CN206974888U - The spuious electro-optical device that disappears of CCD fluorescence biosensor chip scanners - Google Patents
The spuious electro-optical device that disappears of CCD fluorescence biosensor chip scanners Download PDFInfo
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- CN206974888U CN206974888U CN201720790805.XU CN201720790805U CN206974888U CN 206974888 U CN206974888 U CN 206974888U CN 201720790805 U CN201720790805 U CN 201720790805U CN 206974888 U CN206974888 U CN 206974888U
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Abstract
It the utility model is related to the spuious electro-optical device that disappears of CCD fluorescence biosensor chip scanners, including delustring darkroom, light limiting means, diaphragm and the attenuator set gradually from the bottom up, delustring darkroom upper end is provided with the pallet that can outwards extract out and be used to place biochip, there is the ladder that is in the light to stretch out on the downside of pallet, have the light absorbent for being laid on delustring darkroom bottom side of the wall and bottom surface on the downside of the ladder that is in the light；Light limiting means include being located at the seal closure of delustring darkroom upper end open, the tilting limited light block in side of seal closure, and limit light block middle part is provided with the through hole of sharp light direct projection to biochip on pallet；Diaphragm is arranged on the upper end of seal closure and positioned at the surface of pallet；Attenuator includes the delustring cylinder that axis overlaps with the axis of diaphragm, and the madial wall of delustring cylinder sets delustring screw thread.The utility model is designed reasonably, the veiling glare in light path system can be substantially eliminated, solve the problems, such as that veiling glare easily floods fluorescence in Fluorescence Scanner detects.
Description
Technical field：
It the utility model is related to a kind of spuious electro-optical device that disappears of CCD fluorescence biosensor chips scanner.
Background technology：
Patent（Application number：CN201610597471.4）It is proposed a kind of micro-array chip fluoroscopic examination side of great power LED
Method, it is characterised in that excited to biochip by the annular LED illumination array of design, then gathered using CCD camera
The fluorescence of transmitting.Patent（Application number：CN02252864.4）It is proposed a kind of CCD biochip tests with uniform illumination system
The design of instrument, the white light for being sent xenon lamp by optical element are filtered into parallel monochromatic light, and oblique its then is mapped into biology
Fluorescent dye is excited on chip, then the fluorescence of transmitting is captured with CCD camera.
Biochip technology is the new and high technology to be emerged rapidly in life science, and it is with slide, silicon chip or Buddhist nun
Dragon etc. is carrier, arranges substantial amounts of biomaterial to high-density on its surface, is realized to DNA, protein, cell and other lifes
Accurate, quick, parallel and large information capacity the detection and analysis of thing component, can be widely applied to drug research, medical diagnosis on disease, base
Because of fields such as function research.The detection mode of the current main flow of fluoroscopic examination of biochip has two kinds：One kind is to be based on
The mode of the laser co-focusing of photomultiplier, another kind are the imagings of high pressure xenon gas lamp, mercury lamp or high-power LED combined CCD
Mode.Wherein, CCD imaging modes are irradiated to the large area region of chip and made by the way that light source is filtered into narrowband wavelength ranges
Fluorescent marker is excited to produce fluorescence, then exposes and collect by CCD camera, has the advantages of simple in construction, detection speed is fast.
But CCD imaging modes have a problem that, that is, because the light source of high intensity disposably irradiates biochip
On so that substantial amounts of veiling glare is remained on light path system, as long as and seldom veiling glare just can be by biochip into CCD camera
On the fluorescence that emits flood.Therefore the present invention proposes a kind of design of the veiling glare that disappears of CCD fluorescence biosensor chips scanner,
The veiling glare on light path system can substantially be eliminated.
Utility model content：
The purpose of this utility model is to be directed to above weak point, there is provided a kind of CCD fluorescence biosensor chips scanner
Disappear spuious electro-optical device, reasonable in design, can substantially eliminate the veiling glare on light path system.
To achieve these goals, the technical solution adopted in the utility model is：A kind of CCD fluorescence biosensor chips scanner
The spuious electro-optical device that disappears, including delustring darkroom, light limiting means, diaphragm and the attenuator set gradually from the bottom up be described to disappear
The upper end of brightness room, which is provided with one, can outwards extract and be used for the pallet for placing biochip out, and the downside setting of the pallet is oriented
The ladder that is in the light of outside extension, the downside of the ladder that is in the light are provided with the extinction material for being laid on delustring darkroom bottom side of the wall and bottom surface
Material；The light limiting means include a seal closure for being located at delustring darkroom upper end, and the side of the seal closure is obliquely installed limited
Light block, the light direct projection in favor of excitation source is offered to the through hole of biochip on pallet in the middle part of the limit light block；Institute
State diaphragm and be arranged on the upper end of seal closure and positioned at the surface of pallet；The attenuator includes the axis weight of an axis and diaphragm
The delustring cylinder of conjunction, the upper end of the delustring cylinder are connected with CCD camera, and the madial wall of delustring cylinder sets delustring screw thread.
