CN206440600U - A kind of biochip objective table - Google Patents
A kind of biochip objective table Download PDFInfo
- Publication number
- CN206440600U CN206440600U CN201621469235.6U CN201621469235U CN206440600U CN 206440600 U CN206440600 U CN 206440600U CN 201621469235 U CN201621469235 U CN 201621469235U CN 206440600 U CN206440600 U CN 206440600U
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- China
- Prior art keywords
- biochip
- base
- light guide
- guide structure
- objective table
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Abstract
A kind of biochip objective table is disclosed, it includes：Base, the base is provided with chute so that biochip can be along the slide；Locking mechanism, on the base, for the biochip to be fixed on into the base；Light guide structure, including the collimation lens and optical fiber intercoupled；And light guide structure mounting seat, the light guide structure is arranged on the base by the light guide structure mounting seat so that excite luminous energy to be incident upon the biochip via the collimation lens of the light guide structure in collimated light beam form from what the optical fiber of the light guide structure was imported.The utility model utilizes the collimation lens and fiber optic conduction exciting light intercoupled, it is possible to increase to the utilization rate of exciting light sources energy.By adjusting the injection angle that light guide structure mounting seat can adjust the injection biochip of the exciting light.Therefore, the biochip objective table volume is smaller, and capacity usage ratio is higher, and detection mode is more flexible.
Description
Technical field
The utility model is related to biochip test field, more particularly, to a kind of biochip objective table.
Background technology
Biochip is the new and high technology developed rapidly in recent years in life science, and it is mainly
Refer to the chemistry of micro-organisms system in only several square centimeters of solid chip surface construction by micro-processing technology, with realization pair
Quick, the accurate and high-throughout detection of the biological samples such as DNA, protein, cell.Its main Cleaning Principle is：Using change
Learn or physical method, a large amount of probes are solidified in the surface of holder, then according to the affinity interaction between biomolecule, such as core
Base pairing effect, combination of antigen-antibody of acid molecule etc. are reacted, then reaction signal is tested and analyzed, you can
To the relevant information of the sample.Because substantial amounts of probe can be fixed on holder by the technology simultaneously, therefore only need once
Substantial amounts of biomolecule can just be tested and analyzed, with height automation, high-throughout feature.
With the development of biochip technology, higher requirement is it is also proposed to biological chip testing technology.Biochip
Detection means can be divided into fluoroscopic examination and non-fluorescence detection, and fluoroscopic examination has problems, rather than fluoroscopic examination again with resonance
Light scattering mode is representative.
Existing bio-chip test device, generally comprises biochip objective table, loader mechanism and photoelectric sensor
Deng.Loader mechanism is used to biochip loading biochip objective table, and biochip sets coupled lens group to connect with LED/light source
Connect, the exciting light that LED/light source is sent is by coupled lens to beam shaping, and the exciting light after shaping injects biological core to be detected
In piece, after receiving the exciting of exciting light resonant light scattering occurs for the sample on biochip, to the resonance of external radiation specific wavelength
Scattered light, collects above-mentioned resonance light scattering using photoelectric sensor and converts optical signal into electric signal, by the electric signal
Analysis is so as to realize the detection to biochip.
It is applied in combination however, said apparatus is generally mated two or more LED/light sources with coupled lens, equipment is overall
Volume is larger, while the fit system of LED/light source and coupled lens causes light source utilization rate relatively low.
Utility model content
In view of the above problems, the purpose of this utility model is to provide a kind of biochip objective table, and its structure is simplified, profit
The utilization rate to exciting light sources energy is improved with the collimation lens and optical fiber intercoupled.
A kind of biochip objective table provided according to the utility model, it includes：Base, the base is provided with cunning
Groove so that biochip can be along the slide；Locking mechanism, on the base, for the biochip to be consolidated
It is scheduled on the base；Light guide structure, including the collimation lens and optical fiber intercoupled；And light guide structure mounting seat, it is described
The light guide structure is arranged on the base by light guide structure mounting seat so that imported from the optical fiber of the light guide structure
Excite luminous energy to be incident upon the biochip via the collimation lens of the light guide structure in collimated light beam form.
Preferably, the collimation lens is self-focusing collimation lens.
Preferably, the fiber coupling lens that the light guide structure is integrated.
Preferably, the base is U-shaped, including openend, the blind end relative with openend and relative two points
Branch.
