CN209791576U - Liquid drop mass production device - Google Patents
Liquid drop mass production device Download PDFInfo
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- CN209791576U CN209791576U CN201920065302.5U CN201920065302U CN209791576U CN 209791576 U CN209791576 U CN 209791576U CN 201920065302 U CN201920065302 U CN 201920065302U CN 209791576 U CN209791576 U CN 209791576U
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- oil phase
- chip
- water phase
- valve body
- valve
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- 239000007788 liquid Substances 0.000 title claims abstract description 35
- 238000004519 manufacturing process Methods 0.000 title abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 67
- 238000003825 pressing Methods 0.000 claims abstract description 48
- 238000007789 sealing Methods 0.000 claims description 9
- 239000003921 oil Substances 0.000 description 51
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- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 3
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 3
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- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
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- 238000011161 development Methods 0.000 description 1
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- 238000009585 enzyme analysis Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
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- 238000003754 machining Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 229920002120 photoresistant polymer Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
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- 229910052710 silicon Inorganic materials 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
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- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Abstract
The utility model discloses a liquid drop production device, which comprises at least one group of liquid drop generation group, wherein the liquid drop generation group comprises a valve body, a cock valve block is fixedly arranged on the valve body, the side surface of the cock valve block is provided with a through water phase main runner and an oil phase main runner, the cock valve block is respectively connected with a vertical water phase branch runner and an oil phase branch runner, and the cock valve block is through; the plug valve block is provided with a chip position for placing a microfluidic chip, and the valve body is provided with a chip frame for fixing the microfluidic chip and a pressing mechanism for pressing the chip frame; a pair of valve holes which respectively horizontally penetrate through the water phase branch flow passage and the oil phase branch flow passage are formed in the side surface of the valve body, a pair of cock valve rods are inserted in the valve holes, and through holes are formed in the cock valve rods; when the cock valve rod is rotated, the on-off of the water phase branch flow channel and the oil phase branch flow channel can be realized. The utility model discloses a liquid drop volume production device only needs rotatory cock valve rod just to realize the break-make of runner, and is convenient to use.
Description
Technical Field
The utility model relates to a microfluid control technology field, concretely relates to liquid drop volume produces device.
Background
With the development and maturity of droplet control technology, microfluidic droplet systems have become an important platform for chemical and biological research on microscopic dimensions, and have been successfully applied to the research fields of molecular and cell biology and analytical chemistry, such as protein crystallization, enzyme analysis, chemical synthesis, single molecule/single cell research, etc., where droplet diameters have a crucial influence on experimental effects.
at present, microfluidic chip-based methods have been widely used to generate micro-droplets. Researchers have utilized soft lithography to process micro-droplet chips with micron dimensions. First, researchers have used thick photoresists (e.g., SU-8 thick resist) and conventional photolithography techniques to fabricate high aspect ratio molds with micron precision on the surface of silicon-based substrates. Then, a mixed solution of PDMS precursor and its crosslinking agent is poured on the surface of the mold. And heating, curing and separating the die to prepare the elastic PDMS microfluidic structure chip with a complementary structure. The PDMS microfluidic structure chip and the glass substrate are subjected to a reversible bonding step to finally form a packaged microfluidic chip for generating liquid drops.
and after the micro-droplet chip is successfully prepared, punching holes at the sample inlet and the micro-droplet generation outlet by using a machining process, and assembling a sample inlet pipe and a sample outlet pipe. The "oil phase" sample, the "water phase" sample was manually drawn into the syringe. Then, the "oil phase" sample and the "water phase" sample are injected into the micro-droplet chip through the sample injection tube by an external injection pump. Finally, the generated micro-droplets are collected into a conventional experimental consumable, such as an EP tube, through a sample outlet tube.
At present, the on-off of a water phase flow channel and an oil phase flow channel of the existing liquid drop mass production device is realized by adopting a rotary drawing structure or a needle valve type structure, but the drawing structure has low efficiency and large force, and the scheme is feasible but has unsatisfactory actual use effect.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is to provide a device is produced to liquid drop volume adopts cock mechanism control runner's break-make, only needs rotatory cock valve rod just to realize runner's break-make, convenient to use.