Further, the light absorbent is aterrimus extinction flannelette.
Further, the upper end in the delustring darkroom is provided with a chute, and the chute is connected with tray both slid, and chute is opened
Mouth is located at the leading flank upper end in delustring darkroom；A light-transmitting opening passed through with sharp light is offered in the middle part of the pallet, it is described
The location indentations for being used to place biochip are symmetrically arranged with the middle part of the rear and front end of optical port.
Further, at left and right sides of the upper end of the seal closure it is intilted inclined-plane, the inclined-plane is used to install
Light block is limited, a cylindrical installation groove for being used to install excitation source, the installation groove are offered in the middle part of the limit light block
Both sides be respectively arranged with a circular arc-shaped recess；The through hole is arranged on the middle part of installation groove, and through hole is square shape, through hole
Side wall is provided with internal thread.
Further, the diaphragm is in cylinder, and the loophole of a square shape is offered in the middle part of diaphragm.
Further, the size of the loophole is identical with the size of microarray dot matrix on biochip.
Further, the top of the delustring screw thread is in 30 ° of tip shape.
Compared with prior art, the utility model has the following effects that：The utility model is reasonable in design, can substantially disappear
Except the veiling glare in light path system, solve the problems, such as that veiling glare easily floods fluorescence in Fluorescence Scanner detects, but also
Signal to noise ratio and the sensitivity of scanner detection can be improved, lowering apparatus is purchased for the rigors of filter performance so as to reduce
Buy the cost of optical filter.
Brief description of the drawings：
Fig. 1 is the structural representation of the utility model embodiment；
Fig. 2 is the structural representation for limiting light block；
Fig. 3 is the workflow diagram of the utility model embodiment.
In figure：
1- delustrings darkroom；101- is in the light ladder；102- light absorbents；2- light limiting means；201- seal closures；202- limits light
Block；203- installation grooves；204- circular arc-shaped recess；205- through holes；206- internal threads；3- diaphragms；301- loopholes；4- delustrings
Device；401- delustring cylinders；402- delustring screw threads；5- pallets；501- light-transmitting openings；502- location indentations.
Embodiment:
The utility model is described in more detail with reference to the accompanying drawings and detailed description.
As Figure 1-3, the spuious electro-optical device that disappears of a kind of CCD fluorescence biosensor chips scanner of the utility model, including from
Under the delustring darkroom 1, light limiting means 2, diaphragm 3 and the attenuator 4 that up set gradually, the upper end in the delustring darkroom 1 is set
There is one can outwards extract out and for placing the pallet 5 of biochip, the downside of the pallet 5 is provided with being in the light of extending laterally
Ladder 101, the downside of the ladder 101 that is in the light are provided with the light absorbent 102 for being laid on the bottom side of the wall of delustring darkroom 1 and bottom surface；
The light limiting means 2 include a seal closure 201 for being located at the upper end of delustring darkroom 1, and the side of the seal closure 201 is obliquely installed
Limited light block 202, the middle part of the limit light block 202 offer light direct projection in favor of excitation source to biological core on pallet 5
The through hole 205 of piece；The diaphragm 3 is arranged on the upper end of seal closure 1 and positioned at the surface of pallet 5；The attenuator 4 includes one
The delustring cylinder 401 that axis overlaps with the axis of diaphragm 3, the upper end of the delustring cylinder 401 are connected with CCD camera, delustring circle
The madial wall of cylinder 401 sets delustring screw thread 402；During work, limit light block 202 first enters to the veiling glare at large radiation angle in excitation source
Row limitation, veiling glare enter in delustring darkroom 1 through biochip, and delustring darkroom 1 absorbs veiling glare, and then veiling glare passes through successively
The blocking of diaphragm 3, the absorption of attenuator 4 are crossed, completes the elimination of veiling glare on light path system.
In the present embodiment, the light absorbent 102 is aterrimus extinction flannelette, and extinction works well.
In the present embodiment, the upper end in the delustring darkroom 1 is provided with a chute, and the chute is slidably connected with pallet 5, chute
Opening positioned at delustring darkroom 1 leading flank upper end；The middle part of the pallet 5 offers a light-transmitting opening passed through with sharp light
501, the rear and front end middle part of the light-transmitting opening 501 is symmetrically arranged with the location indentations 502 for being used to place biochip.
It is intilted inclined-plane at left and right sides of the upper end of the seal closure 201, the inclined-plane is used in the present embodiment
Installation limit light block 202, the middle part of the limit light block 202 offer a cylindrical installation groove 203 for being used to install excitation source,
The both sides of the installation groove 203 are respectively arranged with a circular arc-shaped recess 204, ensure that excitation source is accurate, reliably installs；Institute
The middle part that through hole 205 is arranged on installation groove 203 is stated, through hole 205 is square shape, and the side wall of through hole 205 is provided with internal thread
206, it the setting of internal thread 206, can prevent exciting light from producing interference, be easy to finally to present in ccd image between bright dark phase
Provision.
