arranged on a rotor of the linear motor module; the reagent card cartridge clip is box-shaped, and all opens from top to bottom, and both sides all open the logical groove that the piece of being convenient for to stir passes through around the bottom.
Furthermore, the incubation assembly comprises an incubation chamber, a temperature control device and a heat dissipation assembly, wherein the width of the incubation chamber is consistent with that of the reagent card, and the front end and the rear end of the incubation chamber are provided with openings; the temperature control device is a semiconductor cold and hot device and is arranged on the incubation chamber to adjust the temperature in the incubation chamber; the heat radiation component is arranged on the temperature control device and consists of heat radiation fins, a heat radiation fan and a temperature protection switch.
Furthermore, the optical detection assembly A and the optical detection assembly B are both composed of a support, a linear driving mechanism arranged on the support and an optical module arranged on the linear driving mechanism.
Further, optical module includes the module main part, the vertical detection aperture that is equipped with in the module main part, from the top down is equipped with optical sensor, filter A, lens A, dichroscope, lens B, grating in proper order in the detection aperture, and wherein, dichroscope and detection aperture are 45 degrees angles, and one side that corresponds dichroscope in the module main part is equipped with the income light aperture perpendicular with detection aperture, goes into the light aperture and is equipped with filter B, lens C from the outside in proper order.
Further, the module main part is formed by two half-parts concatenation, and the both sides in detection aperture and the income light aperture in two half-parts all are equipped with light barrier band.
Further, the liquid-transfering component comprises a three-axis driving mechanism, a taking and placing motor, a plunger pump and a liquid-transfering tube, wherein the three-axis driving mechanism is arranged on the mainframe box, the plunger pump and the taking and placing motor are arranged on the three-axis driving mechanism, the liquid-transfering tube is arranged on the taking and placing motor, and the liquid-transfering tube is connected with the plunger pump.
Further, the consumable replacing component comprises a bracket, and a kit and a suction head are arranged on the bracket.
The utility model has the advantages that: the utility model realizes full automation from the processes of sample code input, sample adding, sampling, dilution, mixing, incubation, optical detection and the like, can improve the detection efficiency, and reduces errors and mistakes caused by artificial participation;
the utility model can be provided with a plurality of reagent card inlet channels, can be used for placing reagent cards with various parameters, and ensures the diversity of measurement parameters;
the utility model adopts a special design, not only reduces the volume of the instrument, but also designs good heat dissipation and temperature isolation, and ensures that the instrument has higher stability and accuracy under a harsher temperature environment;
the utility model discloses an optical module has designed the light barrier zone, has effectively prevented the entering of external disturbance light to block the crosstalk of the inside light of optical module, guarantee that the instrument has higher stability and accuracy under comparatively complicated luminous environment.
Drawings
FIG. 1 is a perspective view of a multi-parameter high-throughput fluorescence immunoassay device according to an embodiment of the present invention.
Fig. 2 is a perspective view of the card loading assembly according to the embodiment of the present invention.
Fig. 3 is a perspective view of the card hopper according to the embodiment of the present invention.
Fig. 4 is an exploded view of an incubation assembly of an embodiment of the invention.
Fig. 5 is a perspective view of an optical detection assembly B according to an embodiment of the present invention.
Fig. 6 is a perspective view of an optical module according to an embodiment of the present invention.
Fig. 7 is a schematic diagram of an internal structure of an optical module according to an embodiment of the present invention.
Fig. 8 is a perspective view of a pipetting assembly according to an embodiment of the invention.
Fig. 9 is a perspective view of a consumable replacement assembly according to an embodiment of the present invention.
Detailed Description
It should be noted that, in the present application, the embodiments and features of the embodiments may be combined with each other without conflict, and the present invention is further described in detail with reference to the accompanying drawings and specific embodiments.
In the embodiment of the present invention, if there is directional indication (such as upper, lower, left, right, front, and rear … …) only for explaining the relative position relationship between the components and the motion situation under a certain posture (as shown in the drawing), if the certain posture is changed, the directional indication is changed accordingly.
In addition, the descriptions of the first, second, etc. in the present invention are for descriptive purposes only and are not to be construed as indicating or implying any relative importance or implicit indication of the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature.
