CN206266631U - Circular multi-medicament screens biochip - Google Patents
Circular multi-medicament screens biochip Download PDFInfo
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- CN206266631U CN206266631U CN201621278791.5U CN201621278791U CN206266631U CN 206266631 U CN206266631 U CN 206266631U CN 201621278791 U CN201621278791 U CN 201621278791U CN 206266631 U CN206266631 U CN 206266631U
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- biochip
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- medicament
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Abstract
Utility model provides a kind of circular multi-medicament screening biochip, is rearranged by circular radiation by the functional unit comprising aerating system and screening system.Centre point of the functional unit with gas access as chip, it is radiation by gas passage, 4 functional units are uniformly distributed in a circular multi-medicament screening biochip, or on a circular multi-medicament screening biochip, 4+2n functional unit of circular radiation arranged distribution uniformly is pressed, n is the integer of n >=1.The utility model provides identical cell growth environment on a single die, realize under the conditions of its dependent variable is all immovable, it is single to change administration species or dosage, by observing the change of the physical signs such as the cellular morphology in the case where medicine is acted on, screen the purpose of medicine.
Description
Technical field
The utility model is related to a kind of biological microanalysis chip of newtype drug screening, from using being a kind of utilization
In living cells culture systems, a kind of circular multi-medicament screening biochip.
Background technology
High-flux medicaments sifting refer to based on the experimental technique of molecular level and cellular level, using microplate format as
Experimental tool carrier, process of the test is performed with automation operating system, with sensitive quick detecting instrument collection experimental result number
According to, treatment is analyzed to experimental data with computer, same time logarithm with ten million sample detection, and with corresponding database
Support the technical system of overall system's operating.High-flux medicaments sifting system is the one of new drug development research in original new drug screening
Individual key areas, have been widely used in the screening of candidate compound microbic activity.The Dominant Plat not only may be used
For finding new drug, it can also be used to drug research.But conventional medicament screening chip is unable under the effect of real-time monitored medicine
Cellular morphology changes.This problem is solved, need to be by multiple steps such as the addition of medicine, the culture of experimental cell, detection of effect of drugs
Suddenly chip piece is integrated into, realizes the automated analysis of drug screening, reduce the experimental period and error of observation immediately.
Therefore, the utility model provides a kind of circular multi-medicament screening biochip, to solve the above problems.
The content of the invention
The purpose of this utility model is using a kind of circular multi-medicament screening biochip of air chamber design, by giving for medicine
Multiple experiential functions such as sample, cell culture, effect of drugs detection are integrated on chip piece.
The technical scheme of this experiment is：A kind of circular multi-medicament screening biochip is provided.By comprising aerating system and
The functional unit of screening system is rearranged by circular radiation, it is characterised in that：Aerating system is processed on chip upper strata, with
The air chamber passage and airway of " ten " word cross arrangement, and be the One function area that crossing center point is constituted by air chamber.Air chamber
One of passage is machined with gas access, and other end is machined with gas vent, is processed on one middle level of each UNICOM in airway two
Culture detection zone.Screening system is on middle level, to be started with gas access one end, along using air chamber passage as symmetry axis, two
2 " V " type passages of side symmetry arrangement processing, 2 culture detection zones；And on the axis of symmetry axis, the waste liquid pool of processing,
Apocenosis passage, outlet.Each " V " type passage is to be confluxed to form by 2 injection ports and 2 " V " type passage connections.2 a pair
The opening of " V " type passage is towards the outside of symmetry axis, " V " word vertical symmetry axis.In each 2 " V " type passage river outlet, plus
Work has turbine structure, and the effect of the structure is mixed flow, and each laminar flow in microchannel is mixed.Each symmetrical " V " type
After passage confluxes, it is connected with 2 straight channels parallel to symmetry axis respectively, every straight channel is connected with curved channel.It is semicircle
2 curved channels in the middle of be machined with one culture detection zone, two culture detection zones by airway share air chamber.Rectangle gives up
Liquid pool short side both sides are connected to culture detection zone by curved channel, and side one end long is connected by apocenosis passage with outlet.More than
The One function unit of compositing chip.
In above-mentioned technical proposal, the chip is divided into upper strata, middle level, three layers of bottom.Bottom is the substrate of chip, and material is
Transparent material, such as glass, acrylic.Injection port, outlet insertion upper strata and middle level.
In above-mentioned technical proposal, a kind of circular multi-medicament screening biochip is disc；The functional unit
It is the centre point with gas access as chip, is radiation by gas passage, in a circular multi-medicament screening biochip
It is uniformly distributed on 4 functional units, or a circular multi-medicament screening biochip, uniformly presses circular radiation arranged distribution 4+
2n functional unit, n is the integer of n >=1.
In above-mentioned technical proposal, the culture detection zone cultivates the curved channel that detection zone is connected with waste liquid pool at two
Side, is respectively machined with " U " type structure, and " U " type structure is a width of 30 μm, waits the semicircular arc wall higher than culture detection zone.
Inside " U " type structure of detection zone is cultivated, makes cell in fixed region growing, be easy to real-time monitored in different pharmaceutical（Or not
With the medicine of concentration）The situation of change of the lower cellular morphology of effect.
