CN206641842U - A kind of toy fluoroscopic imaging device applied to upper conversion - Google Patents
A kind of toy fluoroscopic imaging device applied to upper conversion Download PDFInfo
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- CN206641842U CN206641842U CN201621268036.9U CN201621268036U CN206641842U CN 206641842 U CN206641842 U CN 206641842U CN 201621268036 U CN201621268036 U CN 201621268036U CN 206641842 U CN206641842 U CN 206641842U
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- toy
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- body case
- fixing device
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Abstract
The utility model discloses a kind of toy fluoroscopic imaging device applied to upper conversion, including body case, laser, main control computer and the fluorescence detection device with being electrically connected in body case and with main control computer, base portion base I in the body case is provided with groove, toy fixing device is installed, the toy fixing device is located at the underface of fluorescence detection device in the groove；The toy fixing device includes the base II that can be slid back and forth in groove and the Y type fixing devices on base II, and the cylinder for loading toy of inner hollow is fixed with the Y types fixing device.Excitation source is improved by the utility model, meet requirement of the upper conversion imaging for excitation wavelength, and transformation is designed to toy fixing device, fixation and anesthesia in real time to toy can be realized in experimentation, greatly accelerates experiment process.
Description
Technical field
The utility model belongs to medical imaging technology field, and in particular to a kind of toy fluorescence applied to upper conversion into
As device.
Background technology
With the development of fluorescent probe technique, bioluminescence imaging technology is by feat of its quick, not damaged, directly perceived, sensitive
Spending the features such as high is widely used, especially in the field such as clinical conditions and life medical research.Bioluminescence
Imaging technique is highly dependent on fluorescence probe, and effect of the fluorescence probe in bioluminescence imaging is that detected material is tracked
And mark.
Up-conversion fluorescence is the electronic energy level structure enriched using rare earth ion, passes through the multiple photons of continuous absorption and energy
Transfer, low-energy light radiation is converted into the process of high-energy light radiation.Rare earth luminescent material is visited as a kind of new fluorescence
Pin, the photochemical stability having by feat of it is good, transmitting band is narrow, long lifespan, big Stokes displacements the advantages that, in bioluminescence
Paid high attention in terms of imaging.Wherein rare earth up-conversion fluorescent nano material, excitation source is made using near infrared laser,
Damage of the burst of ultraviolel light source to cell or tissue is effectively reduced, there is stronger light penetration capacity, while biomolecule is to red
Outer light does not almost absorb, and the background fluorescence interference of biological tissue is avoided, in biological cell and living body fluorescent imaging applications side
Face causes the highest attention of researcher.
The instrument of fluorescence imaging is primarily directed to traditional fluorescent dye (such as rhodamine, FITC, CY5) at present, these
The excitation wavelength of dyestuff is mostly in the range of visible ray, and what up-conversion fluorescence was imaged excites optical range more near infrared region
Domain, therefore, it is impossible to meet the needs of up-conversion fluorescence reagent, and existing small animal imaging device, it can not realize to toy
It is fixed.Existing apparatus can not realize the real-time anesthesia of toy, and during experiment, mouse can usually come to life, and cause
Experiment is interrupted.
The content of the invention
The purpose of this utility model is to establish a kind of toy fluoroscopic imaging device applied to upper conversion, and it can be realized
The real-time monitoring carried out to up-conversion fluorescence material in toy body, and the diseased region in toy body is carried out accurately to determine
Position.
The utility model patent is achieved through the following technical solutions：
A kind of toy fluoroscopic imaging device applied to upper conversion, including body case, two lasers, master control calculating
Machine, and fluorescence detection device and toy fixing device in body case：
Described fluorescence detection device, including CCD camera, slide rail and installing plate, CCD camera pass through data wire or power supply
Line is connected with main control computer：Described slide rail, in the vertical direction for the back face wall being installed on inside box body, CCD camera
The back side corresponding railroad is installed so that CCD camera slides up and down in slide rail；Described installing plate is provided with 3 peaces
Hole is filled, optical filter is placed on mounting hole；The side of described installing plate, which is provided with one, can move left and right peace in the horizontal direction
The selector bar of loading board；The camera of described CCD camera slides up and down along slide rail, selector bar pulls installing plate in the horizontal direction
Move left and right, so that camera is co-located with optical filter；
Described toy fixing device includes base I, base II, two Y type fixing devices, can load toy,
The cylinder of inner hollow：Described base I is the base portion base of body case, which is provided with groove；Described base II, bottom
Provided with the device that can be slided in base I groove, so that grooves of the base II along base I slides back and forth；Described base
II is upper to be provided with two row's spacing holes along fore-and-aft direction, and the end of described two Y type fixing devices is installed on same a line spacing hole
On；Described cylinder is positioned at the Y word mouths at the top of Y type fixing devices；
Described toy fixing device is located at the underface of fluorescence detection device；
Described fluorescence detection device is connected by data wire or power line with main control computer；
Two described lasers are located at the left and right sides of body case respectively, and optical fiber, the end of optical fiber are connected with laser
End is connected with beam expanding lens and beam expanding lens is located inside body case；The oral area of described beam expanding lens is towards described cylinder.
