CN204972334U - Separation and purification device of hawthorn leaf extract product - Google Patents
Separation and purification device of hawthorn leaf extract product Download PDFInfo
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- CN204972334U CN204972334U CN201520521211.XU CN201520521211U CN204972334U CN 204972334 U CN204972334 U CN 204972334U CN 201520521211 U CN201520521211 U CN 201520521211U CN 204972334 U CN204972334 U CN 204972334U
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- separation device
- membrane separation
- receive
- dalton
- spiral wound
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- 238000000926 separation method Methods 0.000 title claims abstract description 58
- 239000000284 extract Substances 0.000 title claims abstract description 15
- 238000000746 purification Methods 0.000 title claims abstract description 13
- 235000009917 Crataegus X brevipes Nutrition 0.000 title abstract 4
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 title abstract 4
- 235000009685 Crataegus X maligna Nutrition 0.000 title abstract 4
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 title abstract 4
- 235000009486 Crataegus bullatus Nutrition 0.000 title abstract 4
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 title abstract 4
- 235000009682 Crataegus limnophila Nutrition 0.000 title abstract 4
- 235000004423 Crataegus monogyna Nutrition 0.000 title abstract 4
- 235000002313 Crataegus paludosa Nutrition 0.000 title abstract 4
- 235000009840 Crataegus x incaedua Nutrition 0.000 title abstract 4
- 240000000171 Crataegus monogyna Species 0.000 title 1
- 239000012528 membrane Substances 0.000 claims abstract description 62
- 239000000919 ceramic Substances 0.000 claims abstract description 19
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 5
- 238000001728 nano-filtration Methods 0.000 claims description 13
- 239000000243 solution Substances 0.000 claims description 9
- 239000000385 dialysis solution Substances 0.000 claims description 8
- 238000005096 rolling process Methods 0.000 claims description 6
- 238000005204 segregation Methods 0.000 claims description 5
- 239000012535 impurity Substances 0.000 abstract description 5
- 241001092040 Crataegus Species 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 238000001914 filtration Methods 0.000 abstract description 3
- 239000012141 concentrate Substances 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 description 12
- 230000017531 blood circulation Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229930003944 flavone Natural products 0.000 description 3
- 235000011949 flavones Nutrition 0.000 description 3
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000002212 flavone derivatives Chemical class 0.000 description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
- 241000003910 Baronia <angiosperm> Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000003177 cardiotonic effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000011034 membrane dialysis Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The utility model discloses a separation and purification device of hawthorn leaf extract product, its characterized in that: include the material liquid tank who connects gradually through the pipeline, ceramic membrane separation device, roll up formula ultrafiltration membrane separation device, receive and strain membrane separation device, product jar, ceramic membrane separation device's dislysate exit linkage roll up formula ultrafiltration membrane separation device, book formula ultrafiltration membrane separation device's dislysate exit linkage receive and strain membrane separation device, receive and strain membrane separation device concentrate exit linkage product jar, ceramic membrane separation device in the ceramic membrane aperture be 50 -100nm, book formula ultrafiltration separator in roll up formula milipore filter cutting molecular weight and be 3000 -5000 dalton, receive to strain and receive the filtration membrane retention molecular weight for 150 -350 dalton among the membrane separation device. Separation and purification device of hawthorn leaf extract product, can effectively get rid of the impurity among the hawthorn extracting solution from leave, have advantages such as simple process, product purity are good, yield height.
Description
Technical field
This utility model relates to Folium Crataegi and extracts field, particularly a kind of separation and purification device of Folium Crataegi extract.
Background technology
Folium Crataegi is the dried leaves of Rosaceae Crataegus plant Fructus Pyri Pashiae or Fructus Crataegi, and Folium Crataegi is used for activating blood circulation to dissipate blood stasis, regulates the flow of vital energy and promotes blood circulation.In the Eastern Jin Dynasty " Handbook of Prescriptions for Emergencies ", just have the record of Folium Crataegi " stem and leaf liquor, washes dermatitis rhus ", the local medical material standard in Guangxi, Jiangxi is all loaded with Folium Crataegi, 2005 version " Chinese Pharmacopoeia " also formally record Folium Crataegi.Along with being widely used in Cardiovarscular in recent years, the pharmaceutical research of Folium Crataegi has had larger progress, modern pharmacology thinks Folium Crataegi energy prevention and cure of cardiovascular disease, has blood vessel dilating, increases coronary flow, improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, vessel softening and diuresis and sedation; Crataegutt also has cardiotonic, also benefits to senile heart disease; Folium Crataegi has effect of activating blood circulation to dissipate blood stasis, contributes to removing local congestion state, has auxiliary curative effect to traumatic injury.
Modern Pharmaceutical Chemistry research is thought: Folium Crataegi total flavones is the material base of Folium Crataegi cardio-cerebrovascular pharmacology effect, and along with deepening continuously of research, Folium Crataegi extract is applicable to clinical widely.Such as: Yixintong sheet etc.There is the technical problem that cost is high, general flavone content is low in the preparation method of existing Folium Crataegi extract.
Summary of the invention
For the problems referred to above, the purpose of this utility model is to provide the separation and purification device of the Folium Crataegi extract that a kind of technique is simple, good product purity, yield are high.
