CN208303355U - Magnetic bead cleans separator and chemical illumination immunity analysis instrument - Google Patents
Magnetic bead cleans separator and chemical illumination immunity analysis instrument Download PDFInfo
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- CN208303355U CN208303355U CN201820226350.3U CN201820226350U CN208303355U CN 208303355 U CN208303355 U CN 208303355U CN 201820226350 U CN201820226350 U CN 201820226350U CN 208303355 U CN208303355 U CN 208303355U
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Abstract
The utility model provides a kind of magnetic bead cleaning separator, including Magneto separate component and liquid injection component.Magneto separate component includes transhipment disk and magnetic part, and transhipment disk is used to the reaction cup for filling magnetic bead being transported to corresponding operation position.Operating position includes fluid injection position and drain location, and magnetic part is arranged in the transhipment path side of transhipment disk.Liquid injection component includes fluid-filling structure, lifting structure and drainage structure, and fluid-filling structure includes injection needle, and injection needle is fixedly installed on fluid injection position.The utility model also provides a kind of chemical illumination immunity analysis instrument including above-mentioned magnetic bead cleaning separator.Above-mentioned magnetic bead cleaning separator and chemical illumination immunity analysis instrument, injection needle is fixedly installed on the top of fluid injection position, in magnetic bead cleaning process only drainage structure with lifting structure synchronization lifting repeatedly, the cleaning energy consumption for reducing magnetic bead cleaning separator thereby reduces the cleaning cost of magnetic bead cleaning separator.
Description
Technical field
The utility model relates to medical device cleaning technique fields, clean separator and change more particularly to a kind of magnetic bead
Learn luminescence immunoassay instrument.
Background technique
Chemiluminescence immune assay is a kind of novel ultramicron point for combining luminesceence analysis and immune response and establishing
Analysis technology.The technology is anti-so as to quantitative detection using chemistry or bio-luminescence system as the instruction system of antigen-antibody reaction
Former or antibody method.This method is with the high sensitivity of luminesceence analysis and the high degree of specificity of antigen-antibody reaction.Magnetic
Pearl cleaning is the important preparation process of chemiluminescence immune assay.The injection needle of traditional magnetic bead cleaning separator is in cleaning process
In go up and down repeatedly, cause magnetic bead cleaning separator cleaning energy consumption and cleaning higher cost.
Utility model content
Based on this, it is necessary to be risen repeatedly in the process of cleaning for injection needle existing for traditional magnetic bead cleaning separator
Drop, cleaning energy consumption and cleaning problem at high cost, provide a kind of cleaning energy consumption and the lower-cost magnetic bead cleaning separation of cleaning fills
It sets and chemical illumination immunity analysis instrument.
A kind of magnetic bead cleaning separator, comprising:
Magneto separate component, including transhipment disk and magnetic part, the transhipment disk is for the reaction cup for filling magnetic bead to be transported to
Corresponding operation position, the operating position include fluid injection position and drain location, and the magnetic part is arranged in the transhipment disk
Transhipment path side；
Liquid injection component, including fluid-filling structure, lifting structure and drainage structure, the fluid-filling structure include injection needle, institute
It states injection needle and is fixedly installed on the fluid injection position, it is dynamic that the drainage structure executes lifting under the drive of the lifting structure
Make, the drainage structure is used to siphon away the liquid in reaction cup in the drain location.
The extending direction of the injection needle prolongs with the reaction cup in the fluid injection position in one of the embodiments,
Stretch the angle having between 0 ° to 75 ° between direction.
The fluid-filling structure further includes fluid injection pedestal in one of the embodiments, and the fluid injection pedestal is fixedly installed on
The fluid injection position, the fluid injection pedestal have fixation hole, and the position of the fixation hole is opposite with the fluid injection position, described solid
Determine to have between 0 ° to 75 ° between the extending direction in hole and the extending direction for the reaction cup for being transported to the fluid injection position
Angle, the injection needle are arranged in the fixation hole.
The side that the export direction of the injection needle is assembled towards magnetic bead in reaction cup in one of the embodiments,.
The drainage structure includes drain needle and cleaning swab in one of the embodiments, and the cleaning swab is arranged
On the outside of the drain needle, for cleaning the drain needle；The lifting structure drives the drain needle in the drain location
Lifting is to drain the liquid in reaction cup.
The cleaning swab has cleaning through-hole, cleaning entrance and washing outlet, the row in one of the embodiments,
Liquid needle is arranged in the cleaning through-hole；The cleaning entrance and the washing outlet are connected to the cleaning through-hole respectively, described
Cleaning entrance and the washing outlet are respectively used to introduce cleaning solution and cleaning solution are discharged.
The drainage structure further includes negative pressure pump in one of the embodiments, the negative pressure pump and the cleaning swab
Washing outlet connection to drain the cleaning waste liquid after cleaning the drain needle.
The drainage structure further includes negative pressure pump in one of the embodiments, and the drainage structure further includes negative-pressure cup,
The negative pressure pump is connect with the negative-pressure cup, and one end of the drain needle is connect with the negative-pressure cup, the drain needle it is another
End is used in intercalation reaction cup, to siphon away the liquid in reaction cup.
The magnetic bead cleaning separator further includes Magneto separate pot in one of the embodiments, the Magneto separate cookware
There is hollow cavity, the transhipment disk is rotatably dispose in the hollow cavity of the Magneto separate pot；The hollow cavity of the Magneto separate pot
Internal wall is also provided with the transhipment slot extended along the rotation direction of the transhipment disk, and the transhipment disk drives reaction cup at described turn
It is moved in fortune slot.
Mounting groove is also provided in the Magneto separate pot in one of the embodiments, the mounting groove is for installing institute
Magnetic part is stated, the side of the transhipment slot is arranged in the mounting groove；Magnetic bead cleans separator magnetic bead and cleans separator institute
The opening of mounting groove is stated towards the side of the Magneto separate pot far from the injection needle.
The magnetic bead cleaning separator further includes magnetic shielding cover in one of the embodiments, the magnetic shielding cover cover
Set on the outer peripheral edge of the Magneto separate component.
The operating position includes three fluid injection positions and three drain locations, three institutes in one of the embodiments,
It states fluid injection position and is alternately arranged with three drain locations along the transhipment path of reaction cup；The fluid-filling structure includes three notes
Liquid needle, three injection needles are correspondingly arranged with three fluid injection positions respectively；The drainage structure includes three drain needles
With three cleaning swabs, three drain needles and three cleaning swabs are corresponding with three drain locations respectively sets
It sets；The magnetic bead cleaning separator is used to carry out magnetic bead the cleaning separation of three ranks.
Three fluid injection positions are respectively single order fluid injection position, second order fluid injection position and three ranks in one of the embodiments,
Fluid injection position, three drain locations are respectively single order drain position, second order drain position and three rank drain positions；The operating position is also
Including interval location, the magnetic bead is assembled at the interval location；Between single order fluid injection position and single order drain position
Be sequentially arranged several interval locations, be sequentially arranged between second order fluid injection position and second order drain position it is several it is described between
Every position, several interval locations are sequentially arranged between the three ranks fluid injection position and the three ranks drain position；Between described in each
One magnetic part is set every the side of position, a magnetic part is arranged in the side of each drain location.