Preferably, the number of the light guide structure is two, is symmetrically mounted in the Liang Ge branches of the base.
Preferably, the locking mechanism includes being arranged on first shell fragment at the base openings end and is arranged on the base
Second shell fragment of blind end.
Preferably, the distance between described chute at first shell fragment and the base openings end is more than described second
The distance between described chute at shell fragment and the base blind end.
Preferably, the distance between described chute at first shell fragment and the base openings end is more than the biology
The distance between described chute at the thickness of chip, second shell fragment and the base blind end is less than the biochip
Thickness.
Preferably, the surface of the installation light guide structure of the Liang Ge branches of the base is arranged to sunk structure so that
Luminous energy is excited to incide institute from the light guide structure when the biochip is fixed on the biochip objective table
State the side of biochip.
Preferably, the base also includes multiple positioning holes, for the biochip objective table and other devices to be connected
Connect.
Preferably, the biochip objective table：Protective cover, it is arranged on the base and accommodates the light guide structure
Mounting seat.
According to biochip objective table of the present utility model, light guide structure includes the collimation lens and optical fiber intercoupled,
Exciting light is conducted using the light guide structure, it is possible to increase to the utilization rate of exciting light sources energy.By being installed to light guide structure
The regulation of seat can adjust the injection angle that the exciting light injects biochip.Therefore, the biochip objective table volume is more
Small, capacity usage ratio is higher, and detection mode is more flexible.
Biochip objective table of the present utility model includes locking mechanism, and locking mechanism includes being arranged on the base openings
At least one energy in first shell fragment at end and the second shell fragment for being arranged on the base blind end, the first shell fragment and the second shell fragment
Biochip is pressed on the chute of base, the position of biochip is more stablized, is easy to detection.
The distance between described chute at first shell fragment and the base openings end is more than the biochip
Thickness, facilitates the smooth insertion of biochip.Between the chute at second shell fragment and the base blind end away from
From the thickness less than the biochip so that there is certain frictional force, the second shell fragment and chute during biochip insertion chute
Being engaged makes the position of biochip more firm.
Base also includes multiple positioning holes, so that convenient be connected the biochip objective table with other devices, and
Make position between biochip objective table and other devices more accurate.
In a preferred embodiment, biochip objective table also includes protective cover, and it is arranged on the base and accommodated
The light guide structure mounting seat, so as to be that light guide structure mounting seat and light guide structure provide protection.
Brief description of the drawings
By description referring to the drawings to the utility model embodiment, of the present utility model above-mentioned and other mesh
, feature and advantage will be apparent from, in the accompanying drawings：
Fig. 1 and Fig. 2 show the stereogram in different angles according to the biochip objective table of the utility model embodiment.
Fig. 3 and Fig. 4 show according to the biochip objective table of the utility model embodiment load biochip when in difference
The stereogram of angle.
Embodiment
The utility model is more fully described hereinafter with reference to accompanying drawing.For the sake of clarity, the various pieces in accompanying drawing do not have
Have drawn to scale.Furthermore, it is possible to not shown some known parts.It describe hereinafter of the present utility model many specific
Details, but just as the skilled person will understand, this can not be realized according to these specific details
Utility model.
It should be appreciated that when describing the structure of part, being referred to as being located at another floor, another area when by a floor, a region
When domain " above " or " top ", can refer to above another layer, another region, or its with another layer, it is another
Also comprising other layers or region between individual region.Also, if by part turnover, this layer, a region will be located at it is another
Layer, another region " following " or " lower section ".
The biochip objective table that the utility model is provided can be used in the biochip test of resonant light scattering mode, this
The bio-chip test device of mode generally comprises biochip objective table, loader mechanism and photoelectric sensor etc..Loading machine
Structure is used to biochip loading biochip objective table, and photoelectric sensor is used for the resonance light scattering for collecting above-mentioned biochip
And handled.
Fig. 1 and Fig. 2 show the biochip objective table according to the utility model embodiment in the stereogram of different angles, figure
3 and Fig. 4 show the biochip objective table 100 load biochip 200 when different angles stereogram.