In order to solve the technical problem, the utility model provides a liquid drop production device, which comprises at least one group of liquid drop generation group;
The liquid drop generating set comprises a valve body, a cock valve block is fixedly arranged on the valve body, a communicated water phase main flow channel and an oil phase main flow channel are arranged on the side surface of the cock valve block, vertical water phase branch flow channels and oil phase branch flow channels are respectively connected to the water phase main flow channel and the oil phase main flow channel, and the water phase branch flow channels and the oil phase branch flow channels are communicated with the cock valve block; the plug valve block is provided with a chip position for placing a microfluidic chip, and the valve body is provided with a chip frame for fixing the microfluidic chip and a pressing mechanism for pressing the chip frame;
a pair of valve holes which respectively horizontally penetrate through the water phase branch flow channel and the oil phase branch flow channel are formed in the side surface of the valve body, a pair of cock valve rods are inserted in the valve holes, and through holes are formed in the cock valve rods; when the cock valve rod is rotated, the on-off of the water phase branch flow channel and the oil phase branch flow channel can be realized.
preferably, the positions of the cock valve rod, which are positioned at two sides of the water phase branch flow passage and the oil phase branch flow passage, are both sleeved with sealing rings.
Preferably, the faucet valve block is provided with filters at the outlets of the water phase branch flow passage and the oil phase branch flow passage.
Preferably, the faucet valve block is provided with a groove at the outlet of the water phase branch flow channel and the oil phase branch flow channel, and a chip sealing gasket is arranged in the groove.
Preferably, the chip rack comprises a first chip rack and a second chip rack, the first chip rack is L-shaped, one end of the first chip rack is inserted into the slot on the valve body, and the other end of the first chip rack is attached to the valve body; the second chip frame is horizontally and fixedly connected to the first chip frame and is pressed tightly through the pressing mechanism.
Preferably, the front end of the second chip frame is provided with a rubber mat positioning strip.
preferably, the pressing mechanism comprises a pressing block, a connecting block, a pressing rod and a pair of connecting rods, the pressing block is used for pressing the chip frame, and the top of the pressing block is rotatably connected to the connecting block; the valve body clamping plates are fixedly arranged on two sides of the valve body, the connecting blocks and the pressing rods are hinged to the valve body clamping plates, and the connecting blocks and the pressing rods are movably connected through a pair of connecting rods.
Preferably, the droplet mass production device comprises at least two groups of droplet generation groups connected in parallel, the water phase main channel and the oil phase main channel on two adjacent droplet generation groups are correspondingly communicated, and a sealing ring is arranged at the communication position.
Preferably, the droplet mass production apparatus further comprises a valve body support, and the plurality of droplet generation sets connected in parallel are locked to the valve body support through a fixing member.
Preferably, the valve body holder is formed with a water phase joint and an oil phase joint respectively communicating with the water phase main flow passage and the oil phase main flow passage.
Preferably, the droplet mass production device further comprises two groups of constant pressure pumps and raw material storage sealing bottles which are communicated with each other, and the raw material storage sealing bottles are respectively connected to the water phase connector and the oil phase connector through rubber tubes.
The utility model has the advantages that:
The utility model discloses a liquid drop mass production device, set up the valve opening that link up water phase branch runner and oil phase branch runner in the side of valve body, peg graft the cock valve rod in the valve opening, and have the through-hole on the cock valve rod; the on-off of the water phase branch flow channel and the oil phase branch flow channel can be realized by rotating the cock valve rod, so that a complicated operation flow after the chip is blocked is avoided, and the yield is ensured;
The utility model discloses a liquid drop mass production device, which comprises a variable number of liquid drop generating groups arranged in parallel, and can produce liquid drops in batches; according to the requirement of the productivity, the productivity can be adjusted by increasing and reducing the liquid drop generating groups; the quality of liquid drop production can be monitored in a single group, when a liquid drop problem occurs in one group, the operation can be stopped for the group without influencing the production of other groups, and therefore the bottleneck of quantity and efficiency of conventional single-group liquid drop production is overcome.
drawings
Fig. 1 is a schematic structural view of a droplet mass production apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of the structure of a single drop generator set of FIG. 1;
FIG. 3 is a side view of a single drop generating group of FIG. 1;
FIG. 4 is a cross-sectional view taken along section A-A of FIG. 3;
FIG. 5 is a cross-sectional view taken along section B-B of FIG. 3;
FIG. 6 is a cross-sectional view taken along section C-C of FIG. 3;
The reference numbers in the figures illustrate:
100. A valve body support; 110. a water phase joint; 120. an oil phase joint; 130. a fixing member;
200. A droplet generation group; 210. a valve body; 211. a valve body clamping plate; 220. a cock valve block; 221. a water phase main flow channel; 222. an oil phase main flow channel; 223. a water phase branch flow channel; 224. an oil phase branch flow channel; 230. a plug valve stem; 231. a torsion bar; 232. a through hole; 241. a first chip holder; 242. a second chip holder; 243. a rubber pad positioning strip; 251. a compression block; 252. connecting blocks; 253. a connecting rod; 254. a pressure lever; 260. and (5) sealing rings.