Multiple magnetic parts are distributed in the transhipment path two sides of the transhipment disk in one of the embodiments,.
The operating position further includes substrate injection phase in one of the embodiments, on the substrate injection phase
It is provided with substrate inlet, the substrate inlet connection substrate and constant displacement pump, substrate is injected by the substrate by constant displacement pump
Reaction cup at injection phase.
A kind of chemical illumination immunity analysis instrument, including analytical equipment and the described in any item magnetic bead cleaning separation of above scheme
Device；The analytical equipment is used to analyze the magnetic bead after the magnetic bead cleaning separator cleaning.
Above-mentioned magnetic bead cleaning separator and chemical illumination immunity analysis instrument, injection needle are fixedly installed on the top of fluid injection position
Portion, only drainage structure reduces magnetic bead cleaning separator with lifting structure synchronization lifting repeatedly in magnetic bead cleaning process
Energy consumption is cleaned, the cleaning cost of magnetic bead cleaning separator is thereby reduced.
Detailed description of the invention
Fig. 1 is that the magnetic bead that an embodiment of the present invention provides cleans separator schematic side view；
Fig. 2 is that the magnetic bead that an embodiment of the present invention provides cleans separator schematic front view；
Fig. 3 is the cleaning swab structure schematic side view that an embodiment of the present invention provides；
Fig. 4 is the cleaning swab structural profile illustration that an embodiment of the present invention provides；
Fig. 5 is the cleaning swab structure schematic side view that another embodiment of the utility model provides；
Fig. 6 is the cleaning swab structural profile illustration that another embodiment of the utility model provides；
Cleaning solution structural schematic diagram in the negative pressure suction reaction cup that Fig. 7 provides for an embodiment of the present invention；
Cleaning solution control principle schematic diagram in the negative pressure suction reaction cup that Fig. 8 provides for an embodiment of the present invention；
Cleaning solution structural schematic diagram in the multiple reaction cups of negative pressure suction that Fig. 9 provides for an embodiment of the present invention；
Figure 10 is the fluid injection pedestal and injection needle Standard schematic diagram that an embodiment of the present invention provides；
Figure 11 is the magnetic bead cleaning device structural schematic diagram that another embodiment of the utility model provides；
Figure 12 is internal structure partial schematic diagram in Figure 10；
Figure 13 is that the magnetic bead that an embodiment of the present invention provides cleans separation process schematic diagram；
Figure 14 is that the three rank magnetic beads that another embodiment of the utility model provides clean separation process schematic diagram；
Figure 15 is that the magnetic bead that an embodiment of the present invention provides cleans separation method；
Figure 16 is that the magnetic bead that another embodiment of the utility model provides cleans separation method.
Wherein:
10- magnetic bead cleans separator
100- Magneto separate component
110- transports disk
120- magnetic part
130- gear
140- code-disc
200- liquid injection component
210- fluid-filling structure
211- injection needle
212- fluid injection pedestal
220- lifting structure
221- lifting motor
222- screw rod
230- drainage structure
231- drain needle
232- cleans swab
2321- cleans through-hole
2322- cleans entrance
2323- washing outlet
233- negative-pressure cup
234- negative pressure pump
235- pressure sensor
236- controller
300- Magneto separate pot
310- transports slot
320- mounting groove
330- bottom plate
400- Magneto separate cover board
410- picks and places mouth
420- substrate inlet
500- magnetic shielding cover
600- operating position
610- fluid injection position
611- single order fluid injection position
612- second order fluid injection position
The tri- rank fluid injection position 613-
620- drain location
621- single order drain position
622- second order drain position
The tri- rank drain position 623-
630- interval location
The first gap digit of 6301-
The second gap digit of 6302-
6303- third gap digit
The 4th gap digit of 6304-
The 5th gap digit of 6305-
The 6th gap digit of 6306-
The 7th gap digit of 6307-
The 8th gap digit of 6308-
The 9th gap digit of 6309-
The tenth gap digit of 6310-
640- access position
650- substrate injection phase
700- reaction cup
Specific embodiment
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, by the following examples, it and ties
Attached drawing is closed, separator is cleaned to a kind of magnetic bead of utility model and chemical illumination immunity analysis instrument carries out further specifically
It is bright.
It should be noted that it can directly on the other element when element is referred to as " being fixed on " another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it, which can be, is directly connected to
To another element or it may be simultaneously present centering elements.On the contrary, when element is referred to as " directly existing " another element "upper",
There is no intermediary elements.Term as used herein "vertical", "horizontal", "left" and "right" and similar statement are
For illustrative purposes.Various difference objects are in the ratio drafting convenient for enumerating explanation in embodiment attached drawing, rather than press practical group
The ratio of part is drawn.
As shown in Figures 1 and 2, an embodiment of the present invention provides a kind of magnetic bead cleaning separator 10, including magnetic point
From component 100 and liquid injection component 200.Wherein, Magneto separate component 100 includes transhipment disk 110 and magnetic part 120.Transport disk 110
For the reaction cup 700 for filling magnetic bead to be transported to corresponding operation position, operating position includes fluid injection position and drain location,
Magnetic part 120 is arranged in the transhipment path side of transhipment disk 110.Liquid injection component 200 includes fluid-filling structure 210, lifting structure
220 and drainage structure 230.Drainage structure 230 includes drain needle 231 and cleaning swab 232, and cleaning swab 232 is set to drain
Position, cleaning swab 232 are sheathed on 231 outside of drain needle.Lifting structure 220 drive drain needle 231 drain location go up and down with
Drain the liquid in reaction cup 700, swab 232 is cleaned after drain and cleans drain needle 231.Fluid-filling structure 210 is used for reaction cup
Cleaning solution is injected in 700.
Above-mentioned magnetic bead cleaning separator 10 will clean swab 232 and be correspondingly arranged with drain location, directly in drain location
Cleaning operation is carried out to drain needle 231, is saved when drain needle 231 cleans between drain location and additional cleaning positions
Reciprocation time directly shortens magnetic bead single and cleans the isolated time, further improves magnetic bead cleaning separator 10
Test flux.Drain needle 231 is cleaned in drain location, is saved and is driven drain needle 231 in drain location and additional
The movement mechanism moved back and forth between cleaning positions simplifies the structure of magnetic bead cleaning separator 10.
The effect of cleaning swab 232 is cleaning drain needle 231, cleans the various structures of swab 232, the utility model is not
The specific structure of limitation cleaning swab 232.As shown in Figures 3 to 6, in an embodiment of the utility model, swab 232 is cleaned
Shape is cylindrical, and cleaning swab 232 has cleaning through-hole 2321, cleaning entrance 2322 and washing outlet 2323, drain needle 231
It is arranged in cleaning through-hole 2321.Further, cleaning through-hole 2321 is opened up along the extending direction of cleaning swab 232, cleans entrance
2322 and washing outlet 2323 along cleaning swab 232 radial direction open up.Clean entrance 2322 and washing outlet 2323 respectively and clearly
The connection of through-hole 2321 is washed, entrance 2322 is cleaned and washing outlet 2323 is respectively used to introduce cleaning solution and discharge cleaning waste liquid.?