Preferably, edge of the edge of described base I groove provided with scale I, described base II is provided with scale II,
Scale I and scale II match.
Preferably, the edge of described spacing hole is provided with different numberings, and the Y types fixing device selects to pacify as needed
In different spacing holes.
Preferably, the cylinder, one end open, one end closing, one end of the oral area direction opening of beam expanding lens, closing
One end is provided with circular aperture；The top of described cylinder is provided with switch；The limit that can be moved is provided with inside described cylinder
Determine valve.
Preferably, the cylinder, wall thickness 2-3mm, internal diameter 25-35mm, it is made up of makrolon material；Described
Cylinder 14 can be rotated in Y type fixing devices.
Preferably, the described toy fluoroscopic imaging device applied to upper conversion also includes the container for containing anesthetic,
On body wall outside body case；Described container is connected by silicone tube from described circular aperture with cylinder.
Preferably, the front body wall of described body case is provided with observation window.
Preferably, the top of described container is provided with lid, and container content has absorbent cotton.
Preferably, described silicone tube is provided with detection switch.
Preferably, the wavelength of the laser of the laser transmitting is 980nm.
Application method of the present utility model：The utility model patent is provided with toy fixator, by toy fixing device
Take out, toy is put into by the switch for opening the upper end of cylinder, promotes the activity for limiting valve limitation toy in cylinder
Region, the detection switch on silicone tube is opened so that the anesthetic in container enters in cylinder, and fiber crops are carried out to toy
It is liquor-saturated；Computer is opened, toy is observed by CCD camera, selects suitable spacing hole regulation toy fixing device
Position so that toy appears in the visual field center of whole CCD camera, adjusts the position of CCD camera, is passed on slide rail
The distance for changing camera and experimental animal is slided, obtains optimum photographing position, pulls optical filtering change lever, selects suitable filter
Mating plate, start to be imaged toy, during imaging, staff can see toy by observation panel
Examine.
The beneficial effects of the utility model are：Excitation source is improved by the utility model patent, meets conversion
The requirement for excitation wavelength is imaged, and the utility model patent is designed transformation to toy fixing device, is testing
During can realize fixation to toy and in real time anesthesia, greatly accelerate experiment process.
Brief description of the drawings
Fig. 1 is the external structure schematic diagram of the utility model device；
Fig. 2 is the internal structure schematic diagram of the utility model device；
Fig. 3 is the structural representation of the toy fixing device of the utility model device；
Fig. 4 is the structural representation of the Y type fixing devices of the utility model device；
Reference：1st, body case；2nd, laser；3rd, main control computer；4th, CCD camera；5th, slide rail；6th, installing plate；7、
Selector bar；8th, mounting hole；9th, optical filter；10th, base I；11st, base II；12nd, Y types fixing device；13rd, spacing hole；14th, cylinder
Body；15th, switch；16th, valve is limited；17th, container；18th, silicone tube；19th, optical fiber；20th, beam expanding lens；21st, observation window；22nd, detection is opened
Close.
Embodiment
The utility model is described in further detail with reference to the accompanying drawings and detailed description.
A kind of toy fluoroscopic imaging device applied to upper conversion, including 1, two laser 2 of body case, master control calculate
Machine 3, and fluorescence detection device and toy fixing device in body case；As Figure 1-4：
Described fluorescence detection device, including CCD camera 4, slide rail 5 and installing plate 6, CCD camera by data wire or
Power line is connected with main control computer, and CCD camera be can be used to gather images, while imaging results are supervised in real time
Survey, the image collected is delivered to main control computer and handled；Described slide rail, the back face wall being installed on inside box body
Vertical direction on, the back side of CCD camera is provided with corresponding railroad so that CCD camera slides up and down in slide rail, with
Optimal shooting angle is found, image is preferably gathered to experimental subjects；Described installing plate is provided with 3 mounting holes 8, mounting hole
Upper placement optical filter 9；The side of described installing plate is provided with a conversion that can move left and right installing plate in the horizontal direction
Bar 7；The camera of described CCD camera slides up and down along slide rail, selector bar pulls installing plate to move left and right in the horizontal direction,
So that camera is co-located with optical filter；Before optical filter is positioned over CCD camera, selected by moving horizontally selector bar
Suitable optical filter, meet different experiment conditions, experimental error can be reduced with this；The multiple optical filters of device can be to non-hair
Penetrate light to be filtered, to reduce the interference of the fluorescence such as sample, instrument self-luminous；
Described toy fixing device includes base I 10, base II 11, two Y types fixing devices 12, can load small
Animal, inner hollow cylinder 14：Described base I is the base portion base of body case, which is provided with groove；Described bottom
Seat II, bottom is provided with the device that can be slided in base I groove, so that grooves of the base II along base I slides back and forth；Institute
Two row's spacing holes 13 are provided with along fore-and-aft direction on the base II stated, the end of described two Y type fixing devices is installed on together
On a line spacing hole；Described cylinder is positioned at the Y word mouths at the top of Y type fixing devices；
Described toy fixing device is located at the underface of fluorescence detection device；
Described fluorescence detection device is connected by data wire or power line with main control computer；
Two described lasers are located at the left and right sides of body case respectively, and optical fiber 19 is connected with laser, optical fiber
End is connected with beam expanding lens 20 and beam expanding lens is located inside body case；The hot spot of laser can be enlarged by beam expanding lens 20, be made
Whole toy can be covered by obtaining laser beam.