Referring to fig. 1 to 9, the multi-parameter high-throughput fluorescence immunoassay device of the embodiment of the present invention includes a main chassis 10, a card storage box 20 is disposed in the main chassis 10, a reagent card cartridge 21 is disposed in the card storage box 20, and a card loading assembly 30 is correspondingly disposed below the reagent card cartridge 21.
The reagent card cartridge 21 is provided with an optical detection assembly A40, an incubation assembly 50 and an optical detection assembly B60 in sequence on one side corresponding to the card-out direction. One end of the reagent card cartridge clip 21 is provided with a test tube rack assembly 70, and the other end is correspondingly provided with a reagent card recovery box 13. The main cabinet 10 is correspondingly provided with a liquid-transfering component 80, and the main cabinet 10 is also internally provided with a bar code scanning component 11.
The card storage box 20, the reagent card clip 21, the card loading assembly 30, the optical detection assembly A40, the incubation assembly 50, the optical detection assembly B60, the test tube rack assembly 70 and the bar code scanning assembly 11 are all arranged on the bottom plate of the main case 10, and the liquid moving assembly 80 is arranged on two sides in the main case 10. The test tube rack assembly 70 includes test tubes, test tube racks, and test tube rack guide rails.
In one embodiment, a consumable exchange assembly 90 and a position self-alignment assembly 12 are disposed in the main housing 10 at an end corresponding to the test tube rack assembly 70.
In one embodiment, the upper clamping assembly 30 includes a linear motor module 31, a dial plate 32, and a dial plate mounting bracket 33, wherein the dial plate 32 is disposed on the dial plate mounting bracket 33, and the dial plate mounting bracket 33 is disposed on a mover of the linear motor module 31. The reagent card cartridge clip 21 is box-shaped and has openings at the upper and lower sides, and the front and rear sides of the bottom are provided with through grooves for the poking pieces 32 to pass through. The card loading assembly 30 mainly realizes that the reagent card moves from the card storage box 20 to the sample loading position and the optical detection position of the incubation assembly 50. The upper clamping assembly 30 preferably has 3 toggle pieces 32 connected to the upper surface of the mounting bracket of the toggle pieces 32 by torsion springs and rotating shafts. The linear motor module 31 drives the poking piece mounting rack 33 to move back and forth, so that the reagent card is pushed to move. The upper clamping assembly 30 further includes a photoelectric switch mounted on the main housing 10, and the photoelectric switch is used for limiting the starting position and the stroke of the mover. The card storage box 20 is used for storing the reagent cards, the inside of the card storage box 20 is separated by a partition plate, and at least 6 reagent card clips 21 can be placed in the card storage box 20, namely at least 6 channels are formed.
As an embodiment, the incubation assembly 50 includes an incubation chamber, a temperature control device 54 and a heat dissipation assembly, wherein the width of the incubation chamber is the same as that of the reagent card, and the front end and the rear end are open; the temperature control device 54 is a semiconductor cold-hot device, is arranged on the incubation chamber and is used for adjusting the temperature in the incubation chamber; the heat dissipation assembly is disposed on the temperature control device 54 and is composed of a heat dissipation fin 51, a heat dissipation fan 52 and a temperature protection switch 53. The incubation assembly 50 is mainly used for performing constant-temperature incubation of the reagent card, and can adjust the temperature inside the incubation chamber. Because the temperature control device 54 is a semiconductor cold-hot device, it has two sides, one side is heating and the other side is refrigerating; the effective surface for incubation is the bottom surface of the temperature control device, which is in contact with the incubation chamber. The smaller the temperature difference between the two surfaces is, the better the temperature control effect is; in order to reduce the temperature difference and increase the heat exchange between the top surface of the temperature control device 54 and the air, the heat dissipation fins 51 are installed above the temperature control device, and the heat of the heat dissipation fins 51 is taken away by the heat dissipation system consisting of the heat dissipation fan 52 and the heat dissipation cover. Meanwhile, in order to prevent the generation of condensed water around the temperature control device 54, a heat insulating pad 57 surrounds the temperature control device 54, and the temperature control device 54 is distributed in a W shape. The incubation chamber is composed of an incubation cover plate 55 and an incubation bottom plate 56, the incubation cover plate 55 is arranged below the temperature control device 54, heat is guided into the incubation chamber and onto the incubation bottom plate 56, and in order to prevent the heat in the incubation chamber from being dissipated rapidly, a heat insulation pad 57 is also arranged below the incubation bottom plate 56.