In the utility model others embodiment, the extending direction for cleaning entrance 2322 and washing outlet 2323 can also be with cleaning through-hole
2321 extending direction is obliquely installed or cleans the shape of swab 232 in cuboid etc..Clean 2321 row of not only allowing for of through-hole
Liquid needle 231 is inserted into clean to drain needle 231, also has auxiliary positioning effect to the elevating movement of drain needle 231.Pass through
Cleaning entrance 2322 and washing outlet 2323 introduce cleaning solution and discharge cleaning waste liquid respectively, while using cleaning through-hole 2321
Structure type realizes the direct cleaning to drain needle 231, and drain needle 231 is not interfered not only to drain cleaning solution in reaction cup 700, and
Have the characteristics that structure is simple, easy to process.
Further, area of section of the cleaning through-hole 2321 close to 100 one end of Magneto separate component is greater than far from Magneto separate
The area of section of 100 one end of component, to guarantee to have centainly between the inner wall of cleaning through-hole 2321 and the outer wall of drain needle 231
Gap prevents drain needle 231 from directly contacting in lifting process with the inner wall generation of cleaning through-hole 2321, guarantees drain needle 231
Cleaning effect and extend drain needle 231 service life.The section of cleaning through-hole 2321 refers to the extension with cleaning through-hole 2321
The vertical plane in direction.As a kind of achievable mode, cleaning through-hole 2321 is stepped hole.Step pore structure is simple, is easy to
Processing.As another achievable mode, the inner diameter values for cleaning through-hole 2321 are gentle along the extending direction of cleaning through-hole 2321
Variation.
The effect of cleaning entrance 2322 and washing outlet 2323 is to introduce cleaning solution and discharge cleaning waste liquid respectively, as long as energy
Realize its function, the utility model does not limit the specific location of cleaning entrance 2322 and washing outlet 2323.Such as Fig. 3 and figure
Shown in 4, in an embodiment of the utility model, entrance 2322 and washing outlet 2323 are cleaned along the extension side of cleaning through-hole 2321
It is arranged to interval.As a kind of achievable mode, entrance 2322 is cleaned close to the top of cleaning swab 232, washing outlet
2323 close to the bottom end of cleaning swab 232.As shown in figs. 5 and 6, in another embodiment of the utility model, entrance is cleaned
2322 with washing outlet 2323 along cleaning through-hole 2321 extending direction it is opposite, concordant be arranged.Optionally, clean entrance 2322 and
Washing outlet 2323 is integrally formed with the main body of cleaning swab 232 respectively or removably connect.It is real in the utility model one
It applies in example, cleans entrance 2322 and washing outlet 2323 and removably connect with the main body of cleaning swab 232 respectively, the side of being conducive to
Being individually replaced to each section of cleaning swab 232 just, reduces the use cost of cleaning swab 232.
Washing outlet 2323 drains the cleaning waste liquid in cleaning swab 232 by suction function, as a kind of achievable side
Formula, as shown in fig. 7, drainage structure 230 further includes negative pressure pump 234, the washing outlet 2323 of negative pressure pump 234 and cleaning swab 232
Connection is to drain the cleaning waste liquid after cleaning drain needle 231.Further, drainage structure 230 further includes negative-pressure cup 233, negative-pressure cup
233, which are connected as drain needle with negative pressure pump 234, provides power, specifically, one end of drain needle 231 is connect with negative-pressure cup 233, drain
The other end of needle 231 is interior to siphon away the liquid in reaction cup 700 for intercalation reaction cup 700.Negative pressure value energy in negative-pressure cup 233
Enough to keep in a certain range, being connected to using negative-pressure cup 233 with drain needle 231, drain needle 231 drains the process of cleaning waste liquid
Be able to maintain it is relatively stable, guarantee 231 removal waste fluid of drain needle flow substantially constant, siphon away magnetic bead so that flow is excessive.Negative pressure
Pump 234 and washing outlet 2323 between and negative pressure pump 234 and negative-pressure cup 233 between be arranged switching control element, negative pressure pump 234 with
Control switch is respectively set between washing outlet 2323 and between negative-pressure cup 233 and drain needle 231, to guarantee in reaction cup 700
Discharge opeing process and cleaning swab 232 discharge opeing process it is mutually indepedent, and then improve magnetic bead provided by the utility model cleaning point
Cleaning efficiency from device 10.Use the same negative pressure pump 234 as power source drain cleaning swab 232 in cleaning waste liquid and
Cleaning solution in reaction cup 700, simplifies the structure of magnetic bead cleaning separator 10 provided by the utility model, and then reduces
The volume of magnetic bead cleaning separator 10 provided by the utility model.Optionally, negative pressure pump 234 can divide with multiple negative-pressure cups 233
It does not connect, to improve the service efficiency of negative pressure pump 234.
As shown in Figures 7 and 8, in an embodiment of the utility model, drainage structure 230 further includes pressure sensor 235
With controller 236.Pressure sensor 235, which is arranged in negative-pressure cup 233 and with controller 236, be electrically connected, controller 236 also with bear
Press pump 234 connects.When pressure sensor 235 monitors the pressure spilling setting value in negative-pressure cup 233, issues and overflow to controller 236
Signal out, controller 236 control the operating status of negative pressure pump 234 to adjust the negative pressure value in negative-pressure cup 233.Further, such as Fig. 9
Shown, negative-pressure cup 233 is connected with multiple drain needles 231, and control is respectively set between each drain needle 231 and negative-pressure cup 233 and opens
It closes, to guarantee the independent discharge opeing process of each drain needle 231.Further, negative-pressure cup 233 can also be in entire chemiluminescence
After testing process, drain the waste liquid in reaction cup 700.
Swab 232 will be cleaned, the cleaning efficiency that drain location substantially increases drain needle 231 is set.Clean swab 232
Drain needle 231 can be cleaned in the up and down of drain needle 231, static any state or continuous multiple states.Make
For a kind of achievable mode, swab 232 is cleaned in the uphill process after drain needle 231 drains 700 cleaning liquid inside of reaction cup
Clean drain needle 231.As another achievable mode, cleaning swab 232 is drained clear in reaction cup 700 in drain needle 231
Drain needle 231 is cleaned in uphill process after washing lotion and in quiescing process, wherein main wash is arranged when drain needle 231 is static
The syringe needle of liquid needle 231.