In the utility model patent, the edge of described base I 10 groove is provided with scale I, described base II 11
Edge be provided with scale II, scale I and scale II and match, so as to can accurate judgement toy fixing device shift position,
The horizontal level of fixing device can be recorded in imaging.
In the utility model patent, the edge of described spacing hole 13 is provided with different numberings, the Y types fixing device 12
It is selectively mounted to as needed in different spacing holes.
In the utility model patent, the cylinder 14, one end open, one end closing, the oral area direction opening of beam expanding lens
One end, one end of closing is provided with circular aperture；The top of described cylinder is provided with switch 15, opens switch 15 by toy
Be put into cylinder 14, can with the either on or off switch 15 it is sterilized after clean, sterile environment is provided for experimental animal, be naked
The special experimental animal such as mouse provides a good experiment condition；The restriction valve that can be moved is provided with inside described cylinder
16。
In the utility model patent, the cylinder 14, wall thickness 2-3mm, internal diameter 25-35mm, by makrolon material
Material is made, and is less than 30% to the optical attenuation of 440-1000nm wavelength, to reduce the interference of non-experiment condition, while cylinder 14 can
It is convenient that the ad-hoc locations such as toy belly, oxter, back are imaged to be rotated.
In the utility model patent, include containing the container 17 of anesthetic, container is by silicone tube 18 from circular aperture
Connected with cylinder, anesthetic can be anaesthetized by silica gel pipeline into cylinder to toy.
In the utility model patent, observation window 21, the process of imaging are preferably provided with the front body wall of described body case 1
In, staff can be observed toy by observation window.
In the utility model patent, the top of described container 17 is provided with lid, prevents the anesthetic such as ether from volatilizing；Container
Built with absorbent cotton, for adsorbing the anesthetic of some liquid.
In the utility model patent, described silicone tube 18 is provided with detection switch 22, and detection switch 22 can be examined in time
The amount that anesthetic enters is surveyed, prevents anesthetic from excessively causing the death of experimental animal.
In the utility model patent, the wavelength for the laser that the laser 2 is launched is 980nm.
Preferred embodiment of the present utility model is the foregoing is only, it is all in this practicality not to limit the utility model
Within new spirit and principle, any modification, equivalent substitution and improvements made etc., guarantor of the present utility model should be included in
Within the scope of shield.
Claims (10)
1. a kind of toy fluoroscopic imaging device applied to upper conversion, including body case (1), two lasers (2), master control meters
Calculation machine (3), and fluorescence detection device and toy fixing device in body case；It is characterized in that：
Described fluorescence detection device, including CCD camera (4), slide rail (5) and installing plate (6), CCD camera by data wire or
Person's power line is connected with main control computer：Described slide rail, in the vertical direction for the back face wall being installed on inside box body,
The back side of CCD camera is provided with corresponding railroad so that CCD camera slides up and down in slide rail；Set on described installing plate
There are 3 mounting holes (8), optical filter (9) is placed on mounting hole；The side of described installing plate is provided with one can be along level side
Move left and right the selector bar (7) of installing plate；The camera of described CCD camera is slided up and down along slide rail, selector bar (7) is drawn
Dynamic installing plate moves left and right in the horizontal direction, so that camera is co-located with optical filter；
Described toy fixing device includes base I (10), base II (11), two Y types fixing devices (12), can load small
Animal, inner hollow cylinder (14)：Described base I is the base portion base of body case, which is provided with groove；Described
Base II, bottom is provided with the device that can be slided in base I groove, so that grooves of the base II along base I slides back and forth；
On described base II two row's spacing holes (13), the end installation of described two Y type fixing devices are provided with along fore-and-aft direction
In on same a line spacing hole；Described cylinder is positioned at the Y word mouths at the top of Y type fixing devices；
Described toy fixing device is located at the underface of fluorescence detection device；
Described fluorescence detection device is connected by data wire or power line with main control computer (3)；
Two described lasers are located at the left and right sides of body case respectively, and optical fiber (19), the end of optical fiber are connected with laser
End is connected with beam expanding lens (20) and beam expanding lens is located inside body case；The oral area of described beam expanding lens is towards described cylinder.