In one embodiment, each of the optical detection module a40 and the optical detection module B60 includes a support, a linear driving mechanism 61 disposed on the support, and an optical module 62 disposed on the linear driving mechanism 61. The optical detection assembly A40 mainly realizes optical detection of reagent cards on each channel, and is mainly used for detecting two-dimensional codes and the like on the reagent cards. The linear driving mechanism 61 comprises an optical module mounting bracket, a nut bracket, a linear motor, an optical detection mounting bracket, an optical tow chain and an optical tow chain bracket, wherein the optical module 62 is fixed on the optical module mounting bracket which is connected with the nut bracket, and the linear motor rotates to drive the optical module 62 to move, so that each channel is scanned; the optical drag chain is fixed on the optical detection mounting bracket, and one section of the optical drag chain is connected with the optical drag chain bracket and used for routing optical related wires.
As an implementation mode, the optical module 62 includes a module main body, a detection aperture is vertically arranged in the module main body, the optical sensor 41, the filter a42, the lens a43, the dichroic mirror 44, the lens B45 and the grating 46 are sequentially arranged in the detection aperture from top to bottom, wherein the dichroic mirror forms an angle of 45 degrees with the detection aperture, a light entrance aperture perpendicular to the detection aperture is arranged on one side of the module main body corresponding to the dichroic mirror, and the filter B47 and the lens C48 are sequentially arranged in the light entrance aperture from outside to inside.
Preferably, the optical module 62 has a left and a right set of detection apertures and an entrance aperture in the module body. The left side and the right side are structurally symmetrical. Is divided into two halves as a whole. Because the fluorescent substance can only be excited by the light with a specific wavelength, and in order to prevent stray light from interfering the whole light path, the light firstly passes through the filter B47 to let the light with the specific wavelength pass through, then passes through the lens C48 to make the light become parallel light, the parallel light is reflected by the dichroic mirror 44 and is gathered through the lens B45, because the width of the fluorescent substance of the test card is limited, and in order to reduce the interference of external light and ensure the stability and accuracy of detection, the grating 46 is arranged at the outlet of the light, and finally the light is irradiated on the test card through the grating 46 to excite fluorescence; the fluorescence is transmitted in reverse direction, passes through the grating 46, is changed into parallel light by the lens B45, and is transmitted through the dichroic mirror 44, and the dichroic mirror 44 can reflect the light with short wavelength and transmit the light with long wavelength; the parallel fluorescence is condensed by the lens a43, passes through the filter a42, and finally enters the optical sensor 41, so that the fluorescence intensity is measured.
As an implementation mode, the module main body is formed by splicing two half parts, and the two sides of the detection aperture and the light inlet aperture in the two half parts are provided with light ray blocking belts 63. The module body is integrally divided into two halves, one half having a raised light blocking strip 63 and the other half having a recessed light blocking strip 63. The light blocking belt 63 can effectively prevent stray light from entering, and can prevent crosstalk of light inside, so that the sensitivity and accuracy of optical detection of the optical module 62 are effectively improved.
In one embodiment, the pipetting assembly 80 includes a three-axis driving mechanism 81, a pick-and-place motor 82, a plunger pump 83 and a pipette 84, the three-axis driving mechanism 81 is disposed on the main housing 10, the plunger pump 83 and the pick-and-place motor 82 are disposed on the three-axis driving mechanism 81, the pipette 84 is disposed on the pick-and-place motor 82, and the pipette 84 is connected to the plunger pump 83. The pipetting assembly 80 is mainly used for realizing the motion of the pipette 84 (pipetting needle) in three directions of XYZ and sucking and discharging liquid, and the picking and placing motor 82 is used for picking and placing the sucker 93. The pipette 84 is moved in the Z (up and down) direction by driving a linear motor. The three-axis driving mechanism 81 mainly comprises a Z-axis fixing support, an XZ connecting plate, an X-axis belt connecting plate and an X-axis transmission mounting plate, wherein the liquid suction pipe 84 and the linear motor are fixed on the Z-axis fixing support, the Z-axis fixing support is fixed on a slide rail and a synchronous pulley synchronous belt through the XZ connecting plate and the X-axis belt connecting plate, the synchronous pulley synchronous belt is driven by a motor to realize the movement in the X direction, the components are fixed on the X-axis transmission mounting plate, the X-axis transmission mounting plate is also arranged on the other slide rail, and the synchronous pulley synchronous belt is driven by the motor to realize the movement in the Y direction; thus, the XYZ three axial movements of the whole assembly are realized, and the liquid suction and discharge are controlled by the plunger pump 83.