As shown in Figure 1, Figure 2 and shown in Figure 10, in an embodiment of the utility model, fluid-filling structure 210 includes injection needle 211,
Injection needle 211 is fixedly installed on fluid injection position.Above-mentioned magnetic bead cleans separator 10, and injection needle 211 is fixedly installed on fluid injection position
The top set, only it is clear to reduce magnetic bead with the synchronization lifting repeatedly of lifting structure 220 for drainage structure 230 in magnetic bead cleaning process
The cleaning energy consumption for washing separator 10 thereby reduces the cleaning cost of magnetic bead cleaning separator 10.Further, injection needle
211 extending direction and the extending direction for the reaction cup 700 for being transported to fluid injection position are obliquely installed, to realize that cleaning solution is direct
It is injected to the side wall of reaction cup 700, cleaning solution flows down in reaction cup 700 and generates liquid stream in the bottom of reaction cup 700, helps
In sufficiently breaing up magnetic bead and enhancing to the cleaning effect of magnetic bead.
More further, the extending direction of injection needle 211 be transported to fluid injection position reaction cup 700 extending direction it
Between there is angle between 0 ° to 75 °.As a kind of achievable mode, liquid injection component 200 further includes fluid injection pedestal
212, fluid injection pedestal 212 is fixedly installed on fluid injection position, and fluid injection pedestal 212 has fixation hole, the position and fluid injection position of fixation hole
Set it is opposite, the extending direction of fixation hole and be transported to fluid injection position reaction cup 700 extending direction between have between 0 ° extremely
Angle between 75 °, injection needle 211 are arranged in fixation hole.Fluid injection pedestal 212 convenient for control injection needle 211 extending direction with
The angle being transported between the extending direction of the reaction cup 700 of fluid injection position.Preferably, the extending direction of injection needle 211 with turn
The angle between the extending direction of the reaction cup 700 of fluid injection position is transported between 10 ° -50 °.For example, can for 11 °,
15 °, 20 ° etc..Correspondingly, between the extending direction of fixation hole and the extending direction of reaction cup 700 for being transported to fluid injection position
Angle is between 0 ° to 75 °.
It is furthermore preferred that between the extending direction of injection needle 211 and the extending direction of reaction cup 700 for being transported to fluid injection position
Angle be 30 °, reduce the kinetic energy rejection of cleaning solution when cleaning solution is injected to the inner wall of reaction cup 700, guarantee the stream of liquid stream
The cleaning effect of speed and magnetic bead.Correspondingly, the extension side of the extending direction of fixation hole and the reaction cup 700 for being transported to fluid injection position
Angle between is 30 °.In an embodiment of the utility model, the export direction of injection needle 211 is towards magnetic in reaction cup 700
The side of pearl aggregation is conducive to the cleaning solution of the injection of injection needle 211 and adequately breaks up magnetic in downflow processes and when forming vortex
Pearl is adequately to be cleaned.
As a kind of achievable mode, the transhipment path for transporting disk 110 is circle, is transferred to fluid injection in reaction cup 700
Before position, the magnetic bead in reaction cup 700 is gathered in reaction cup 700 along the inside in transhipment path, the corresponding injection needle in fluid injection position
211 outlets are also towards the inside in transhipment path.As another achievable mode, the transhipment path of transhipment disk 110 is circle,
Before reaction cup 700 is transferred to fluid injection position, the magnetic bead in reaction cup 700 be gathered in reaction cup 700 along transhipment path outside,
The corresponding outlet of injection needle 211 in fluid injection position is also towards the outside in transhipment path.In another embodiment of the utility model, transhipment
The transhipment path of disk 110 is straight line, and arrangement form of the injection needle 211 in fluid injection position is similar to the above, and which is not described herein again.
As shown in FIG. 11 and 12, in an embodiment of the utility model, magnetic bead cleaning separator 10 further includes magnetic point
From pot 300, Magneto separate pot 300 has hollow cavity, and transhipment disk 110 is rotatably dispose in the hollow cavity of Magneto separate pot 300.Magnetic
The hollow cavity inner wall of separation pot 300 is also provided with the transhipment slot 310 extended along the rotation direction of transhipment disk 110, transports disk 110
Reaction cup 700 is driven to move in transhipment slot 310.Transhipment disk 110 is rotatably arranged in the hollow cavity of Magneto separate pot 300, real
Compact-sizedization for having showed magnetic bead cleaning separator 10 provided by the utility model, further reduces the utility model offer
Magnetic bead cleaning separator 10 volume.Reaction cup 700 is transported in transhipment slot 310, avoids the reaction cup in motion process
700 are in contact with other elements and are damaged.As a kind of achievable mode, the hollow cavity inner wall of Magneto separate pot 300 has
There is the flange that the rotation direction along transhipment disk 110 extends, flange is bent to form transhipment slot 310.As another achievable side
Formula, the hollow cavity inner wall of Magneto separate pot 300 directly open up out transhipment slot 310.
Further, mounting groove 320 is also provided in Magneto separate pot 300, mounting groove 320 is pacified for installing magnetic part 120
The side of transhipment slot 310 is arranged in tankage 320.The opening of mounting groove 320 is towards Magneto separate pot 300 far from cleaning swab 232
Side allows that magnetic part 120 is installed and dismantled from the bottom of Magneto separate pot 300.Magnetic part 120 is from the bottom of Magneto separate pot 300
Extending direction along reaction cup 700 is installed, and the distance between the transhipment path for reducing magnetic part 120 and reaction cup 700 is conducive to,
And then the distance between the outer wall of magnetic part 120 and reaction cup 700 is reduced, increase the congregational rate of magnetic bead.Optionally, in magnetic point
Bottom setting bottom plate 330 from pot 300 is magnetic part 120 to be pressed in mounting groove 320.In an embodiment of the present invention
In, it further includes Magneto separate cover board 400 that magnetic bead, which cleans separator 10, and Magneto separate cover board 400 is covered on the top of Magneto separate pot 300
Portion.Lifting structure 220 is set to side of the Magneto separate cover board 400 far from transhipment disk 110.Clean swab 232 and liquid injection seat difference
It is fixedly installed on side of the Magneto separate cover board 400 far from transhipment disk 110.Various Components are realized using a Magneto separate cover board 400
Supporting role, realize compact-sizedization of magnetic bead provided by the utility model cleaning separator 10, simplify, further
Reduce the volume of magnetic bead cleaning separator 10 provided by the utility model.
As shown in figure 11, in another embodiment of the utility model, it further includes magnetic shielding cover that magnetic bead, which cleans separator 10,
500, magnetic shielding cover 500 covers at the outer peripheral edge of Magneto separate component 100.Magnetic shielding cover 500 can be by magnetic in Magneto separate component 100
Property part 120 magnetic action be limited in magnetic bead cleaning separator 10 in, avoid magnetic part 120 to magnetic bead cleaning separator 10 it is attached
Close electromagnetism magnetic element generates interference, allows for being arranged near magnetic bead provided by the utility model cleaning separator 10
Corresponding magnetic element, increases the space utilization rate of magnetic bead cleaning separator 10 provided by the utility model, and then reduces
The package size of chemical illumination immunity analysis instrument.Optionally, the magnetic part 120 in Magneto separate component 100 can be permanent magnet or
Person's electromagnet.As a kind of achievable mode, the magnetic part 120 in Magneto separate component 100 is permanent magnet, and magnetic part 120 wraps
Include rubidium magnet.