Detailed Description
The present invention is further described with reference to the following drawings and specific embodiments so that those skilled in the art can better understand the present invention and can implement the present invention, but the embodiments are not to be construed as limiting the present invention.
Referring to fig. 1, an embodiment of a droplet mass production apparatus according to the present invention is used for producing micro droplets in cooperation with a micro-fluidic chip. The valve body support 100 is positioned at two sides of the liquid drop generating group 200, and the six liquid drop generating groups 200 are locked and fixed together through a fixing piece 130. A water phase joint 110 and an oil phase joint 120 are screwed on a valve body support 100 for communicating the external water phase and the oil phase.
specifically, referring to fig. 2-3, each droplet generation set 200 includes a valve body 210, a cock valve block 220 is fixedly disposed on the valve body 210, and valve body clamping plates 211 are fixedly disposed on two sides of the valve body 210.
The faucet valve block 220 is provided with a water phase main flow channel 221 and an oil phase main flow channel 222 which are communicated with each other on the side surface, the water phase main flow channel 221 and the oil phase main flow channel 222 are respectively connected with a vertical water phase branch flow channel 223 and an oil phase branch flow channel, and the water phase branch flow channel 223 and the oil phase branch flow channel are communicated with the faucet valve block 220. The water phase main flow channel 221 and the oil phase main flow channel 222 are used for conveying the water phase and the oil phase between the valves, and the water phase branch flow channel 223 and the oil phase branch flow channel are used for guiding the water phase and the oil phase into the microfluidic chip to generate micro-droplets. When a plurality of groups of liquid drop generating groups 200 are connected in parallel, the water phase main flow channel 221 and the oil phase main flow channel 222 on two adjacent liquid drop generating groups 200 are correspondingly communicated, and a sealing ring 260 is arranged at the communication position to prevent liquid leakage.
In order to realize the break-make of water phase subchannel 223 and oil phase subchannel to the production of control micro-droplet, the utility model discloses in, set up a pair of level respectively and link up in the side of valve body 210 the valve opening of water phase subchannel 223 and oil phase subchannel all pegs graft in every valve opening and have a cock valve rod 230, and the part that cock valve rod 230 is arranged in water phase subchannel 223 or oil phase subchannel has through-hole 232. Therefore, when the cock valve rod 230 is rotated to make the direction of the through hole 232 consistent with the water phase branch flow passage 223 or the oil phase branch flow passage, the water phase branch flow passage 223 or the oil phase branch flow passage is conducted; when the cock valve rod 230 is rotated such that the through hole 232 faces the inner wall of the water phase branched flow passage 223 or the oil phase branched flow passage, the water phase branched flow passage 223 or the oil phase branched flow passage is interrupted. To facilitate rotation of the plug valve stem 230, in this embodiment, a torsion bar 231 is provided on a portion of the plug valve stem 230 that extends out of the valve hole. In addition, in order to prevent leakage, the positions of the cock valve stem 230 on both sides of the water phase branch flow passage 223 and the oil phase branch flow passage 224 are provided with packing 260.
Referring to fig. 4-6, the faucet valve block 220 is provided with grooves at the outlets of the water phase branch flow passage 223 and the oil phase branch flow passage, and the grooves are provided with chip gaskets 212212. When the micro-fluidic chip is placed on the chip position, the water phase inlet and the oil phase inlet on the chip are respectively communicated with the corresponding grooves, so that the water phase and the oil phase can enter the micro-channel corresponding to the chip. In this embodiment, filters are further disposed at the outlets of the water phase branch flow passage 223 and the oil phase branch flow passage.
the valve body clamping plate 211 is further provided with a chip holder for fixing the microfluidic chip, in this embodiment, the chip holder specifically comprises a first chip holder 241 and a second chip holder 242, wherein the first chip holder 241 is L-shaped, one end of the first chip holder is inserted into the slot on the valve body 210, and the other end of the first chip holder is attached to the top of the valve body clamping plate 211; the second chip frame 242 is horizontally and fixedly connected to the first chip frame 241 by screws.