For achieving the above object, the technical scheme that this utility model proposes is: a kind of separation and purification device of Folium Crataegi extract, it is characterized in that: comprise the material liquid tank, ceramic membrane separation device, spiral wound membrane separation device, nanofiltration membrane separation device, the products pot that are connected successively by pipeline, the dialysis solution outlet of described ceramic membrane separation device connects spiral wound membrane separation device, the dialysis solution outlet of described spiral wound membrane separation device connects nanofiltration membrane separation device, and described nanofiltration membrane separation device concentrated solution outlet connects products pot; Ceramic membrane aperture in described ceramic membrane separation device is 50-100nm, in described spiral wound segregation apparatus, rolling ultrafiltration membrane molecular weight cut off is 3000-5000 dalton, and the NF membrane molecular cut off in described nanofiltration membrane separation device is 150-350 dalton.
Preferably, in described spiral wound segregation apparatus, rolling ultrafiltration membrane molecular weight cut off is 3500 dalton.
Adopt technique scheme, the separation and purification device of Folium Crataegi extract described in the utility model, by ceramic membrane except solid impurity, the further separation and purification of spiral wound, NF membrane are except small molecular weight impurity, effectively can remove the impurity in Folium Crataegi extracting solution, have that technique is simple, good product purity, yield advantages of higher.
Accompanying drawing explanation
Fig. 1 is the separation and purification apparatus structure schematic diagram of Folium Crataegi extract described in the utility model.
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, this utility model is described further.
As shown in Figure 1, the separation and purification device of Folium Crataegi extract described in the utility model, comprise the material liquid tank 10, ceramic membrane separation device 11, spiral wound membrane separation device 12, nanofiltration membrane separation device 13, the products pot 14 that are connected successively by pipeline, the dialysis solution outlet of described ceramic membrane separation device 11 connects spiral wound membrane separation device 12, the dialysis solution outlet of described spiral wound membrane separation device 12 connects nanofiltration membrane separation device 13, and described nanofiltration membrane separation device 13 concentrated solution outlet connects products pot 14; Ceramic membrane aperture in described ceramic membrane separation device 11 is 50-100nm, in described spiral wound segregation apparatus 12, rolling ultrafiltration membrane molecular weight cut off is 3000-5000 dalton, and the NF membrane molecular cut off in described nanofiltration membrane separation device 13 is 150-350 dalton.
During concrete use, Folium Crataegi extracting solution containing filtering residue directly enters in ceramic membrane separation device and carries out solid-liquid separation, effectively eliminate the particulate matters such as the filtering residue in extracting solution, then ceramic membrane dialysis solution enters in spiral wound membrane separation device, rolling ultrafiltration membrane molecular weight cut off is 3000-5000 dalton, in spiral wound membrane separation device, macromole impurity is retained by ultrafilter membrane, and the small organic molecule such as effective ingredient in extracting solution enters in dialysis solution through ultrafilter membrane, enter again in nanofiltration membrane separation device and go out small-molecule substance further, obtain Folium Crataegi extracting solution, Folium Crataegi extracting solution general flavone content is greater than 95.9%, yield 1.58%.
Although specifically show in conjunction with preferred embodiment and describe this utility model; but those skilled in the art should be understood that; not departing from the spirit and scope of the present utility model that appended claims limits; in the form and details this utility model is made a variety of changes, be protection domain of the present utility model.
Claims (2)
1. the separation and purification device of a Folium Crataegi extract, it is characterized in that: comprise the material liquid tank, ceramic membrane separation device, spiral wound membrane separation device, nanofiltration membrane separation device, the products pot that are connected successively by pipeline, the dialysis solution outlet of described ceramic membrane separation device connects spiral wound membrane separation device, the dialysis solution outlet of described spiral wound membrane separation device connects nanofiltration membrane separation device, and described nanofiltration membrane separation device concentrated solution outlet connects products pot; Ceramic membrane aperture in described ceramic membrane separation device is 50-100nm, in described spiral wound segregation apparatus, rolling ultrafiltration membrane molecular weight cut off is 3000-5000 dalton, and the NF membrane molecular cut off in described nanofiltration membrane separation device is 150-350 dalton.
2. the separation and purification device of a kind of Folium Crataegi extract according to claim 1, is characterized in that: in described spiral wound segregation apparatus, rolling ultrafiltration membrane molecular weight cut off is 3500 dalton.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520521211.XU CN204972334U (en) | 2015-07-19 | 2015-07-19 | Separation and purification device of hawthorn leaf extract product |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520521211.XU CN204972334U (en) | 2015-07-19 | 2015-07-19 | Separation and purification device of hawthorn leaf extract product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204972334U true CN204972334U (en) | 2016-01-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520521211.XU Active CN204972334U (en) | 2015-07-19 | 2015-07-19 | Separation and purification device of hawthorn leaf extract product |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111701338A (en) * | 2020-07-07 | 2020-09-25 | 深圳市美瑞健康科技有限公司 | Plant extract that possesses multistage filtering capability is with separation and purification device |
-
2015
- 2015-07-19 CN CN201520521211.XU patent/CN204972334U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111701338A (en) * | 2020-07-07 | 2020-09-25 | 深圳市美瑞健康科技有限公司 | Plant extract that possesses multistage filtering capability is with separation and purification device |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170908 Address after: 361026, 02, building seventh, building 1, Xiamen bio Pharmaceutical Industrial Park, 2050 West Weng Road, Haicang District, Fujian, Xiamen Patentee after: Sun tree (Xiamen) Biological Engineering Co., Ltd. Address before: 362300 Fujian city of Quanzhou province Nanan City Guan Qiao Zhen Dong tou Cun Si Jia No. 313 Patentee before: Chen Meiling |