Magnetic bead provided by the utility model cleaning separator 10 can be suitable for the single order of magnetic bead to multistage cleaning.Such as figure
Shown in 13, in an embodiment of the utility model, operating position 600 is including between fluid injection position 610, drain location 620 and two
Every position 630, the two sides of interval location 630 and drain location 620 are arranged in along transhipment path for magnetic part 120.It is reacted in transhipment
Magnetic bead is broken up with the realization of magnetic part 120 during cup 700.In the magnetic bead cleaning that another embodiment of the utility model provides
In separator 10, operating position 600 includes three fluid injection positions 610 and three drain locations 620, three fluid injection positions 610
It is alternately arranged with three drain locations 620 along the transhipment path of reaction cup 700.Fluid-filling structure 210 includes three injection needles 211,
Three injection needles 211 are correspondingly arranged with three fluid injection positions 610 respectively.Drainage structure 230 includes three drain needles 231 and three
Swab 232 is cleaned, three drain needles 231 and three cleaning swabs 232 are correspondingly arranged with three drain locations 620 respectively.Magnetic bead
Separator 10 is cleaned to be used to carry out magnetic bead the cleaning separation of three ranks.Three ranks cleaning separation can adequately carry out magnetic bead clear
It washes.Specifically, the transhipment path of transhipment disk 110 is circle in the present embodiment, magnetic bead cleaning provided by the utility model is realized
Compact-sizedization of separator 10 further reduces the volume of magnetic bead cleaning separator 10 provided by the utility model.
Further, three fluid injection positions 610 are respectively single order fluid injection position 611, second order fluid injection position 612 and three rank fluid injection positions
613, three drain locations 620 are respectively single order drain position 621, second order drain position 622 and three rank drain positions 623.Operating position
600 further include interval location 630, and magnetic bead is assembled at interval location 630.Between single order fluid injection position 611 and single order drain position 621
Several interval locations 630 are sequentially arranged, are sequentially arranged several interval locations between second order fluid injection position 612 and second order drain position 622
630, several interval locations 630 are sequentially arranged between three rank fluid injection positions 613 and three rank drain positions 623.Each interval location 630
A magnetic part 120 is arranged in side, and the side of each drain location 620 is also provided with a magnetic part 120.In interval location 630
Side magnetic part 120 is set, facilitate after magnetic bead disperse in transfer process again in the aggregation of interval location 630.In drain
Magnetic part 120 is arranged in the side of position 620, when being conducive to drain needle 231 and draining cleaning solution, aggregation magnetic bead as much as possible, and drop
The loss late of low magnetic bead.
Further, multiple magnetic parts 120 are distributed in the transhipment path two sides of transhipment disk 110.Multiple magnetic parts 120 exist
The transhipment path two sides setting of disk 110 is transported, when can be realized reaction cup 700 by different interval locations 630, magnetic bead is anti-
The two sides for answering cup 700 different are alternately assembled, and magnetic bead is sufficiently broken up in cleaning solution, increase the contact area of magnetic bead and cleaning solution,
The progress such as enzyme to magnetic bead internal residual sufficiently, are effectively cleaned, and the additional production and maintenance cost for mixing structure is saved.
Specifically, as shown in figure 14, transhipment path is circle, operating position 600 includes ten interval locations 630, respectively
For the first gap digit 6301, the second gap digit 6302, third gap digit 6303, the 4th gap digit 6304, the 5th gap digit 6305,
6th gap digit 6306, the 7th gap digit 6307, the 8th gap digit 6308, the 9th gap digit 6309, the tenth gap digit 6310.Turn
It transports and is set gradually between single order fluid injection position 611, the first gap digit 6301, the second gap digit 6302, third on the transhipment path of disk 110
Every position 6303, single order drain position 621, second order fluid injection position 612, the 4th gap digit 6304, the 5th gap digit 6305, the 6th gap digit
6306, second order drain position 622, three rank fluid injection positions 613, the 7th gap digit 6307, the 8th gap digit 6308, the 9th gap digit
6309, the tenth gap digit 6310, three rank drain positions 623.Reaction cup 700 successively passes through upper rheme under the drive of transhipment disk 110
It sets, to realize the single order cleaning separation, second order cleaning separation and the cleaning separation of three ranks of magnetic bead.
A magnetic part 120 is respectively set in ten interval locations 630 and three drain locations 620.Wherein the first gap digit
6301, the 4th gap digit 6304 of the second gap digit 6302, the 5th gap digit 6305, the 7th gap digit 6307, the 8th gap digit
6308 and the corresponding magnetic part 120 of the 9th gap digit 6309 be separately positioned on transhipment path inside.Third gap digit 6303, one
Rank drain position 621, the 6th gap digit 6306, second order drain position 622, the tenth gap digit 6310 and three rank drain positions 623 are corresponding
Magnetic part 120 is separately positioned on the outside in transhipment path.Corresponding, the magnetic bead of reaction cup 700 is on corresponding operation position 600
It is gathered in the side of setting magnet respectively, to realize sufficiently the breaing up to magnetic bead in transport process, and then realizes that this is practical new
Abundant, effective cleaning of the magnetic bead cleaning separator 10 that type provides to magnetic bead.In the other embodiments of the utility model, peace
The heteropleural in transhipment path is arranged in the corresponding magnetic part 120 in adjacent operator position 600 equipped with magnetic part 120.Magnetic part 120 is set
Setting the effect in transhipment path two sides is that magnetic bead is gathered in the heteropleural in transhipment path to realize pair in different operating positions 600
Magnetic bead is broken up, and the utility model is not intended to limit magnetic part 120 in the specific arrangement form of transhipment path two sides, beats as long as realizing
Dissipate the function of magnetic bead.
As shown in Figure 1, Figure 2 and shown in Figure 14, in an embodiment of the utility model, operating position 600 further includes access position
640 and substrate injection phase 650.Access position 640 is set to single order fluid injection position 611 along the upstream in transhipment direction, and being used for will be anti-
It answers cup 700 to be put into transhipment disk 110 or reaction cup 700 will be taken out from transhipment disk 110.Substrate injection phase 650 is set to three
Rank drain position 623 is along the downstream in transhipment direction, for luminous substrate (enzyme-catalyzed chemical luminescence) to be added into reaction cup 700 or aoxidizes
Agent (direct chemiluminescence).Corresponding, Magneto separate, which covers to offer, picks and places mouth 410 and substrate inlet 420.By reaction cup 700
It is put into transhipment disk 110 from mouth 410 is picked and placed, transhipment disk 110 rotates an operating position counterclockwise after fixed interval
600, then reaction cup 700 reaches single order fluid injection position 611, interval location 630 and single order drain position 621 successively to realize that single order is infused
Liquid, magnetic bead are broken up to be separated with single order drain, the single order cleaning for completing magnetic bead, completes second order, the cleaning separation of three ranks in this way.Finally exist
Luminous substrate (enzyme-catalyzed chemical luminescence) or oxidant (directly chemistry are injected in substrate injection phase 650 where substrate inlet 420
Shine), it finally goes back to and picks and places the corresponding access position 640 of mouth 410, then take out reaction cup 700.As a kind of achievable
Mode, substrate inlet 420 connect substrate and constant displacement pump, will be anti-at substrate injection substrate injection phase 650 by constant displacement pump
Answer cup 700.