In one embodiment, the consumable exchange assembly 90 includes a bracket 91, and the kit 92 and the pipette tip 93 are disposed on the bracket 91. The consumable replacement assembly 90 mainly realizes replacement of consumables.
The utility model discloses a theory of operation does:
sample barcode scanning: when the test tube rack with the sample begins to slide into the detection device along the guide rail of the test tube rack, the bar code scanning component 11 begins to scan and identify the bar codes on the test tube rack and the test tubes, and the test tube rack begins to detect after completely entering the test tube rack;
the kit 92 is bundled into a film: when the detection is started, controlling the pipetting assembly 80 to move the pipette 84 above the reagent kit 92 of the consumable replacing assembly 90, then controlling the pipette 84 to move downwards to puncture the coating film of the reagent kit 92, then controlling the pipette 84 to ascend, and controlling the pipette 84 to come out of the reagent kit 92 and stop ascending;
taking and washing hair: moving to the position with the sucker 93 right above the consumable replacing component 90, then controlling the pipette 84 to move downwards, rotating the pick-and-place motor 82, picking up the disposable sucker 93 and stopping rotating; in the process of moving the pipetting assembly 80, the card loading assembly 30 enables the shifting sheet 32 to move forwards, so as to push the reagent cards in the reagent card cartridge 21 to move forwards, enter the sample loading position and stop;
sample mixing: after the pipetting assembly 80 successfully picks up the pipette tip 93, controlling the pipette tip 84 to move reversely, and stopping moving when the pipette tip 93 is completely removed from the bracket 91; the pipette 84 is moved to above the test tube of the tube rack assembly 70, and then the tip 93 is inserted into the test tube, and the sample is sucked by controlling the plunger pump 83; then the pipette 84 moves upwards and moves to the upper part of the reagent box 92, and the sample is uniformly mixed by controlling the plunger pump 83;
sampling: after the mixture is mixed, the mixed solution is sucked by controlling the plunger pump 83, and the pipette 84 moves upwards until the mixed solution is removed from the kit 92;
sample adding: then the pipette 84 is driven by the triaxial driving mechanism 81 to move to the sample adding position of the incubation component 50, the plunger pump 83 is controlled to drain liquid, sample adding is completed, and after the sample adding is completed, incubation timing is started;
discarding the suction head 93: then the pipette 84 is driven by the three-axis driving mechanism 81 to move to the position above the reagent card recovery box 13, the pick-and-place motor 82 rotates reversely, and the pipette 84 moves upwards, so that the sucker 93 falls off into the reagent card recovery box 13;
optical detection: when the incubation time is up, the linear motor module 31 positively rotates to enable the reagent card to reach the position below the optical detection assembly A40, the linear motor module 31 stops rotating, and after the first detection is finished, the linear motor module 31 positively rotates to move the reagent card to an incubation chamber; after the incubation is finished, the linear motor module 31 continues to rotate to perform secondary optical detection; after the optical detection is finished, the linear motor module 31 continues to rotate forward to push the reagent card out of the incubation chamber; and at this moment, the detection of one channel is finished, the actions are repeated, and the detection of other channels is finished in sequence.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (9)

1. A multi-parameter high-flux fluorescence immunoassay device comprises a mainframe box and is characterized in that a card storage box is arranged in the mainframe box, a reagent card cartridge clip is arranged in the card storage box, an upper card assembly is correspondingly arranged below the reagent card cartridge clip, and an optical detection assembly A, an incubation assembly and an optical detection assembly B are sequentially arranged on one side of the reagent card cartridge clip corresponding to a card discharging direction; one end of the reagent card cartridge clip is provided with a test tube rack assembly, and the other end is correspondingly provided with a reagent card recovery box; the mainframe box is also correspondingly provided with a liquid transfer assembly, and a bar code scanning assembly is also arranged in the mainframe box.