The valve body 210 is further fixedly provided with a pressing mechanism for pressing the chip rack, in this embodiment, the pressing mechanism includes a pressing block 251, a connecting block 252, a pressing rod 254 and a pair of connecting rods 253, a cylindrical rotating rod 255 is formed at the top of the pressing block 251, the connecting block 252 is overall triangular, a groove matched with the rotating rod 255 is formed at the front end of the bottom of the connecting block 252, and the rotating rod 255 is embedded in the groove, so that the pressing block 251 can rotate along the connecting block 252. The lower position of the rear end of the connecting block 252 and the middle position of the pressure lever 254 are both hinged on the valve body clamping plate 211, and the upper position of the rear end of the connecting block 252 and the front end of the pressure lever 254 are movably connected through a pair of connecting rods 253. The working flow of the pressing mechanism of the embodiment is as follows: when the pressing rod 254 is pulled upwards, the front end of the pressing rod 254 moves downwards to drive the connecting rod 253, so that the connecting block 252 rotates clockwise along the hinged position of the lower portion of the connecting block 252, the front end of the connecting block 252 tilts upwards to drive the pressing block 251 to lift, and loosening is achieved. When the pressure rod 254 is pulled downwards, the front end of the pressure rod 254 moves upwards to drive the connecting rod 253, so that the connecting block 252 rotates anticlockwise along the hinge joint at the lower position of the connecting block 252, and the front end of the connecting block 252 moves downwards to drive the pressing block 251 to descend; when the pressing rod 254 is in a horizontal state, the pressing mechanism is in a critical state, at this time, the pressing force of the pressing block 251 on the chip holder is suddenly increased, and the pressing rod 254 is in a self-locking state.
because the chip is provided with a plurality of micro-droplet outlets, a plurality of external pipelines are required to be connected so as to lead out micro-droplets. In this embodiment, a plurality of pipeline positioning rubber pads, preferably fluorine rubber pads, are disposed at the connection between the external pipeline and the micro-droplet outlet, and serve to position the pipeline and seal the pipeline. In addition, a rubber mat positioning bar 243 for fixing a pipe positioning rubber mat is provided at the front end of the second chip holder 242.
In one embodiment, the droplet mass production apparatus further comprises two sets of constant pressure pumps and raw material storage sealed bottles which are connected to the water phase connector 110 and the oil phase connector 120 through rubber tubes. Wherein, the raw material storage sealed bottle is used for storing the water phase and the oil phase, and the water phase or the oil phase is pressed onto the water phase joint 110 and the oil phase joint 120 by the pressure generated by the constant pressure pump. In other embodiments, a filter and/or a flow meter is disposed between the raw material storage sealed bottle and the water phase joint 110 and the oil phase joint 120.
In the droplet mass production device of the embodiment, a valve hole penetrating through a water phase branch flow channel and an oil phase branch flow channel is formed in the side surface of a valve body, a cock valve rod is inserted in the valve hole, and a through hole is formed in the cock valve rod; the on-off of the water phase branch flow channel and the oil phase branch flow channel can be realized by rotating the cock valve rod, so that a complicated operation flow after the chip is blocked is avoided, and the yield is ensured;
Secondly, the droplet mass production device of the embodiment is composed of variable number of droplet generation groups arranged in parallel, and can produce droplets in batches; according to the requirement of the productivity, the productivity can be adjusted by increasing and reducing the liquid drop generating groups; in addition, each liquid drop generation group can independently generate liquid drops without influencing each other, so that the quality of liquid drop production can be monitored in a single group, when a certain group has a liquid drop problem, the group can be stopped without influencing the production of other groups, and the bottleneck of the quantity and the efficiency of the conventional single-group liquid drop production is overcome;
Thirdly, the droplet mass production device of the embodiment has a unique pressing mechanism, when the pressing rod is in a horizontal state, the pressing mechanism is in a critical state, the pressing force of the pressing block on the chip rack is suddenly increased at the moment, so that the chip rack is firmly pressed, and the pressing rod is in a self-locking state at the moment, so that the pressing mechanism can be effectively prevented from being loosened in the working process.
The above-mentioned embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of the present invention is not limited thereto. Equivalent substitutes or changes made by the technical personnel in the technical field on the basis of the utility model are all within the protection scope of the utility model. The protection scope of the present invention is subject to the claims.