As shown in Figures 1 and 2, in an embodiment of the utility model, lifting structure 220 includes lifting motor 221 and silk
Bar 222, one end of screw rod 222 and the output shaft of lifting motor 221 are sequentially connected, and motor realizes lifting by screw rod 222, in turn
Drain needle 231 is driven to realize lifting.Further, the bottom for transporting disk 110 is provided with the gear being sequentially connected with transhipment disk 110
130, gear 130 is driven by additional force piece, and then transhipment disk 110 is driven to rotate.Synchronous turn is provided on gear 130
Dynamic code-disc 140, in order to which the rotation of gear 130 controls.As a kind of achievable mode, external motor drives gear 130
Realize rotation, the code tooth and optocoupler cooperation on code-disc 140 realize the positioning of operating position 600 at reaction cup 700.
As shown in figure 15, the utility model also provides a kind of magnetic bead cleaning separation method, comprising the following steps: to accommodating
Cleaning solution is injected in the reaction cup 700 of magnetic bead；Break up the magnetic bead in reaction cup 700；By the magnetic bead aggregation in reaction cup 700；Row
The drain needle 231 that liquid level sets 620 drops in reaction cup 700 and drains the cleaning waste liquid in reaction cup 700；In drain location
620 cleaning drain needles 231.Above-mentioned magnetic bead cleaning separation method directly carries out cleaning behaviour to drain needle 231 in drain location 620
Make, saves reciprocation time when drain needle 231 cleans between drain location 620 and additional cleaning positions, directly
It shortens magnetic bead single and cleans the isolated time, further improve the test flux of magnetic bead cleaning separator 10.Drain needle
231 are cleaned in drain location 620, are saved and are driven drain needle 231 between drain location 620 and additional cleaning positions
The movement mechanism of reciprocating motion simplifies the structure of magnetic bead cleaning separator 10.
The cleaning efficiency that drain needle 231 substantially increases drain needle 231 is cleaned in drain location 620.Cleaning swab 232 can
To clean drain needle 231 in the up and down of drain needle 231, static any state or continuous multiple states.At this
In one embodiment of utility model, drain location 620 clean drain needle 231 the step of in include drain needle 231 rising and/
Or decline Cleaning Process drain needle 231.In another embodiment of the utility model, drain needle is cleaned in drain location 620
231 the step of includes the cleaning drain needle 231 in the quiescing process of drain needle 231.As a kind of achievable mode, using clear
It washes the cleaning of swab 232 and cleans drain needle 231 in drain location 620, cleaning swab 232 is drained in reaction cup 700 in drain needle 231
Drain needle 231 is cleaned in uphill process after cleaning solution.As another achievable mode, swab 232 is cleaned in drain needle
231 drain in the uphill process after 700 cleaning liquid inside of reaction cup and clean in quiescing process drain needle 231, wherein in drain needle
231 it is static when main wash drain needle 231 syringe needle.
In an embodiment of the utility model, the cleaning waste liquid after cleaning drain needle 231 is discharged by negative pressure pump 234,
And the cleaning waste liquid that negative pressure pump 234 and 233 collective effect of negative-pressure cup draw drain needle 231 is discharged, and simplifies negative pressure equipment
Structure reduces cost.
In an embodiment of the utility model, it is injecting in cleaning solution step, is leading into the reaction cup 700 for accommodate magnetic bead
The injection needle 211 for crossing fixed setting injects cleaning solution into reaction cup 700.Injection needle 211 is fixedly installed on fluid injection position 610,
Only drainage structure 230 reduces magnetic bead cleaning separator with the synchronization lifting repeatedly of lifting structure 220 in magnetic bead cleaning process
10 cleaning energy consumption thereby reduces the cleaning cost of magnetic bead cleaning separator 10.Further, injection needle 211 is by cleaning solution
Inclination is injected to the inner sidewall of reaction cup 700, to realize that by cleaning solution direct injection, cleaning solution exists to the side wall of reaction cup 700
It flows down in reaction cup 700 and generates vortex in the bottom of reaction cup 700, help sufficiently to break up magnetic bead and enhancing to the clear of magnetic bead
Wash effect.Further, cleaning solution is injected to the side that magnetic bead is assembled in reaction cup 700 by injection needle 211, is conducive to fluid injection
The cleaning solution that needle 211 injects breaks up magnetic bead adequately in downflow processes and when forming vortex adequately to be cleaned.
As a kind of achievable mode, the transhipment path for transporting disk 110 is circle, is transferred to fluid injection in reaction cup 700
Before position 610, the magnetic bead in reaction cup 700 is gathered in reaction cup 700 along the inside in transhipment path, and fluid injection position 610 is corresponding
The outlet of injection needle 211 is also towards the inside in transhipment path.As another achievable mode, the transhipment path of disk 110 is transported
For circle, before reaction cup 700 is transferred to fluid injection position 610, the magnetic bead in reaction cup 700 is gathered in reaction cup 700 along transhipment
The outside in path, the outlet of the corresponding injection needle 211 in fluid injection position 610 is also towards the outside in transhipment path.It is another in the utility model
In one embodiment, the transhipment path of transhipment disk 110 is straight line, arrangement form and above-mentioned class of the injection needle 211 in fluid injection position 610
Seemingly, which is not described herein again.
As shown in figure 16, in an embodiment of the utility model, magnetic bead cleans separation method the following steps are included: in fluid injection
Cleaning solution is injected into the reaction cup 700 for accommodating magnetic bead in position 610；It is broken up in reaction cup 700 during transfer reaction cup 700
Magnetic bead；When reaction cup turn 700 moves to drain location 620, magnetic bead completes aggregation in reaction cup 700；Positioned at drain location 620
Drain needle 231 drops in reaction cup 700 and drains the cleaning waste liquid in reaction cup 700；Drain needle is cleaned in drain location 620
231.Further, it is broken up during transfer reaction cup 700 in the magnetic bead step in reaction cup 700, reaction cup 700 is by fluid injection position
610 are set into 620 transfer process of drain location, magnetic bead is handed over the variation of position two positions opposite in reaction cup 700
For aggregation.When reaction cup 700 is transferred to different operating positions 600, magnetic bead assembles position and corresponding variation occurs, and is conducive to magnetic
Coming into full contact with for pearl and cleaning solution, increases the cleaning effect of magnetic bead.As a kind of achievable mode, in the behaviour of reaction cup 700
Make 600 two sides of position setting magnet and breaks up magnetic bead in the transport process of reaction cup 700 to realize.