The light argument setting of the size of through hole excitation source according to used in, to ensure that the size of through hole is avoided that
The light at large radiation angle enters light path so that exciting light is just only radiated at the effective coverage of biochip.
In the present embodiment, for the diaphragm 3 in cylinder, the middle part of diaphragm 3 offers the loophole 301 of a square shape, institute
The size for stating loophole 301 is identical with the size of microarray dot matrix on biochip.
In the present embodiment, the top of the delustring screw thread 402 is in 30 ° of tip shape, is easy to more preferable delustring.
Specific implementation process：Biochip is placed on pallet 5, CCD camera is connected with attenuator 4, excitation source peace
On limit light block 202；Excitation source launches exciting light, and 202 veiling glare first larger to radiation angle in exciting light of limit light block enters
Row limitation, then veiling glare is through inside arrival delustring darkroom 1, the veiling glare in delustring darkroom 1 passes through extinction after biochip
Material 102 absorbs and is in the light reflection upwards after the blocking of ladder 101, and the veiling glare reflected upwards passes through the screening of diaphragm 3 successively
Keep off, enter CCD camera after the delustring of attenuator 4, realize the veiling glare eliminated on light path system.
The foregoing is only preferred embodiment of the present utility model, it is all done according to present utility model application the scope of the claims it is equal
Deng change and modification, it should all belong to covering scope of the present utility model.
Claims (7)
- A kind of 1. spuious electro-optical device that disappears of CCD fluorescence biosensor chips scanner, it is characterised in that：Including setting gradually from the bottom up Delustring darkroom, light limiting means, diaphragm and attenuator, the upper end in the delustring darkroom, which is provided with one, outwards to extract out and be used for The pallet of biochip is placed, the ladder that is in the light extended laterally is provided with the downside of the pallet, it is described to be in the light under ladder Side is provided with the light absorbent for being laid on delustring darkroom bottom side of the wall and bottom surface；The light limiting means are located at delustring darkroom including one The seal closure of upper end, the side of the seal closure are obliquely installed limited light block, offered in the middle part of the limit light block in favor of swashing Through hole of the light direct projection of light emitting source to biochip on pallet；The diaphragm is arranged on the upper end of seal closure and positioned at pallet Surface；The attenuator includes the delustring cylinder that an axis overlaps with the axis of diaphragm, the upper end of the delustring cylinder and CCD Camera connects, and the madial wall of delustring cylinder sets delustring screw thread.
- 2. the spuious electro-optical device that disappears of CCD fluorescence biosensor chips scanner according to claim 1, it is characterised in that：It is described Light absorbent is aterrimus extinction flannelette.
- 3. the spuious electro-optical device that disappears of CCD fluorescence biosensor chips scanner according to claim 1, it is characterised in that：It is described The upper end in delustring darkroom is provided with a chute, and the chute is connected with tray both slid, and the opening of chute is positioned at the front side in delustring darkroom Face upper end；A light-transmitting opening passed through with sharp light is offered in the middle part of the pallet, the rear and front end middle part of the light-transmitting opening is right Claim to be provided with the location indentations for being used to place biochip.
- 4. the spuious electro-optical device that disappears of CCD fluorescence biosensor chips scanner according to claim 1, it is characterised in that：It is described It is intilted inclined-plane at left and right sides of the upper end of seal closure, the inclined-plane is used to install limit light block, described to limit in light block Portion offers a cylindrical installation groove for being used to install excitation source, and the both sides of the installation groove are respectively arranged with a circular arc Shape recess；The through hole is arranged on the middle part of installation groove, and through hole is square shape, and the side wall of through hole is provided with internal thread.
- 5. the spuious electro-optical device that disappears of CCD fluorescence biosensor chips scanner according to claim 1, it is characterised in that：It is described Diaphragm is in cylinder, and the loophole of a square shape is offered in the middle part of diaphragm.
- 6. the spuious electro-optical device that disappears of CCD fluorescence biosensor chips scanner according to claim 5, it is characterised in that：It is described The size of loophole is identical with the size of microarray dot matrix on biochip.
- 7. according to the spuious electro-optical device that disappears of CCD fluorescence biosensor chips scanner according to claim 1, it is characterised in that： The top of the delustring screw thread is in 30 ° of tip shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720790805.XU CN206974888U (en) | 2017-07-03 | 2017-07-03 | The spuious electro-optical device that disappears of CCD fluorescence biosensor chip scanners |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720790805.XU CN206974888U (en) | 2017-07-03 | 2017-07-03 | The spuious electro-optical device that disappears of CCD fluorescence biosensor chip scanners |
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| CN206974888U true CN206974888U (en) | 2018-02-06 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110376851A (en) * | 2019-07-23 | 2019-10-25 | 东莞科视自动化科技有限公司 | A kind of light source of exposure machine |
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2017
- 2017-07-03 CN CN201720790805.XU patent/CN206974888U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110376851A (en) * | 2019-07-23 | 2019-10-25 | 东莞科视自动化科技有限公司 | A kind of light source of exposure machine |
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