2. The multiparameter high-throughput fluorescence immunoassay device of claim 1, wherein a consumable replacement module and a position self-calibration module are provided at an end of the main housing corresponding to the cuvette holder assembly.
3. The multiparameter high-flux fluorescence immunoassay device of claim 1, wherein the upper clamping assembly comprises a linear motor module, a dial plate and a dial plate mounting frame, the dial plate is arranged on the dial plate mounting frame, and the dial plate mounting frame is arranged on a rotor of the linear motor module; the reagent card cartridge clip is box-shaped, and all opens from top to bottom, and both sides all open the logical groove that the piece of being convenient for to stir passes through around the bottom.
4. The multiparameter high-throughput fluorescence immunoassay device of claim 1, wherein the incubation assembly comprises an incubation chamber, a temperature control device and a heat dissipation assembly, the width of the incubation chamber is consistent with that of the reagent card, and the front end and the rear end of the incubation chamber are open; the temperature control device is a semiconductor cold and hot device and is arranged on the incubation chamber to adjust the temperature in the incubation chamber; the heat radiation component is arranged on the temperature control device and consists of heat radiation fins, a heat radiation fan and a temperature protection switch.
5. The multiparameter high-throughput fluorescence immunoassay device of claim 1, wherein the optical detection assembly a and the optical detection assembly B each comprise a support, a linear driving mechanism disposed on the support, and an optical module disposed on the linear driving mechanism.
6. The multiparameter high-throughput fluorescence immunoassay device according to claim 5, wherein the optical module comprises a module body, a detection aperture is vertically formed in the module body, the detection aperture is internally provided with the optical sensor, the filter A, the lens A, the dichroic mirror, the lens B and the grating in sequence from top to bottom, wherein the dichroic mirror forms an angle of 45 degrees with the detection aperture, one side of the module body corresponding to the dichroic mirror is provided with a light entrance aperture perpendicular to the detection aperture, and the filter B and the lens C are sequentially arranged in the light entrance aperture from outside to inside.
7. The multiparameter high-throughput fluorescence immunoassay device of claim 6, wherein the module body is formed by splicing two halves, and light blocking bands are disposed on both sides of the detection aperture and the light entrance aperture in the two halves.
8. The multiparameter high-throughput fluorescence immunoassay device of claim 1, wherein the pipetting assembly comprises a three-axis driving mechanism, a pick-and-place motor, a plunger pump and a pipette, the three-axis driving mechanism is disposed on the main housing, the plunger pump and the pick-and-place motor are disposed on the three-axis driving mechanism, the pipette is disposed on the pick-and-place motor, and the pipette is connected to the plunger pump.
9. The multiparameter high-throughput fluoroimmunoassay device of claim 2, wherein the consumable replacement assembly comprises a carrier on which the reagent cartridge and the pipette tip are disposed.
CN201920906114.0U 2019-06-14 2019-06-14 Multi-parameter high-flux fluorescence immunoassay device Active CN210090485U (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113495087A (en) * 2020-04-03 2021-10-12 深圳市帝迈生物技术有限公司 POCT blood cell analyzer and detection method thereof
CN114324783A (en) * 2021-12-30 2022-04-12 辽宁华一检测认证中心有限公司 Fluorescence immunoassay appearance of contraband medicine in short-term test food

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113495087A (en) * 2020-04-03 2021-10-12 深圳市帝迈生物技术有限公司 POCT blood cell analyzer and detection method thereof
CN114324783A (en) * 2021-12-30 2022-04-12 辽宁华一检测认证中心有限公司 Fluorescence immunoassay appearance of contraband medicine in short-term test food

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Address after: Room 401, Building 2, Wilde Medical Electronics Industrial Factory, No. 24 Qinglan Third Road, Jinsha Community, Kengzi Street, Pingshan District, Shenzhen City, Guangdong Province, 518000

Patentee after: Gua Teng Biotechnology (Shenzhen) Co.,Ltd.

Address before: Building C, Haikexing Study Abroad Production Park, No. 16 Baoshan Road, Liulian Community, Pingshan Street, Pingshan District, Shenzhen City, Guangdong Province, 518000, 605-606

Patentee before: Guateng Technology (Shenzhen) Co.,Ltd.