Magnetic bead provided by the utility model cleaning separation method can be suitable for the single order of magnetic bead to multistage cleaning.In this reality
With in a novel embodiment, fluid injection position 610 includes single order fluid injection position 611, second order fluid injection position 612 and three rank fluid injection positions 613, row
It includes single order drain position 621, second order drain position 622 and three rank drain positions 623 that liquid level, which sets 620,.The reaction cup of magnetic bead will be accommodated
700 are successively transported to single order drain position 621, second order fluid injection position 612, second order drain from single order fluid injection position 611 in a rotating manner
622, three rank fluid injection positions 613 of position and three rank drain positions 623 complete to clean separation to three ranks of magnetic bead.The cleaning separation of three ranks can
Adequately magnetic bead is cleaned.Further, in breaing up the magnetic bead step in reaction cup 700, magnetic bead phase in reaction cup 700
Between two positions move back and forth, increase the motion path of magnetic bead, and then guarantee coming into full contact with for magnetic bead and cleaning solution, enhance
The cleaning effect of magnetic bead.
It in an embodiment of the utility model, include several gap digits between single order fluid injection position 611 and single order drain position 621
630 are set, includes several interval locations 630, three rank fluid injection positions 613 and three ranks between second order fluid injection position 612 and second order drain position 622
It include several interval locations 630 between drain position 623.Reaction cup 700 turns between each interval location 630 and drain location 620
When shifting, magnetic bead is gathered in corresponding side in reaction cup 700 respectively.As a kind of achievable mode, each interval location 630
Side magnetic part 120 is set, magnetic part 120 is arranged in the side of each drain location 620.It is set in the side of interval location 630
Magnetic part 120 is set, facilitates after magnetic bead disperses in transfer process to assemble in interval location 630 again.In drain location 620
Magnetic part 120 is arranged in side, and when being conducive to drain needle 231 and draining cleaning solution, aggregation magnetic bead as much as possible reduces the damage of magnetic bead
Mistake rate.
Further, when reaction cup 700 is by different interval locations 630, the magnetic bead two sides different in reaction cup 700
Alternately assemble, sufficiently break up magnetic bead in cleaning solution, increase the contact area of magnetic bead and cleaning solution, to magnetic bead carry out sufficiently, have
The cleaning of effect.A kind of several interval locations as achievable mode, between single order fluid injection position 611 and single order drain position 621
630 corresponding magnetic parts 120 are staggered in 630 two sides of interval location.Second order fluid injection position 612 and second order drain position 622
Between the corresponding magnetic part 120 of several interval locations 630 be staggered in 630 two sides of interval location.Three rank fluid injection positions
613 and the three corresponding magnetic parts 120 of several interval locations 630 between rank drain position 623 be staggered in interval location
630 two sides.
Specifically, transhipment path is circle, operating position 600 includes ten interval locations 630, respectively the first gap digit
6301, the second gap digit 6302, third gap digit 6303, the 4th gap digit 6304, the 5th gap digit 6305, the 6th gap digit
6306, the 7th gap digit 6307, the 8th gap digit 6308, the 9th gap digit 6309, the tenth gap digit 6310.Transport disk 110
Transhipment path on set gradually single order fluid injection position 611, the first gap digit 6301, the second gap digit 6302, third gap digit 6303,
Single order drain position 621, second order fluid injection position 612, the 4th gap digit 6304, the 5th gap digit 6305, the 6th gap digit 6306, second order
Drain position 622, three rank fluid injection positions 613, the 7th gap digit 6307, the 8th gap digit 6308, the 9th gap digit the 6309, the tenth interval
6310, three rank drain positions 623 of position.Reaction cup 700 passes through above-mentioned position, successively under the drive of transhipment disk 110 to realize magnetic bead
Single order cleaning separation, second order cleaning separation and three ranks cleaning separation.
A magnetic part 120 is respectively set in ten interval locations 630 and three drain locations 620.Wherein the first gap digit
6301, the 4th gap digit 6304 of the second gap digit 6302, the 5th gap digit 6305, the 7th gap digit 6307, the 8th gap digit
6308 and the corresponding magnetic part 120 of the 9th gap digit 6309 be separately positioned on transhipment path inside.Third gap digit 6303, one
Rank drain position 621, the 6th gap digit 6306, second order drain position 622, the tenth gap digit 6310 and three rank drain positions 623 are corresponding
Magnetic part 120 is separately positioned on the outside in transhipment path.Corresponding, the magnetic bead of reaction cup 700 is on corresponding operation position 600
It is gathered in the side of setting magnet respectively, to realize sufficiently the breaing up to magnetic bead in transport process, and then realizes that this is practical new
Abundant, effective cleaning of the magnetic bead cleaning separator 10 that type provides to magnetic bead.In the other embodiments of the utility model, peace
The heteropleural in transhipment path is arranged in the corresponding magnetic part 120 in adjacent operator position 600 equipped with magnetic part 120.Magnetic part 120 is set
Setting the effect in transhipment path two sides is that magnetic bead is gathered in the heteropleural in transhipment path to realize pair in different operating positions 600
Magnetic bead is broken up, and the utility model is not intended to limit magnetic part 120 in the specific arrangement form of transhipment path two sides, beats as long as realizing
Dissipate the function of magnetic bead.
The utility model also provides a kind of chemical illumination immunity analysis instrument, including magnetic described in analytical equipment and above scheme
Pearl cleans separator 10.Analytical equipment is used to analyze the magnetic bead after magnetic bead cleaning separator 10 cleans.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
Above-described embodiments merely represent several embodiments of the utility model, the description thereof is more specific and detailed,
But it should not be understood as limiting the scope of the patent of the utility model.It should be pointed out that for the common of this field
For technical staff, without departing from the concept of the premise utility, various modifications and improvements can be made, these all belong to
In the protection scope of the utility model.Therefore, the scope of protection shall be subject to the appended claims for the utility model patent.
Claims (16)
1. a kind of magnetic bead cleans separator characterized by comprising
Magneto separate component, including transhipment disk and magnetic part, the transhipment disk is for the reaction cup for filling magnetic bead to be transported to accordingly
Operating position, the operating position includes fluid injection position and drain location, and the magnetic part is arranged in turning for the transhipment disk
Transport path side；
Liquid injection component, including fluid-filling structure, lifting structure and drainage structure, the fluid-filling structure include injection needle, the note
Liquid needle is fixedly installed on the fluid injection position, and the drainage structure executes lifting action, institute under the drive of the lifting structure
Drainage structure is stated for siphoning away the liquid in reaction cup in the drain location.
2. magnetic bead according to claim 1 cleans separator, which is characterized in that the extending direction of the injection needle and place
There is the angle between 0 ° to 75 ° between the extending direction of the reaction cup of the fluid injection position.
3. magnetic bead according to claim 2 cleans separator, which is characterized in that the fluid-filling structure further includes fluid injection bottom
Seat, the fluid injection pedestal are fixedly installed on the fluid injection position, and the fluid injection pedestal has fixation hole, the position of the fixation hole
It is opposite with the fluid injection position, the extending direction of the extending direction of the fixation hole and the reaction cup for being transported to the fluid injection position
Between there is angle between 0 ° to 75 °, the injection needle is arranged in the fixation hole.