The biochip objective table 100 of the utility model embodiment includes：Base 110, locking mechanism, light guide structure 120,
And light guide structure mounting seat 130.Wherein, base 110 is provided with chute 111 so that biochip 200 can be along the chute 111
Slide.Locking mechanism is located on base 110, for biochip 200 to be fixed on into base 110.Light guide structure 120 includes phase
The collimation lens and optical fiber of mutual coupling.Light guide structure 120 is arranged on base 110 by light guide structure mounting seat 130 so that from leading
What the optical fiber of photo structure 120 was imported excites luminous energy via the collimation lens of light guide structure 120 in collimated light beam form
Biochip 200 is incident upon, the injection angle of the exciting light can be adjusted by adjusting light guide structure mounting seat 130.
Base 110 is substantially U-shaped, including openend, the blind end relative with openend and relative Liang Ge branches, its
Middle chute 111 can be arranged between above-mentioned two branch.
Collimation lens is preferably self-focusing collimation lens.Further, the collimation lens that is intercoupled in the present embodiment and
The light guide structure 120 of optical fiber composition is using integral fiber coupling lens.
In the present embodiment, fiber coupling lens 120 are a pair, and light guide structure mounting seat 130 is also a pair, and a pair guide-lighting
Structure mounting seat 130 corresponds to and fiber coupling lens described in a pair 120 is symmetrically mounted in the Liang Ge branches of base 110 respectively.
The position of a pair of light guide structure mounting seats 130 can be set according to actual needs, for example its position correspondence biochip to be detected
200 center.Light guide structure mounting seat 130 is provided with least two openings, including the first opening and the second opening, with leaded light knot
The bolt that structure mounting seat 130 is connected has two, including the first bolt 161 and the second bolt 162.Wherein first opening and light
The first opening is stretched into the fine shape of coupled lens 120 correspondence, the part of fiber coupling lens 120, and will using the first bolt 161
Fiber coupling lens 120 are fixed with light guide structure mounting seat 130.Second is open towards biochip 200 so that fiber coupling is saturating
Mirror 120 sends collimation and excites luminous energy to inject biochip 200.Light guide structure mounting seat 130 can be fixed on bottom by the second bolt 162
On seat 110, when being that light guide structure mounting seat 130 is rotated different angles and is fixed by axle with the second bolt 162, the second opening
Direction can also follow change so that adjust exciting light inject biochip 200 injection angle.Certainly, it is guide-lighting by adjusting
The height of the mounting seat of structure mounting seat 130 can also adjust the injection direction that exciting light injects biochip 200.In addition, by adjusting
The position and orientation of first opening in light guide structure mounting seat 130 are saved, exciting light can be also adjusted and inject biochip 200
Inject angle so that the detection to biochip 200 is more flexible.
Biochip 200 is that it includes in the chemistry of micro-organisms system of solid chip surface construction by micro-processing technology
Relative first surface and second surface.
In the present embodiment, two bossings being symmetrically extended on the inside of the Liang Ge branches of base 110 form above-mentioned cunning
Groove 111.Two bossings are contacted with the second surface of biochip 200, wherein two bossings and biochip 200
The surfacing that is contacted and in sustained height, common support biochip 200 to be detected.The chute 111 of the present embodiment
Including two symmetrical bossings for being separated by setting, it is to be understood that in alternate embodiments, two bossings also may be used
To be connected as a single entity so as to form chute, chute can also be that other can be with the shape of support biochip 200 to be detected.
Locking mechanism includes the first shell fragment 141 and the second shell fragment 142 in the present embodiment.Wherein the first shell fragment 141 is set
In the openend of base 110, the second shell fragment 142 is arranged near the blind end of base 110.
First shell fragment 141 and the second shell fragment 142 of the present embodiment all across between the Liang Ge branches of base 110, are utilized
Set up the bolt at the first shell fragment 141, the two ends of the second shell fragment 142 separately to be fastened on base 110.First shell fragment 141 and chute 111 it
Between and the second shell fragment 142 and chute 111 between all have certain distance, so as to accommodate biochip 200.
Preferably, the distance between the first shell fragment 141 and described chute 111 at the openend of base 110 are more than the second bullet
The distance between described chute 111 at piece 142 and the blind end of base 110.In the present embodiment, the first shell fragment 141 and base
The distance between described chute 111 at 110 openends is slightly larger than the thickness of biochip 200, the second shell fragment 142 and base
The distance between described chute 111 at 110 blind ends is slightly less than the thickness of biochip 200.With the thickness of biochip 200
It is that it is 1.2mm that can set the distance between described chute 111 at the first shell fragment 141 and the openend of base 110 exemplified by 1mm,
It is slightly larger than the thickness of biochip 200, so as to facilitate the smooth insertion of biochip 200；The second shell fragment can be set simultaneously
142 be 0.8mm or 0.9mm with the distance between the chute 111 at the blind end of base 110, and it is slightly less than biochip 200
Thickness so that biochip 200 insertion chute when there is certain frictional force, during detection, the second shell fragment 142 and biochip
200 first surface contact, biochip 200 is pressed on chute 111, so that the position of biochip 200 is more steady
Gu.