2. device according to claim 1, it is characterised in that the edge of described base I (10) groove is provided with scale
I, described base II (11) edge are provided with scale II, scale I and scale II and matched.
3. device according to claim 1, it is characterised in that the edge of described spacing hole (13) is provided with different volumes
Number, the Y types fixing device (12) is selectively mounted in different spacing holes as needed.
4. device according to claim 1, it is characterised in that the cylinder (14), one end open, one end closing, expand
For Shu Jing oral area towards open one end, one end of closing is provided with circular aperture；The top of described cylinder is provided with switch
(15)；The restriction valve (16) that can be moved is provided with inside described cylinder.
5. device according to claim 1, it is characterised in that the cylinder (14), wall thickness 2-3mm, internal diameter 25-
35mm, it is made up of makrolon material；Described cylinder 14 can be rotated in Y type fixing devices.
6. device according to claim 4, it is characterised in that the described toy fluorescence imaging applied to upper conversion fills
Putting also includes the container (17) for containing anesthetic, on the outside body wall of body case (1)；Described container passes through silicone tube (18)
Connected from described circular aperture with cylinder.
7. device according to claim 1, it is characterised in that the front body wall of described body case (1) is provided with observation
Window (21).
8. device according to claim 6, it is characterised in that the top of described container (17) is provided with lid, in container
Equipped with absorbent cotton.
9. device according to claim 6, it is characterised in that described silicone tube (18) is provided with detection switch (22).
10. device according to claim 1, it is characterised in that the wavelength of the laser of the laser (2) transmitting is
980nm。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621268036.9U CN206641842U (en) | 2016-11-23 | 2016-11-23 | A kind of toy fluoroscopic imaging device applied to upper conversion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621268036.9U CN206641842U (en) | 2016-11-23 | 2016-11-23 | A kind of toy fluoroscopic imaging device applied to upper conversion |
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| Publication Number | Publication Date |
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| CN206641842U true CN206641842U (en) | 2017-11-17 |
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| CN201621268036.9U Active CN206641842U (en) | 2016-11-23 | 2016-11-23 | A kind of toy fluoroscopic imaging device applied to upper conversion |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108680508A (en) * | 2018-05-18 | 2018-10-19 | 中国检验检疫科学研究院 | Incorporated light fuel factor detector |
| CN109009549A (en) * | 2018-08-20 | 2018-12-18 | 中国人民解放军军事科学院军事医学研究院 | Record the device of animal pharmaceuticals Addictive Behaviors and related brain areas nervous activity rule |
| CN112998660A (en) * | 2021-03-01 | 2021-06-22 | 无锡博医光电技术有限公司 | Biological safety bin for small animal living body fluorescence imaging instrument and fluorescence imaging instrument |
| CN112998656A (en) * | 2021-02-24 | 2021-06-22 | 广东工业大学 | Living body fluorescence imaging system capable of intelligently tracking target and control method thereof |
| CN113109307A (en) * | 2021-04-01 | 2021-07-13 | 南京超维景生物科技有限公司 | Displacement control method and device, electronic equipment and multi-photon fluorescence imaging equipment |
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2016
- 2016-11-23 CN CN201621268036.9U patent/CN206641842U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108680508A (en) * | 2018-05-18 | 2018-10-19 | 中国检验检疫科学研究院 | Incorporated light fuel factor detector |
| CN109009549A (en) * | 2018-08-20 | 2018-12-18 | 中国人民解放军军事科学院军事医学研究院 | Record the device of animal pharmaceuticals Addictive Behaviors and related brain areas nervous activity rule |
| CN112998656A (en) * | 2021-02-24 | 2021-06-22 | 广东工业大学 | Living body fluorescence imaging system capable of intelligently tracking target and control method thereof |
| CN112998660A (en) * | 2021-03-01 | 2021-06-22 | 无锡博医光电技术有限公司 | Biological safety bin for small animal living body fluorescence imaging instrument and fluorescence imaging instrument |
| CN113109307A (en) * | 2021-04-01 | 2021-07-13 | 南京超维景生物科技有限公司 | Displacement control method and device, electronic equipment and multi-photon fluorescence imaging equipment |
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