4. magnetic bead according to claim 3 cleans separator, which is characterized in that the export direction direction of the injection needle
The side that magnetic bead is assembled in reaction cup.
5. magnetic bead according to claim 2 cleans separator, which is characterized in that the drainage structure include drain needle and
Swab is cleaned, the cleaning swab is sheathed on the outside of the drain needle, for cleaning the drain needle；The lifting structure drives
The drain needle is gone up and down in the drain location to drain the liquid in reaction cup.
6. magnetic bead according to claim 5 cleans separator, which is characterized in that the cleaning swab has cleaning logical
Hole, cleaning entrance and washing outlet, the drain needle are arranged in the cleaning through-hole；The cleaning entrance and the washing outlet
It is connected to respectively with the cleaning through-hole, the cleaning entrance and the washing outlet are respectively used to introduce cleaning solution and discharge cleaning
Liquid.
7. magnetic bead according to claim 6 cleans separator, which is characterized in that the drainage structure further includes negative pressure
Pump, the negative pressure pump connect useless to drain the cleaning after cleaning the drain needle with the washing outlet of the cleaning swab
Liquid.
8. magnetic bead according to claim 7 cleans separator, which is characterized in that the drainage structure further includes negative pressure
Tank, the negative pressure pump are connect with the negative-pressure cup, and one end of the drain needle is connect with the negative-pressure cup, the drain needle it is another
One end is used in intercalation reaction cup, to siphon away the liquid in reaction cup.
9. magnetic bead according to claim 1 cleans separator, which is characterized in that further include Magneto separate pot, the magnetic point
There is hollow cavity from cookware, the transhipment disk is rotatably dispose in the hollow cavity of the Magneto separate pot；The Magneto separate pot
Hollow cavity inner wall is also provided with the transhipment slot extended along the rotation direction of the transhipment disk, and the transhipment disk drives reaction cup to exist
It is moved in the transhipment slot.
10. magnetic bead according to claim 9 cleans separator, which is characterized in that be also provided in the Magneto separate pot
The side of the transhipment slot is arranged in for installing the magnetic part, the mounting groove in mounting groove, the mounting groove；Magnetic bead cleaning
Separator magnetic bead cleans the opening of mounting groove described in separator towards the side of the Magneto separate pot far from the injection needle.
11. magnetic bead according to claim 1 cleans separator, which is characterized in that the magnetic bead cleaning separator is also
Including magnetic shielding cover, the magnetic shielding cover covers at the outer peripheral edge of the Magneto separate component.
12. -11 described in any item magnetic beads clean separator according to claim 1, which is characterized in that the operating position packet
Three fluid injection positions and three drain locations are included, three fluid injection positions are with three drain locations along the transhipment of reaction cup
Path is alternately arranged；The fluid-filling structure include three injection needles, three injection needles respectively with three fluid injection positions
It is correspondingly arranged；The drainage structure include three drain needles and three cleaning swabs, three drain needles and three it is described clearly
Swab is washed to be correspondingly arranged with three drain locations respectively；The magnetic bead cleaning separator is used to carry out three ranks to magnetic bead clear
Wash separation.
13. magnetic bead according to claim 12 cleans separator, which is characterized in that three fluid injection positions are respectively
Single order fluid injection position, second order fluid injection position and three rank fluid injection positions, three drain locations are respectively single order drain position, second order drain position
And three rank drain position；The operating position further includes interval location, and the magnetic bead is assembled at the interval location；The single order
Several interval locations are sequentially arranged between fluid injection position and single order drain position, second order fluid injection position and the second order are arranged
Several interval locations are sequentially arranged between liquid level, if being sequentially arranged between the three ranks fluid injection position and the three ranks drain position
Do the interval location；A magnetic part, the side of each drain location is arranged in the side of each interval location
One magnetic part is set.
14. magnetic bead according to claim 13 cleans separator, which is characterized in that multiple magnetic parts are distributed in institute
State the transhipment path two sides of transhipment disk.
15. magnetic bead according to claim 1 cleans separator, which is characterized in that the operating position further includes substrate
Injection phase is provided with substrate inlet, the substrate inlet connection substrate and constant displacement pump on the substrate injection phase, leads to
It crosses constant displacement pump and substrate is injected to reaction cup at the substrate injection phase.
16. a kind of chemical illumination immunity analysis instrument, which is characterized in that including described in analytical equipment and claim any one of 1-15
Magnetic bead clean separator；The analytical equipment is used to analyze the magnetic bead after the magnetic bead cleaning separator cleaning.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820226350.3U CN208303355U (en) | 2018-02-08 | 2018-02-08 | Magnetic bead cleans separator and chemical illumination immunity analysis instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820226350.3U CN208303355U (en) | 2018-02-08 | 2018-02-08 | Magnetic bead cleans separator and chemical illumination immunity analysis instrument |
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| Publication Number | Publication Date |
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| CN208303355U true CN208303355U (en) | 2019-01-01 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109909245A (en) * | 2019-03-13 | 2019-06-21 | 中国科学院成都生物研究所 | A kind of automatic flushing device |
| CN110006877A (en) * | 2019-05-08 | 2019-07-12 | 苏州仁端生物医药科技有限公司 | A kind of magnetic separating device and magnetism separate method for chemical luminescence detector |
| CN110125075A (en) * | 2018-02-08 | 2019-08-16 | 成都深迈瑞医疗电子技术研究院有限公司 | Magnetic bead cleans separator and chemical illumination immunity analysis instrument |
| CN111912975A (en) * | 2019-05-09 | 2020-11-10 | 深圳华迈兴微医疗科技有限公司 | Magnetic separation device and chemiluminescence immunoassay analyzer |
| CN115156215A (en) * | 2022-08-02 | 2022-10-11 | 宋世琦 | Magnetic particle cleaning device and cleaning method for immunoassay device |
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2018
- 2018-02-08 CN CN201820226350.3U patent/CN208303355U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110125075A (en) * | 2018-02-08 | 2019-08-16 | 成都深迈瑞医疗电子技术研究院有限公司 | Magnetic bead cleans separator and chemical illumination immunity analysis instrument |
| CN109909245A (en) * | 2019-03-13 | 2019-06-21 | 中国科学院成都生物研究所 | A kind of automatic flushing device |
| CN110006877A (en) * | 2019-05-08 | 2019-07-12 | 苏州仁端生物医药科技有限公司 | A kind of magnetic separating device and magnetism separate method for chemical luminescence detector |
| CN111912975A (en) * | 2019-05-09 | 2020-11-10 | 深圳华迈兴微医疗科技有限公司 | Magnetic separation device and chemiluminescence immunoassay analyzer |
| CN115156215A (en) * | 2022-08-02 | 2022-10-11 | 宋世琦 | Magnetic particle cleaning device and cleaning method for immunoassay device |
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