It is understood that locking mechanism can be not limited to include two shell fragments or other quantity, even adopting
With two shell fragments, the position of two shell fragments is also not necessarily limited to the correspondingly openend of base and blind end or in base
Openend and blind end between any suitable position.
The biochip objective table 100 of the utility model embodiment can also include the guarantor in protective cover 150, the present embodiment
The number of shield 150 corresponds to the number of light guide structure 120 and light guide structure mounting seat 130, is two, protective cover 150 is pacified
A light guide structure mounting seat 130 is accommodated on base 110 and respectively, wherein in accompanying drawing 1 and Fig. 2, clearly to show
Light guide structure 120 and the structure of light guide structure mounting seat 130, by the agent structure of protective cover 150 and biochip objective table 100
Appropriate separation is illustrated.It can be that light guide structure mounting seat 130 and light guide structure 120 provide protection to set protective cover 150, simultaneously
Structure can be made more attractive.
In addition, base also includes multiple positioning holes 112, for by the biochip objective table of the utility model embodiment
100 are connected with other devices.The biochip objective table 100 of the present embodiment for example can be by multiple positioning holes 112 with loading
Mechanism is connected, and biochip 200 can be fitted into the chute 111 of biochip objective table 100 by the loader mechanism, or from chute
Biochip 200 is taken out in 111, so as to realize the automatic loading of biochip and unloading during biochip test.
According to biochip objective table 100 of the present utility model, light guide structure 120 include the collimation lens that intercouples and
Optical fiber, conducts exciting light, it is possible to increase to the utilization rate of exciting light sources energy using the light guide structure 120.By to leaded light
The regulation of structure mounting seat 130 can adjust the injection angle that the exciting light injects biochip.Therefore, the biochip is carried
The volume of thing platform 100 is smaller, and capacity usage ratio is higher, and detection mode is more flexible.
Locking mechanism includes including being arranged on the first shell fragment 141 of the openend of base 110 and setting with biochip 200
At least one put in the second shell fragment 142 in the blind end of base 110, the first shell fragment 141 and the second shell fragment 142 can be by life
Thing chip 200 is pressed on the chute 111 of base 110, the position of biochip 200 is more stablized, is easy to detection.
Wherein, the distance between the first shell fragment 141 and chute 111 at the openend of base 110 are more than biochip 200
Thickness, facilitates the smooth insertion of biochip.Second shell fragment 142 and the distance between the chute 111 at the blind end of base 110 are small
In the thickness of biochip 200 so that have certain frictional force during biochip insertion chute, during detection, the second shell fragment 142 will
Biochip 200 is pressed on chute 111, so that the position of biochip 200 is more firm.
Biochip objective table 110 is conveniently connected by the multiple positioning holes 112 set on base 110 with other devices, and
And make position between biochip objective table and other devices more accurate.Protective cover 150 on base 110 can be leaded light
Structure mounting seat 130 and light guide structure 120 provide protection.
It should be noted that herein, such as first and second or the like relational terms are used merely to a reality
Body or operation make a distinction with another entity or operation, and not necessarily require or imply these entities or deposited between operating
In any this actual relation or order.Moreover, term " comprising ", "comprising" or its any other variant are intended to
Nonexcludability is included, so that process, method, article or equipment including a series of key elements not only will including those
Element, but also other key elements including being not expressly set out, or also include being this process, method, article or equipment
Intrinsic key element.In the absence of more restrictions, the key element limited by sentence "including a ...", it is not excluded that
Also there is other identical element in process, method, article or equipment including the key element.
According to embodiment of the present utility model as described above, these embodiments do not have all details of detailed descriptionthe,
Also it is only described specific embodiment not limit the utility model.Obviously, as described above, many modifications and change can be made
Change.This specification is chosen and specifically describes these embodiments, be in order to preferably explain principle of the present utility model and it is actual should
With so that skilled artisan can repairing using the utility model and on the basis of the utility model well
Change and use.The utility model is only limited by claims and its four corner and equivalent.