Claims (10)
1. a liquid drop yield measuring device comprises at least one group of liquid drop generating group, and is characterized in that the liquid drop generating group comprises a valve body, a cock valve block is fixedly arranged on the valve body, a communicated water phase main flow channel and an oil phase main flow channel are arranged on the side surface of the cock valve block, vertical water phase branch flow channels and oil phase branch flow channels are respectively connected to the water phase main flow channel and the oil phase main flow channel, and the water phase branch flow channels and the oil phase branch flow channels are communicated with the cock valve block; the plug valve block is provided with a chip position for placing a microfluidic chip, and the valve body is provided with a chip frame for fixing the microfluidic chip and a pressing mechanism for pressing the chip frame;
A pair of valve holes which respectively horizontally penetrate through the water phase branch flow channel and the oil phase branch flow channel are formed in the side surface of the valve body, a pair of cock valve rods are inserted in the valve holes, and through holes are formed in the cock valve rods; when the cock valve rod is rotated, the on-off of the water phase branch flow channel and the oil phase branch flow channel can be realized.
2. The apparatus of claim 1, wherein the plug valve rod is sleeved with a sealing ring at both sides of the water phase branch channel and the oil phase branch channel.
3. the apparatus for mass producing droplets according to claim 1, wherein the faucet valve block is provided with a filter at each of the outlets of the water phase branch flow passage and the oil phase branch flow passage.
4. The apparatus for mass producing droplets according to claim 1, wherein the faucet valve block has a groove at the outlet of the water phase branch channel and the oil phase branch channel, and a chip gasket is disposed in the groove.
5. The apparatus for mass producing droplets according to claim 1, wherein the chip holder comprises a first chip holder and a second chip holder, the first chip holder is L-shaped, one end of the first chip holder is inserted into the slot of the valve body, and the other end of the first chip holder is attached to the valve body; the second chip frame is horizontally and fixedly connected to the first chip frame and is pressed tightly through the pressing mechanism.
6. the apparatus for mass producing droplets according to claim 5, wherein a rubber mat positioning strip is disposed at the front end of the second chip frame.
7. The apparatus for mass producing droplets according to claim 5, wherein the pressing mechanism comprises a pressing block, a connecting block, a pressing rod and a pair of connecting rods, the pressing block is used for pressing the chip holder, and the top of the pressing block is rotatably connected to the connecting block; the valve body clamping plates are fixedly arranged on two sides of the valve body, the connecting blocks and the pressing rods are hinged to the valve body clamping plates, and the connecting blocks and the pressing rods are movably connected through a pair of connecting rods.
8. The apparatus for mass producing droplets according to claim 1, comprising at least two droplet generating groups connected in parallel, wherein the main water phase channel and the main oil phase channel of two adjacent droplet generating groups are correspondingly connected, and the connection is provided with a sealing ring.
9. The apparatus of claim 8, further comprising a valve body frame, wherein the plurality of parallel droplet generators are locked and fixed to the valve body frame by a fixing member.
10. the apparatus for mass producing droplets according to claim 9, wherein the valve body holder is formed with a water phase joint and an oil phase joint respectively communicating with the water phase main flow passage and the oil phase main flow passage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920065302.5U CN209791576U (en) | 2019-01-15 | 2019-01-15 | Liquid drop mass production device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920065302.5U CN209791576U (en) | 2019-01-15 | 2019-01-15 | Liquid drop mass production device |
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| Publication Number | Publication Date |
|---|---|
| CN209791576U true CN209791576U (en) | 2019-12-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920065302.5U Withdrawn - After Issue CN209791576U (en) | 2019-01-15 | 2019-01-15 | Liquid drop mass production device |
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| Country | Link |
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| CN (1) | CN209791576U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109569755A (en) * | 2019-01-15 | 2019-04-05 | 苏州汶颢微流控技术股份有限公司 | Drop mass production device |
| CN114247493A (en) * | 2020-10-20 | 2022-03-29 | 深圳铭毅基因科技有限公司 | Fixing device for chip for chemical reaction |
-
2019
- 2019-01-15 CN CN201920065302.5U patent/CN209791576U/en not_active Withdrawn - After Issue
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109569755A (en) * | 2019-01-15 | 2019-04-05 | 苏州汶颢微流控技术股份有限公司 | Drop mass production device |
| CN109569755B (en) * | 2019-01-15 | 2024-03-12 | 苏州汶颢微流控技术股份有限公司 | Liquid drop mass production device |
| CN114247493A (en) * | 2020-10-20 | 2022-03-29 | 深圳铭毅基因科技有限公司 | Fixing device for chip for chemical reaction |
| CN114247493B (en) * | 2020-10-20 | 2023-06-27 | 深圳铭毅智造科技有限公司 | Chip fixing device for chemical reaction |
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