Effect feature of the present utility model：It is the basis with good cell culture, by the improvement of structure, by miniflow
Control technology is combined with cell culture technology and is applied to drug screening field.Identical cell is provided on a kind of chip
Growing environment, it is single to change administration species or dosage under the conditions of its dependent variable is all immovable, by observing in medicine
Cellular morphology change under effect, reaches the purpose of drug screening.
Brief description of the drawings
Fig. 1 is the overlooking the structure diagram of functional unit of the present utility model.
Fig. 2 is the overlooking the structure diagram A-A sectional views of functional unit of the present utility model.
Fig. 3 is of the present utility model a kind of have 4 schematic top plan views of functional unit.
Wherein：1. injection port；2. " V " type passage；3. gas access；4. air chamber passage；5. turbine structure；6. arc leads to
Road；7. detection zone is cultivated；8. airway；9. air chamber；10. waste liquid pool；11. apocenosis passages；12. outlets；13. gas vents；14.
" U " type structure；15. straight channels；16. upper stratas；17. middle levels；18. bottoms.
Specific embodiment
1-3 and embodiment are further illustrated to the utility model below in conjunction with the accompanying drawings.
Specific embodiment
With reference to plan structure Fig. 3, the utility model has 4 functional units, and design structure of the chip on circular substrate is
It is circular chip center with gas access 3, circular chip is divided evenly into four parts by gas passage 4 for quadrature axis.4 work(
Energy unit has 8 pairs of injection ports, 1,8 culture detection zones, 7, gas access 3, and various passages.Wherein each pair injection port 1,
Contain the function of cell and its nutrient solution import and Imported Medicines；The air chamber passage of gas access 3 to each air chamber 9 is isometric,
Ensure that each culture detection zone 7 gas supply is identical, it is consistent with reference to 8 culture detection zone 7 size dimensions, sight in real time can be realized
Survey the action effect of the medicine to allogenic cell of various concentrations.
Claims (3)
1. a kind of circular multi-medicament screening biochip, circular spoke is pressed by the functional unit comprising aerating system and screening system
Penetrate and rearrange, it is characterised in that：Aerating system is on chip upper strata（16）Processing, it is logical with the air chamber of " ten " word cross arrangement
Road（4）And airway（8）, and by air chamber（9）It is the One function area of crossing center point composition；Air chamber passage（4）One
It is machined with gas access（3）, other end is machined with gas vent（13）, airway（8）One middle level of each UNICOM in two（17）On
The culture detection zone of processing（7）；Screening system is in middle level（17）On, with gas access（3）One end starts, along with air chamber passage
（4）As symmetry axis, two " V " type passages of both sides symmetry arrangement processing（2）, two culture detection zones（7）, and symmetrical
On the axis of axle, the waste liquid pool of processing（10）, apocenosis passage（11）, outlet（12）；Each " V " type passage（2）It is by 2, passage
2 injection ports of end machining（1）Arrangement connections " V "-shaped with 2 passages are confluxed composition；Two paired " V " type passages
（2）Opening towards the outside of symmetry axis, " V " word vertical symmetry axis；In each 2 " V " type passage（2）River outlet, plus
Work has turbine structure（5）；" V " type passage of each pair（2）After confluxing, respectively with 2 straight channels parallel to symmetry axis（15）Phase
Even, every straight channel（18）With curved channel（6）Connection；Semicircular 2 curved channels（6）Centre is machined with a culture inspection
Survey area（7）；Two culture detection zones（7）By airway（8）Share air chamber（9）；Rectangle waste liquid pool（10）Short side both sides pass through
Curved channel（6）It is connected to culture detection zone（7）, side one end long passes through apocenosis passage（11）With outlet（12）Connection；Above group
Into the One function unit of chip.
2. a kind of circular multi-medicament according to claim 1 screens biochip, it is characterised in that：Chip is divided into upper strata
（16）, middle level（17）, bottom（18）Three layers；Bottom（18）It is the substrate of chip, material is transparent material；Injection port（1）, go out
Mouthful（12）Insertion upper strata（16）And middle level（17）.
3. a kind of circular multi-medicament according to claim 1 screens biochip, it is characterised in that：It is described a kind of circular
Multi-medicament screening biochip is disc；The functional unit is with gas access（3）It is the centre point of chip, by gas
Passage（4）It is radiation, 4 functional units, or a circle is uniformly distributed in a circular multi-medicament screening biochip
On multi-medicament screening biochip, 4+2n functional unit of circular radiation arranged distribution uniformly is pressed, n is the integer of n >=1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621278791.5U CN206266631U (en) | 2016-11-27 | 2016-11-27 | Circular multi-medicament screens biochip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621278791.5U CN206266631U (en) | 2016-11-27 | 2016-11-27 | Circular multi-medicament screens biochip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206266631U true CN206266631U (en) | 2017-06-20 |
Family
ID=59041524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621278791.5U Expired - Fee Related CN206266631U (en) | 2016-11-27 | 2016-11-27 | Circular multi-medicament screens biochip |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206266631U (en) |
-
2016
- 2016-11-27 CN CN201621278791.5U patent/CN206266631U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170620 Termination date: 20211127 |