Claims (11)
1. a kind of biochip objective table, it is characterised in that including：
Base, the base is provided with chute so that biochip can be along the slide；
Locking mechanism, on the base, for the biochip to be fixed on into the base；
Light guide structure, including the collimation lens and optical fiber intercoupled；And
The light guide structure is arranged on the base by light guide structure mounting seat, the light guide structure mounting seat so that from institute
State light guide structure the optical fiber import excite luminous energy via the collimation lens of the light guide structure with collimated light beam shape
Formula is incident upon the biochip.
2. biochip objective table according to claim 1, it is characterised in that the collimation lens is that autohemagglutination focus collimation is saturating
Mirror.
3. biochip objective table according to claim 1, it is characterised in that the optical fiber coupling that the light guide structure is integrated
Close lens.
4. biochip objective table according to claim 1, it is characterised in that the base is U-shaped, including openend,
The blind end relative with openend and relative Liang Ge branches.
5. biochip objective table according to claim 4, it is characterised in that the number of the light guide structure is two,
It is symmetrically mounted in the Liang Ge branches of the base.
6. biochip objective table according to claim 4, it is characterised in that the locking mechanism is described including being arranged on
First shell fragment at base openings end and the second shell fragment for being arranged on the base blind end.
7. biochip objective table according to claim 6, it is characterised in that first shell fragment and the base openings
The distance between described chute at end be more than between the chute at second shell fragment and the base blind end away from
From.
8. biochip objective table according to claim 6, it is characterised in that first shell fragment and the base openings
The distance between described chute at end is more than at the thickness of the biochip, second shell fragment and the base blind end
The distance between the chute be less than the thickness of the biochip.
9. biochip objective table according to claim 5, it is characterised in that the installation institute of the Liang Ge branches of the base
The surface for stating light guide structure is arranged to sunk structure so that when the biochip is fixed on the biochip objective table
Luminous energy is excited to incide the side of the biochip from the light guide structure.
10. biochip objective table according to claim 1, it is characterised in that the base also includes multiple positioning holes,
For the biochip objective table to be connected with other devices.
11. biochip objective table according to claim 1, it is characterised in that also include：Protective cover, it is arranged on institute
State on base and accommodate the light guide structure mounting seat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621469235.6U CN206440600U (en) | 2016-12-28 | 2016-12-28 | A kind of biochip objective table |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621469235.6U CN206440600U (en) | 2016-12-28 | 2016-12-28 | A kind of biochip objective table |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206440600U true CN206440600U (en) | 2017-08-25 |
Family
ID=59642044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621469235.6U Expired - Fee Related CN206440600U (en) | 2016-12-28 | 2016-12-28 | A kind of biochip objective table |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206440600U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106769866A (en) * | 2016-12-28 | 2017-05-31 | 吉林大学 | A kind of biochip objective table |
| CN109108473A (en) * | 2018-09-06 | 2019-01-01 | 重庆科技学院 | A kind of application method of overhead type biochip objective table |
| CN109794308A (en) * | 2017-11-17 | 2019-05-24 | 长光华大基因测序设备（长春）有限公司 | A kind of biochip carrier |
| CN110794566A (en) * | 2018-08-01 | 2020-02-14 | 深圳华大生命科学研究院 | Positioning device, optical imaging system and assembling method thereof |
-
2016
- 2016-12-28 CN CN201621469235.6U patent/CN206440600U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106769866A (en) * | 2016-12-28 | 2017-05-31 | 吉林大学 | A kind of biochip objective table |
| CN109794308A (en) * | 2017-11-17 | 2019-05-24 | 长光华大基因测序设备（长春）有限公司 | A kind of biochip carrier |
| CN110794566A (en) * | 2018-08-01 | 2020-02-14 | 深圳华大生命科学研究院 | Positioning device, optical imaging system and assembling method thereof |
| CN110794566B (en) * | 2018-08-01 | 2021-09-07 | 深圳华大生命科学研究院 | Positioning device, optical imaging system and assembling method thereof |
| CN109108473A (en) * | 2018-09-06 | 2019-01-01 | 重庆科技学院 | A kind of application method of overhead type biochip objective table |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170825 Termination date: 20171228 |